MRPL42 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MRPL42
Entrez Gene ID	28977
Full Name	mitochondrial ribosomal protein L42
Synonyms	HSPC204,L31MT,L42MT,MRP-L31,MRP-L42,MRP-S32,MRPL31,MRPS32,PTD007,RPML31,S32MT
General protein information	Preferred Names mitochondrial ribosomal protein L42 Names 39S ribosomal protein L42, mitochondrial 28S ribosomal protein S32, mitochondrial 39S ribosomal protein L31, mitochondrial mitochondrial large ribosomal subunit protein mL42
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q22
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by RefSeq, May 2011].
Disorder MIM:	611847

mRNA and Protein(s)

mRNA	Protein	Name
NM_172177.3	NP_751917.1	39S ribosomal protein L42, mitochondrial precursor
NM_172177.5	NP_751917.1	39S ribosomal protein L42, mitochondrial precursor
NM_014050.4	NP_054769.1	39S ribosomal protein L42, mitochondrial precursor
NM_014050.3	NP_054769.1	39S ribosomal protein L42, mitochondrial precursor
NM_172177.4	NP_751917.1	39S ribosomal protein L42, mitochondrial precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MRPL42	NP_001032711.1
Gallus gallus (chicken)	MRPL42	XP_416141.3
Danio rerio (zebrafish)	LOC568235	XP_696647.1
Xenopus tropicalis (tropical clawed frog)	mrpl42	NP_001072400.1
Rattus norvegicus (Norway rat)	LOC100361098	XP_003749292.1
Homo sapiens (human)	MRPL42	NP_054769.1
Pan troglodytes (chimpanzee)	MRPL42	XP_509266.2
	LOC715676	XP_001106011.2
Canis lupus familiaris (dog)	MRPL42	XP_532651.1
Rattus norvegicus (Norway rat)	Mrpl42	NP_001100252.1
Mus musculus (house mouse)	Mrpl42	NP_080341.1

Gene Ontology
Bibliography

Related articles in PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nature structural & molecular biology24(10)866-869(2017 Oct)

[Comparative analysis of the role of CD4(+) and CD8(+) T cells in severe asthma development].
Wang X, Wang J, Xing CY, Zang R, Pu YY, Yin ZX
Molekuliarnaia biologiia49(3)482-90(2015 May-Jun)

Structure of the large ribosomal subunit from human mitochondria.
Brown A, Amunts A, Bai XC, Sugimoto Y, Edwards PC, Murshudov G, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)346(6210)718-722(2014 Nov)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MPO and BPI in CD4(+)T-lymphocytes, and PDHA1 and MRPL42 in CD8(+) T-lymphocytes might be used as specific biomarkers of severe asthma progression.
Title: [Comparative analysis of the role of CD4(+) and CD8(+) T cells in severe asthma development].

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Observational study of gene-disease association. (HuGE Navigator)
Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.

The following MRPL42 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPL42 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11063	NM_172177.5 Latest version!	Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu11063	NM_014050.4 Latest version!	Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu11063	NM_172177.3	Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu11063	NM_014050.3	Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu11063	NM_172177.4	Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MRPL42 ( NM_172177.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_751917.1 Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11063
Clone ID Related Accession (Same CDS sequence)	NM_172177.3 , NM_172177.5 , NM_014050.4 , NM_014050.3 , NM_172177.4
Accession Version	NM_172177.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	39S ribosomal protein L42, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM147739.1, CD385500.1, BC040240.2, AC025260.29 and AA211087.1. On May 3, 2011 this sequence version replaced NM_172177.2. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.8610.1, SRR1803613.271603.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTAG CTGCAGTAAA ATGGGTGATG TCAAAGAGAA CTATCTTGAA ACATTTATTT 
CCAGTCCAAA ATGGAGCTTT ATATTGTGTT TGTCATAAAT CTACGTATTC TCCTCTACCA 
GATGACTATA ATTGCAACGT AGAGCTTGCT CTGACTTCTG ATGGCAGGAC AATAGTATGC 
TACCACCCTT CTGTGGACAT TCCATATGAA CACACAAAAC CTATCCCTCG GCCAGATCCT 
GTGCATAATA ATGAAGAAAC ACATGATCAA GTGCTGAAAA CCAGATTGGA AGAAAAAGTT 
GAACACCTTG AGGAAGGACC TATGATAGAA CAACTTAGCA AAATGTTCTT TACTACTAAG 
CACCGTTGGT ATCCTCATGG ACGGTATCAC AGATGTCGTA AGAATCTGAA TCCTCCAAAA 
GACAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_751917.1
CDS	163..591
Translation	MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQVLKTRLEEKVEHLEEGPMIEQLSKMFFTTKHRWYPHGRYHRCRKNLNPPKDR

Target ORF information:

RefSeq Version	NM_172177.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172177.3

ORF Insert Sequence:

ATGGCTGTAG CTGCAGTAAA ATGGGTGATG TCAAAGAGAA CTATCTTGAA ACATTTATTT 
CCAGTCCAAA ATGGAGCTTT ATATTGTGTT TGTCATAAAT CTACGTATTC TCCTCTACCA 
GATGACTATA ATTGCAACGT AGAGCTTGCT CTGACTTCTG ATGGCAGGAC AATAGTATGC 
TACCACCCTT CTGTGGACAT TCCATATGAA CACACAAAAC CTATCCCTCG GCCAGATCCT 
GTGCATAATA ATGAAGAAAC ACATGATCAA GTGCTGAAAA CCAGATTGGA AGAAAAAGTT 
GAACACCTTG AGGAAGGACC TATGATAGAA CAACTTAGCA AAATGTTCTT TACTACTAAG 
CACCGTTGGT ATCCTCATGG ACGGTATCAC AGATGTCGTA AGAATCTGAA TCCTCCAAAA 
GACAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL42 ( NM_172177.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_751917.1 Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11063
Clone ID Related Accession (Same CDS sequence)	NM_172177.3 , NM_172177.5 , NM_014050.4 , NM_014050.3 , NM_172177.4
Accession Version	NM_172177.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	39S ribosomal protein L42, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC025260.29. On May 17, 2019 this sequence version replaced NM_172177.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.8610.1, SRR1803615.242807.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTAG CTGCAGTAAA ATGGGTGATG TCAAAGAGAA CTATCTTGAA ACATTTATTT 
CCAGTCCAAA ATGGAGCTTT ATATTGTGTT TGTCATAAAT CTACGTATTC TCCTCTACCA 
GATGACTATA ATTGCAACGT AGAGCTTGCT CTGACTTCTG ATGGCAGGAC AATAGTATGC 
TACCACCCTT CTGTGGACAT TCCATATGAA CACACAAAAC CTATCCCTCG GCCAGATCCT 
GTGCATAATA ATGAAGAAAC ACATGATCAA GTGCTGAAAA CCAGATTGGA AGAAAAAGTT 
GAACACCTTG AGGAAGGACC TATGATAGAA CAACTTAGCA AAATGTTCTT TACTACTAAG 
CACCGTTGGT ATCCTCATGG ACGGTATCAC AGATGTCGTA AGAATCTGAA TCCTCCAAAA 
GACAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_751917.1
CDS	139..567
Translation	MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQVLKTRLEEKVEHLEEGPMIEQLSKMFFTTKHRWYPHGRYHRCRKNLNPPKDR

Target ORF information:

RefSeq Version	NM_172177.5
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172177.5

ORF Insert Sequence:

ATGGCTGTAG CTGCAGTAAA ATGGGTGATG TCAAAGAGAA CTATCTTGAA ACATTTATTT 
CCAGTCCAAA ATGGAGCTTT ATATTGTGTT TGTCATAAAT CTACGTATTC TCCTCTACCA 
GATGACTATA ATTGCAACGT AGAGCTTGCT CTGACTTCTG ATGGCAGGAC AATAGTATGC 
TACCACCCTT CTGTGGACAT TCCATATGAA CACACAAAAC CTATCCCTCG GCCAGATCCT 
GTGCATAATA ATGAAGAAAC ACATGATCAA GTGCTGAAAA CCAGATTGGA AGAAAAAGTT 
GAACACCTTG AGGAAGGACC TATGATAGAA CAACTTAGCA AAATGTTCTT TACTACTAAG 
CACCGTTGGT ATCCTCATGG ACGGTATCAC AGATGTCGTA AGAATCTGAA TCCTCCAAAA 
GACAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL42 ( NM_014050.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_054769.1 Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11063
Clone ID Related Accession (Same CDS sequence)	NM_172177.3 , NM_172177.5 , NM_014050.4 , NM_014050.3 , NM_172177.4
Accession Version	NM_014050.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	39S ribosomal protein L42, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC025260.29. On May 17, 2019 this sequence version replaced NM_014050.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.48438.1, SRR1803615.266571.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTAG CTGCAGTAAA ATGGGTGATG TCAAAGAGAA CTATCTTGAA ACATTTATTT 
CCAGTCCAAA ATGGAGCTTT ATATTGTGTT TGTCATAAAT CTACGTATTC TCCTCTACCA 
GATGACTATA ATTGCAACGT AGAGCTTGCT CTGACTTCTG ATGGCAGGAC AATAGTATGC 
TACCACCCTT CTGTGGACAT TCCATATGAA CACACAAAAC CTATCCCTCG GCCAGATCCT 
GTGCATAATA ATGAAGAAAC ACATGATCAA GTGCTGAAAA CCAGATTGGA AGAAAAAGTT 
GAACACCTTG AGGAAGGACC TATGATAGAA CAACTTAGCA AAATGTTCTT TACTACTAAG 
CACCGTTGGT ATCCTCATGG ACGGTATCAC AGATGTCGTA AGAATCTGAA TCCTCCAAAA 
GACAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054769.1
CDS	136..564
Translation	MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQVLKTRLEEKVEHLEEGPMIEQLSKMFFTTKHRWYPHGRYHRCRKNLNPPKDR

Target ORF information:

RefSeq Version	NM_014050.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014050.4

ORF Insert Sequence:

ATGGCTGTAG CTGCAGTAAA ATGGGTGATG TCAAAGAGAA CTATCTTGAA ACATTTATTT 
CCAGTCCAAA ATGGAGCTTT ATATTGTGTT TGTCATAAAT CTACGTATTC TCCTCTACCA 
GATGACTATA ATTGCAACGT AGAGCTTGCT CTGACTTCTG ATGGCAGGAC AATAGTATGC 
TACCACCCTT CTGTGGACAT TCCATATGAA CACACAAAAC CTATCCCTCG GCCAGATCCT 
GTGCATAATA ATGAAGAAAC ACATGATCAA GTGCTGAAAA CCAGATTGGA AGAAAAAGTT 
GAACACCTTG AGGAAGGACC TATGATAGAA CAACTTAGCA AAATGTTCTT TACTACTAAG 
CACCGTTGGT ATCCTCATGG ACGGTATCAC AGATGTCGTA AGAATCTGAA TCCTCCAAAA 
GACAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL42 ( NM_014050.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_054769.1 Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu11063
Clone ID Related Accession (Same CDS sequence)	NM_172177.3 , NM_172177.5 , NM_014050.4 , NM_014050.3 , NM_172177.4
Accession Version	NM_014050.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Homo sapiens(human)
Product	39S ribosomal protein L42, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM147739.1, AL136659.1, BC040240.2, AC025260.29 and AA211087.1. On May 3, 2011 this sequence version replaced NM_014050.2. Transcript Variant: This variant (1) encodes the supported protein. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.221613.1, SRR1803615.266571.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTAG CTGCAGTAAA ATGGGTGATG TCAAAGAGAA CTATCTTGAA ACATTTATTT 
CCAGTCCAAA ATGGAGCTTT ATATTGTGTT TGTCATAAAT CTACGTATTC TCCTCTACCA 
GATGACTATA ATTGCAACGT AGAGCTTGCT CTGACTTCTG ATGGCAGGAC AATAGTATGC 
TACCACCCTT CTGTGGACAT TCCATATGAA CACACAAAAC CTATCCCTCG GCCAGATCCT 
GTGCATAATA ATGAAGAAAC ACATGATCAA GTGCTGAAAA CCAGATTGGA AGAAAAAGTT 
GAACACCTTG AGGAAGGACC TATGATAGAA CAACTTAGCA AAATGTTCTT TACTACTAAG 
CACCGTTGGT ATCCTCATGG ACGGTATCAC AGATGTCGTA AGAATCTGAA TCCTCCAAAA 
GACAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054769.1
CDS	160..588
Translation	MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQVLKTRLEEKVEHLEEGPMIEQLSKMFFTTKHRWYPHGRYHRCRKNLNPPKDR

Target ORF information:

RefSeq Version	NM_014050.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014050.3

ORF Insert Sequence:

ATGGCTGTAG CTGCAGTAAA ATGGGTGATG TCAAAGAGAA CTATCTTGAA ACATTTATTT 
CCAGTCCAAA ATGGAGCTTT ATATTGTGTT TGTCATAAAT CTACGTATTC TCCTCTACCA 
GATGACTATA ATTGCAACGT AGAGCTTGCT CTGACTTCTG ATGGCAGGAC AATAGTATGC 
TACCACCCTT CTGTGGACAT TCCATATGAA CACACAAAAC CTATCCCTCG GCCAGATCCT 
GTGCATAATA ATGAAGAAAC ACATGATCAA GTGCTGAAAA CCAGATTGGA AGAAAAAGTT 
GAACACCTTG AGGAAGGACC TATGATAGAA CAACTTAGCA AAATGTTCTT TACTACTAAG 
CACCGTTGGT ATCCTCATGG ACGGTATCAC AGATGTCGTA AGAATCTGAA TCCTCCAAAA 
GACAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MRPL42 ( NM_172177.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_751917.1 Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11063
Clone ID Related Accession (Same CDS sequence)	NM_172177.3 , NM_172177.5 , NM_014050.4 , NM_014050.3 , NM_172177.4
Accession Version	NM_172177.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-28
Organism	Homo sapiens(human)
Product	39S ribosomal protein L42, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC025260.29. On Dec 1, 2018 this sequence version replaced NM_172177.3. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.97046.1, SRR1660809.8610.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTAG CTGCAGTAAA ATGGGTGATG TCAAAGAGAA CTATCTTGAA ACATTTATTT 
CCAGTCCAAA ATGGAGCTTT ATATTGTGTT TGTCATAAAT CTACGTATTC TCCTCTACCA 
GATGACTATA ATTGCAACGT AGAGCTTGCT CTGACTTCTG ATGGCAGGAC AATAGTATGC 
TACCACCCTT CTGTGGACAT TCCATATGAA CACACAAAAC CTATCCCTCG GCCAGATCCT 
GTGCATAATA ATGAAGAAAC ACATGATCAA GTGCTGAAAA CCAGATTGGA AGAAAAAGTT 
GAACACCTTG AGGAAGGACC TATGATAGAA CAACTTAGCA AAATGTTCTT TACTACTAAG 
CACCGTTGGT ATCCTCATGG ACGGTATCAC AGATGTCGTA AGAATCTGAA TCCTCCAAAA 
GACAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_751917.1
CDS	139..567
Translation	MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQVLKTRLEEKVEHLEEGPMIEQLSKMFFTTKHRWYPHGRYHRCRKNLNPPKDR

Target ORF information:

RefSeq Version	NM_172177.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mitochondrial ribosomal protein L42 (MRPL42), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172177.4

ORF Insert Sequence:

ATGGCTGTAG CTGCAGTAAA ATGGGTGATG TCAAAGAGAA CTATCTTGAA ACATTTATTT 
CCAGTCCAAA ATGGAGCTTT ATATTGTGTT TGTCATAAAT CTACGTATTC TCCTCTACCA 
GATGACTATA ATTGCAACGT AGAGCTTGCT CTGACTTCTG ATGGCAGGAC AATAGTATGC 
TACCACCCTT CTGTGGACAT TCCATATGAA CACACAAAAC CTATCCCTCG GCCAGATCCT 
GTGCATAATA ATGAAGAAAC ACATGATCAA GTGCTGAAAA CCAGATTGGA AGAAAAAGTT 
GAACACCTTG AGGAAGGACC TATGATAGAA CAACTTAGCA AAATGTTCTT TACTACTAAG 
CACCGTTGGT ATCCTCATGG ACGGTATCAC AGATGTCGTA AGAATCTGAA TCCTCCAAAA 
GACAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structures of the human mitochondrial ribosome in native states of assembly.
Nature structural & molecular biology24(10)866-869(2017 Oct)
Brown A,Rathore S,Kimanius D,Aibara S,Bai XC,Rorbach J,Amunts A,Ramakrishnan V

[Comparative analysis of the role of CD4(+) and CD8(+) T cells in severe asthma development].
Molekuliarnaia biologiia49(3)482-90(2015 May-Jun)
Wang X,Wang J,Xing CY,Zang R,Pu YY,Yin ZX

Structure of the large ribosomal subunit from human mitochondria.
Science (New York, N.Y.)346(6210)718-722(2014 Nov)
Brown A,Amunts A,Bai XC,Sugimoto Y,Edwards PC,Murshudov G,Scheres SHW,Ramakrishnan V

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

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MRPL42 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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