IFNW1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNW1
Entrez Gene ID	3467
Full Name	interferon omega 1
General protein information	Preferred Names interferon omega 1 Names interferon omega-1 IFN-omega 1, interferon omega-1 interferon alpha-II-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.3
Summary	The protein encoded by this gene is an interferon and possesses antiviral activity. The encoded protein binds to the interferon alpha/beta receptor but not to the interferon gamma receptor. This intronless gene has several pseudogenes spread throughout the genome. [provided by RefSeq, Nov 2015].
Disorder MIM:	147553

mRNA and Protein(s)

mRNA	Protein	Name
NM_002177.1	NP_002168.1	interferon omega-1 precursor
NM_002177.2	NP_002168.1	interferon omega-1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IFNW1	NP_002168.1
Bos taurus (cattle)	LOC100299481	XP_002689578.2
Bos taurus (cattle)	LOC523509	XP_002689580.1
Bos taurus (cattle)	LOC618859	XP_002689570.1
Bos taurus (cattle)	LOC513706	XP_002689557.2
Bos taurus (cattle)	LOC781948	XP_002689561.1
Bos taurus (cattle)	LOC619113	XP_002689554.2
Bos taurus (cattle)	LOC100298573	XP_002689567.1
Bos taurus (cattle)	LOC781778	XP_002689563.1
Bos taurus (cattle)	LOC100298530	XP_002689566.1
Bos taurus (cattle)	LOC618801	XP_002689555.1
Bos taurus (cattle)	LOC781853	XP_005209954.1
Bos taurus (cattle)	LOC617135	XP_002689569.1
Bos taurus (cattle)	LOC100336885	XP_002684025.1
Bos taurus (cattle)	LOC618943	XP_002689576.1
Pan troglodytes (chimpanzee)	IFNW1	XP_528554.1
	IFNW1	XP_001108113.1
Bos taurus (cattle)	IFNT	NP_001161751.1
Bos taurus (cattle)	LOC617112	XP_005209955.1
Bos taurus (cattle)	IFNW1	NP_776776.1
Bos taurus (cattle)	LOC781815	XP_002707880.3
Bos taurus (cattle)	LOC618985	XP_002689573.1
Bos taurus (cattle)	LOC100847720	XP_003586413.1
Bos taurus (cattle)	IFN-TAU	NP_001232865.1

Gene Ontology
Bibliography

Related articles in PubMed

Interferon-omega: Current status in clinical applications.
Li SF, Zhao FR, Shao JJ, Xie YL, Chang HY, Zhang YG
International immunopharmacology52253-260(2017 Nov)

Structural linkage between ligand discrimination and receptor activation by type I interferons.
Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, Lee C, Yarden G, Vleck SE, Glenn JS, Nolan GP, Piehler J, Schreiber G, Garcia KC
Cell146(4)621-32(2011 Aug)

Type I interferon pathway in adult and juvenile dermatomyositis.
Baechler EC, Bilgic H, Reed AM
Arthritis research & therapy13(6)249(2011)

Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG
European journal of human genetics : EJHG18(11)1221-7(2010 Nov)

An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K
Human genetics128(4)433-41(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The crystal structures of two human type I IFN ternary signaling complexes containing IFNalpha2 and IFNomega reveal recognition modes and heterotrimeric architectures that are unique among the cytokine receptor superfamily but conserved between type I IFNs.
Title: Structural linkage between ligand discrimination and receptor activation by type I interferons.

Studies indicate that upregulation of the type I interferon protein signature has added additional markers of disease activity and insight into the pathogenesis of the disease.
Title: Type I interferon pathway in adult and juvenile dermatomyositis.

Observational study of gene-disease association. (HuGE Navigator)
Title: Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.

Observational study of gene-disease association. (HuGE Navigator)
Title: Dengue hemorrhagic fever is associated with polymorphisms in JAK1.

Observational study of gene-disease association. (HuGE Navigator)
Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.

The following IFNW1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNW1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30794	NM_002177.2 Latest version!	Homo sapiens interferon omega 1 (IFNW1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30794	NM_002177.1	Homo sapiens interferon, omega 1 (IFNW1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNW1 ( NM_002177.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_002168.1 Homo sapiens interferon, omega 1 (IFNW1), mRNA.

Price & Availability↑

CloneID	OHu30794
Clone ID Related Accession (Same CDS sequence)	NM_002177.1 , NM_002177.2
Accession Version	NM_002177.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2014-01-31
Organism	Homo sapiens(Human)
Product	interferon omega-1 precursor
Comment

ATGGCCCTCC TGTTCCCTCT ACTGGCAGCC CTAGTGATGA CCAGCTATAG CCCTGTTGGA 
TCTCTGGGCT GTGATCTGCC TCAGAACCAT GGCCTACTTA GCAGGAACAC CTTGGTGCTT 
CTGCACCAAA TGAGGAGAAT CTCCCCTTTC TTGTGTCTCA AGGACAGAAG AGACTTCAGG 
TTCCCCCAGG AGATGGTAAA AGGGAGCCAG TTGCAGAAGG CCCATGTCAT GTCTGTCCTC 
CATGAGATGC TGCAGCAGAT CTTCAGCCTC TTCCACACAG AGCGCTCCTC TGCTGCCTGG 
AACATGACCC TCCTAGACCA ACTCCACACT GGACTTCATC AGCAACTGCA ACACCTGGAG 
ACCTGCTTGC TGCAGGTAGT GGGAGAAGGA GAATCTGCTG GGGCAATTAG CAGCCCTGCA 
CTGACCTTGA GGAGGTACTT CCAGGGAATC CGTGTCTACC TGAAAGAGAA GAAATACAGC 
GACTGTGCCT GGGAAGTTGT CAGAATGGAA ATCATGAAAT CCTTGTTCTT ATCAACAAAC 
ATGCAAGAAA GACTGAGAAG TAAAGATAGA GACCTGGGCT CATCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002168.1
Translation	MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFRFPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNMTLLDQLHTGLHQQLQHLETCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTNMQERLRSKDRDLGSS

Target ORF information:

RefSeq Version	NM_002177.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens interferon, omega 1 (IFNW1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002177.1

ORF Insert Sequence:

ATGGCCCTCC TGTTCCCTCT ACTGGCAGCC CTAGTGATGA CCAGCTATAG CCCTGTTGGA 
TCTCTGGGCT GTGATCTGCC TCAGAACCAT GGCCTACTTA GCAGGAACAC CTTGGTGCTT 
CTGCACCAAA TGAGGAGAAT CTCCCCTTTC TTGTGTCTCA AGGACAGAAG AGACTTCAGG 
TTCCCCCAGG AGATGGTAAA AGGGAGCCAG TTGCAGAAGG CCCATGTCAT GTCTGTCCTC 
CATGAGATGC TGCAGCAGAT CTTCAGCCTC TTCCACACAG AGCGCTCCTC TGCTGCCTGG 
AACATGACCC TCCTAGACCA ACTCCACACT GGACTTCATC AGCAACTGCA ACACCTGGAG 
ACCTGCTTGC TGCAGGTAGT GGGAGAAGGA GAATCTGCTG GGGCAATTAG CAGCCCTGCA 
CTGACCTTGA GGAGGTACTT CCAGGGAATC CGTGTCTACC TGAAAGAGAA GAAATACAGC 
GACTGTGCCT GGGAAGTTGT CAGAATGGAA ATCATGAAAT CCTTGTTCTT ATCAACAAAC 
ATGCAAGAAA GACTGAGAAG TAAAGATAGA GACCTGGGCT CATCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IFNW1 ( NM_002177.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002168.1 Homo sapiens interferon omega 1 (IFNW1), mRNA.

Price & Availability↑

CloneID	OHu30794
Clone ID Related Accession (Same CDS sequence)	NM_002177.1 , NM_002177.2
Accession Version	NM_002177.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	interferon omega-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL390882.12, AI860608.1 and X02669.1. On Nov 24, 2015 this sequence version replaced NM_002177.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCCTCC TGTTCCCTCT ACTGGCAGCC CTAGTGATGA CCAGCTATAG CCCTGTTGGA 
TCTCTGGGCT GTGATCTGCC TCAGAACCAT GGCCTACTTA GCAGGAACAC CTTGGTGCTT 
CTGCACCAAA TGAGGAGAAT CTCCCCTTTC TTGTGTCTCA AGGACAGAAG AGACTTCAGG 
TTCCCCCAGG AGATGGTAAA AGGGAGCCAG TTGCAGAAGG CCCATGTCAT GTCTGTCCTC 
CATGAGATGC TGCAGCAGAT CTTCAGCCTC TTCCACACAG AGCGCTCCTC TGCTGCCTGG 
AACATGACCC TCCTAGACCA ACTCCACACT GGACTTCATC AGCAACTGCA ACACCTGGAG 
ACCTGCTTGC TGCAGGTAGT GGGAGAAGGA GAATCTGCTG GGGCAATTAG CAGCCCTGCA 
CTGACCTTGA GGAGGTACTT CCAGGGAATC CGTGTCTACC TGAAAGAGAA GAAATACAGC 
GACTGTGCCT GGGAAGTTGT CAGAATGGAA ATCATGAAAT CCTTGTTCTT ATCAACAAAC 
ATGCAAGAAA GACTGAGAAG TAAAGATAGA GACCTGGGCT CATCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002168.1
CDS	332..919
Translation	MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFRFPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNMTLLDQLHTGLHQQLQHLETCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTNMQERLRSKDRDLGSS

Target ORF information:

RefSeq Version	NM_002177.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon omega 1 (IFNW1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002177.2

ORF Insert Sequence:

ATGGCCCTCC TGTTCCCTCT ACTGGCAGCC CTAGTGATGA CCAGCTATAG CCCTGTTGGA 
TCTCTGGGCT GTGATCTGCC TCAGAACCAT GGCCTACTTA GCAGGAACAC CTTGGTGCTT 
CTGCACCAAA TGAGGAGAAT CTCCCCTTTC TTGTGTCTCA AGGACAGAAG AGACTTCAGG 
TTCCCCCAGG AGATGGTAAA AGGGAGCCAG TTGCAGAAGG CCCATGTCAT GTCTGTCCTC 
CATGAGATGC TGCAGCAGAT CTTCAGCCTC TTCCACACAG AGCGCTCCTC TGCTGCCTGG 
AACATGACCC TCCTAGACCA ACTCCACACT GGACTTCATC AGCAACTGCA ACACCTGGAG 
ACCTGCTTGC TGCAGGTAGT GGGAGAAGGA GAATCTGCTG GGGCAATTAG CAGCCCTGCA 
CTGACCTTGA GGAGGTACTT CCAGGGAATC CGTGTCTACC TGAAAGAGAA GAAATACAGC 
GACTGTGCCT GGGAAGTTGT CAGAATGGAA ATCATGAAAT CCTTGTTCTT ATCAACAAAC 
ATGCAAGAAA GACTGAGAAG TAAAGATAGA GACCTGGGCT CATCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interferon-omega: Current status in clinical applications.
International immunopharmacology52253-260(2017 Nov)
Li SF,Zhao FR,Shao JJ,Xie YL,Chang HY,Zhang YG

Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell146(4)621-32(2011 Aug)
Thomas C,Moraga I,Levin D,Krutzik PO,Podoplelova Y,Trejo A,Lee C,Yarden G,Vleck SE,Glenn JS,Nolan GP,Piehler J,Schreiber G,Garcia KC

Type I interferon pathway in adult and juvenile dermatomyositis.
Arthritis research & therapy13(6)249(2011)
Baechler EC,Bilgic H,Reed AM

Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
European journal of human genetics : EJHG18(11)1221-7(2010 Nov)
Silva LK,Blanton RE,Parrado AR,Melo PS,Morato VG,Reis EA,Dias JP,Castro JM,Vasconcelos PF,Goddard KA,Barreto ML,Reis MG,Teixeira MG

An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Human genetics128(4)433-41(2010 Oct)
Shimada M,Miyagawa T,Kawashima M,Tanaka S,Honda Y,Honda M,Tokunaga K

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IFNW1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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