PABPC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PABPC1
Entrez Gene ID	26986
Full Name	poly(A) binding protein cytoplasmic 1
Synonyms	PAB1,PABP,PABP1,PABPC2,PABPL1
General protein information	Preferred Names poly(A) binding protein cytoplasmic 1 Names polyadenylate-binding protein 1 poly(A) binding protein, cytoplasmic 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q22.3
Summary	This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010].
Disorder MIM:	604679

mRNA and Protein(s)

mRNA	Protein	Name
NM_002568.3	NP_002559.2	polyadenylate-binding protein 1
NM_002568.4	NP_002559.2	polyadenylate-binding protein 1
XM_005250861.2	XP_005250918.1	polyadenylate-binding protein 1 isoform X1
XM_005250861.3	XP_005250918.1	polyadenylate-binding protein 1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PABPC1	NP_002559.2
Mus musculus (house mouse)	Pabpc1	NP_032800.2
Gallus gallus (chicken)	PABPC1	NP_001026768.1
Caenorhabditis elegans (roundworm)	pab-2	NP_510260.1
Danio rerio (zebrafish)	pabpc1b	NP_957176.1
Arabidopsis thaliana (thale cress)	PAB8	NP_564554.1
Xenopus tropicalis (tropical clawed frog)	pabpc1	NP_001005051.1
Rattus norvegicus (Norway rat)	Pabpc1	NP_599180.1
Canis lupus familiaris (dog)	PABPC1	XP_856708.1
Caenorhabditis elegans (roundworm)	pab-1	NP_001021709.1
Oryza sativa (rice)	Os04g0504800	NP_001053248.1
Bos taurus (cattle)	PABPC1	NP_776993.1
Arabidopsis thaliana (thale cress)	PAB2	NP_195137.5
Oryza sativa (rice)	Os09g0115400	NP_001062583.1
Oryza sativa (rice)	Os08g0314800	NP_001061515.1

Gene Ontology
Bibliography

Related articles in PubMed

The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.
Copsey AC, Cooper S, Parker R, Lineham E, Lapworth C, Jallad D, Sweet S, Morley SJ
The Biochemical journal474(18)3109-3120(2017 08)

Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay.
Silva AL, Ribeiro P, In?cio A, Liebhaber SA, Rom?o L
RNA (New York, N.Y.)14(3)563-76(2008 Mar)

Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein.
Siddiqui N, Mangus DA, Chang TC, Palermino JM, Shyu AB, Gehring K
The Journal of biological chemistry282(34)25067-75(2007 Aug)

Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms.
Kahvejian A, Svitkin YV, Sukarieh R, M'Boutchou MN, Sonenberg N
Genes & development19(1)104-13(2005 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that DEAD-box helicase 3 (DDX3X) physically interacts and co-localizes with poly(A)-binding cytoplasmic protein 1 (PABPC1) and caprin-1 in lamellipodia at the leading edge of spreading cells; these interactions are dependent on mRNA; depletion of DDX3X (via gene silencing with the CRISPR-Cas system) leads to decreased cell motility. These studies were conducted using MRC5 lung fibroblast cell line.
Title: The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.

Data suggest that hnRNPLL specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL = heterogeneous nuclear ribonucleoprotein L-like protein; PABPC1 = cytoplasmic poly[A]-binding protein 1)
Title: Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the RNA-binding protein hnRNPLL and thereby regulates immunoglobulin secretion in plasma cells.

PABP enhances the productive binding of the eRF1-eRF3 complex to the ribosome, via interactions with the N-terminal domain of eRF3a which itself has an active role in translation termination.
Title: PABP enhances release factor recruitment and stop codon recognition during translation termination.

Unr stimulated the binding of PABP1 to mRNA, and that Unr was required for the stable interaction of PABP1 and eIF4G in cells.
Title: Stimulation of translation by human Unr requires cold shock domains 2 and 4, and correlates with poly(A) binding protein interaction.

BTG2 stimulates mRNA deadenylation via CAF1 activation through interaction with PABPC1. Interaction of BTG2 with the first RRM domain of PABPC1 is required for BTG2 to control cell proliferation.
Title: BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation.

The following PABPC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PABPC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19269	NM_002568.4 Latest version!	Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu19269	XM_005250861.3 Latest version!	Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu19269	NM_002568.3	Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu19269	XM_005250861.2	Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PABPC1 ( NM_002568.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002559.2 Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), mRNA.

Price & Availability↑

CloneID	OHu19269
Clone ID Related Accession (Same CDS sequence)	NM_002568.3 , NM_002568.4 , XM_005250861.2 , XM_005250861.3
Accession Version	NM_002568.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1911bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	polyadenylate-binding protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AK130523.1 and AL135187.1. This sequence is a reference standard in the RefSeqGene project. On Dec 16, 2004 this sequence version replaced NM_002568.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041863.1, SRR1163655.225224.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGAACCCCA GTGCCCCCAG CTACCCCATG GCCTCGCTCT ACGTGGGGGA CCTCCACCCC 
GACGTGACCG AGGCGATGCT CTACGAGAAG TTCAGCCCGG CCGGGCCCAT CCTCTCCATC 
CGGGTCTGCA GGGACATGAT CACCCGCCGC TCCTTGGGCT ACGCGTATGT GAACTTCCAG 
CAGCCGGCGG ACGCGGAGCG TGCTTTGGAC ACCATGAATT TTGATGTTAT AAAGGGCAAG 
CCAGTACGCA TCATGTGGTC TCAGCGTGAT CCATCACTTC GCAAAAGTGG AGTAGGCAAC 
ATATTCATTA AAAATCTGGA CAAATCCATT GATAATAAAG CACTGTATGA TACATTTTCT 
GCTTTTGGTA ACATCCTTTC ATGTAAGGTG GTTTGTGATG AAAATGGTTC CAAGGGCTAT 
GGATTTGTAC ACTTTGAGAC GCAGGAAGCA GCTGAAAGAG CTATTGAAAA AATGAATGGA 
ATGCTCCTAA ATGATCGCAA AGTATTTGTT GGACGATTTA AGTCTCGTAA AGAACGAGAA 
GCTGAACTTG GAGCTAGGGC AAAAGAATTC ACCAATGTTT ACATCAAGAA TTTTGGAGAA 
GACATGGATG ATGAGCGCCT TAAGGATCTC TTTGGCAAGT TTGGGCCTGC CTTAAGTGTG 
AAAGTAATGA CTGATGAAAG TGGAAAATCC AAAGGATTTG GATTTGTAAG CTTTGAAAGG 
CATGAAGATG CACAGAAAGC TGTGGATGAG ATGAACGGAA AGGAGCTCAA TGGAAAACAA 
ATTTATGTTG GTCGAGCTCA GAAAAAGGTG GAACGGCAGA CGGAACTTAA GCGCAAATTT 
GAACAGATGA AACAAGATAG GATCACCAGA TACCAGGGTG TTAATCTTTA TGTGAAAAAT 
CTTGATGATG GTATTGATGA TGAACGTCTC CGGAAAGAGT TTTCTCCATT TGGTACAATC 
ACTAGTGCAA AGGTTATGAT GGAGGGTGGT CGCAGCAAAG GGTTTGGTTT TGTATGTTTC 
TCCTCCCCAG AAGAAGCCAC TAAAGCAGTT ACAGAAATGA ACGGTAGAAT TGTGGCCACA 
AAGCCATTGT ATGTAGCTTT AGCTCAGCGC AAAGAAGAGC GCCAGGCTCA CCTCACTAAC 
CAGTATATGC AGAGAATGGC AAGTGTACGA GCTGTTCCCA ACCCTGTAAT CAACCCCTAC 
CAGCCAGCAC CTCCTTCAGG TTACTTCATG GCAGCTATCC CACAGACTCA GAACCGTGCT 
GCATACTATC CTCCTAGCCA AATTGCTCAA CTAAGACCAA GTCCTCGCTG GACTGCTCAG 
GGTGCCAGAC CTCATCCATT CCAAAATATG CCCGGTGCTA TCCGCCCAGC TGCTCCTAGA 
CCACCATTTA GTACTATGAG ACCAGCTTCT TCACAGGTTC CACGAGTCAT GTCAACACAG 
CGTGTTGCTA ACACATCAAC ACAGACAATG GGTCCACGTC CTGCAGCTGC AGCCGCTGCA 
GCTACTCCTG CTGTCCGCAC CGTTCCACAG TATAAATATG CTGCAGGAGT TCGCAATCCT 
CAGCAACATC TTAATGCACA GCCACAAGTT ACAATGCAAC AGCCTGCTGT TCATGTACAA 
GGTCAGGAAC CTTTGACTGC TTCCATGTTG GCATCTGCCC CTCCTCAAGA GCAAAAGCAA 
ATGTTGGGTG AACGGCTGTT TCCTCTTATT CAAGCCATGC ACCCTACTCT TGCTGGTAAA 
ATCACTGGCA TGTTGTTGGA GATTGATAAT TCAGAACTTC TTCATATGCT CGAGTCTCCA 
GAGTCACTCC GTTCTAAGGT TGATGAAGCT GTAGCTGTAC TACAAGCCCA CCAAGCTAAA 
GAGGCTGCCC AGAAAGCAGT TAACAGTGCC ACCGGTGTTC CAACTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002559.2
CDS	505..2415
Translation	MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV

Target ORF information:

RefSeq Version	NM_002568.3
Organism	Homo sapiens(human)
Definition	Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002568.3

ORF Insert Sequence:

ATGAACCCCA GTGCCCCCAG CTACCCCATG GCCTCGCTCT ACGTGGGGGA CCTCCACCCC 
GACGTGACCG AGGCGATGCT CTACGAGAAG TTCAGCCCGG CCGGGCCCAT CCTCTCCATC 
CGGGTCTGCA GGGACATGAT CACCCGCCGC TCCTTGGGCT ACGCGTATGT GAACTTCCAG 
CAGCCGGCGG ACGCGGAGCG TGCTTTGGAC ACCATGAATT TTGATGTTAT AAAGGGCAAG 
CCAGTACGCA TCATGTGGTC TCAGCGTGAT CCATCACTTC GCAAAAGTGG AGTAGGCAAC 
ATATTCATTA AAAATCTGGA CAAATCCATT GATAATAAAG CACTGTATGA TACATTTTCT 
GCTTTTGGTA ACATCCTTTC ATGTAAGGTG GTTTGTGATG AAAATGGTTC CAAGGGCTAT 
GGATTTGTAC ACTTTGAGAC GCAGGAAGCA GCTGAAAGAG CTATTGAAAA AATGAATGGA 
ATGCTCCTAA ATGATCGCAA AGTATTTGTT GGACGATTTA AGTCTCGTAA AGAACGAGAA 
GCTGAACTTG GAGCTAGGGC AAAAGAATTC ACCAATGTTT ACATCAAGAA TTTTGGAGAA 
GACATGGATG ATGAGCGCCT TAAGGATCTC TTTGGCAAGT TTGGGCCTGC CTTAAGTGTG 
AAAGTAATGA CTGATGAAAG TGGAAAATCC AAAGGATTTG GATTTGTAAG CTTTGAAAGG 
CATGAAGATG CACAGAAAGC TGTGGATGAG ATGAACGGAA AGGAGCTCAA TGGAAAACAA 
ATTTATGTTG GTCGAGCTCA GAAAAAGGTG GAACGGCAGA CGGAACTTAA GCGCAAATTT 
GAACAGATGA AACAAGATAG GATCACCAGA TACCAGGGTG TTAATCTTTA TGTGAAAAAT 
CTTGATGATG GTATTGATGA TGAACGTCTC CGGAAAGAGT TTTCTCCATT TGGTACAATC 
ACTAGTGCAA AGGTTATGAT GGAGGGTGGT CGCAGCAAAG GGTTTGGTTT TGTATGTTTC 
TCCTCCCCAG AAGAAGCCAC TAAAGCAGTT ACAGAAATGA ACGGTAGAAT TGTGGCCACA 
AAGCCATTGT ATGTAGCTTT AGCTCAGCGC AAAGAAGAGC GCCAGGCTCA CCTCACTAAC 
CAGTATATGC AGAGAATGGC AAGTGTACGA GCTGTTCCCA ACCCTGTAAT CAACCCCTAC 
CAGCCAGCAC CTCCTTCAGG TTACTTCATG GCAGCTATCC CACAGACTCA GAACCGTGCT 
GCATACTATC CTCCTAGCCA AATTGCTCAA CTAAGACCAA GTCCTCGCTG GACTGCTCAG 
GGTGCCAGAC CTCATCCATT CCAAAATATG CCCGGTGCTA TCCGCCCAGC TGCTCCTAGA 
CCACCATTTA GTACTATGAG ACCAGCTTCT TCACAGGTTC CACGAGTCAT GTCAACACAG 
CGTGTTGCTA ACACATCAAC ACAGACAATG GGTCCACGTC CTGCAGCTGC AGCCGCTGCA 
GCTACTCCTG CTGTCCGCAC CGTTCCACAG TATAAATATG CTGCAGGAGT TCGCAATCCT 
CAGCAACATC TTAATGCACA GCCACAAGTT ACAATGCAAC AGCCTGCTGT TCATGTACAA 
GGTCAGGAAC CTTTGACTGC TTCCATGTTG GCATCTGCCC CTCCTCAAGA GCAAAAGCAA 
ATGTTGGGTG AACGGCTGTT TCCTCTTATT CAAGCCATGC ACCCTACTCT TGCTGGTAAA 
ATCACTGGCA TGTTGTTGGA GATTGATAAT TCAGAACTTC TTCATATGCT CGAGTCTCCA 
GAGTCACTCC GTTCTAAGGT TGATGAAGCT GTAGCTGTAC TACAAGCCCA CCAAGCTAAA 
GAGGCTGCCC AGAAAGCAGT TAACAGTGCC ACCGGTGTTC CAACTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PABPC1 ( NM_002568.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002559.2 Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), mRNA.

Price & Availability↑

CloneID	OHu19269
Clone ID Related Accession (Same CDS sequence)	NM_002568.3 , NM_002568.4 , XM_005250861.2 , XM_005250861.3
Accession Version	NM_002568.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1911bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	polyadenylate-binding protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AP001205.3, AK130523.1 and AL135187.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002568.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041863.1, SRR3476690.837939.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000318607.10/ ENSP00000313007.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACCCCA GTGCCCCCAG CTACCCCATG GCCTCGCTCT ACGTGGGGGA CCTCCACCCC 
GACGTGACCG AGGCGATGCT CTACGAGAAG TTCAGCCCGG CCGGGCCCAT CCTCTCCATC 
CGGGTCTGCA GGGACATGAT CACCCGCCGC TCCTTGGGCT ACGCGTATGT GAACTTCCAG 
CAGCCGGCGG ACGCGGAGCG TGCTTTGGAC ACCATGAATT TTGATGTTAT AAAGGGCAAG 
CCAGTACGCA TCATGTGGTC TCAGCGTGAT CCATCACTTC GCAAAAGTGG AGTAGGCAAC 
ATATTCATTA AAAATCTGGA CAAATCCATT GATAATAAAG CACTGTATGA TACATTTTCT 
GCTTTTGGTA ACATCCTTTC ATGTAAGGTG GTTTGTGATG AAAATGGTTC CAAGGGCTAT 
GGATTTGTAC ACTTTGAGAC GCAGGAAGCA GCTGAAAGAG CTATTGAAAA AATGAATGGA 
ATGCTCCTAA ATGATCGCAA AGTATTTGTT GGACGATTTA AGTCTCGTAA AGAACGAGAA 
GCTGAACTTG GAGCTAGGGC AAAAGAATTC ACCAATGTTT ACATCAAGAA TTTTGGAGAA 
GACATGGATG ATGAGCGCCT TAAGGATCTC TTTGGCAAGT TTGGGCCTGC CTTAAGTGTG 
AAAGTAATGA CTGATGAAAG TGGAAAATCC AAAGGATTTG GATTTGTAAG CTTTGAAAGG 
CATGAAGATG CACAGAAAGC TGTGGATGAG ATGAACGGAA AGGAGCTCAA TGGAAAACAA 
ATTTATGTTG GTCGAGCTCA GAAAAAGGTG GAACGGCAGA CGGAACTTAA GCGCAAATTT 
GAACAGATGA AACAAGATAG GATCACCAGA TACCAGGGTG TTAATCTTTA TGTGAAAAAT 
CTTGATGATG GTATTGATGA TGAACGTCTC CGGAAAGAGT TTTCTCCATT TGGTACAATC 
ACTAGTGCAA AGGTTATGAT GGAGGGTGGT CGCAGCAAAG GGTTTGGTTT TGTATGTTTC 
TCCTCCCCAG AAGAAGCCAC TAAAGCAGTT ACAGAAATGA ACGGTAGAAT TGTGGCCACA 
AAGCCATTGT ATGTAGCTTT AGCTCAGCGC AAAGAAGAGC GCCAGGCTCA CCTCACTAAC 
CAGTATATGC AGAGAATGGC AAGTGTACGA GCTGTTCCCA ACCCTGTAAT CAACCCCTAC 
CAGCCAGCAC CTCCTTCAGG TTACTTCATG GCAGCTATCC CACAGACTCA GAACCGTGCT 
GCATACTATC CTCCTAGCCA AATTGCTCAA CTAAGACCAA GTCCTCGCTG GACTGCTCAG 
GGTGCCAGAC CTCATCCATT CCAAAATATG CCCGGTGCTA TCCGCCCAGC TGCTCCTAGA 
CCACCATTTA GTACTATGAG ACCAGCTTCT TCACAGGTTC CACGAGTCAT GTCAACACAG 
CGTGTTGCTA ACACATCAAC ACAGACAATG GGTCCACGTC CTGCAGCTGC AGCCGCTGCA 
GCTACTCCTG CTGTCCGCAC CGTTCCACAG TATAAATATG CTGCAGGAGT TCGCAATCCT 
CAGCAACATC TTAATGCACA GCCACAAGTT ACAATGCAAC AGCCTGCTGT TCATGTACAA 
GGTCAGGAAC CTTTGACTGC TTCCATGTTG GCATCTGCCC CTCCTCAAGA GCAAAAGCAA 
ATGTTGGGTG AACGGCTGTT TCCTCTTATT CAAGCCATGC ACCCTACTCT TGCTGGTAAA 
ATCACTGGCA TGTTGTTGGA GATTGATAAT TCAGAACTTC TTCATATGCT CGAGTCTCCA 
GAGTCACTCC GTTCTAAGGT TGATGAAGCT GTAGCTGTAC TACAAGCCCA CCAAGCTAAA 
GAGGCTGCCC AGAAAGCAGT TAACAGTGCC ACCGGTGTTC CAACTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002559.2
CDS	506..2416
Translation	MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV

Target ORF information:

RefSeq Version	NM_002568.4
Organism	Homo sapiens(human)
Definition	Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002568.4

ORF Insert Sequence:

ATGAACCCCA GTGCCCCCAG CTACCCCATG GCCTCGCTCT ACGTGGGGGA CCTCCACCCC 
GACGTGACCG AGGCGATGCT CTACGAGAAG TTCAGCCCGG CCGGGCCCAT CCTCTCCATC 
CGGGTCTGCA GGGACATGAT CACCCGCCGC TCCTTGGGCT ACGCGTATGT GAACTTCCAG 
CAGCCGGCGG ACGCGGAGCG TGCTTTGGAC ACCATGAATT TTGATGTTAT AAAGGGCAAG 
CCAGTACGCA TCATGTGGTC TCAGCGTGAT CCATCACTTC GCAAAAGTGG AGTAGGCAAC 
ATATTCATTA AAAATCTGGA CAAATCCATT GATAATAAAG CACTGTATGA TACATTTTCT 
GCTTTTGGTA ACATCCTTTC ATGTAAGGTG GTTTGTGATG AAAATGGTTC CAAGGGCTAT 
GGATTTGTAC ACTTTGAGAC GCAGGAAGCA GCTGAAAGAG CTATTGAAAA AATGAATGGA 
ATGCTCCTAA ATGATCGCAA AGTATTTGTT GGACGATTTA AGTCTCGTAA AGAACGAGAA 
GCTGAACTTG GAGCTAGGGC AAAAGAATTC ACCAATGTTT ACATCAAGAA TTTTGGAGAA 
GACATGGATG ATGAGCGCCT TAAGGATCTC TTTGGCAAGT TTGGGCCTGC CTTAAGTGTG 
AAAGTAATGA CTGATGAAAG TGGAAAATCC AAAGGATTTG GATTTGTAAG CTTTGAAAGG 
CATGAAGATG CACAGAAAGC TGTGGATGAG ATGAACGGAA AGGAGCTCAA TGGAAAACAA 
ATTTATGTTG GTCGAGCTCA GAAAAAGGTG GAACGGCAGA CGGAACTTAA GCGCAAATTT 
GAACAGATGA AACAAGATAG GATCACCAGA TACCAGGGTG TTAATCTTTA TGTGAAAAAT 
CTTGATGATG GTATTGATGA TGAACGTCTC CGGAAAGAGT TTTCTCCATT TGGTACAATC 
ACTAGTGCAA AGGTTATGAT GGAGGGTGGT CGCAGCAAAG GGTTTGGTTT TGTATGTTTC 
TCCTCCCCAG AAGAAGCCAC TAAAGCAGTT ACAGAAATGA ACGGTAGAAT TGTGGCCACA 
AAGCCATTGT ATGTAGCTTT AGCTCAGCGC AAAGAAGAGC GCCAGGCTCA CCTCACTAAC 
CAGTATATGC AGAGAATGGC AAGTGTACGA GCTGTTCCCA ACCCTGTAAT CAACCCCTAC 
CAGCCAGCAC CTCCTTCAGG TTACTTCATG GCAGCTATCC CACAGACTCA GAACCGTGCT 
GCATACTATC CTCCTAGCCA AATTGCTCAA CTAAGACCAA GTCCTCGCTG GACTGCTCAG 
GGTGCCAGAC CTCATCCATT CCAAAATATG CCCGGTGCTA TCCGCCCAGC TGCTCCTAGA 
CCACCATTTA GTACTATGAG ACCAGCTTCT TCACAGGTTC CACGAGTCAT GTCAACACAG 
CGTGTTGCTA ACACATCAAC ACAGACAATG GGTCCACGTC CTGCAGCTGC AGCCGCTGCA 
GCTACTCCTG CTGTCCGCAC CGTTCCACAG TATAAATATG CTGCAGGAGT TCGCAATCCT 
CAGCAACATC TTAATGCACA GCCACAAGTT ACAATGCAAC AGCCTGCTGT TCATGTACAA 
GGTCAGGAAC CTTTGACTGC TTCCATGTTG GCATCTGCCC CTCCTCAAGA GCAAAAGCAA 
ATGTTGGGTG AACGGCTGTT TCCTCTTATT CAAGCCATGC ACCCTACTCT TGCTGGTAAA 
ATCACTGGCA TGTTGTTGGA GATTGATAAT TCAGAACTTC TTCATATGCT CGAGTCTCCA 
GAGTCACTCC GTTCTAAGGT TGATGAAGCT GTAGCTGTAC TACAAGCCCA CCAAGCTAAA 
GAGGCTGCCC AGAAAGCAGT TAACAGTGCC ACCGGTGTTC CAACTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PABPC1 ( XM_005250861.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005250918.1 Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), transcript variant X1, mRNA.

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CloneID	OHu19269
Clone ID Related Accession (Same CDS sequence)	NM_002568.3 , NM_002568.4 , XM_005250861.2 , XM_005250861.3
Accession Version	XM_005250861.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1911bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	polyadenylate-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005250861.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCCCA GTGCCCCCAG CTACCCCATG GCCTCGCTCT ACGTGGGGGA CCTCCACCCC 
GACGTGACCG AGGCGATGCT CTACGAGAAG TTCAGCCCGG CCGGGCCCAT CCTCTCCATC 
CGGGTCTGCA GGGACATGAT CACCCGCCGC TCCTTGGGCT ACGCGTATGT GAACTTCCAG 
CAGCCGGCGG ACGCGGAGCG TGCTTTGGAC ACCATGAATT TTGATGTTAT AAAGGGCAAG 
CCAGTACGCA TCATGTGGTC TCAGCGTGAT CCATCACTTC GCAAAAGTGG AGTAGGCAAC 
ATATTCATTA AAAATCTGGA CAAATCCATT GATAATAAAG CACTGTATGA TACATTTTCT 
GCTTTTGGTA ACATCCTTTC ATGTAAGGTG GTTTGTGATG AAAATGGTTC CAAGGGCTAT 
GGATTTGTAC ACTTTGAGAC GCAGGAAGCA GCTGAAAGAG CTATTGAAAA AATGAATGGA 
ATGCTCCTAA ATGATCGCAA AGTATTTGTT GGACGATTTA AGTCTCGTAA AGAACGAGAA 
GCTGAACTTG GAGCTAGGGC AAAAGAATTC ACCAATGTTT ACATCAAGAA TTTTGGAGAA 
GACATGGATG ATGAGCGCCT TAAGGATCTC TTTGGCAAGT TTGGGCCTGC CTTAAGTGTG 
AAAGTAATGA CTGATGAAAG TGGAAAATCC AAAGGATTTG GATTTGTAAG CTTTGAAAGG 
CATGAAGATG CACAGAAAGC TGTGGATGAG ATGAACGGAA AGGAGCTCAA TGGAAAACAA 
ATTTATGTTG GTCGAGCTCA GAAAAAGGTG GAACGGCAGA CGGAACTTAA GCGCAAATTT 
GAACAGATGA AACAAGATAG GATCACCAGA TACCAGGGTG TTAATCTTTA TGTGAAAAAT 
CTTGATGATG GTATTGATGA TGAACGTCTC CGGAAAGAGT TTTCTCCATT TGGTACAATC 
ACTAGTGCAA AGGTTATGAT GGAGGGTGGT CGCAGCAAAG GGTTTGGTTT TGTATGTTTC 
TCCTCCCCAG AAGAAGCCAC TAAAGCAGTT ACAGAAATGA ACGGTAGAAT TGTGGCCACA 
AAGCCATTGT ATGTAGCTTT AGCTCAGCGC AAAGAAGAGC GCCAGGCTCA CCTCACTAAC 
CAGTATATGC AGAGAATGGC AAGTGTACGA GCTGTTCCCA ACCCTGTAAT CAACCCCTAC 
CAGCCAGCAC CTCCTTCAGG TTACTTCATG GCAGCTATCC CACAGACTCA GAACCGTGCT 
GCATACTATC CTCCTAGCCA AATTGCTCAA CTAAGACCAA GTCCTCGCTG GACTGCTCAG 
GGTGCCAGAC CTCATCCATT CCAAAATATG CCCGGTGCTA TCCGCCCAGC TGCTCCTAGA 
CCACCATTTA GTACTATGAG ACCAGCTTCT TCACAGGTTC CACGAGTCAT GTCAACACAG 
CGTGTTGCTA ACACATCAAC ACAGACAATG GGTCCACGTC CTGCAGCTGC AGCCGCTGCA 
GCTACTCCTG CTGTCCGCAC CGTTCCACAG TATAAATATG CTGCAGGAGT TCGCAATCCT 
CAGCAACATC TTAATGCACA GCCACAAGTT ACAATGCAAC AGCCTGCTGT TCATGTACAA 
GGTCAGGAAC CTTTGACTGC TTCCATGTTG GCATCTGCCC CTCCTCAAGA GCAAAAGCAA 
ATGTTGGGTG AACGGCTGTT TCCTCTTATT CAAGCCATGC ACCCTACTCT TGCTGGTAAA 
ATCACTGGCA TGTTGTTGGA GATTGATAAT TCAGAACTTC TTCATATGCT CGAGTCTCCA 
GAGTCACTCC GTTCTAAGGT TGATGAAGCT GTAGCTGTAC TACAAGCCCA CCAAGCTAAA 
GAGGCTGCCC AGAAAGCAGT TAACAGTGCC ACCGGTGTTC CAACTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005250918.1
CDS	1416..3326
Translation	MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV

Target ORF information:

RefSeq Version	XM_005250861.2
Organism	Homo sapiens(human)
Definition	Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005250861.2

ORF Insert Sequence:

ATGAACCCCA GTGCCCCCAG CTACCCCATG GCCTCGCTCT ACGTGGGGGA CCTCCACCCC 
GACGTGACCG AGGCGATGCT CTACGAGAAG TTCAGCCCGG CCGGGCCCAT CCTCTCCATC 
CGGGTCTGCA GGGACATGAT CACCCGCCGC TCCTTGGGCT ACGCGTATGT GAACTTCCAG 
CAGCCGGCGG ACGCGGAGCG TGCTTTGGAC ACCATGAATT TTGATGTTAT AAAGGGCAAG 
CCAGTACGCA TCATGTGGTC TCAGCGTGAT CCATCACTTC GCAAAAGTGG AGTAGGCAAC 
ATATTCATTA AAAATCTGGA CAAATCCATT GATAATAAAG CACTGTATGA TACATTTTCT 
GCTTTTGGTA ACATCCTTTC ATGTAAGGTG GTTTGTGATG AAAATGGTTC CAAGGGCTAT 
GGATTTGTAC ACTTTGAGAC GCAGGAAGCA GCTGAAAGAG CTATTGAAAA AATGAATGGA 
ATGCTCCTAA ATGATCGCAA AGTATTTGTT GGACGATTTA AGTCTCGTAA AGAACGAGAA 
GCTGAACTTG GAGCTAGGGC AAAAGAATTC ACCAATGTTT ACATCAAGAA TTTTGGAGAA 
GACATGGATG ATGAGCGCCT TAAGGATCTC TTTGGCAAGT TTGGGCCTGC CTTAAGTGTG 
AAAGTAATGA CTGATGAAAG TGGAAAATCC AAAGGATTTG GATTTGTAAG CTTTGAAAGG 
CATGAAGATG CACAGAAAGC TGTGGATGAG ATGAACGGAA AGGAGCTCAA TGGAAAACAA 
ATTTATGTTG GTCGAGCTCA GAAAAAGGTG GAACGGCAGA CGGAACTTAA GCGCAAATTT 
GAACAGATGA AACAAGATAG GATCACCAGA TACCAGGGTG TTAATCTTTA TGTGAAAAAT 
CTTGATGATG GTATTGATGA TGAACGTCTC CGGAAAGAGT TTTCTCCATT TGGTACAATC 
ACTAGTGCAA AGGTTATGAT GGAGGGTGGT CGCAGCAAAG GGTTTGGTTT TGTATGTTTC 
TCCTCCCCAG AAGAAGCCAC TAAAGCAGTT ACAGAAATGA ACGGTAGAAT TGTGGCCACA 
AAGCCATTGT ATGTAGCTTT AGCTCAGCGC AAAGAAGAGC GCCAGGCTCA CCTCACTAAC 
CAGTATATGC AGAGAATGGC AAGTGTACGA GCTGTTCCCA ACCCTGTAAT CAACCCCTAC 
CAGCCAGCAC CTCCTTCAGG TTACTTCATG GCAGCTATCC CACAGACTCA GAACCGTGCT 
GCATACTATC CTCCTAGCCA AATTGCTCAA CTAAGACCAA GTCCTCGCTG GACTGCTCAG 
GGTGCCAGAC CTCATCCATT CCAAAATATG CCCGGTGCTA TCCGCCCAGC TGCTCCTAGA 
CCACCATTTA GTACTATGAG ACCAGCTTCT TCACAGGTTC CACGAGTCAT GTCAACACAG 
CGTGTTGCTA ACACATCAAC ACAGACAATG GGTCCACGTC CTGCAGCTGC AGCCGCTGCA 
GCTACTCCTG CTGTCCGCAC CGTTCCACAG TATAAATATG CTGCAGGAGT TCGCAATCCT 
CAGCAACATC TTAATGCACA GCCACAAGTT ACAATGCAAC AGCCTGCTGT TCATGTACAA 
GGTCAGGAAC CTTTGACTGC TTCCATGTTG GCATCTGCCC CTCCTCAAGA GCAAAAGCAA 
ATGTTGGGTG AACGGCTGTT TCCTCTTATT CAAGCCATGC ACCCTACTCT TGCTGGTAAA 
ATCACTGGCA TGTTGTTGGA GATTGATAAT TCAGAACTTC TTCATATGCT CGAGTCTCCA 
GAGTCACTCC GTTCTAAGGT TGATGAAGCT GTAGCTGTAC TACAAGCCCA CCAAGCTAAA 
GAGGCTGCCC AGAAAGCAGT TAACAGTGCC ACCGGTGTTC CAACTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PABPC1 ( XM_005250861.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005250918.1 Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu19269
Clone ID Related Accession (Same CDS sequence)	NM_002568.3 , NM_002568.4 , XM_005250861.2 , XM_005250861.3
Accession Version	XM_005250861.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1911bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	polyadenylate-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005250861.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCCCA GTGCCCCCAG CTACCCCATG GCCTCGCTCT ACGTGGGGGA CCTCCACCCC 
GACGTGACCG AGGCGATGCT CTACGAGAAG TTCAGCCCGG CCGGGCCCAT CCTCTCCATC 
CGGGTCTGCA GGGACATGAT CACCCGCCGC TCCTTGGGCT ACGCGTATGT GAACTTCCAG 
CAGCCGGCGG ACGCGGAGCG TGCTTTGGAC ACCATGAATT TTGATGTTAT AAAGGGCAAG 
CCAGTACGCA TCATGTGGTC TCAGCGTGAT CCATCACTTC GCAAAAGTGG AGTAGGCAAC 
ATATTCATTA AAAATCTGGA CAAATCCATT GATAATAAAG CACTGTATGA TACATTTTCT 
GCTTTTGGTA ACATCCTTTC ATGTAAGGTG GTTTGTGATG AAAATGGTTC CAAGGGCTAT 
GGATTTGTAC ACTTTGAGAC GCAGGAAGCA GCTGAAAGAG CTATTGAAAA AATGAATGGA 
ATGCTCCTAA ATGATCGCAA AGTATTTGTT GGACGATTTA AGTCTCGTAA AGAACGAGAA 
GCTGAACTTG GAGCTAGGGC AAAAGAATTC ACCAATGTTT ACATCAAGAA TTTTGGAGAA 
GACATGGATG ATGAGCGCCT TAAGGATCTC TTTGGCAAGT TTGGGCCTGC CTTAAGTGTG 
AAAGTAATGA CTGATGAAAG TGGAAAATCC AAAGGATTTG GATTTGTAAG CTTTGAAAGG 
CATGAAGATG CACAGAAAGC TGTGGATGAG ATGAACGGAA AGGAGCTCAA TGGAAAACAA 
ATTTATGTTG GTCGAGCTCA GAAAAAGGTG GAACGGCAGA CGGAACTTAA GCGCAAATTT 
GAACAGATGA AACAAGATAG GATCACCAGA TACCAGGGTG TTAATCTTTA TGTGAAAAAT 
CTTGATGATG GTATTGATGA TGAACGTCTC CGGAAAGAGT TTTCTCCATT TGGTACAATC 
ACTAGTGCAA AGGTTATGAT GGAGGGTGGT CGCAGCAAAG GGTTTGGTTT TGTATGTTTC 
TCCTCCCCAG AAGAAGCCAC TAAAGCAGTT ACAGAAATGA ACGGTAGAAT TGTGGCCACA 
AAGCCATTGT ATGTAGCTTT AGCTCAGCGC AAAGAAGAGC GCCAGGCTCA CCTCACTAAC 
CAGTATATGC AGAGAATGGC AAGTGTACGA GCTGTTCCCA ACCCTGTAAT CAACCCCTAC 
CAGCCAGCAC CTCCTTCAGG TTACTTCATG GCAGCTATCC CACAGACTCA GAACCGTGCT 
GCATACTATC CTCCTAGCCA AATTGCTCAA CTAAGACCAA GTCCTCGCTG GACTGCTCAG 
GGTGCCAGAC CTCATCCATT CCAAAATATG CCCGGTGCTA TCCGCCCAGC TGCTCCTAGA 
CCACCATTTA GTACTATGAG ACCAGCTTCT TCACAGGTTC CACGAGTCAT GTCAACACAG 
CGTGTTGCTA ACACATCAAC ACAGACAATG GGTCCACGTC CTGCAGCTGC AGCCGCTGCA 
GCTACTCCTG CTGTCCGCAC CGTTCCACAG TATAAATATG CTGCAGGAGT TCGCAATCCT 
CAGCAACATC TTAATGCACA GCCACAAGTT ACAATGCAAC AGCCTGCTGT TCATGTACAA 
GGTCAGGAAC CTTTGACTGC TTCCATGTTG GCATCTGCCC CTCCTCAAGA GCAAAAGCAA 
ATGTTGGGTG AACGGCTGTT TCCTCTTATT CAAGCCATGC ACCCTACTCT TGCTGGTAAA 
ATCACTGGCA TGTTGTTGGA GATTGATAAT TCAGAACTTC TTCATATGCT CGAGTCTCCA 
GAGTCACTCC GTTCTAAGGT TGATGAAGCT GTAGCTGTAC TACAAGCCCA CCAAGCTAAA 
GAGGCTGCCC AGAAAGCAGT TAACAGTGCC ACCGGTGTTC CAACTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005250918.1
CDS	505..2415
Translation	MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV

Target ORF information:

RefSeq Version	XM_005250861.3
Organism	Homo sapiens(human)
Definition	Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005250861.3

ORF Insert Sequence:

ATGAACCCCA GTGCCCCCAG CTACCCCATG GCCTCGCTCT ACGTGGGGGA CCTCCACCCC 
GACGTGACCG AGGCGATGCT CTACGAGAAG TTCAGCCCGG CCGGGCCCAT CCTCTCCATC 
CGGGTCTGCA GGGACATGAT CACCCGCCGC TCCTTGGGCT ACGCGTATGT GAACTTCCAG 
CAGCCGGCGG ACGCGGAGCG TGCTTTGGAC ACCATGAATT TTGATGTTAT AAAGGGCAAG 
CCAGTACGCA TCATGTGGTC TCAGCGTGAT CCATCACTTC GCAAAAGTGG AGTAGGCAAC 
ATATTCATTA AAAATCTGGA CAAATCCATT GATAATAAAG CACTGTATGA TACATTTTCT 
GCTTTTGGTA ACATCCTTTC ATGTAAGGTG GTTTGTGATG AAAATGGTTC CAAGGGCTAT 
GGATTTGTAC ACTTTGAGAC GCAGGAAGCA GCTGAAAGAG CTATTGAAAA AATGAATGGA 
ATGCTCCTAA ATGATCGCAA AGTATTTGTT GGACGATTTA AGTCTCGTAA AGAACGAGAA 
GCTGAACTTG GAGCTAGGGC AAAAGAATTC ACCAATGTTT ACATCAAGAA TTTTGGAGAA 
GACATGGATG ATGAGCGCCT TAAGGATCTC TTTGGCAAGT TTGGGCCTGC CTTAAGTGTG 
AAAGTAATGA CTGATGAAAG TGGAAAATCC AAAGGATTTG GATTTGTAAG CTTTGAAAGG 
CATGAAGATG CACAGAAAGC TGTGGATGAG ATGAACGGAA AGGAGCTCAA TGGAAAACAA 
ATTTATGTTG GTCGAGCTCA GAAAAAGGTG GAACGGCAGA CGGAACTTAA GCGCAAATTT 
GAACAGATGA AACAAGATAG GATCACCAGA TACCAGGGTG TTAATCTTTA TGTGAAAAAT 
CTTGATGATG GTATTGATGA TGAACGTCTC CGGAAAGAGT TTTCTCCATT TGGTACAATC 
ACTAGTGCAA AGGTTATGAT GGAGGGTGGT CGCAGCAAAG GGTTTGGTTT TGTATGTTTC 
TCCTCCCCAG AAGAAGCCAC TAAAGCAGTT ACAGAAATGA ACGGTAGAAT TGTGGCCACA 
AAGCCATTGT ATGTAGCTTT AGCTCAGCGC AAAGAAGAGC GCCAGGCTCA CCTCACTAAC 
CAGTATATGC AGAGAATGGC AAGTGTACGA GCTGTTCCCA ACCCTGTAAT CAACCCCTAC 
CAGCCAGCAC CTCCTTCAGG TTACTTCATG GCAGCTATCC CACAGACTCA GAACCGTGCT 
GCATACTATC CTCCTAGCCA AATTGCTCAA CTAAGACCAA GTCCTCGCTG GACTGCTCAG 
GGTGCCAGAC CTCATCCATT CCAAAATATG CCCGGTGCTA TCCGCCCAGC TGCTCCTAGA 
CCACCATTTA GTACTATGAG ACCAGCTTCT TCACAGGTTC CACGAGTCAT GTCAACACAG 
CGTGTTGCTA ACACATCAAC ACAGACAATG GGTCCACGTC CTGCAGCTGC AGCCGCTGCA 
GCTACTCCTG CTGTCCGCAC CGTTCCACAG TATAAATATG CTGCAGGAGT TCGCAATCCT 
CAGCAACATC TTAATGCACA GCCACAAGTT ACAATGCAAC AGCCTGCTGT TCATGTACAA 
GGTCAGGAAC CTTTGACTGC TTCCATGTTG GCATCTGCCC CTCCTCAAGA GCAAAAGCAA 
ATGTTGGGTG AACGGCTGTT TCCTCTTATT CAAGCCATGC ACCCTACTCT TGCTGGTAAA 
ATCACTGGCA TGTTGTTGGA GATTGATAAT TCAGAACTTC TTCATATGCT CGAGTCTCCA 
GAGTCACTCC GTTCTAAGGT TGATGAAGCT GTAGCTGTAC TACAAGCCCA CCAAGCTAAA 
GAGGCTGCCC AGAAAGCAGT TAACAGTGCC ACCGGTGTTC CAACTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.
The Biochemical journal474(18)3109-3120(2017 08)
Copsey AC,Cooper S,Parker R,Lineham E,Lapworth C,Jallad D,Sweet S,Morley SJ

Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay.
RNA (New York, N.Y.)14(3)563-76(2008 Mar)
Silva AL,Ribeiro P,In?cio A,Liebhaber SA,Rom?o L

Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein.
The Journal of biological chemistry282(34)25067-75(2007 Aug)
Siddiqui N,Mangus DA,Chang TC,Palermino JM,Shyu AB,Gehring K

Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms.
Genes & development19(1)104-13(2005 Jan)
Kahvejian A,Svitkin YV,Sukarieh R,M'Boutchou MN,Sonenberg N

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PABPC1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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