CSNK2A3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CSNK2A3
Entrez Gene ID	283106
Full Name	casein kinase 2 alpha 3
Synonyms	CSNK2A1P
General protein information	Preferred Names casein kinase 2 alpha 3 Names casein kinase 2, alpha 1 polypeptide-like casein kinase 2, alpha 1 polypeptide pseudogene casein kinase 2, alpha 3 polypeptide
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.4
Summary	This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001256686.2	NP_001243615.1	casein kinase II subunit alpha 3
NM_001256686.1	NP_001243615.1	casein kinase II subunit alpha 3

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	ck2a1	NP_571327.1
Oryza sativa (rice)	Os07g0114400	NP_001058752.1
Homo sapiens (human)	CSNK2A3	NP_001243615.1
Danio rerio (zebrafish)	zgc:86598	NP_001002164.1
Arabidopsis thaliana (thale cress)	CKA2	NP_190569.2
Arabidopsis thaliana (thale cress)	CKA1	NP_201539.2

Gene Ontology
Bibliography

Related articles in PubMed

Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.
Hung MS, Lin YC, Mao JH, Kim IJ, Xu Z, Yang CT, Jablons DM, You L
PloS one5(7)e11418(2010 Jul)

Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.
Trembley JH, Tatsumi S, Sakashita E, Loyer P, Slaughter CA, Suzuki H, Endo H, Kidd VJ, Mayeda A
Molecular and cellular biology25(4)1446-57(2005 Feb)

Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.
Pechkova E, Zanotti G, Nicolini C
Acta crystallographica. Section D, Biological crystallography59(Pt 12)2133-9(2003 Dec)

Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.
Ermakova I, Boldyreff B, Issinger OG, Niefind K
Journal of molecular biology330(5)925-34(2003 Jul)

p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.
Keller DM, Lu H
The Journal of biological chemistry277(51)50206-13(2002 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.

The following CSNK2A3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CSNK2A3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00214	NM_001256686.2 Latest version!	Homo sapiens casein kinase 2 alpha 3 (CSNK2A3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu00214	NM_001256686.1	Homo sapiens casein kinase 2 alpha 3 (CSNK2A3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CSNK2A3 ( NM_001256686.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243615.1 Homo sapiens casein kinase 2 alpha 3 (CSNK2A3), mRNA.

Price & Availability↑

CloneID	OHu00214
Clone ID Related Accession (Same CDS sequence)	NM_001256686.2 , NM_001256686.1
Accession Version	NM_001256686.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	casein kinase II subunit alpha 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC023946.5. On May 17, 2019 this sequence version replaced NM_001256686.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AY112721.1, SRR1660809.191092.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000528848.3/ ENSP00000473553.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTCGGGAC CCGTGCCAAG CAGGGCCAGA GTTTACACAG ATGTTAATAC ACACAGACCT 
CGAGAATACT GGGATTACGA GTCACATGTG GTGGAATGGG GAAATCAAGA TGACTACCAG 
CTGGTTCGAA AATTAGGCCG AGGTAAATAC AGTGAAGTAT TTGAAGCCAT CAACATCACA 
AATAATGAAA AAGTTGTTGT TAAAATTCTC AAGCCAGTAA AAAAGAAGAA AATTAAGCGT 
GAAATAAAGA TTTTGGAGAA TTTGAGAGGA GGTCCCAACA TCATCACACT GGCAGACATT 
GTAAAAGACC CTGTGTCACG AACCCCCGCC TTGGTTTTTG AACACGTAAA CAACACAGAC 
TTCAAGCAAT TGTACCAGAC GTTAACAGAC TATGATATTC GATTTTACAT GTATGAGATT 
CTGAAGGCCC TGGATTATTG TCACAGCATG GGAATTATGC ACAGAGATGT CAAGCCCCAT 
AATGTCATGA TTGATCATGA GCACAGAAAG CTACGACTAA TAGACTGGGG TTTGGCTGAG 
TTTTATCATC CTGGCCAAGA ATATAATGTC CGAGTTGCTT CCCGATACTT CAAAGGTCCT 
GAGCTACTTG TAGACTATCA GATGTACGAT TATAGTTTGG ATATGTGGAG ATTGGGTTGT 
ATGCTGGCAA GTATGATCTT TCGGAAGGAG CCATTTTTCC ATGGACGTGA CAATTATGAT 
CAGTTGGTGA GGATAGCCAA GTTTCTGGGG ACAGAAGATT TATATGGCTA TATTGACAAA 
TACAACATTG AATTAGATCC ACGTTTCAAT GATATCTTGG GCAGACACTC TCGAAAGCGA 
TGGGAACGCT TTGTCCACAG TGAAAATCAG CACCTTGTCA GCCCTGAGGC CTTGGATTTC 
CTGGACAAAC TGCTGCGATA TGACCACCAG TCACGGCTTA CTGCAAGAGA GGCCATGGAG 
CACCCCTATT TCTACACTGT TGTGAAGGAC CAGGCTCGAA TGGGTTCATC TAGCATGCCA 
GGGGGCAGTA CGCCCGTCAG CAGCGCCAAT GTGATGTCAG GGATTTCTTC AGTGCCAACT 
CCTTCACCCC TTGGACCTCT GGCAGGCTCA CCAGTGATTG CTGCTGCCAA CCCCCTTGGG 
ATGCCTGTTC CAGCTGCCAC TGGCGCTCAG CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243615.1
CDS	132..1307
Translation	MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWRLGCMLASMIFRKEPFFHGRDNYDQLVRIAKFLGTEDLYGYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANVMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAATGAQQ

Target ORF information:

RefSeq Version	NM_001256686.2
Organism	Homo sapiens(human)
Definition	Homo sapiens casein kinase 2 alpha 3 (CSNK2A3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256686.2

ORF Insert Sequence:

ATGTCGGGAC CCGTGCCAAG CAGGGCCAGA GTTTACACAG ATGTTAATAC ACACAGACCT 
CGAGAATACT GGGATTACGA GTCACATGTG GTGGAATGGG GAAATCAAGA TGACTACCAG 
CTGGTTCGAA AATTAGGCCG AGGTAAATAC AGTGAAGTAT TTGAAGCCAT CAACATCACA 
AATAATGAAA AAGTTGTTGT TAAAATTCTC AAGCCAGTAA AAAAGAAGAA AATTAAGCGT 
GAAATAAAGA TTTTGGAGAA TTTGAGAGGA GGTCCCAACA TCATCACACT GGCAGACATT 
GTAAAAGACC CTGTGTCACG AACCCCCGCC TTGGTTTTTG AACACGTAAA CAACACAGAC 
TTCAAGCAAT TGTACCAGAC GTTAACAGAC TATGATATTC GATTTTACAT GTATGAGATT 
CTGAAGGCCC TGGATTATTG TCACAGCATG GGAATTATGC ACAGAGATGT CAAGCCCCAT 
AATGTCATGA TTGATCATGA GCACAGAAAG CTACGACTAA TAGACTGGGG TTTGGCTGAG 
TTTTATCATC CTGGCCAAGA ATATAATGTC CGAGTTGCTT CCCGATACTT CAAAGGTCCT 
GAGCTACTTG TAGACTATCA GATGTACGAT TATAGTTTGG ATATGTGGAG ATTGGGTTGT 
ATGCTGGCAA GTATGATCTT TCGGAAGGAG CCATTTTTCC ATGGACGTGA CAATTATGAT 
CAGTTGGTGA GGATAGCCAA GTTTCTGGGG ACAGAAGATT TATATGGCTA TATTGACAAA 
TACAACATTG AATTAGATCC ACGTTTCAAT GATATCTTGG GCAGACACTC TCGAAAGCGA 
TGGGAACGCT TTGTCCACAG TGAAAATCAG CACCTTGTCA GCCCTGAGGC CTTGGATTTC 
CTGGACAAAC TGCTGCGATA TGACCACCAG TCACGGCTTA CTGCAAGAGA GGCCATGGAG 
CACCCCTATT TCTACACTGT TGTGAAGGAC CAGGCTCGAA TGGGTTCATC TAGCATGCCA 
GGGGGCAGTA CGCCCGTCAG CAGCGCCAAT GTGATGTCAG GGATTTCTTC AGTGCCAACT 
CCTTCACCCC TTGGACCTCT GGCAGGCTCA CCAGTGATTG CTGCTGCCAA CCCCCTTGGG 
ATGCCTGTTC CAGCTGCCAC TGGCGCTCAG CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSNK2A3 ( NM_001256686.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243615.1 Homo sapiens casein kinase 2 alpha 3 (CSNK2A3), mRNA.

Price & Availability↑

CloneID	OHu00214
Clone ID Related Accession (Same CDS sequence)	NM_001256686.2 , NM_001256686.1
Accession Version	NM_001256686.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	casein kinase II subunit alpha 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC023946.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AY112721.1 [ECO:0000345] ##Evidence-Data-END##

ATGTCGGGAC CCGTGCCAAG CAGGGCCAGA GTTTACACAG ATGTTAATAC ACACAGACCT 
CGAGAATACT GGGATTACGA GTCACATGTG GTGGAATGGG GAAATCAAGA TGACTACCAG 
CTGGTTCGAA AATTAGGCCG AGGTAAATAC AGTGAAGTAT TTGAAGCCAT CAACATCACA 
AATAATGAAA AAGTTGTTGT TAAAATTCTC AAGCCAGTAA AAAAGAAGAA AATTAAGCGT 
GAAATAAAGA TTTTGGAGAA TTTGAGAGGA GGTCCCAACA TCATCACACT GGCAGACATT 
GTAAAAGACC CTGTGTCACG AACCCCCGCC TTGGTTTTTG AACACGTAAA CAACACAGAC 
TTCAAGCAAT TGTACCAGAC GTTAACAGAC TATGATATTC GATTTTACAT GTATGAGATT 
CTGAAGGCCC TGGATTATTG TCACAGCATG GGAATTATGC ACAGAGATGT CAAGCCCCAT 
AATGTCATGA TTGATCATGA GCACAGAAAG CTACGACTAA TAGACTGGGG TTTGGCTGAG 
TTTTATCATC CTGGCCAAGA ATATAATGTC CGAGTTGCTT CCCGATACTT CAAAGGTCCT 
GAGCTACTTG TAGACTATCA GATGTACGAT TATAGTTTGG ATATGTGGAG ATTGGGTTGT 
ATGCTGGCAA GTATGATCTT TCGGAAGGAG CCATTTTTCC ATGGACGTGA CAATTATGAT 
CAGTTGGTGA GGATAGCCAA GTTTCTGGGG ACAGAAGATT TATATGGCTA TATTGACAAA 
TACAACATTG AATTAGATCC ACGTTTCAAT GATATCTTGG GCAGACACTC TCGAAAGCGA 
TGGGAACGCT TTGTCCACAG TGAAAATCAG CACCTTGTCA GCCCTGAGGC CTTGGATTTC 
CTGGACAAAC TGCTGCGATA TGACCACCAG TCACGGCTTA CTGCAAGAGA GGCCATGGAG 
CACCCCTATT TCTACACTGT TGTGAAGGAC CAGGCTCGAA TGGGTTCATC TAGCATGCCA 
GGGGGCAGTA CGCCCGTCAG CAGCGCCAAT GTGATGTCAG GGATTTCTTC AGTGCCAACT 
CCTTCACCCC TTGGACCTCT GGCAGGCTCA CCAGTGATTG CTGCTGCCAA CCCCCTTGGG 
ATGCCTGTTC CAGCTGCCAC TGGCGCTCAG CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243615.1
CDS	239..1414
Translation	MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWRLGCMLASMIFRKEPFFHGRDNYDQLVRIAKFLGTEDLYGYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANVMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAATGAQQ

Target ORF information:

RefSeq Version	NM_001256686.1
Organism	Homo sapiens(human)
Definition	Homo sapiens casein kinase 2 alpha 3 (CSNK2A3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256686.1

ORF Insert Sequence:

ATGTCGGGAC CCGTGCCAAG CAGGGCCAGA GTTTACACAG ATGTTAATAC ACACAGACCT 
CGAGAATACT GGGATTACGA GTCACATGTG GTGGAATGGG GAAATCAAGA TGACTACCAG 
CTGGTTCGAA AATTAGGCCG AGGTAAATAC AGTGAAGTAT TTGAAGCCAT CAACATCACA 
AATAATGAAA AAGTTGTTGT TAAAATTCTC AAGCCAGTAA AAAAGAAGAA AATTAAGCGT 
GAAATAAAGA TTTTGGAGAA TTTGAGAGGA GGTCCCAACA TCATCACACT GGCAGACATT 
GTAAAAGACC CTGTGTCACG AACCCCCGCC TTGGTTTTTG AACACGTAAA CAACACAGAC 
TTCAAGCAAT TGTACCAGAC GTTAACAGAC TATGATATTC GATTTTACAT GTATGAGATT 
CTGAAGGCCC TGGATTATTG TCACAGCATG GGAATTATGC ACAGAGATGT CAAGCCCCAT 
AATGTCATGA TTGATCATGA GCACAGAAAG CTACGACTAA TAGACTGGGG TTTGGCTGAG 
TTTTATCATC CTGGCCAAGA ATATAATGTC CGAGTTGCTT CCCGATACTT CAAAGGTCCT 
GAGCTACTTG TAGACTATCA GATGTACGAT TATAGTTTGG ATATGTGGAG ATTGGGTTGT 
ATGCTGGCAA GTATGATCTT TCGGAAGGAG CCATTTTTCC ATGGACGTGA CAATTATGAT 
CAGTTGGTGA GGATAGCCAA GTTTCTGGGG ACAGAAGATT TATATGGCTA TATTGACAAA 
TACAACATTG AATTAGATCC ACGTTTCAAT GATATCTTGG GCAGACACTC TCGAAAGCGA 
TGGGAACGCT TTGTCCACAG TGAAAATCAG CACCTTGTCA GCCCTGAGGC CTTGGATTTC 
CTGGACAAAC TGCTGCGATA TGACCACCAG TCACGGCTTA CTGCAAGAGA GGCCATGGAG 
CACCCCTATT TCTACACTGT TGTGAAGGAC CAGGCTCGAA TGGGTTCATC TAGCATGCCA 
GGGGGCAGTA CGCCCGTCAG CAGCGCCAAT GTGATGTCAG GGATTTCTTC AGTGCCAACT 
CCTTCACCCC TTGGACCTCT GGCAGGCTCA CCAGTGATTG CTGCTGCCAA CCCCCTTGGG 
ATGCCTGTTC CAGCTGCCAC TGGCGCTCAG CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.
PloS one5(7)e11418(2010 Jul)
Hung MS,Lin YC,Mao JH,Kim IJ,Xu Z,Yang CT,Jablons DM,You L

Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.
Molecular and cellular biology25(4)1446-57(2005 Feb)
Trembley JH,Tatsumi S,Sakashita E,Loyer P,Slaughter CA,Suzuki H,Endo H,Kidd VJ,Mayeda A

Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.
Acta crystallographica. Section D, Biological crystallography59(Pt 12)2133-9(2003 Dec)
Pechkova E,Zanotti G,Nicolini C

Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.
Journal of molecular biology330(5)925-34(2003 Jul)
Ermakova I,Boldyreff B,Issinger OG,Niefind K

p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.
The Journal of biological chemistry277(51)50206-13(2002 Dec)
Keller DM,Lu H