GFER cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GFER
Entrez Gene ID	2671
Full Name	growth factor, augmenter of liver regeneration
Synonyms	ALR,ERV1,HERV1,HPO,HPO1,HPO2,HSS
General protein information	Preferred Names growth factor, augmenter of liver regeneration Names FAD-linked sulfhydryl oxidase ALR ERV1 homolog erv1-like growth factor hepatic regenerative stimulation substance hepatopoietin protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	600924
Disorder Html:	Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay, 613076 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005262.3	NP_005253.3	FAD-linked sulfhydryl oxidase ALR
NM_005262.2	NP_005253.3	FAD-linked sulfhydryl oxidase ALR

Pathways from BioSystems

Homologies

Caenorhabditis elegans (roundworm)	F56C11.3	NP_490690.1
Canis lupus familiaris (dog)	GFER	XP_537010.4
Homo sapiens (human)	GFER	NP_005253.3
	GFER	XP_001082639.1
Bos taurus (cattle)	GFER	NP_001180117.1
Gallus gallus (chicken)	GFER	XP_414848.2
Mus musculus (house mouse)	Gfer	NP_075527.2
Rattus norvegicus (Norway rat)	Gfer	NP_037354.2
Danio rerio (zebrafish)	gfer	NP_001082855.1
Xenopus tropicalis (tropical clawed frog)	gfer	XP_002935903.1

Gene Ontology
Bibliography

Related articles in PubMed

The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics.
Meliambro K, Wong JS, Ray J, Calizo RC, Towne S, Cole B, El Salem F, Gordon RE, Kaufman L, He JC, Azeloglu EU, Campbell KN
The Journal of biological chemistry292(51)21137-21148(2017 Dec)

Decreased expression of the augmenter of liver regeneration results in growth inhibition and increased chemosensitivity of acute T lymphoblastic leukemia cells.
Shen Y, Liu Q, Lou S, Luo Y, Sun H, Zeng H, Deng J
Oncology reports38(5)3130-3136(2017 Nov)

Regulation of the Hippo Pathway Transcription Factor TEAD.
Lin KC, Park HW, Guan KL
Trends in biochemical sciences42(11)862-872(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

role in regulating the mitochondrial fission machinery
Title: Hepatic stimulator substance resists hepatic ischemia/reperfusion injury by regulating Drp1 translocation and activation.

Overexpression of augmenter of liver regeneration (ALR) in liver cancer was studied and found to improve sensitivity to antitumor drugs by increasing the retention of intracellular drugs, at least partly through the modulation of the ABCB1 and ABCG2 signaling pathway.
Title: Augmenter of liver regeneration potentiates doxorubicin anticancer efficacy by reducing the expression of ABCB1 and ABCG2 in hepatocellular carcinoma.

It evidence demonstrating Hippo-independent regulation of TEADs and the potential impacts these studies may have on new cancer therapeutics.
Title: Regulation of the Hippo Pathway Transcription Factor TEAD.

ALR protects steatotic hepatocytes from ischemia reperfusion injury by attenuating oxidative stress and mitochondrial dysfunction.
Title: Alleviation of Ischemia-Reperfusion Injury in Liver Steatosis by Augmenter of Liver Regeneration Is Attributed to Antioxidation and Preservation of Mitochondria.

HPO interaction with MOB1 is not essential for development and tissue growth control.
Title: Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.

The following GFER gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GFER cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18880	NM_005262.3 Latest version!	Homo sapiens growth factor, augmenter of liver regeneration (GFER), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu18880	NM_005262.2	Homo sapiens growth factor, augmenter of liver regeneration (GFER), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GFER ( NM_005262.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005253.3 Homo sapiens growth factor, augmenter of liver regeneration (GFER), mRNA.

Price & Availability↑

CloneID	OHu18880
Clone ID Related Accession (Same CDS sequence)	NM_005262.3 , NM_005262.2
Accession Version	NM_005262.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	FAD-linked sulfhydryl oxidase ALR
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG705583.1, AF306863.1 and BC002429.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_005262.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002429.1, SRR3476690.738756.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000248114.7/ ENSP00000248114.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGC CCGGCGAGCG GGGCCGCTTC CACGGCGGGA ACCTCTTCTT CCTGCCGGGG 
GGCGCGCGCT CCGAGATGAT GGACGACCTG GCGACCGACG CGCGGGGCCG GGGCGCGGGG 
CGGAGAGACG CGGCCGCCTC GGCCTCGACG CCAGCCCAGG CGCCGACCTC CGATTCTCCT 
GTCGCCGAGG ACGCCTCCCG GAGGCGGCCG TGCCGGGCCT GCGTCGACTT CAAGACGTGG 
ATGCGGACGC AGCAGAAGCG GGACACCAAG TTTAGGGAGG ACTGCCCGCC GGATCGCGAG 
GAACTGGGCC GCCACAGCTG GGCTGTCCTC CACACCCTGG CCGCCTACTA CCCCGACCTG 
CCCACCCCAG AACAGCAGCA AGACATGGCC CAGTTCATAC ATTTATTTTC TAAGTTTTAC 
CCCTGTGAGG AGTGTGCTGA AGACCTAAGA AAAAGGCTGT GCAGGAACCA CCCAGACACC 
CGCACCCGGG CATGCTTCAC ACAGTGGCTG TGCCACCTGC ACAATGAAGT GAACCGCAAG 
CTGGGCAAGC CTGACTTCGA CTGCTCAAAA GTGGATGAGC GCTGGCGCGA CGGCTGGAAG 
GATGGCTCCT GTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005253.3
CDS	27..644
Translation	MAAPGERGRFHGGNLFFLPGGARSEMMDDLATDARGRGAGRRDAAASASTPAQAPTSDSPVAEDASRRRPCRACVDFKTWMRTQQKRDTKFREDCPPDREELGRHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLCRNHPDTRTRACFTQWLCHLHNEVNRKLGKPDFDCSKVDERWRDGWKDGSCD

Target ORF information:

RefSeq Version	NM_005262.3
Organism	Homo sapiens(human)
Definition	Homo sapiens growth factor, augmenter of liver regeneration (GFER), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005262.3

ORF Insert Sequence:

ATGGCGGCGC CCGGCGAGCG GGGCCGCTTC CACGGCGGGA ACCTCTTCTT CCTGCCGGGG 
GGCGCGCGCT CCGAGATGAT GGACGACCTG GCGACCGACG CGCGGGGCCG GGGCGCGGGG 
CGGAGAGACG CGGCCGCCTC GGCCTCGACG CCAGCCCAGG CGCCGACCTC CGATTCTCCT 
GTCGCCGAGG ACGCCTCCCG GAGGCGGCCG TGCCGGGCCT GCGTCGACTT CAAGACGTGG 
ATGCGGACGC AGCAGAAGCG GGACACCAAG TTTAGGGAGG ACTGCCCGCC GGATCGCGAG 
GAACTGGGCC GCCACAGCTG GGCTGTCCTC CACACCCTGG CCGCCTACTA CCCCGACCTG 
CCCACCCCAG AACAGCAGCA AGACATGGCC CAGTTCATAC ATTTATTTTC TAAGTTTTAC 
CCCTGTGAGG AGTGTGCTGA AGACCTAAGA AAAAGGCTGT GCAGGAACCA CCCAGACACC 
CGCACCCGGG CATGCTTCAC ACAGTGGCTG TGCCACCTGC ACAATGAAGT GAACCGCAAG 
CTGGGCAAGC CTGACTTCGA CTGCTCAAAA GTGGATGAGC GCTGGCGCGA CGGCTGGAAG 
GATGGCTCCT GTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GFER ( NM_005262.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005253.3 Homo sapiens growth factor, augmenter of liver regeneration (GFER), mRNA.

Price & Availability↑

CloneID	OHu18880
Clone ID Related Accession (Same CDS sequence)	NM_005262.3 , NM_005262.2
Accession Version	NM_005262.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	FAD-linked sulfhydryl oxidase ALR
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG705583.1, AF306863.1 and BC002429.1. This sequence is a reference standard in the RefSeqGene project. On Oct 13, 2004 this sequence version replaced NM_005262.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002429.1, U31176.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC CCGGCGAGCG GGGCCGCTTC CACGGCGGGA ACCTCTTCTT CCTGCCGGGG 
GGCGCGCGCT CCGAGATGAT GGACGACCTG GCGACCGACG CGCGGGGCCG GGGCGCGGGG 
CGGAGAGACG CGGCCGCCTC GGCCTCGACG CCAGCCCAGG CGCCGACCTC CGATTCTCCT 
GTCGCCGAGG ACGCCTCCCG GAGGCGGCCG TGCCGGGCCT GCGTCGACTT CAAGACGTGG 
ATGCGGACGC AGCAGAAGCG GGACACCAAG TTTAGGGAGG ACTGCCCGCC GGATCGCGAG 
GAACTGGGCC GCCACAGCTG GGCTGTCCTC CACACCCTGG CCGCCTACTA CCCCGACCTG 
CCCACCCCAG AACAGCAGCA AGACATGGCC CAGTTCATAC ATTTATTTTC TAAGTTTTAC 
CCCTGTGAGG AGTGTGCTGA AGACCTAAGA AAAAGGCTGT GCAGGAACCA CCCAGACACC 
CGCACCCGGG CATGCTTCAC ACAGTGGCTG TGCCACCTGC ACAATGAAGT GAACCGCAAG 
CTGGGCAAGC CTGACTTCGA CTGCTCAAAA GTGGATGAGC GCTGGCGCGA CGGCTGGAAG 
GATGGCTCCT GTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005253.3
CDS	71..688
Translation	MAAPGERGRFHGGNLFFLPGGARSEMMDDLATDARGRGAGRRDAAASASTPAQAPTSDSPVAEDASRRRPCRACVDFKTWMRTQQKRDTKFREDCPPDREELGRHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLCRNHPDTRTRACFTQWLCHLHNEVNRKLGKPDFDCSKVDERWRDGWKDGSCD

Target ORF information:

RefSeq Version	NM_005262.2
Organism	Homo sapiens(human)
Definition	Homo sapiens growth factor, augmenter of liver regeneration (GFER), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005262.2

ORF Insert Sequence:

ATGGCGGCGC CCGGCGAGCG GGGCCGCTTC CACGGCGGGA ACCTCTTCTT CCTGCCGGGG 
GGCGCGCGCT CCGAGATGAT GGACGACCTG GCGACCGACG CGCGGGGCCG GGGCGCGGGG 
CGGAGAGACG CGGCCGCCTC GGCCTCGACG CCAGCCCAGG CGCCGACCTC CGATTCTCCT 
GTCGCCGAGG ACGCCTCCCG GAGGCGGCCG TGCCGGGCCT GCGTCGACTT CAAGACGTGG 
ATGCGGACGC AGCAGAAGCG GGACACCAAG TTTAGGGAGG ACTGCCCGCC GGATCGCGAG 
GAACTGGGCC GCCACAGCTG GGCTGTCCTC CACACCCTGG CCGCCTACTA CCCCGACCTG 
CCCACCCCAG AACAGCAGCA AGACATGGCC CAGTTCATAC ATTTATTTTC TAAGTTTTAC 
CCCTGTGAGG AGTGTGCTGA AGACCTAAGA AAAAGGCTGT GCAGGAACCA CCCAGACACC 
CGCACCCGGG CATGCTTCAC ACAGTGGCTG TGCCACCTGC ACAATGAAGT GAACCGCAAG 
CTGGGCAAGC CTGACTTCGA CTGCTCAAAA GTGGATGAGC GCTGGCGCGA CGGCTGGAAG 
GATGGCTCCT GTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics.
The Journal of biological chemistry292(51)21137-21148(2017 Dec)
Meliambro K,Wong JS,Ray J,Calizo RC,Towne S,Cole B,El Salem F,Gordon RE,Kaufman L,He JC,Azeloglu EU,Campbell KN

Decreased expression of the augmenter of liver regeneration results in growth inhibition and increased chemosensitivity of acute T lymphoblastic leukemia cells.
Oncology reports38(5)3130-3136(2017 Nov)
Shen Y,Liu Q,Lou S,Luo Y,Sun H,Zeng H,Deng J

Regulation of the Hippo Pathway Transcription Factor TEAD.
Trends in biochemical sciences42(11)862-872(2017 Nov)
Lin KC,Park HW,Guan KL

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GFER cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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