SERPIND1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SERPIND1
Entrez Gene ID	3053
Full Name	serpin family D member 1
Synonyms	D22S673,HC2,HCF2,HCII,HLS2,LS2,THPH10
General protein information	Preferred Names serpin family D member 1 Names heparin cofactor 2 leuserpin 2 protease inhibitor leuserpin-2 serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 serpin D1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q11.21
Summary	This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015].
Disorder MIM:	142360
Disorder Html:	Thrombophilia due to heparin cofactor II deficiency, 612356 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000185.3	NP_000176.2	heparin cofactor 2 precursor
NM_000185.4	NP_000176.2	heparin cofactor 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SERPIND1	NP_000176.2
Bos taurus (cattle)	SERPIND1	NP_001098516.1
	SERPIND1	XP_001086464.1
Pan troglodytes (chimpanzee)	SERPIND1	XP_001167967.1
Rattus norvegicus (Norway rat)	Serpind1	NP_077358.1
Mus musculus (house mouse)	Serpind1	NP_032249.3

Gene Ontology
Bibliography

Related articles in PubMed

The Role of Heparin Cofactor ? in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice.
Kurahashi K, Inoue S, Yoshida S, Ikeda Y, Morimoto K, Uemoto R, Ishikawa K, Kondo T, Yuasa T, Endo I, Miyake M, Oyadomari S, Matsumoto T, Abe M, Sakaue H, Aihara KI
Journal of atherosclerosis and thrombosis24(12)1215-1230(2017 Dec)

Alpha-2-macroglobulin and heparin cofactor II and the vulnerability of carotid atherosclerotic plaques: An iTRAQ-based analysis.
Li J, Liu X, Xiang Y, Ding X, Wang T, Liu Y, Yin M, Tan C, Deng F, Chen L
Biochemical and biophysical research communications483(3)964-971(2017 02)

Analysis of the gene expression profile in response to human epididymis protein 4 in epithelial ovarian cancer cells.
Zhu L, Guo Q, Jin S, Feng H, Zhuang H, Liu C, Tan M, Liu J, Li X, Lin B
Oncology reports36(3)1592-604(2016 Sep)

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M
Cardiovascular research110(3)419-30(2016 06)

Heparin co-factor II enhances cell motility and promotes metastasis in non-small cell lung cancer.
Liao WY, Ho CC, Hou HH, Hsu TH, Tsai MF, Chen KY, Chen HY, Lee YC, Yu CJ, Lee CH, Yang PC
The Journal of pathology235(1)50-64(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The plasma level of alpha2M was found positively correlated, while HCII level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII may be potential biomarkers for evaluation of the vulnerability of carotid ...
Title: Alpha-2-macroglobulin and heparin cofactor II and the vulnerability of carotid atherosclerotic plaques: An iTRAQ-based analysis.

We found that SERPIND1 may act as a potential oncogene in the development of ovarian cancer
Title: Analysis of the gene expression profile in response to human epididymis protein 4 in epithelial ovarian cancer cells.

heparin co-factor II is a novel metastasis enhancer and may be used as a prognostic predictor for heparin treatment in non-small cell lung cancer
Title: Heparin co-factor II enhances cell motility and promotes metastasis in non-small cell lung cancer.

In this study, we demonstrate a previously unknown role for HCII in host defense.
Title: Proteolytic activation transforms heparin cofactor II into a host defense molecule.

Molecular modelling of HCII 1-75 predicted those portions of the acidic extension that had been previously visualized in crystal structures, and suggested that an alpha-helix found between residues 26 and 36 stabilizes one found between residues 61-67.
Title: The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand.

The following SERPIND1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SERPIND1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22804	NM_000185.4 Latest version!	Homo sapiens serpin family D member 1 (SERPIND1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu22804	NM_000185.3	Homo sapiens serpin family D member 1 (SERPIND1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SERPIND1 ( NM_000185.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000176.2 Homo sapiens serpin family D member 1 (SERPIND1), mRNA.

Price & Availability↑

CloneID	OHu22804
Clone ID Related Accession (Same CDS sequence)	NM_000185.3 , NM_000185.4
Accession Version	NM_000185.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1500bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	heparin cofactor 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP237845.1, AC007308.13 and BC035028.2. This sequence is a reference standard in the RefSeqGene project. On Aug 29, 2005 this sequence version replaced NM_000185.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035028.2, SRR1803613.60943.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAAACACT CATTAAACGC ACTTCTCATT TTCCTCATCA TAACATCTGC GTGGGGTGGG 
AGCAAAGGCC CGCTGGATCA GCTAGAGAAA GGAGGGGAAA CTGCTCAGTC TGCAGATCCC 
CAGTGGGAGC AGTTAAATAA CAAAAACCTG AGCATGCCTC TTCTCCCTGC CGACTTCCAC 
AAGGAAAACA CCGTCACCAA CGACTGGATT CCAGAGGGGG AGGAGGACGA CGACTATCTG 
GACCTGGAGA AGATATTCAG TGAAGACGAC GACTACATCG ACATCGTCGA CAGTCTGTCA 
GTTTCCCCGA CAGACTCTGA TGTGAGTGCT GGGAACATCC TCCAGCTTTT TCATGGCAAG 
AGCCGGATCC AGCGTCTTAA CATCCTCAAC GCCAAGTTCG CTTTCAACCT CTACCGAGTG 
CTGAAAGACC AGGTCAACAC TTTCGATAAC ATCTTCATAG CACCCGTTGG CATTTCTACT 
GCGATGGGTA TGATTTCCTT AGGTCTGAAG GGAGAGACCC ATGAACAAGT GCACTCGATT 
TTGCATTTTA AAGACTTTGT TAATGCCAGC AGCAAGTATG AAATCACGAC CATTCATAAT 
CTCTTCCGTA AGCTGACTCA TCGCCTCTTC AGGAGGAATT TTGGGTACAC ACTGCGGTCA 
GTCAATGACC TTTATATCCA GAAGCAGTTT CCAATCCTGC TTGACTTCAA AACTAAAGTA 
AGAGAGTATT ACTTTGCTGA GGCCCAGATA GCTGACTTCT CAGACCCTGC CTTCATATCA 
AAAACCAACA ACCACATCAT GAAGCTCACC AAGGGCCTCA TAAAAGATGC TCTGGAGAAT 
ATAGACCCTG CTACCCAGAT GATGATTCTC AACTGCATCT ACTTCAAAGG ATCCTGGGTG 
AATAAATTCC CAGTGGAAAT GACACACAAC CACAACTTCC GGCTGAATGA GAGAGAGGTA 
GTTAAGGTTT CCATGATGCA GACCAAGGGG AACTTCCTCG CAGCAAATGA CCAGGAGCTG 
GACTGCGACA TCCTCCAGCT GGAATACGTG GGGGGCATCA GCATGCTAAT TGTGGTCCCA 
CACAAGATGT CTGGGATGAA GACCCTCGAA GCGCAACTGA CACCCCGGGT GGTGGAGAGA 
TGGCAAAAAA GCATGACAAA CAGAACTCGA GAAGTGCTTC TGCCGAAATT CAAGCTGGAG 
AAGAACTACA ATCTAGTGGA GTCCCTGAAG TTGATGGGGA TCAGGATGCT GTTTGACAAA 
AATGGCAACA TGGCAGGCAT CTCAGACCAA AGGATCGCCA TCGACCTGTT CAAGCACCAA 
GGCACGATCA CAGTGAACGA GGAAGGCACC CAAGCCACCA CTGTGACCAC GGTGGGGTTC 
ATGCCGCTGT CCACCCAAGT CCGCTTCACT GTCGACCGCC CCTTTCTTTT CCTCATCTAC 
GAGCATCGCA CCAGCTGCCT GCTCTTCATG GGAAGAGTGG CCAACCCCAG CAGGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000176.2
CDS	68..1567
Translation	MKHSLNALLIFLIITSAWGGSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDYLDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS

Target ORF information:

RefSeq Version	NM_000185.3
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family D member 1 (SERPIND1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000185.3

ORF Insert Sequence:

ATGAAACACT CATTAAACGC ACTTCTCATT TTCCTCATCA TAACATCTGC GTGGGGTGGG 
AGCAAAGGCC CGCTGGATCA GCTAGAGAAA GGAGGGGAAA CTGCTCAGTC TGCAGATCCC 
CAGTGGGAGC AGTTAAATAA CAAAAACCTG AGCATGCCTC TTCTCCCTGC CGACTTCCAC 
AAGGAAAACA CCGTCACCAA CGACTGGATT CCAGAGGGGG AGGAGGACGA CGACTATCTG 
GACCTGGAGA AGATATTCAG TGAAGACGAC GACTACATCG ACATCGTCGA CAGTCTGTCA 
GTTTCCCCGA CAGACTCTGA TGTGAGTGCT GGGAACATCC TCCAGCTTTT TCATGGCAAG 
AGCCGGATCC AGCGTCTTAA CATCCTCAAC GCCAAGTTCG CTTTCAACCT CTACCGAGTG 
CTGAAAGACC AGGTCAACAC TTTCGATAAC ATCTTCATAG CACCCGTTGG CATTTCTACT 
GCGATGGGTA TGATTTCCTT AGGTCTGAAG GGAGAGACCC ATGAACAAGT GCACTCGATT 
TTGCATTTTA AAGACTTTGT TAATGCCAGC AGCAAGTATG AAATCACGAC CATTCATAAT 
CTCTTCCGTA AGCTGACTCA TCGCCTCTTC AGGAGGAATT TTGGGTACAC ACTGCGGTCA 
GTCAATGACC TTTATATCCA GAAGCAGTTT CCAATCCTGC TTGACTTCAA AACTAAAGTA 
AGAGAGTATT ACTTTGCTGA GGCCCAGATA GCTGACTTCT CAGACCCTGC CTTCATATCA 
AAAACCAACA ACCACATCAT GAAGCTCACC AAGGGCCTCA TAAAAGATGC TCTGGAGAAT 
ATAGACCCTG CTACCCAGAT GATGATTCTC AACTGCATCT ACTTCAAAGG ATCCTGGGTG 
AATAAATTCC CAGTGGAAAT GACACACAAC CACAACTTCC GGCTGAATGA GAGAGAGGTA 
GTTAAGGTTT CCATGATGCA GACCAAGGGG AACTTCCTCG CAGCAAATGA CCAGGAGCTG 
GACTGCGACA TCCTCCAGCT GGAATACGTG GGGGGCATCA GCATGCTAAT TGTGGTCCCA 
CACAAGATGT CTGGGATGAA GACCCTCGAA GCGCAACTGA CACCCCGGGT GGTGGAGAGA 
TGGCAAAAAA GCATGACAAA CAGAACTCGA GAAGTGCTTC TGCCGAAATT CAAGCTGGAG 
AAGAACTACA ATCTAGTGGA GTCCCTGAAG TTGATGGGGA TCAGGATGCT GTTTGACAAA 
AATGGCAACA TGGCAGGCAT CTCAGACCAA AGGATCGCCA TCGACCTGTT CAAGCACCAA 
GGCACGATCA CAGTGAACGA GGAAGGCACC CAAGCCACCA CTGTGACCAC GGTGGGGTTC 
ATGCCGCTGT CCACCCAAGT CCGCTTCACT GTCGACCGCC CCTTTCTTTT CCTCATCTAC 
GAGCATCGCA CCAGCTGCCT GCTCTTCATG GGAAGAGTGG CCAACCCCAG CAGGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SERPIND1 ( NM_000185.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000176.2 Homo sapiens serpin family D member 1 (SERPIND1), mRNA.

Price & Availability↑

CloneID	OHu22804
Clone ID Related Accession (Same CDS sequence)	NM_000185.3 , NM_000185.4
Accession Version	NM_000185.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1500bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-25
Organism	Homo sapiens(human)
Product	heparin cofactor 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007308.13 and BC035028.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000185.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035028.2, SRR1803613.60943.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000215727.10/ ENSP00000215727.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAACACT CATTAAACGC ACTTCTCATT TTCCTCATCA TAACATCTGC GTGGGGTGGG 
AGCAAAGGCC CGCTGGATCA GCTAGAGAAA GGAGGGGAAA CTGCTCAGTC TGCAGATCCC 
CAGTGGGAGC AGTTAAATAA CAAAAACCTG AGCATGCCTC TTCTCCCTGC CGACTTCCAC 
AAGGAAAACA CCGTCACCAA CGACTGGATT CCAGAGGGGG AGGAGGACGA CGACTATCTG 
GACCTGGAGA AGATATTCAG TGAAGACGAC GACTACATCG ACATCGTCGA CAGTCTGTCA 
GTTTCCCCGA CAGACTCTGA TGTGAGTGCT GGGAACATCC TCCAGCTTTT TCATGGCAAG 
AGCCGGATCC AGCGTCTTAA CATCCTCAAC GCCAAGTTCG CTTTCAACCT CTACCGAGTG 
CTGAAAGACC AGGTCAACAC TTTCGATAAC ATCTTCATAG CACCCGTTGG CATTTCTACT 
GCGATGGGTA TGATTTCCTT AGGTCTGAAG GGAGAGACCC ATGAACAAGT GCACTCGATT 
TTGCATTTTA AAGACTTTGT TAATGCCAGC AGCAAGTATG AAATCACGAC CATTCATAAT 
CTCTTCCGTA AGCTGACTCA TCGCCTCTTC AGGAGGAATT TTGGGTACAC ACTGCGGTCA 
GTCAATGACC TTTATATCCA GAAGCAGTTT CCAATCCTGC TTGACTTCAA AACTAAAGTA 
AGAGAGTATT ACTTTGCTGA GGCCCAGATA GCTGACTTCT CAGACCCTGC CTTCATATCA 
AAAACCAACA ACCACATCAT GAAGCTCACC AAGGGCCTCA TAAAAGATGC TCTGGAGAAT 
ATAGACCCTG CTACCCAGAT GATGATTCTC AACTGCATCT ACTTCAAAGG ATCCTGGGTG 
AATAAATTCC CAGTGGAAAT GACACACAAC CACAACTTCC GGCTGAATGA GAGAGAGGTA 
GTTAAGGTTT CCATGATGCA GACCAAGGGG AACTTCCTCG CAGCAAATGA CCAGGAGCTG 
GACTGCGACA TCCTCCAGCT GGAATACGTG GGGGGCATCA GCATGCTAAT TGTGGTCCCA 
CACAAGATGT CTGGGATGAA GACCCTCGAA GCGCAACTGA CACCCCGGGT GGTGGAGAGA 
TGGCAAAAAA GCATGACAAA CAGAACTCGA GAAGTGCTTC TGCCGAAATT CAAGCTGGAG 
AAGAACTACA ATCTAGTGGA GTCCCTGAAG TTGATGGGGA TCAGGATGCT GTTTGACAAA 
AATGGCAACA TGGCAGGCAT CTCAGACCAA AGGATCGCCA TCGACCTGTT CAAGCACCAA 
GGCACGATCA CAGTGAACGA GGAAGGCACC CAAGCCACCA CTGTGACCAC GGTGGGGTTC 
ATGCCGCTGT CCACCCAAGT CCGCTTCACT GTCGACCGCC CCTTTCTTTT CCTCATCTAC 
GAGCATCGCA CCAGCTGCCT GCTCTTCATG GGAAGAGTGG CCAACCCCAG CAGGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000176.2
CDS	50..1549
Translation	MKHSLNALLIFLIITSAWGGSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDYLDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS

Target ORF information:

RefSeq Version	NM_000185.4
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family D member 1 (SERPIND1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000185.4

ORF Insert Sequence:

ATGAAACACT CATTAAACGC ACTTCTCATT TTCCTCATCA TAACATCTGC GTGGGGTGGG 
AGCAAAGGCC CGCTGGATCA GCTAGAGAAA GGAGGGGAAA CTGCTCAGTC TGCAGATCCC 
CAGTGGGAGC AGTTAAATAA CAAAAACCTG AGCATGCCTC TTCTCCCTGC CGACTTCCAC 
AAGGAAAACA CCGTCACCAA CGACTGGATT CCAGAGGGGG AGGAGGACGA CGACTATCTG 
GACCTGGAGA AGATATTCAG TGAAGACGAC GACTACATCG ACATCGTCGA CAGTCTGTCA 
GTTTCCCCGA CAGACTCTGA TGTGAGTGCT GGGAACATCC TCCAGCTTTT TCATGGCAAG 
AGCCGGATCC AGCGTCTTAA CATCCTCAAC GCCAAGTTCG CTTTCAACCT CTACCGAGTG 
CTGAAAGACC AGGTCAACAC TTTCGATAAC ATCTTCATAG CACCCGTTGG CATTTCTACT 
GCGATGGGTA TGATTTCCTT AGGTCTGAAG GGAGAGACCC ATGAACAAGT GCACTCGATT 
TTGCATTTTA AAGACTTTGT TAATGCCAGC AGCAAGTATG AAATCACGAC CATTCATAAT 
CTCTTCCGTA AGCTGACTCA TCGCCTCTTC AGGAGGAATT TTGGGTACAC ACTGCGGTCA 
GTCAATGACC TTTATATCCA GAAGCAGTTT CCAATCCTGC TTGACTTCAA AACTAAAGTA 
AGAGAGTATT ACTTTGCTGA GGCCCAGATA GCTGACTTCT CAGACCCTGC CTTCATATCA 
AAAACCAACA ACCACATCAT GAAGCTCACC AAGGGCCTCA TAAAAGATGC TCTGGAGAAT 
ATAGACCCTG CTACCCAGAT GATGATTCTC AACTGCATCT ACTTCAAAGG ATCCTGGGTG 
AATAAATTCC CAGTGGAAAT GACACACAAC CACAACTTCC GGCTGAATGA GAGAGAGGTA 
GTTAAGGTTT CCATGATGCA GACCAAGGGG AACTTCCTCG CAGCAAATGA CCAGGAGCTG 
GACTGCGACA TCCTCCAGCT GGAATACGTG GGGGGCATCA GCATGCTAAT TGTGGTCCCA 
CACAAGATGT CTGGGATGAA GACCCTCGAA GCGCAACTGA CACCCCGGGT GGTGGAGAGA 
TGGCAAAAAA GCATGACAAA CAGAACTCGA GAAGTGCTTC TGCCGAAATT CAAGCTGGAG 
AAGAACTACA ATCTAGTGGA GTCCCTGAAG TTGATGGGGA TCAGGATGCT GTTTGACAAA 
AATGGCAACA TGGCAGGCAT CTCAGACCAA AGGATCGCCA TCGACCTGTT CAAGCACCAA 
GGCACGATCA CAGTGAACGA GGAAGGCACC CAAGCCACCA CTGTGACCAC GGTGGGGTTC 
ATGCCGCTGT CCACCCAAGT CCGCTTCACT GTCGACCGCC CCTTTCTTTT CCTCATCTAC 
GAGCATCGCA CCAGCTGCCT GCTCTTCATG GGAAGAGTGG CCAACCCCAG CAGGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Role of Heparin Cofactor ? in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice.
Journal of atherosclerosis and thrombosis24(12)1215-1230(2017 Dec)
Kurahashi K,Inoue S,Yoshida S,Ikeda Y,Morimoto K,Uemoto R,Ishikawa K,Kondo T,Yuasa T,Endo I,Miyake M,Oyadomari S,Matsumoto T,Abe M,Sakaue H,Aihara KI

Alpha-2-macroglobulin and heparin cofactor II and the vulnerability of carotid atherosclerotic plaques: An iTRAQ-based analysis.
Biochemical and biophysical research communications483(3)964-971(2017 02)
Li J,Liu X,Xiang Y,Ding X,Wang T,Liu Y,Yin M,Tan C,Deng F,Chen L

Analysis of the gene expression profile in response to human epididymis protein 4 in epithelial ovarian cancer cells.
Oncology reports36(3)1592-604(2016 Sep)
Zhu L,Guo Q,Jin S,Feng H,Zhuang H,Liu C,Tan M,Liu J,Li X,Lin B

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Cardiovascular research110(3)419-30(2016 06)
Barallobre-Barreiro J,Oklu R,Lynch M,Fava M,Baig F,Yin X,Barwari T,Potier DN,Albadawi H,Jahangiri M,Porter KE,Watkins MT,Misra S,Stoughton J,Mayr M

Heparin co-factor II enhances cell motility and promotes metastasis in non-small cell lung cancer.
The Journal of pathology235(1)50-64(2015 Jan)
Liao WY,Ho CC,Hou HH,Hsu TH,Tsai MF,Chen KY,Chen HY,Lee YC,Yu CJ,Lee CH,Yang PC

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SERPIND1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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