LCE2B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LCE2B
Entrez Gene ID	26239
Full Name	late cornified envelope 2B
Synonyms	LEP10,SPRL1B,XP5
General protein information	Preferred Names late cornified envelope 2B Names late cornified envelope protein 2B late envelope protein 10 skin-specific protein Xp5 small proline rich-like (epidermal differentiation complex) 1B small proline-rich-like epidermal differentiation complex protein 1B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	This gene is one of the at least 20 genes expressed during epidermal differentiation and located on chromosomal band 1q21. This gene is involved in epidermal differentiation, and it is expressed at high levels in normal and psoriatic skin, but not in cultured keratinocytes or in any other tested cell types or tissues. [provided by RefSeq, Jul 2008].
Disorder MIM:	612610

mRNA and Protein(s)

mRNA	Protein	Name
NM_014357.4	NP_055172.1	late cornified envelope protein 2B
NM_014357.5	NP_055172.1	late cornified envelope protein 2B

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC735897	XP_001135441.1
Homo sapiens (human)	LCE2B	NP_055172.1

Gene Ontology
Bibliography

Related articles in PubMed

Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.
Jackson B, Tilli CM, Hardman MJ, Avilion AA, MacLeod MC, Ashcroft GS, Byrne C
The Journal of investigative dermatology124(5)1062-70(2005 May)

Differentially expressed late constituents of the epidermal cornified envelope.
Marshall D, Hardman MJ, Nield KM, Byrne C
Proceedings of the National Academy of Sciences of the United States of America98(23)13031-6(2001 Nov)

Creation of genome-wide protein expression libraries using random activation of gene expression.
Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M
Nature biotechnology19(5)440-5(2001 May)

Positional cloning of novel skin-specific genes from the human epidermal differentiation complex.
Zhao XP, Elder JT
Genomics45(2)250-8(1997 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

paper describing nomenclature changes and expression in range of tissues and in response to UV
Title: Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.

XP5 is part of a cluster of genes (LEP genes) whose proteins incorporate into keratinocyte cornified envelopes. Strong skin expression confirmed.
Title: Differentially expressed late constituents of the epidermal cornified envelope.

The following LCE2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LCE2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31707	NM_014357.5 Latest version!	Homo sapiens late cornified envelope 2B (LCE2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31707	NM_014357.4	Homo sapiens late cornified envelope 2B (LCE2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LCE2B ( NM_014357.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055172.1 Homo sapiens late cornified envelope 2B (LCE2B), mRNA.

Price & Availability↑

CloneID	OHu31707
Clone ID Related Accession (Same CDS sequence)	NM_014357.4 , NM_014357.5
Accession Version	NM_014357.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	late cornified envelope protein 2B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF086289.1 and BG211939.1. On Feb 14, 2009 this sequence version replaced NM_014357.3. ##Evidence-Data-START## Transcript exon combination :: AF086289.1, BX117218.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTGCC AGCAAAACCA GCAGCAGTGC CAGCCCCCTC CCAAGTGTCC TCCCAAGTGT 
ACCCCAAAAT GTCCACCTAA GTGTCCCCCT AAATGCCTGC CCCAGTGCCC AGCTCCATGT 
TCCCCTGCAG TCTCTTCTTG CTGTGGTCCC ATCTCTGGGG GCTGCTGTGG TCCCAGCTCT 
GGGGGCTGCT GCAACTCTGG GGCTGGTGGC TGCTGCCTGA GCCACCACAG GCCCCGTCTC 
TTCCACCGGC GCCGGCACCA GAGCCCCGAC TGCTGTGAGA GTGAACCTTC TGGGGGCTCT 
GGCTGCTGCC ACAGCTCTGG GGGCTGCTGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055172.1
CDS	55..387
Translation	MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCLPQCPAPCSPAVSSCCGPISGGCCGPSSGGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCCHSSGGCC

Target ORF information:

RefSeq Version	NM_014357.4
Organism	Homo sapiens(human)
Definition	Homo sapiens late cornified envelope 2B (LCE2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014357.4

ORF Insert Sequence:

ATGTCTTGCC AGCAAAACCA GCAGCAGTGC CAGCCCCCTC CCAAGTGTCC TCCCAAGTGT 
ACCCCAAAAT GTCCACCTAA GTGTCCCCCT AAATGCCTGC CCCAGTGCCC AGCTCCATGT 
TCCCCTGCAG TCTCTTCTTG CTGTGGTCCC ATCTCTGGGG GCTGCTGTGG TCCCAGCTCT 
GGGGGCTGCT GCAACTCTGG GGCTGGTGGC TGCTGCCTGA GCCACCACAG GCCCCGTCTC 
TTCCACCGGC GCCGGCACCA GAGCCCCGAC TGCTGTGAGA GTGAACCTTC TGGGGGCTCT 
GGCTGCTGCC ACAGCTCTGG GGGCTGCTGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LCE2B ( NM_014357.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055172.1 Homo sapiens late cornified envelope 2B (LCE2B), mRNA.

Price & Availability↑

CloneID	OHu31707
Clone ID Related Accession (Same CDS sequence)	NM_014357.4 , NM_014357.5
Accession Version	NM_014357.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	late cornified envelope protein 2B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF086289.1 and BG211939.1. On May 17, 2019 this sequence version replaced NM_014357.4. ##Evidence-Data-START## Transcript exon combination :: BX117218.1, AF086289.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368780.4/ ENSP00000357769.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTTGCC AGCAAAACCA GCAGCAGTGC CAGCCCCCTC CCAAGTGTCC TCCCAAGTGT 
ACCCCAAAAT GTCCACCTAA GTGTCCCCCT AAATGCCTGC CCCAGTGCCC AGCTCCATGT 
TCCCCTGCAG TCTCTTCTTG CTGTGGTCCC ATCTCTGGGG GCTGCTGTGG TCCCAGCTCT 
GGGGGCTGCT GCAACTCTGG GGCTGGTGGC TGCTGCCTGA GCCACCACAG GCCCCGTCTC 
TTCCACCGGC GCCGGCACCA GAGCCCCGAC TGCTGTGAGA GTGAACCTTC TGGGGGCTCT 
GGCTGCTGCC ACAGCTCTGG GGGCTGCTGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055172.1
CDS	55..387
Translation	MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCLPQCPAPCSPAVSSCCGPISGGCCGPSSGGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCCHSSGGCC

Target ORF information:

RefSeq Version	NM_014357.5
Organism	Homo sapiens(human)
Definition	Homo sapiens late cornified envelope 2B (LCE2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014357.5

ORF Insert Sequence:

ATGTCTTGCC AGCAAAACCA GCAGCAGTGC CAGCCCCCTC CCAAGTGTCC TCCCAAGTGT 
ACCCCAAAAT GTCCACCTAA GTGTCCCCCT AAATGCCTGC CCCAGTGCCC AGCTCCATGT 
TCCCCTGCAG TCTCTTCTTG CTGTGGTCCC ATCTCTGGGG GCTGCTGTGG TCCCAGCTCT 
GGGGGCTGCT GCAACTCTGG GGCTGGTGGC TGCTGCCTGA GCCACCACAG GCCCCGTCTC 
TTCCACCGGC GCCGGCACCA GAGCCCCGAC TGCTGTGAGA GTGAACCTTC TGGGGGCTCT 
GGCTGCTGCC ACAGCTCTGG GGGCTGCTGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.
The Journal of investigative dermatology124(5)1062-70(2005 May)
Jackson B,Tilli CM,Hardman MJ,Avilion AA,MacLeod MC,Ashcroft GS,Byrne C

Differentially expressed late constituents of the epidermal cornified envelope.
Proceedings of the National Academy of Sciences of the United States of America98(23)13031-6(2001 Nov)
Marshall D,Hardman MJ,Nield KM,Byrne C

Creation of genome-wide protein expression libraries using random activation of gene expression.
Nature biotechnology19(5)440-5(2001 May)
Harrington JJ,Sherf B,Rundlett S,Jackson PD,Perry R,Cain S,Leventhal C,Thornton M,Ramachandran R,Whittington J,Lerner L,Costanzo D,McElligott K,Boozer S,Mays R,Smith E,Veloso N,Klika A,Hess J,Cothren K,Lo K,Offenbacher J,Danzig J,Ducar M

Positional cloning of novel skin-specific genes from the human epidermal differentiation complex.
Genomics45(2)250-8(1997 Oct)
Zhao XP,Elder JT

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LCE2B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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