RFPL4A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RFPL4A
Entrez Gene ID	342931
Full Name	ret finger protein like 4A
Synonyms	RFPL4,RNF210
General protein information	Preferred Names ret finger protein like 4A Names ret finger protein-like 4A RING finger protein 210 ret finger protein-like 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.42
Disorder MIM:	612601

mRNA and Protein(s)

mRNA	Protein	Name
XM_011526915.3	XP_011525217.1	ret finger protein-like 4A isoform X1
XM_011526915.2	XP_011525217.1	ret finger protein-like 4A isoform X1
NM_001145014.1	NP_001138486.1	ret finger protein-like 4A

Pathways from BioSystems

Homologies

Homo sapiens (human)	RFPL4A	NP_001138486.1
Homo sapiens (human)	RFPL4AL1	NP_001264326.1
	LOC703723	XP_001092037.2

Gene Ontology
Bibliography

Related articles in PubMed

RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells.
Naito A, Yamamoto H, Kagawa Y, Naito Y, Okuzaki D, Otani K, Iwamoto Y, Maeda S, Kikuta J, Nishikawa K, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Ishii H, Doki Y, Mori M, Ishii M
The Journal of biological chemistry290(10)6326-37(2015 Mar)

Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
, ,
The American journal of psychiatry170(2)207-17(2013 Feb)

Structure of the PRYSPRY-domain: implications for autoinflammatory diseases.
Gr?tter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Gr?tter MG
FEBS letters580(1)99-106(2006 Jan)

The DNA sequence and biology of human chromosome 19.
Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM
Nature428(6982)529-35(2004 Apr)

The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.
Rajkovic A, Lee JH, Yan C, Matzuk MM
Mechanisms of development112(1-2)173-7(2002 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate that RFPL4A is a novel factor that increases the G1 population and decreases sensitivity to chemotherapy and thus may be a promising therapeutic target for refractory tumor conditions.
Title: RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.
Title: The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.

The following RFPL4A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RFPL4A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31620	NM_001145014.1 Latest version!	Homo sapiens ret finger protein like 4A (RFPL4A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu79410	XM_011526915.3 Latest version!	Homo sapiens ret finger protein like 4A (RFPL4A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu79410	XM_011526915.2	Homo sapiens ret finger protein like 4A (RFPL4A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RFPL4A ( NM_001145014.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138486.1 Homo sapiens ret finger protein like 4A (RFPL4A), mRNA.

Price & Availability↑

CloneID	OHu31620
Clone ID Related Accession (Same CDS sequence)	NM_001145014.1
Accession Version	NM_001145014.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	ret finger protein-like 4A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC008749.6. On or before Feb 5, 2009 this sequence version replaced XM_001718457.1, XM_292796.5, XM_001719234.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CA454993.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGGCTGAGC ACTTCAAACA GATCATTAGA TGTCCTGTCT GTCTAAAAGA TCTTGAAGAA 
GCCGTGCAAC TGAAATGTGG ATATGCCTGC TGCCTCCAGT GCCTCAATTC ACTCCAGAAG 
GAGCCCGATG GGGAAGGTTT ACTGTGCCGT TTCTGCTCTG TGGTCTCTCA GAAGGATGAC 
ATCAAGCCCA AGTACAAGCT GAGGGCGCTG GTTTCCATCA TCAAGGAACT AGAGCCCAAG 
CTGAAATCTG TTCTAACAAT GAACCCAAGG ATGAGGAAGT TTCAAGTGGA TATGACGTTC 
GATGTGGACA CAGCCAACAA CTATCTCATC ATTTCTGAAG ACCTGAGGAG TTTCCGAAGT 
GGGGATTTGA GCCAGAATAG GAAGGAGCAA GCTGAGAGGT TCGACACTGC CCTGTGCGTC 
CTGGGCACCC CTCGCTTCAC TTCCGGCCGC CATTACTGGG AGGTGGACGT GGGCACCAGC 
CAAGTGTGGG ATGTGGGCGT GTGCAAGGAA TCTGTGAACC GACAGGGGAA GATTGTGCTT 
TCTTCAGAAC ACGGCTTCTT GACTGTGGGT TGCAGAGAAG GAAAGGTCTT TGCTGCCAGC 
ACTGTGCCTA TGACTCCTCT CTGGGTGAGT CCCCAGTTGC ACAGAGTGGG GATTTTCCTG 
GATGTAGGTA TGAGGTCCAT TGCCTTTTAC AATGTTAGTG ATGGGTGCCA TATCTACACA 
TTCATCGAGA TTCCTGTTTG CGAGCCCTGG CGTCCATTTT TTGCTCATAA ACGTGGAAGT 
CAAGATGATC AGAGCATCCT GAGTATCTGT TCTGTGATCA ATCCATCCGC TGCCAGTGCC 
CCAGTTTCTT CTGAGGGAAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138486.1
CDS	45..908
Translation	MAEHFKQIIRCPVCLKDLEEAVQLKCGYACCLQCLNSLQKEPDGEGLLCRFCSVVSQKDDIKPKYKLRALVSIIKELEPKLKSVLTMNPRMRKFQVDMTFDVDTANNYLIISEDLRSFRSGDLSQNRKEQAERFDTALCVLGTPRFTSGRHYWEVDVGTSQVWDVGVCKESVNRQGKIVLSSEHGFLTVGCREGKVFAASTVPMTPLWVSPQLHRVGIFLDVGMRSIAFYNVSDGCHIYTFIEIPVCEPWRPFFAHKRGSQDDQSILSICSVINPSAASAPVSSEGK

Target ORF information:

RefSeq Version	NM_001145014.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ret finger protein like 4A (RFPL4A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145014.1

ORF Insert Sequence:

ATGGCTGAGC ACTTCAAACA GATCATTAGA TGTCCTGTCT GTCTAAAAGA TCTTGAAGAA 
GCCGTGCAAC TGAAATGTGG ATATGCCTGC TGCCTCCAGT GCCTCAATTC ACTCCAGAAG 
GAGCCCGATG GGGAAGGTTT ACTGTGCCGT TTCTGCTCTG TGGTCTCTCA GAAGGATGAC 
ATCAAGCCCA AGTACAAGCT GAGGGCGCTG GTTTCCATCA TCAAGGAACT AGAGCCCAAG 
CTGAAATCTG TTCTAACAAT GAACCCAAGG ATGAGGAAGT TTCAAGTGGA TATGACGTTC 
GATGTGGACA CAGCCAACAA CTATCTCATC ATTTCTGAAG ACCTGAGGAG TTTCCGAAGT 
GGGGATTTGA GCCAGAATAG GAAGGAGCAA GCTGAGAGGT TCGACACTGC CCTGTGCGTC 
CTGGGCACCC CTCGCTTCAC TTCCGGCCGC CATTACTGGG AGGTGGACGT GGGCACCAGC 
CAAGTGTGGG ATGTGGGCGT GTGCAAGGAA TCTGTGAACC GACAGGGGAA GATTGTGCTT 
TCTTCAGAAC ACGGCTTCTT GACTGTGGGT TGCAGAGAAG GAAAGGTCTT TGCTGCCAGC 
ACTGTGCCTA TGACTCCTCT CTGGGTGAGT CCCCAGTTGC ACAGAGTGGG GATTTTCCTG 
GATGTAGGTA TGAGGTCCAT TGCCTTTTAC AATGTTAGTG ATGGGTGCCA TATCTACACA 
TTCATCGAGA TTCCTGTTTG CGAGCCCTGG CGTCCATTTT TTGCTCATAA ACGTGGAAGT 
CAAGATGATC AGAGCATCCT GAGTATCTGT TCTGTGATCA ATCCATCCGC TGCCAGTGCC 
CCAGTTTCTT CTGAGGGAAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RFPL4A ( XM_011526915.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525217.1 Homo sapiens ret finger protein like 4A (RFPL4A), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu79410
Clone ID Related Accession (Same CDS sequence)	XM_011526915.3 , XM_011526915.2
Accession Version	XM_011526915.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ret finger protein-like 4A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011526915.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAATCAG AATCTGATTG GATTAAAAAG GAGGGAAAGG GTGTGGCTAA GGTGGGTGGA 
GACACCCTCT GGTATAAAAG CCCCTGGCAG GCAGCTCTCA CTCCAGATCT GAGCTGTCCG 
CAGAAGCAGC TGGAGGCCAG GGGAGAAACT CCAGAAGGAG AGACATTTGC CATGGCTGAG 
CACTTCAAAC AGATCATTAG ATGTCCTGTC TGTCTAAAAG ATCTTGAAGA AGCCGTGCAA 
CTGAAATGTG GATATGCCTG CTGCCTCCAG TGCCTCAATT CACTCCAGAA GGAGCCCGAT 
GGGGAAGGTT TACTGTGCCG TTTCTGCTCT GTGGTCTCTC AGAAGGATGA CATCAAGCCC 
AAGTACAAGC TGAGGGCGCT GGTTTCCATC ATCAAGGAAC TAGAGCCCAA GCTGAAATCT 
GTTCTAACAA TGAACCCAAG GATGAGGAAG TTTCAAGTGG ATATGACGTT CGATGTGGAC 
ACAGCCAACA ACTATCTCAT CATTTCTGAA GACCTGAGGA GTTTCCGAAG TGGGGATTTG 
AGCCAGAATA GGAAGGAGCA AGCTGAGAGG TTCGACACTG CCCTGTGCGT CCTGGGCACC 
CCTCGCTTCA CTTCCGGCCG CCATTACTGG GAGGTGGACG TGGGCACCAG CCAAGTGTGG 
GATGTGGGCG TGTGCAAGGA ATCTGTGAAC CGACAGGGGA AGATTGTGCT TTCTTCAGAA 
CACGGCTTCT TGACTGTGGG TTGCAGAGAA GGAAAGGTCT TTGCTGCCAG CACTGTGCCT 
ATGACTCCTC TCTGGGTGAG TCCCCAGTTG CACAGAGTGG GGATTTTCCT GGATGTAGGT 
ATGAGGTCCA TTGCCTTTTA CAATGTTAGT GATGGGTGCC ATATCTACAC ATTCATCGAG 
ATTCCTGTTT GCGAGCCCTG GCGTCCATTT TTTGCTCATA AACGTGGAAG TCAAGATGAT 
CAGAGCATCC TGAGTATCTG TTCTGTGATC AATCCATCCG CTGCCAGTGC CCCAGTTTCT 
TCTGAGGGAA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525217.1
CDS	1162..2196
Translation	MKSESDWIKKEGKGVAKVGGDTLWYKSPWQAALTPDLSCPQKQLEARGETPEGETFAMAEHFKQIIRCPVCLKDLEEAVQLKCGYACCLQCLNSLQKEPDGEGLLCRFCSVVSQKDDIKPKYKLRALVSIIKELEPKLKSVLTMNPRMRKFQVDMTFDVDTANNYLIISEDLRSFRSGDLSQNRKEQAERFDTALCVLGTPRFTSGRHYWEVDVGTSQVWDVGVCKESVNRQGKIVLSSEHGFLTVGCREGKVFAASTVPMTPLWVSPQLHRVGIFLDVGMRSIAFYNVSDGCHIYTFIEIPVCEPWRPFFAHKRGSQDDQSILSICSVINPSAASAPVSSEGK

Target ORF information:

RefSeq Version	XM_011526915.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ret finger protein like 4A (RFPL4A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526915.3

ORF Insert Sequence:

ATGAAATCAG AATCTGATTG GATTAAAAAG GAGGGAAAGG GTGTGGCTAA GGTGGGTGGA 
GACACCCTCT GGTATAAAAG CCCCTGGCAG GCAGCTCTCA CTCCAGATCT GAGCTGTCCG 
CAGAAGCAGC TGGAGGCCAG GGGAGAAACT CCAGAAGGAG AGACATTTGC CATGGCTGAG 
CACTTCAAAC AGATCATTAG ATGTCCTGTC TGTCTAAAAG ATCTTGAAGA AGCCGTGCAA 
CTGAAATGTG GATATGCCTG CTGCCTCCAG TGCCTCAATT CACTCCAGAA GGAGCCCGAT 
GGGGAAGGTT TACTGTGCCG TTTCTGCTCT GTGGTCTCTC AGAAGGATGA CATCAAGCCC 
AAGTACAAGC TGAGGGCGCT GGTTTCCATC ATCAAGGAAC TAGAGCCCAA GCTGAAATCT 
GTTCTAACAA TGAACCCAAG GATGAGGAAG TTTCAAGTGG ATATGACGTT CGATGTGGAC 
ACAGCCAACA ACTATCTCAT CATTTCTGAA GACCTGAGGA GTTTCCGAAG TGGGGATTTG 
AGCCAGAATA GGAAGGAGCA AGCTGAGAGG TTCGACACTG CCCTGTGCGT CCTGGGCACC 
CCTCGCTTCA CTTCCGGCCG CCATTACTGG GAGGTGGACG TGGGCACCAG CCAAGTGTGG 
GATGTGGGCG TGTGCAAGGA ATCTGTGAAC CGACAGGGGA AGATTGTGCT TTCTTCAGAA 
CACGGCTTCT TGACTGTGGG TTGCAGAGAA GGAAAGGTCT TTGCTGCCAG CACTGTGCCT 
ATGACTCCTC TCTGGGTGAG TCCCCAGTTG CACAGAGTGG GGATTTTCCT GGATGTAGGT 
ATGAGGTCCA TTGCCTTTTA CAATGTTAGT GATGGGTGCC ATATCTACAC ATTCATCGAG 
ATTCCTGTTT GCGAGCCCTG GCGTCCATTT TTTGCTCATA AACGTGGAAG TCAAGATGAT 
CAGAGCATCC TGAGTATCTG TTCTGTGATC AATCCATCCG CTGCCAGTGC CCCAGTTTCT 
TCTGAGGGAA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RFPL4A ( XM_011526915.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011525217.1 Homo sapiens ret finger protein like 4A (RFPL4A), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu79410
Clone ID Related Accession (Same CDS sequence)	XM_011526915.3 , XM_011526915.2
Accession Version	XM_011526915.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	ret finger protein-like 4A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011526915.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAATCAG AATCTGATTG GATTAAAAAG GAGGGAAAGG GTGTGGCTAA GGTGGGTGGA 
GACACCCTCT GGTATAAAAG CCCCTGGCAG GCAGCTCTCA CTCCAGATCT GAGCTGTCCG 
CAGAAGCAGC TGGAGGCCAG GGGAGAAACT CCAGAAGGAG AGACATTTGC CATGGCTGAG 
CACTTCAAAC AGATCATTAG ATGTCCTGTC TGTCTAAAAG ATCTTGAAGA AGCCGTGCAA 
CTGAAATGTG GATATGCCTG CTGCCTCCAG TGCCTCAATT CACTCCAGAA GGAGCCCGAT 
GGGGAAGGTT TACTGTGCCG TTTCTGCTCT GTGGTCTCTC AGAAGGATGA CATCAAGCCC 
AAGTACAAGC TGAGGGCGCT GGTTTCCATC ATCAAGGAAC TAGAGCCCAA GCTGAAATCT 
GTTCTAACAA TGAACCCAAG GATGAGGAAG TTTCAAGTGG ATATGACGTT CGATGTGGAC 
ACAGCCAACA ACTATCTCAT CATTTCTGAA GACCTGAGGA GTTTCCGAAG TGGGGATTTG 
AGCCAGAATA GGAAGGAGCA AGCTGAGAGG TTCGACACTG CCCTGTGCGT CCTGGGCACC 
CCTCGCTTCA CTTCCGGCCG CCATTACTGG GAGGTGGACG TGGGCACCAG CCAAGTGTGG 
GATGTGGGCG TGTGCAAGGA ATCTGTGAAC CGACAGGGGA AGATTGTGCT TTCTTCAGAA 
CACGGCTTCT TGACTGTGGG TTGCAGAGAA GGAAAGGTCT TTGCTGCCAG CACTGTGCCT 
ATGACTCCTC TCTGGGTGAG TCCCCAGTTG CACAGAGTGG GGATTTTCCT GGATGTAGGT 
ATGAGGTCCA TTGCCTTTTA CAATGTTAGT GATGGGTGCC ATATCTACAC ATTCATCGAG 
ATTCCTGTTT GCGAGCCCTG GCGTCCATTT TTTGCTCATA AACGTGGAAG TCAAGATGAT 
CAGAGCATCC TGAGTATCTG TTCTGTGATC AATCCATCCG CTGCCAGTGC CCCAGTTTCT 
TCTGAGGGAA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525217.1
CDS	1162..2196
Translation	MKSESDWIKKEGKGVAKVGGDTLWYKSPWQAALTPDLSCPQKQLEARGETPEGETFAMAEHFKQIIRCPVCLKDLEEAVQLKCGYACCLQCLNSLQKEPDGEGLLCRFCSVVSQKDDIKPKYKLRALVSIIKELEPKLKSVLTMNPRMRKFQVDMTFDVDTANNYLIISEDLRSFRSGDLSQNRKEQAERFDTALCVLGTPRFTSGRHYWEVDVGTSQVWDVGVCKESVNRQGKIVLSSEHGFLTVGCREGKVFAASTVPMTPLWVSPQLHRVGIFLDVGMRSIAFYNVSDGCHIYTFIEIPVCEPWRPFFAHKRGSQDDQSILSICSVINPSAASAPVSSEGK

Target ORF information:

RefSeq Version	XM_011526915.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ret finger protein like 4A (RFPL4A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526915.2

ORF Insert Sequence:

ATGAAATCAG AATCTGATTG GATTAAAAAG GAGGGAAAGG GTGTGGCTAA GGTGGGTGGA 
GACACCCTCT GGTATAAAAG CCCCTGGCAG GCAGCTCTCA CTCCAGATCT GAGCTGTCCG 
CAGAAGCAGC TGGAGGCCAG GGGAGAAACT CCAGAAGGAG AGACATTTGC CATGGCTGAG 
CACTTCAAAC AGATCATTAG ATGTCCTGTC TGTCTAAAAG ATCTTGAAGA AGCCGTGCAA 
CTGAAATGTG GATATGCCTG CTGCCTCCAG TGCCTCAATT CACTCCAGAA GGAGCCCGAT 
GGGGAAGGTT TACTGTGCCG TTTCTGCTCT GTGGTCTCTC AGAAGGATGA CATCAAGCCC 
AAGTACAAGC TGAGGGCGCT GGTTTCCATC ATCAAGGAAC TAGAGCCCAA GCTGAAATCT 
GTTCTAACAA TGAACCCAAG GATGAGGAAG TTTCAAGTGG ATATGACGTT CGATGTGGAC 
ACAGCCAACA ACTATCTCAT CATTTCTGAA GACCTGAGGA GTTTCCGAAG TGGGGATTTG 
AGCCAGAATA GGAAGGAGCA AGCTGAGAGG TTCGACACTG CCCTGTGCGT CCTGGGCACC 
CCTCGCTTCA CTTCCGGCCG CCATTACTGG GAGGTGGACG TGGGCACCAG CCAAGTGTGG 
GATGTGGGCG TGTGCAAGGA ATCTGTGAAC CGACAGGGGA AGATTGTGCT TTCTTCAGAA 
CACGGCTTCT TGACTGTGGG TTGCAGAGAA GGAAAGGTCT TTGCTGCCAG CACTGTGCCT 
ATGACTCCTC TCTGGGTGAG TCCCCAGTTG CACAGAGTGG GGATTTTCCT GGATGTAGGT 
ATGAGGTCCA TTGCCTTTTA CAATGTTAGT GATGGGTGCC ATATCTACAC ATTCATCGAG 
ATTCCTGTTT GCGAGCCCTG GCGTCCATTT TTTGCTCATA AACGTGGAAG TCAAGATGAT 
CAGAGCATCC TGAGTATCTG TTCTGTGATC AATCCATCCG CTGCCAGTGC CCCAGTTTCT 
TCTGAGGGAA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells.
The Journal of biological chemistry290(10)6326-37(2015 Mar)
Naito A,Yamamoto H,Kagawa Y,Naito Y,Okuzaki D,Otani K,Iwamoto Y,Maeda S,Kikuta J,Nishikawa K,Uemura M,Nishimura J,Hata T,Takemasa I,Mizushima T,Ishii H,Doki Y,Mori M,Ishii M

Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
The American journal of psychiatry170(2)207-17(2013 Feb)
,,

Structure of the PRYSPRY-domain: implications for autoinflammatory diseases.
FEBS letters580(1)99-106(2006 Jan)
Gr?tter C,Briand C,Capitani G,Mittl PR,Papin S,Tschopp J,Gr?tter MG

The DNA sequence and biology of human chromosome 19.
Nature428(6982)529-35(2004 Apr)
Grimwood J,Gordon LA,Olsen A,Terry A,Schmutz J,Lamerdin J,Hellsten U,Goodstein D,Couronne O,Tran-Gyamfi M,Aerts A,Altherr M,Ashworth L,Bajorek E,Black S,Branscomb E,Caenepeel S,Carrano A,Caoile C,Chan YM,Christensen M,Cleland CA,Copeland A,Dalin E,Dehal P,Denys M,Detter JC,Escobar J,Flowers D,Fotopulos D,Garcia C,Georgescu AM,Glavina T,Gomez M,Gonzales E,Groza M,Hammon N,Hawkins T,Haydu L,Ho I,Huang W,Israni S,Jett J,Kadner K,Kimball H,Kobayashi A,Larionov V,Leem SH,Lopez F,Lou Y,Lowry S,Malfatti S,Martinez D,McCready P,Medina C,Morgan J,Nelson K,Nolan M,Ovcharenko I,Pitluck S,Pollard M,Popkie AP,Predki P,Quan G,Ramirez L,Rash S,Retterer J,Rodriguez A,Rogers S,Salamov A,Salazar A,She X,Smith D,Slezak T,Solovyev V,Thayer N,Tice H,Tsai M,Ustaszewska A,Vo N,Wagner M,Wheeler J,Wu K,Xie G,Yang J,Dubchak I,Furey TS,DeJong P,Dickson M,Gordon D,Eichler EE,Pennacchio LA,Richardson P,Stubbs L,Rokhsar DS,Myers RM,Rubin EM,Lucas SM

The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.
Mechanisms of development112(1-2)173-7(2002 Mar)
Rajkovic A,Lee JH,Yan C,Matzuk MM

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RFPL4A cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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