GPR26 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPR26
Entrez Gene ID	2849
Full Name	G protein-coupled receptor 26
General protein information	Preferred Names G protein-coupled receptor 26 Names G-protein coupled receptor 26
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q26.13
Summary	This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016].
Disorder MIM:	604847

mRNA and Protein(s)

mRNA	Protein	Name
NM_153442.4	NP_703143.1	G-protein coupled receptor 26
NM_153442.3	NP_703143.1	G-protein coupled receptor 26

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gpr26	NP_620196.1
	GPR26	XP_001082036.1
Canis lupus familiaris (dog)	GPR26	XP_544056.2
Mus musculus (house mouse)	Gpr26	NP_775586.1
Gallus gallus (chicken)	GPR26	XP_421809.2
Danio rerio (zebrafish)	LOC564928	XP_693338.2
Homo sapiens (human)	GPR26	NP_703143.1
Pan troglodytes (chimpanzee)	GPR26	XP_521629.2
Xenopus tropicalis (tropical clawed frog)	gpr26	XP_002937850.1

Gene Ontology
Bibliography

Related articles in PubMed

G protein-coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases.
Mori F, Tanji K, Miki Y, Toyoshima Y, Yoshida M, Kakita A, Takahashi H, Utsumi J, Sasaki H, Wakabayashi K
Neuropathology : official journal of the Japanese Society of Neuropathology36(1)50-5(2016 Feb)

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ
Nature504(7479)291-5(2013 Dec)

Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
Yu B, Barbalic M, Brautbar A, Nambi V, Hoogeveen RC, Tang W, Mosley TH, Rotter JI, deFilippi CR, O'Donnell CJ, Kathiresan S, Rice K, Heckbert SR, Ballantyne CM, Psaty BM, Boerwinkle E,
Circulation. Cardiovascular genetics6(1)82-8(2013 Feb)

The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas.
Boulay JL, Ionescu MC, Sivasankaran B, Labuhn M, Dolder-Schlienger B, Taylor E, Morin P Jr, Hemmings BA, Lino MM, Jones G, Maier D, Merlo A
International journal of oncology35(5)1123-31(2009 Nov)

GPR26: a marker for primary glioblastoma?
Carter AN, Cole CL, Playle AG, Ramsay EJ, Shervington AA
Molecular and cellular probes22(2)133-7(2008 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GPR26 may have a common role in the formation or degradation of intranuclear inclusions in several neurodegenerative diseases
Title: G protein-coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

epigenetic silencing is a common mechanism in malignant gliomas that simultaneously inactivates MGMT and GPR26
Title: The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas.

Study has identified GPR26 to be a genetic indicator of primary glioblastoma, suggesting that it could be a suppressor of primary glioblastoma development.
Title: GPR26: a marker for primary glioblastoma?

The following GPR26 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPR26 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01982	NM_153442.4 Latest version!	Homo sapiens G protein-coupled receptor 26 (GPR26), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu01982	NM_153442.3	Homo sapiens G protein-coupled receptor 26 (GPR26), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPR26 ( NM_153442.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_703143.1 Homo sapiens G protein-coupled receptor 26 (GPR26), mRNA.

Price & Availability↑

CloneID	OHu01982
Clone ID Related Accession (Same CDS sequence)	NM_153442.4 , NM_153442.3
Accession Version	NM_153442.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	G-protein coupled receptor 26
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009987.17, AJ505757.1, AK091093.1 and AI076749.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_153442.3. Sequence Note: Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AJ505757.1, SRR1803615.25394.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000284674.2/ ENSP00000284674.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAACTCGT GGGACGCGGG CCTGGCGGGG CTACTGGTGG GCACGATGGG CGTCTCGCTG 
CTGTCCAACG CGCTGGTGCT GCTCTGCCTG CTGCACAGCG CGGACATCCG CCGCCAGGCG 
CCGGCGCTCT TCACCCTGAA CCTCACGTGC GGGAACCTGC TGTGCACCGT GGTCAACATG 
CCGCTCACGC TGGCCGGCGT CGTGGCGCAG CGGCAGCCGG CGGGCGACCG CCTGTGCCGC 
CTGGCTGCCT TCCTCGACAC CTTCCTGGCT GCCAACTCCA TGCTCAGCAT GGCCGCGCTC 
AGCATCGACC GCTGGGTGGC CGTGGTCTTC CCGCTGAGCT ACCGGGCCAA GATGCGCCTC 
CGCGACGCGG CGCTCATGGT GGCCTACACG TGGCTGCACG CGCTCACCTT CCCAGCCGCC 
GCGCTCGCCC TGTCCTGGCT CGGCTTCCAC CAGCTGTACG CCTCGTGCAC GCTGTGCAGC 
CGGCGGCCAG ACGAGCGCCT GCGCTTCGCC GTCTTCACTG GCGCCTTCCA CGCTCTCAGC 
TTCCTGCTCT CCTTCGTCGT GCTCTGCTGC ACGTACCTCA AGGTGCTCAA GGTGGCCCGC 
TTCCATTGCA AGCGCATCGA CGTGATCACC ATGCAGACGC TGGTGCTGCT GGTGGACCTG 
CACCCCAGTG TGCGGGAACG CTGTCTGGAG GAGCAGAAGC GGAGGCGACA GCGAGCCACC 
AAGAAGATCA GCACCTTCAT AGGGACCTTC CTTGTGTGCT TCGCGCCCTA TGTGATCACC 
AGGCTAGTGG AGCTCTTCTC CACGGTGCCC ATCGGCTCCC ACTGGGGGGT GCTGTCCAAG 
TGCTTGGCGT ACAGCAAGGC CGCATCCGAC CCCTTTGTGT ACTCCTTACT GCGACACCAG 
TACCGCAAAA GCTGCAAGGA GATTCTGAAC AGGCTCCTGC ACAGACGCTC CATCCACTCC 
TCTGGCCTCA CAGGCGACTC TCACAGCCAG AACATTCTGC CGGTGTCTGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_703143.1
CDS	54..1067
Translation	MNSWDAGLAGLLVGTMGVSLLSNALVLLCLLHSADIRRQAPALFTLNLTCGNLLCTVVNMPLTLAGVVAQRQPAGDRLCRLAAFLDTFLAANSMLSMAALSIDRWVAVVFPLSYRAKMRLRDAALMVAYTWLHALTFPAAALALSWLGFHQLYASCTLCSRRPDERLRFAVFTGAFHALSFLLSFVVLCCTYLKVLKVARFHCKRIDVITMQTLVLLVDLHPSVRERCLEEQKRRRQRATKKISTFIGTFLVCFAPYVITRLVELFSTVPIGSHWGVLSKCLAYSKAASDPFVYSLLRHQYRKSCKEILNRLLHRRSIHSSGLTGDSHSQNILPVSE

Target ORF information:

RefSeq Version	NM_153442.4
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 26 (GPR26), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153442.4

ORF Insert Sequence:

ATGAACTCGT GGGACGCGGG CCTGGCGGGG CTACTGGTGG GCACGATGGG CGTCTCGCTG 
CTGTCCAACG CGCTGGTGCT GCTCTGCCTG CTGCACAGCG CGGACATCCG CCGCCAGGCG 
CCGGCGCTCT TCACCCTGAA CCTCACGTGC GGGAACCTGC TGTGCACCGT GGTCAACATG 
CCGCTCACGC TGGCCGGCGT CGTGGCGCAG CGGCAGCCGG CGGGCGACCG CCTGTGCCGC 
CTGGCTGCCT TCCTCGACAC CTTCCTGGCT GCCAACTCCA TGCTCAGCAT GGCCGCGCTC 
AGCATCGACC GCTGGGTGGC CGTGGTCTTC CCGCTGAGCT ACCGGGCCAA GATGCGCCTC 
CGCGACGCGG CGCTCATGGT GGCCTACACG TGGCTGCACG CGCTCACCTT CCCAGCCGCC 
GCGCTCGCCC TGTCCTGGCT CGGCTTCCAC CAGCTGTACG CCTCGTGCAC GCTGTGCAGC 
CGGCGGCCAG ACGAGCGCCT GCGCTTCGCC GTCTTCACTG GCGCCTTCCA CGCTCTCAGC 
TTCCTGCTCT CCTTCGTCGT GCTCTGCTGC ACGTACCTCA AGGTGCTCAA GGTGGCCCGC 
TTCCATTGCA AGCGCATCGA CGTGATCACC ATGCAGACGC TGGTGCTGCT GGTGGACCTG 
CACCCCAGTG TGCGGGAACG CTGTCTGGAG GAGCAGAAGC GGAGGCGACA GCGAGCCACC 
AAGAAGATCA GCACCTTCAT AGGGACCTTC CTTGTGTGCT TCGCGCCCTA TGTGATCACC 
AGGCTAGTGG AGCTCTTCTC CACGGTGCCC ATCGGCTCCC ACTGGGGGGT GCTGTCCAAG 
TGCTTGGCGT ACAGCAAGGC CGCATCCGAC CCCTTTGTGT ACTCCTTACT GCGACACCAG 
TACCGCAAAA GCTGCAAGGA GATTCTGAAC AGGCTCCTGC ACAGACGCTC CATCCACTCC 
TCTGGCCTCA CAGGCGACTC TCACAGCCAG AACATTCTGC CGGTGTCTGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPR26 ( NM_153442.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_703143.1 Homo sapiens G protein-coupled receptor 26 (GPR26), mRNA.

Price & Availability↑

CloneID	OHu01982
Clone ID Related Accession (Same CDS sequence)	NM_153442.4 , NM_153442.3
Accession Version	NM_153442.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	G-protein coupled receptor 26
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009987.17, AJ505757.1, AK091093.1 and AI076749.1. This sequence is a reference standard in the RefSeqGene project. On Feb 27, 2009 this sequence version replaced NM_153442.2. Sequence Note: Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AJ505757.1, SRR1803615.25394.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACTCGT GGGACGCGGG CCTGGCGGGG CTACTGGTGG GCACGATGGG CGTCTCGCTG 
CTGTCCAACG CGCTGGTGCT GCTCTGCCTG CTGCACAGCG CGGACATCCG CCGCCAGGCG 
CCGGCGCTCT TCACCCTGAA CCTCACGTGC GGGAACCTGC TGTGCACCGT GGTCAACATG 
CCGCTCACGC TGGCCGGCGT CGTGGCGCAG CGGCAGCCGG CGGGCGACCG CCTGTGCCGC 
CTGGCTGCCT TCCTCGACAC CTTCCTGGCT GCCAACTCCA TGCTCAGCAT GGCCGCGCTC 
AGCATCGACC GCTGGGTGGC CGTGGTCTTC CCGCTGAGCT ACCGGGCCAA GATGCGCCTC 
CGCGACGCGG CGCTCATGGT GGCCTACACG TGGCTGCACG CGCTCACCTT CCCAGCCGCC 
GCGCTCGCCC TGTCCTGGCT CGGCTTCCAC CAGCTGTACG CCTCGTGCAC GCTGTGCAGC 
CGGCGGCCAG ACGAGCGCCT GCGCTTCGCC GTCTTCACTG GCGCCTTCCA CGCTCTCAGC 
TTCCTGCTCT CCTTCGTCGT GCTCTGCTGC ACGTACCTCA AGGTGCTCAA GGTGGCCCGC 
TTCCATTGCA AGCGCATCGA CGTGATCACC ATGCAGACGC TGGTGCTGCT GGTGGACCTG 
CACCCCAGTG TGCGGGAACG CTGTCTGGAG GAGCAGAAGC GGAGGCGACA GCGAGCCACC 
AAGAAGATCA GCACCTTCAT AGGGACCTTC CTTGTGTGCT TCGCGCCCTA TGTGATCACC 
AGGCTAGTGG AGCTCTTCTC CACGGTGCCC ATCGGCTCCC ACTGGGGGGT GCTGTCCAAG 
TGCTTGGCGT ACAGCAAGGC CGCATCCGAC CCCTTTGTGT ACTCCTTACT GCGACACCAG 
TACCGCAAAA GCTGCAAGGA GATTCTGAAC AGGCTCCTGC ACAGACGCTC CATCCACTCC 
TCTGGCCTCA CAGGCGACTC TCACAGCCAG AACATTCTGC CGGTGTCTGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_703143.1
CDS	54..1067
Translation	MNSWDAGLAGLLVGTMGVSLLSNALVLLCLLHSADIRRQAPALFTLNLTCGNLLCTVVNMPLTLAGVVAQRQPAGDRLCRLAAFLDTFLAANSMLSMAALSIDRWVAVVFPLSYRAKMRLRDAALMVAYTWLHALTFPAAALALSWLGFHQLYASCTLCSRRPDERLRFAVFTGAFHALSFLLSFVVLCCTYLKVLKVARFHCKRIDVITMQTLVLLVDLHPSVRERCLEEQKRRRQRATKKISTFIGTFLVCFAPYVITRLVELFSTVPIGSHWGVLSKCLAYSKAASDPFVYSLLRHQYRKSCKEILNRLLHRRSIHSSGLTGDSHSQNILPVSE

Target ORF information:

RefSeq Version	NM_153442.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 26 (GPR26), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153442.3

ORF Insert Sequence:

ATGAACTCGT GGGACGCGGG CCTGGCGGGG CTACTGGTGG GCACGATGGG CGTCTCGCTG 
CTGTCCAACG CGCTGGTGCT GCTCTGCCTG CTGCACAGCG CGGACATCCG CCGCCAGGCG 
CCGGCGCTCT TCACCCTGAA CCTCACGTGC GGGAACCTGC TGTGCACCGT GGTCAACATG 
CCGCTCACGC TGGCCGGCGT CGTGGCGCAG CGGCAGCCGG CGGGCGACCG CCTGTGCCGC 
CTGGCTGCCT TCCTCGACAC CTTCCTGGCT GCCAACTCCA TGCTCAGCAT GGCCGCGCTC 
AGCATCGACC GCTGGGTGGC CGTGGTCTTC CCGCTGAGCT ACCGGGCCAA GATGCGCCTC 
CGCGACGCGG CGCTCATGGT GGCCTACACG TGGCTGCACG CGCTCACCTT CCCAGCCGCC 
GCGCTCGCCC TGTCCTGGCT CGGCTTCCAC CAGCTGTACG CCTCGTGCAC GCTGTGCAGC 
CGGCGGCCAG ACGAGCGCCT GCGCTTCGCC GTCTTCACTG GCGCCTTCCA CGCTCTCAGC 
TTCCTGCTCT CCTTCGTCGT GCTCTGCTGC ACGTACCTCA AGGTGCTCAA GGTGGCCCGC 
TTCCATTGCA AGCGCATCGA CGTGATCACC ATGCAGACGC TGGTGCTGCT GGTGGACCTG 
CACCCCAGTG TGCGGGAACG CTGTCTGGAG GAGCAGAAGC GGAGGCGACA GCGAGCCACC 
AAGAAGATCA GCACCTTCAT AGGGACCTTC CTTGTGTGCT TCGCGCCCTA TGTGATCACC 
AGGCTAGTGG AGCTCTTCTC CACGGTGCCC ATCGGCTCCC ACTGGGGGGT GCTGTCCAAG 
TGCTTGGCGT ACAGCAAGGC CGCATCCGAC CCCTTTGTGT ACTCCTTACT GCGACACCAG 
TACCGCAAAA GCTGCAAGGA GATTCTGAAC AGGCTCCTGC ACAGACGCTC CATCCACTCC 
TCTGGCCTCA CAGGCGACTC TCACAGCCAG AACATTCTGC CGGTGTCTGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

G protein-coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases.
Neuropathology : official journal of the Japanese Society of Neuropathology36(1)50-5(2016 Feb)
Mori F,Tanji K,Miki Y,Toyoshima Y,Yoshida M,Kakita A,Takahashi H,Utsumi J,Sasaki H,Wakabayashi K

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Nature504(7479)291-5(2013 Dec)
Hasson SA,Kane LA,Yamano K,Huang CH,Sliter DA,Buehler E,Wang C,Heman-Ackah SM,Hessa T,Guha R,Martin SE,Youle RJ

Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
Circulation. Cardiovascular genetics6(1)82-8(2013 Feb)
Yu B,Barbalic M,Brautbar A,Nambi V,Hoogeveen RC,Tang W,Mosley TH,Rotter JI,deFilippi CR,O'Donnell CJ,Kathiresan S,Rice K,Heckbert SR,Ballantyne CM,Psaty BM,Boerwinkle E,

The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas.
International journal of oncology35(5)1123-31(2009 Nov)
Boulay JL,Ionescu MC,Sivasankaran B,Labuhn M,Dolder-Schlienger B,Taylor E,Morin P Jr,Hemmings BA,Lino MM,Jones G,Maier D,Merlo A

GPR26: a marker for primary glioblastoma?
Molecular and cellular probes22(2)133-7(2008 Apr)
Carter AN,Cole CL,Playle AG,Ramsay EJ,Shervington AA

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GPR26 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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