APOC2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	APOC2
Entrez Gene ID	344
Full Name	apolipoprotein C2
Synonyms	APO-CII,APOC-II
General protein information	Preferred Names apolipoprotein C2 Names apolipoprotein C-II
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.32
Summary	This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011].
Disorder MIM:	608083
Disorder Html:	Hyperlipoproteinemia, type Ib, 207750 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000483.4	NP_000474.2	apolipoprotein C-II precursor
NM_000483.5	NP_000474.2	apolipoprotein C-II precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	APOC2	NP_000474.2
	APOC2	XP_002801531.1
Rattus norvegicus (Norway rat)	Apoc2	NP_001078821.1
Canis lupus familiaris (dog)	APOC2	NP_001003368.1
Bos taurus (cattle)	APOC2	NP_001095850.1
Mus musculus (house mouse)	Apoc2	NP_001264873.1
Pan troglodytes (chimpanzee)	APOC2	NP_001230828.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus.
Allan CM, Walker D, Segrest JP, Taylor JM
Genomics28(2)291-300(1995 Jul)

Human apolipoprotein C-II: complete nucleic acid sequence of preapolipoprotein C-II.
Fojo SS, Law SW, Brewer HB Jr
Proceedings of the National Academy of Sciences of the United States of America81(20)6354-7(1984 Oct)

The isolation and characterization of cDNA clones for human apolipoprotein CII.
Myklebost O, Williamson B, Markham AF, Myklebost SR, Rogers J, Woods DE, Humphries SE
The Journal of biological chemistry259(7)4401-4(1984 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Triglyceride-raising variant alleles of the APOC2 encoding apo C-II, associated with clinical Cardiovascular endpoints.
Title: Genetics of Triglycerides and the Risk of Atherosclerosis.

The results demonstrate the important role of both intra- and inter-subunit charge interactions in stabilizing apoC-II amyloid fibrils, a process that may be a key factor in determining the general ability of proteins to form amyloid fibrils.
Title: Intra- and Intersubunit Ion-Pair Interactions Determine the Ability of Apolipoprotein C-II Mutants To Form Hybrid Amyloid Fibrils.

The results highlight the importance of charge-pair interactions within the apoC-II fibril core
Title: Hydrogen/Deuterium Exchange and Molecular Dynamics Analysis of Amyloid Fibrils Formed by a D69K Charge-Pair Mutant of Human Apolipoprotein C-II.

Conformational rearrangement of apoC-II at lipoprotein surfaces promotes interaction with LPL.
Title: A Pressure-dependent Model for the Regulation of Lipoprotein Lipase by Apolipoprotein C-II.

Large deletion in APOC2 caused by Alu-Alu homologous recombination is associated with with apolipoprotein C-II deficiency.
Title: Apolipoprotein C-II Tuzla: a novel large deletion in APOC2 caused by Alu-Alu homologous recombination in an infant with apolipoprotein C-II deficiency.

The following APOC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APOC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18281	NM_000483.5 Latest version!	Homo sapiens apolipoprotein C2 (APOC2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18281	NM_000483.4	Homo sapiens apolipoprotein C2 (APOC2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

APOC2 ( NM_000483.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000474.2 Homo sapiens apolipoprotein C2 (APOC2), mRNA.

Price & Availability↑

CloneID	OHu18281
Clone ID Related Accession (Same CDS sequence)	NM_000483.4 , NM_000483.5
Accession Version	NM_000483.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	apolipoprotein C-II precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU596546.1 and AA883870.1. This sequence is a reference standard in the RefSeqGene project. On Mar 10, 2011 this sequence version replaced NM_000483.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU149562.1, ERR279861.395.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGCACAC GACTCCTCCC AGCTCTGTTT CTTGTCCTCC TGGTATTGGG ATTTGAGGTC 
CAGGGGACCC AACAGCCCCA GCAAGATGAG ATGCCTAGCC CGACCTTCCT CACCCAGGTG 
AAGGAATCTC TCTCCAGTTA CTGGGAGTCA GCAAAGACAG CCGCCCAGAA CCTGTACGAG 
AAGACATACC TGCCCGCTGT AGATGAGAAA CTCAGGGACT TGTACAGCAA AAGCACAGCA 
GCCATGAGCA CTTACACAGG CATTTTTACT GACCAAGTTC TTTCTGTGCT GAAGGGAGAG 
GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000474.2
CDS	108..413
Translation	MGTRLLPALFLVLLVLGFEVQGTQQPQQDEMPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE

Target ORF information:

RefSeq Version	NM_000483.4
Organism	Homo sapiens(human)
Definition	Homo sapiens apolipoprotein C2 (APOC2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000483.4

ORF Insert Sequence:

ATGGGCACAC GACTCCTCCC AGCTCTGTTT CTTGTCCTCC TGGTATTGGG ATTTGAGGTC 
CAGGGGACCC AACAGCCCCA GCAAGATGAG ATGCCTAGCC CGACCTTCCT CACCCAGGTG 
AAGGAATCTC TCTCCAGTTA CTGGGAGTCA GCAAAGACAG CCGCCCAGAA CCTGTACGAG 
AAGACATACC TGCCCGCTGT AGATGAGAAA CTCAGGGACT TGTACAGCAA AAGCACAGCA 
GCCATGAGCA CTTACACAGG CATTTTTACT GACCAAGTTC TTTCTGTGCT GAAGGGAGAG 
GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APOC2 ( NM_000483.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000474.2 Homo sapiens apolipoprotein C2 (APOC2), mRNA.

Price & Availability↑

CloneID	OHu18281
Clone ID Related Accession (Same CDS sequence)	NM_000483.4 , NM_000483.5
Accession Version	NM_000483.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	apolipoprotein C-II precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU596546.1 and AA883870.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_000483.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138522.323648.1, DRR138522.1680542.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCACAC GACTCCTCCC AGCTCTGTTT CTTGTCCTCC TGGTATTGGG ATTTGAGGTC 
CAGGGGACCC AACAGCCCCA GCAAGATGAG ATGCCTAGCC CGACCTTCCT CACCCAGGTG 
AAGGAATCTC TCTCCAGTTA CTGGGAGTCA GCAAAGACAG CCGCCCAGAA CCTGTACGAG 
AAGACATACC TGCCCGCTGT AGATGAGAAA CTCAGGGACT TGTACAGCAA AAGCACAGCA 
GCCATGAGCA CTTACACAGG CATTTTTACT GACCAAGTTC TTTCTGTGCT GAAGGGAGAG 
GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000474.2
CDS	39..344
Translation	MGTRLLPALFLVLLVLGFEVQGTQQPQQDEMPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE

Target ORF information:

RefSeq Version	NM_000483.5
Organism	Homo sapiens(human)
Definition	Homo sapiens apolipoprotein C2 (APOC2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000483.5

ORF Insert Sequence:

ATGGGCACAC GACTCCTCCC AGCTCTGTTT CTTGTCCTCC TGGTATTGGG ATTTGAGGTC 
CAGGGGACCC AACAGCCCCA GCAAGATGAG ATGCCTAGCC CGACCTTCCT CACCCAGGTG 
AAGGAATCTC TCTCCAGTTA CTGGGAGTCA GCAAAGACAG CCGCCCAGAA CCTGTACGAG 
AAGACATACC TGCCCGCTGT AGATGAGAAA CTCAGGGACT TGTACAGCAA AAGCACAGCA 
GCCATGAGCA CTTACACAGG CATTTTTACT GACCAAGTTC TTTCTGTGCT GAAGGGAGAG 
GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus.
Genomics28(2)291-300(1995 Jul)
Allan CM,Walker D,Segrest JP,Taylor JM

Human apolipoprotein C-II: complete nucleic acid sequence of preapolipoprotein C-II.
Proceedings of the National Academy of Sciences of the United States of America81(20)6354-7(1984 Oct)
Fojo SS,Law SW,Brewer HB Jr

The isolation and characterization of cDNA clones for human apolipoprotein CII.
The Journal of biological chemistry259(7)4401-4(1984 Apr)
Myklebost O,Williamson B,Markham AF,Myklebost SR,Rogers J,Woods DE,Humphries SE

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APOC2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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