GYPC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GYPC
Entrez Gene ID	2995
Full Name	glycophorin C (Gerbich blood group)
Synonyms	CD236,CD236R,GE,GE:GPC:GPD:GYPD,GPC,GPD,GYPD,PAS-2,PAS-2'
General protein information	Preferred Names glycophorin C (Gerbich blood group) Names glycophorin-C glycoconnectin glycophorin-D glycoprotein beta sialoglycoprotein D
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q14.3
Summary	Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
Disorder MIM:	110750
Disorder Html:	{Malaria, resistance to}, 611162 (3); [Blood group, Gerbich], 616089 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001256584.1	NP_001243513.1	glycophorin-C isoform 3
NM_002101.5	NP_002092.1	glycophorin-C isoform 1
NM_016815.3	NP_058131.1	glycophorin-C isoform 2
XM_006712460.3	XP_006712523.1	glycophorin-C isoform X1
NM_002101.4	NP_002092.1	glycophorin-C isoform 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	GYPC	NP_001004407.1
Rattus norvegicus (Norway rat)	Gypc	NP_001013251.1
Mus musculus (house mouse)	Gypc	NP_001041672.1
Homo sapiens (human)	GYPC	NP_058131.1

Gene Ontology
Bibliography

Related articles in PubMed

Glycophorin-C sialylation regulates Lu/BCAM adhesive capacity during erythrocyte aging.
Klei TRL, de Back DZ, Asif PJ, Verkuijlen PJJH, Veldthuis M, Ligthart PC, Berghuis J, Clifford E, Beuger BM, van den Berg TK, van Zwieten R, El Nemer W, van Bruggen R
Blood advances2(1)14-24(2018 Jan)

Genetic background of the rare Yus and Gerbich blood group phenotypes: homologous regions of the GYPC gene contribute to deletion alleles.
Gourri E, Denomme GA, Merki Y, Scharberg EA, Vrignaud C, Frey BM, Peyrard T, Gassner C
British journal of haematology177(4)630-640(2017 May)

STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting.
Niang M, Bei AK, Madnani KG, Pelly S, Dankwa S, Kanjee U, Gunalan K, Amaladoss A, Yeo KP, Bob NS, Malleret B, Duraisingh MT, Preiser PR
Cell host & microbe16(1)81-93(2014 Jul)

Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes.
Lee WC, Malleret B, Lau YL, Mauduit M, Fong MY, Cho JS, Suwanarusk R, Zhang R, Albrecht L, Costa FT, Preiser P, McGready R, Renia L, Nosten F, Russell B
Blood123(18)e100-9(2014 May)

Glycophorin C is the receptor for the Plasmodium falciparum erythrocyte binding ligand PfEBP-2 (baebl).
Lobo CA, Rodriguez M, Reid M, Lustigman S
Blood101(11)4628-31(2003 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The authors set out to understand the similarities and differences among the GYPC deletion alleles Yus and Gerbich by positional PCR sequence analysis to identify the breakpoints. They developed a set of diagnostic PCRs that can be used to classify both Yus and Gerbich phenotypic variants on the basis of their nucleotide deletion. The Yus phenotype was defined by 4 different breakpoints and the Ger
Title: Genetic background of the rare Yus and Gerbich blood group phenotypes: homologous regions of the GYPC gene contribute to deletion alleles.

Plasmodium falciparum STEVOR functions as an erythrocyte-binding protein that recognizes Glycophorin C (GPC) on the red blood cell (RBC) surface and that its binding correlates with the level of GPC on the RBC surface.
Title: STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting.

Rosetting assays using CD236R knockdown normocytes derived from hematopoietic stem cells further supports the role of glycophorin C as a receptor in P vivax rosette formation.
Title: Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes.

Precise definition of the binding site for the EBA-140 ligand on glycophorin C may be important with respect to human erythrocyte invasion inhibition strategies based on a receptor.
Title: [Human erythrocyte glycophorin C as the receptor for EBA-140 Plasmodium falciparum merozoite ligand].

Glycophorin C delta (exon3) is not associated with protection against severe anaemia in Papua New Guinea.
Title: Glycophorin C delta(exon3) is not associated with protection against severe anaemia in Papua New Guinea.

The following GYPC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GYPC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08043	NM_016815.3 Latest version!	Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu07957	NM_001256584.1 Latest version!	Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu21440	NM_002101.5 Latest version!	Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu36155	XM_006712460.3 Latest version!	Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu21440	NM_002101.4	Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GYPC ( NM_016815.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_058131.1 Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu08043
Clone ID Related Accession (Same CDS sequence)	NM_016815.3
Accession Version	NM_016815.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	glycophorin-C isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC013474.10, CB992018.1 and AA913940.1. On Feb 11, 2012 this sequence version replaced NM_016815.2. Transcript Variant: This variant (2) lacks and in-frame exon in the central coding region, compared to variant 1. The encoded isoform 2 is shorter than isoform 1. This isoform (2) specifies the Yus phenotype. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.351017.1, SRR1163658.74607.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGTCGA CGAGAAGCCC CAACAGCACG GCGTGGCCTC TCAGCCTCGA GCCTGATCCA 
GGGATGTCTG GATGGCCGGA TGGCAGAATG GAGACCTCCA CCCCCACCAT AATGGACATT 
GTCGTCATTG CAGGTGTGAT TGCTGCTGTG GCCATCGTCC TAGTCTCCCT CCTCTTCGTC 
ATGCTGCGCT ACATGTACCG GCACAAGGGC ACGTACCACA CCAATGAGGC CAAGGGCACG 
GAGTTTGCTG AGAGTGCAGA TGCAGCCCTG CAGGGAGACC CTGCCCTCCA AGATGCTGGT 
GATAGCAGCA GAAAGGAGTA CTTTATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058131.1
CDS	330..659
Translation	MWSTRSPNSTAWPLSLEPDPGMSGWPDGRMETSTPTIMDIVVIAGVIAAVAIVLVSLLFVMLRYMYRHKGTYHTNEAKGTEFAESADAALQGDPALQDAGDSSRKEYFI

Target ORF information:

RefSeq Version	NM_016815.3
Organism	Homo sapiens(human)
Definition	Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016815.3

ORF Insert Sequence:

ATGTGGTCGA CGAGAAGCCC CAACAGCACG GCGTGGCCTC TCAGCCTCGA GCCTGATCCA 
GGGATGTCTG GATGGCCGGA TGGCAGAATG GAGACCTCCA CCCCCACCAT AATGGACATT 
GTCGTCATTG CAGGTGTGAT TGCTGCTGTG GCCATCGTCC TAGTCTCCCT CCTCTTCGTC 
ATGCTGCGCT ACATGTACCG GCACAAGGGC ACGTACCACA CCAATGAGGC CAAGGGCACG 
GAGTTTGCTG AGAGTGCAGA TGCAGCCCTG CAGGGAGACC CTGCCCTCCA AGATGCTGGT 
GATAGCAGCA GAAAGGAGTA CTTTATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYPC ( NM_001256584.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243513.1 Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu07957
Clone ID Related Accession (Same CDS sequence)	NM_001256584.1
Accession Version	NM_001256584.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	glycophorin-C isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC013474.10, BC016653.1 and AA913940.1. Transcript Variant: This variant (3) has an additional exon, compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which is associated with a strong Kozak sequence. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016653.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2163105 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCTG CCTCCACCAC AATGCATACT ACCACCATTG CAGAGCCTGA TCCAGGGATG 
TCTGGATGGC CGGATGGCAG AATGGAGACC TCCACCCCCA CCATAATGGA CATTGTCGTC 
ATTGCAGGTG TGATTGCTGC TGTGGCCATC GTCCTAGTCT CCCTCCTCTT CGTCATGCTG 
CGCTACATGT ACCGGCACAA GGGCACGTAC CACACCAATG AGGCCAAGGG CACGGAGTTT 
GCTGAGAGTG CAGATGCAGC CCTGCAGGGA GACCCTGCCC TCCAAGATGC TGGTGATAGC 
AGCAGAAAGG AGTACTTTAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243513.1
CDS	1211..1534
Translation	MASASTTMHTTTIAEPDPGMSGWPDGRMETSTPTIMDIVVIAGVIAAVAIVLVSLLFVMLRYMYRHKGTYHTNEAKGTEFAESADAALQGDPALQDAGDSSRKEYFI

Target ORF information:

RefSeq Version	NM_001256584.1
Organism	Homo sapiens(human)
Definition	Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256584.1

ORF Insert Sequence:

ATGGCCTCTG CCTCCACCAC AATGCATACT ACCACCATTG CAGAGCCTGA TCCAGGGATG 
TCTGGATGGC CGGATGGCAG AATGGAGACC TCCACCCCCA CCATAATGGA CATTGTCGTC 
ATTGCAGGTG TGATTGCTGC TGTGGCCATC GTCCTAGTCT CCCTCCTCTT CGTCATGCTG 
CGCTACATGT ACCGGCACAA GGGCACGTAC CACACCAATG AGGCCAAGGG CACGGAGTTT 
GCTGAGAGTG CAGATGCAGC CCTGCAGGGA GACCCTGCCC TCCAAGATGC TGGTGATAGC 
AGCAGAAAGG AGTACTTTAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYPC ( NM_002101.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002092.1 Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21440
Clone ID Related Accession (Same CDS sequence)	NM_002101.5 , NM_002101.4
Accession Version	NM_002101.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	glycophorin-C isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC106051.1 and AC013474.10. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002101.4. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC106051.1, X12496.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000259254.9/ ENSP00000259254.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGGTCGA CGAGAAGCCC CAACAGCACG GCGTGGCCTC TCAGCCTCGA GCCTGATCCG 
GGGATGGCCT CTGCCTCCAC CACAATGCAT ACTACCACCA TTGCAGAGCC TGATCCAGGG 
ATGTCTGGAT GGCCGGATGG CAGAATGGAG ACCTCCACCC CCACCATAAT GGACATTGTC 
GTCATTGCAG GTGTGATTGC TGCTGTGGCC ATCGTCCTAG TCTCCCTCCT CTTCGTCATG 
CTGCGCTACA TGTACCGGCA CAAGGGCACG TACCACACCA ATGAGGCCAA GGGCACGGAG 
TTTGCTGAGA GTGCAGATGC AGCCCTGCAG GGAGACCCTG CCCTCCAAGA TGCTGGTGAT 
AGCAGCAGAA AGGAGTACTT TATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002092.1
CDS	107..493
Translation	MWSTRSPNSTAWPLSLEPDPGMASASTTMHTTTIAEPDPGMSGWPDGRMETSTPTIMDIVVIAGVIAAVAIVLVSLLFVMLRYMYRHKGTYHTNEAKGTEFAESADAALQGDPALQDAGDSSRKEYFI

Target ORF information:

RefSeq Version	NM_002101.5
Organism	Homo sapiens(human)
Definition	Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002101.5

ORF Insert Sequence:

ATGTGGTCGA CGAGAAGCCC CAACAGCACG GCGTGGCCTC TCAGCCTCGA GCCTGATCCG 
GGGATGGCCT CTGCCTCCAC CACAATGCAT ACTACCACCA TTGCAGAGCC TGATCCAGGG 
ATGTCTGGAT GGCCGGATGG CAGAATGGAG ACCTCCACCC CCACCATAAT GGACATTGTC 
GTCATTGCAG GTGTGATTGC TGCTGTGGCC ATCGTCCTAG TCTCCCTCCT CTTCGTCATG 
CTGCGCTACA TGTACCGGCA CAAGGGCACG TACCACACCA ATGAGGCCAA GGGCACGGAG 
TTTGCTGAGA GTGCAGATGC AGCCCTGCAG GGAGACCCTG CCCTCCAAGA TGCTGGTGAT 
AGCAGCAGAA AGGAGTACTT TATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYPC ( NM_002101.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002092.1 Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21440
Clone ID Related Accession (Same CDS sequence)	NM_002101.5 , NM_002101.4
Accession Version	NM_002101.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	glycophorin-C isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC013474.10, BC106051.1 and AA913940.1. This sequence is a reference standard in the RefSeqGene project. On Feb 11, 2012 this sequence version replaced NM_002101.3. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.449422.1, SRR1163658.144736.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGTCGA CGAGAAGCCC CAACAGCACG GCGTGGCCTC TCAGCCTCGA GCCTGATCCG 
GGGATGGCCT CTGCCTCCAC CACAATGCAT ACTACCACCA TTGCAGAGCC TGATCCAGGG 
ATGTCTGGAT GGCCGGATGG CAGAATGGAG ACCTCCACCC CCACCATAAT GGACATTGTC 
GTCATTGCAG GTGTGATTGC TGCTGTGGCC ATCGTCCTAG TCTCCCTCCT CTTCGTCATG 
CTGCGCTACA TGTACCGGCA CAAGGGCACG TACCACACCA ATGAGGCCAA GGGCACGGAG 
TTTGCTGAGA GTGCAGATGC AGCCCTGCAG GGAGACCCTG CCCTCCAAGA TGCTGGTGAT 
AGCAGCAGAA AGGAGTACTT TATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002092.1
CDS	330..716
Translation	MWSTRSPNSTAWPLSLEPDPGMASASTTMHTTTIAEPDPGMSGWPDGRMETSTPTIMDIVVIAGVIAAVAIVLVSLLFVMLRYMYRHKGTYHTNEAKGTEFAESADAALQGDPALQDAGDSSRKEYFI

Target ORF information:

RefSeq Version	NM_002101.4
Organism	Homo sapiens(human)
Definition	Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002101.4

ORF Insert Sequence:

ATGTGGTCGA CGAGAAGCCC CAACAGCACG GCGTGGCCTC TCAGCCTCGA GCCTGATCCG 
GGGATGGCCT CTGCCTCCAC CACAATGCAT ACTACCACCA TTGCAGAGCC TGATCCAGGG 
ATGTCTGGAT GGCCGGATGG CAGAATGGAG ACCTCCACCC CCACCATAAT GGACATTGTC 
GTCATTGCAG GTGTGATTGC TGCTGTGGCC ATCGTCCTAG TCTCCCTCCT CTTCGTCATG 
CTGCGCTACA TGTACCGGCA CAAGGGCACG TACCACACCA ATGAGGCCAA GGGCACGGAG 
TTTGCTGAGA GTGCAGATGC AGCCCTGCAG GGAGACCCTG CCCTCCAAGA TGCTGGTGAT 
AGCAGCAGAA AGGAGTACTT TATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GYPC ( XM_006712460.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006712523.1 Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu36155
Clone ID Related Accession (Same CDS sequence)	XM_006712460.3
Accession Version	XM_006712460.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 369bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	glycophorin-C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006712460.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGACCA AGCCCCAGGA GCTTCCCAGA CAGCCTGATC CGGGGATGGC CTCTGCCTCC 
ACCACAATGC ATACTACCAC CATTGCAGAG CCTGATCCAG GGATGTCTGG ATGGCCGGAT 
GGCAGAATGG AGACCTCCAC CCCCACCATA ATGGACATTG TCGTCATTGC AGGTGTGATT 
GCTGCTGTGG CCATCGTCCT AGTCTCCCTC CTCTTCGTCA TGCTGCGCTA CATGTACCGG 
CACAAGGGCA CGTACCACAC CAATGAGGCC AAGGGCACGG AGTTTGCTGA GAGTGCAGAT 
GCAGCCCTGC AGGGAGACCC TGCCCTCCAA GATGCTGGTG ATAGCAGCAG AAAGGAGTAC 
TTTATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006712523.1
CDS	216..584
Translation	MLTKPQELPRQPDPGMASASTTMHTTTIAEPDPGMSGWPDGRMETSTPTIMDIVVIAGVIAAVAIVLVSLLFVMLRYMYRHKGTYHTNEAKGTEFAESADAALQGDPALQDAGDSSRKEYFI

Target ORF information:

RefSeq Version	XM_006712460.3
Organism	Homo sapiens(human)
Definition	Homo sapiens glycophorin C (Gerbich blood group) (GYPC), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006712460.3

ORF Insert Sequence:

ATGCTGACCA AGCCCCAGGA GCTTCCCAGA CAGCCTGATC CGGGGATGGC CTCTGCCTCC 
ACCACAATGC ATACTACCAC CATTGCAGAG CCTGATCCAG GGATGTCTGG ATGGCCGGAT 
GGCAGAATGG AGACCTCCAC CCCCACCATA ATGGACATTG TCGTCATTGC AGGTGTGATT 
GCTGCTGTGG CCATCGTCCT AGTCTCCCTC CTCTTCGTCA TGCTGCGCTA CATGTACCGG 
CACAAGGGCA CGTACCACAC CAATGAGGCC AAGGGCACGG AGTTTGCTGA GAGTGCAGAT 
GCAGCCCTGC AGGGAGACCC TGCCCTCCAA GATGCTGGTG ATAGCAGCAG AAAGGAGTAC 
TTTATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glycophorin-C sialylation regulates Lu/BCAM adhesive capacity during erythrocyte aging.
Blood advances2(1)14-24(2018 Jan)
Klei TRL,de Back DZ,Asif PJ,Verkuijlen PJJH,Veldthuis M,Ligthart PC,Berghuis J,Clifford E,Beuger BM,van den Berg TK,van Zwieten R,El Nemer W,van Bruggen R

Genetic background of the rare Yus and Gerbich blood group phenotypes: homologous regions of the GYPC gene contribute to deletion alleles.
British journal of haematology177(4)630-640(2017 May)
Gourri E,Denomme GA,Merki Y,Scharberg EA,Vrignaud C,Frey BM,Peyrard T,Gassner C

STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting.
Cell host & microbe16(1)81-93(2014 Jul)
Niang M,Bei AK,Madnani KG,Pelly S,Dankwa S,Kanjee U,Gunalan K,Amaladoss A,Yeo KP,Bob NS,Malleret B,Duraisingh MT,Preiser PR

Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes.
Blood123(18)e100-9(2014 May)
Lee WC,Malleret B,Lau YL,Mauduit M,Fong MY,Cho JS,Suwanarusk R,Zhang R,Albrecht L,Costa FT,Preiser P,McGready R,Renia L,Nosten F,Russell B

Glycophorin C is the receptor for the Plasmodium falciparum erythrocyte binding ligand PfEBP-2 (baebl).
Blood101(11)4628-31(2003 Jun)
Lobo CA,Rodriguez M,Reid M,Lustigman S

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GYPC cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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ORF Insert Sequence:

Target ORF information:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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