VCX cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VCX
Entrez Gene ID	26609
Full Name	variable charge, X-linked
Synonyms	VCX-10r,VCX-B1,VCX1,VCX10R,VCXB1
General protein information	Preferred Names variable charge, X-linked Names variable charge X-linked protein 1 variable charge protein on X with ten repeats variable charge, X chromosome variably charged protein X-B1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp22.31
Summary	This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008].
Disorder MIM:	300229

mRNA and Protein(s)

mRNA	Protein	Name
XM_011545490.2	XP_011543792.1	variable charge X-linked protein 1 isoform X1
XM_011545490.3	XP_011543792.1	variable charge X-linked protein 1 isoform X1
NM_013452.2	NP_038480.2	variable charge X-linked protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	VCX	NP_038480.2
Homo sapiens (human)	VCX3A	NP_057463.2

Gene Ontology
Bibliography

Related articles in PubMed

Copy number gain of VCX, X-linked multi-copy gene, leads to cell proliferation and apoptosis during spermatogenesis.
Ji J, Qin Y, Wang R, Huang Z, Zhang Y, Zhou R, Song L, Ling X, Hu Z, Miao D, Shen H, Xia Y, Wang X, Lu C
Oncotarget7(48)78532-78540(2016 Nov)

A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.
Taguchi A, Taylor AD, Rodriguez J, Celikta? M, Liu H, Ma X, Zhang Q, Wong CH, Chin A, Girard L, Behrens C, Lam WL, Lam S, Minna JD, Wistuba II, Gazdar AF, Hanash SM
Cancer research74(17)4694-705(2014 Sep)

A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.
Hansen MA, Nielsen JE, Retelska D, Larsen N, Leffers H
Molecular reproduction and development75(2)219-29(2008 Feb)

Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity.
Sy SM, Wong N, Mok TS, Tsao MS, Lee TW, Tse G, Blackhall FH, Johnson PJ, Yim AP
Lung cancer (Amsterdam, Netherlands)41(1)91-9(2003 Jul)

Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis.
Zou SW, Zhang JC, Zhang XD, Miao SY, Zong SD, Sheng Q, Wang LF
Cell research13(3)171-7(2003 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Identified members of the VCX/Y gene family as novel CT antigens.
Title: A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.

Human VCX/Y, SPANX, and CSAG2 gene families together with the murine SPANX gene and the CYPT family may share a common ancestor.
Title: A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.

The following VCX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VCX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29587	NM_013452.2 Latest version!	Homo sapiens variable charge X-linked (VCX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
OHu66972	XM_011545490.3 Latest version!	Homo sapiens variable charge X-linked (VCX), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu66972	XM_011545490.2	Homo sapiens variable charge, X-linked (VCX), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VCX ( NM_013452.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_038480.2 Homo sapiens variable charge X-linked (VCX), mRNA.

Price & Availability↑

CloneID	OHu29587
Clone ID Related Accession (Same CDS sequence)	NM_013452.2
Accession Version	NM_013452.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Homo sapiens(human)
Product	variable charge X-linked protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF167081.2 and AF159129.1. On or before Mar 29, 2008 this sequence version replaced XM_001718499.1, NM_013452.1. ##Evidence-Data-START## Transcript exon combination :: AF167081.2 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCACGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGCG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GGCCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC CGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038480.2
CDS	220..840
Translation	MSPKPRASGPPAKATEAGKRKSSSQPSPSDPKKKTTKVAKKGKAVRRGRRGKKGAATKMAAVTAPEAESAPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQEAELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEEPLSQESQVEEPPSQESEMEELPSV

Target ORF information:

RefSeq Version	NM_013452.2
Organism	Homo sapiens(human)
Definition	Homo sapiens variable charge X-linked (VCX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013452.2

ORF Insert Sequence:

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCACGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGCG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GGCCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC CGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VCX ( XM_011545490.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011543792.1 Homo sapiens variable charge, X-linked (VCX), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu66972
Clone ID Related Accession (Same CDS sequence)	XM_011545490.2 , XM_011545490.3
Accession Version	XM_011545490.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	variable charge X-linked protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011545490.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCACGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGCG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GGCCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011543792.1
CDS	112..672
Translation	MSPKPRASGPPAKATEAGKRKSSSQPSPSDPKKKTTKVAKKGKAVRRGRRGKKGAATKMAAVTAPEAESAPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQEAELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEELPSV

Target ORF information:

RefSeq Version	XM_011545490.2
Organism	Homo sapiens(human)
Definition	Homo sapiens variable charge, X-linked (VCX), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011545490.2

ORF Insert Sequence:

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCACGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGCG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GGCCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VCX ( XM_011545490.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011543792.1 Homo sapiens variable charge X-linked (VCX), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu66972
Clone ID Related Accession (Same CDS sequence)	XM_011545490.2 , XM_011545490.3
Accession Version	XM_011545490.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	variable charge X-linked protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011545490.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCACGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGCG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GGCCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011543792.1
CDS	90..650
Translation	MSPKPRASGPPAKATEAGKRKSSSQPSPSDPKKKTTKVAKKGKAVRRGRRGKKGAATKMAAVTAPEAESAPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQEAELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEELPSV

Target ORF information:

RefSeq Version	XM_011545490.3
Organism	Homo sapiens(human)
Definition	Homo sapiens variable charge X-linked (VCX), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011545490.3

ORF Insert Sequence:

ATGAGTCCAA AGCCGAGAGC CTCGGGACCT CCGGCCAAGG CCACGGAGGC AGGAAAGAGG 
AAGTCCTCCT CTCAGCCGAG CCCCAGTGAC CCGAAGAAGA AGACTACCAA GGTGGCCAAG 
AAGGGAAAAG CAGTTCGTAG AGGGAGACGC GGGAAGAAAG GGGCTGCGAC AAAGATGGCG 
GCCGTGACGG CACCTGAGGC GGAGAGCGCG CCAGCGGCAC CCGGCCCCAG CGACCAGCCC 
AGCCAGGAGC TCCCTCAGCA CGAGCTGCCG CCGGAGGAGC CAGTGAGCGA GGGGACCCAG 
CACGACCCCC TGAGTCAGGA GGCCGAGCTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAAGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGGTG 
GAGGAACCAC TGAGTCAGGA GAGCCAGGTG GAGGAACCAC TGAGTCAGGA GAGCGAGATG 
GAAGAACTAC CGAGTGTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Copy number gain of VCX, X-linked multi-copy gene, leads to cell proliferation and apoptosis during spermatogenesis.
Oncotarget7(48)78532-78540(2016 Nov)
Ji J,Qin Y,Wang R,Huang Z,Zhang Y,Zhou R,Song L,Ling X,Hu Z,Miao D,Shen H,Xia Y,Wang X,Lu C

A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.
Cancer research74(17)4694-705(2014 Sep)
Taguchi A,Taylor AD,Rodriguez J,Celikta? M,Liu H,Ma X,Zhang Q,Wong CH,Chin A,Girard L,Behrens C,Lam WL,Lam S,Minna JD,Wistuba II,Gazdar AF,Hanash SM

A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.
Molecular reproduction and development75(2)219-29(2008 Feb)
Hansen MA,Nielsen JE,Retelska D,Larsen N,Leffers H

Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity.
Lung cancer (Amsterdam, Netherlands)41(1)91-9(2003 Jul)
Sy SM,Wong N,Mok TS,Tsao MS,Lee TW,Tse G,Blackhall FH,Johnson PJ,Yim AP

Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis.
Cell research13(3)171-7(2003 Jun)
Zou SW,Zhang JC,Zhang XD,Miao SY,Zong SD,Sheng Q,Wang LF

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VCX cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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