FDCSP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FDCSP
Entrez Gene ID	260436
Full Name	follicular dendritic cell secreted protein
Synonyms	C4orf7,FDC-SP
General protein information	Preferred Names follicular dendritic cell secreted protein Names follicular dendritic cell secreted peptide FDC secreted protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q13.3\|4q13
Summary	This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011].
Disorder MIM:	607241

mRNA and Protein(s)

mRNA	Protein	Name
NM_152997.4	NP_694542.1	follicular dendritic cell secreted peptide precursor
NM_152997.3	NP_694542.1	follicular dendritic cell secreted peptide precursor

Pathways from BioSystems

Homologies

	FDCSP	XP_001106519.1
Homo sapiens (human)	FDCSP	NP_694542.1
Pan troglodytes (chimpanzee)	FDCSP	XP_001160925.1

Gene Ontology
Bibliography

Related articles in PubMed

Tumor necrosis factor-? regulates human follicular dendritic cell-secreted protein gene transcription in gingival epithelial cells.
Iwai Y, Noda K, Yamazaki M, Kato A, Mezawa M, Takai H, Nakayama Y, Ogata Y
Genes to cells : devoted to molecular & cellular mechanisms(2018 Jan)

Follicular dendritic cell-secreted protein may enhance osteoclastogenesis in periodontal disease.
Liu J, Bian H, Ding R, Chi X, Wang Y
Connective tissue research57(1)38-43(2016)

Decreased expression of follicular dendritic cell-secreted protein correlates with increased immunoglobulin A production in the tonsils of individuals with immunoglobulin A nephropathy.
Meng HX, Li HN, Geng JS, Ohe R, Yu XY, E XQ, Ye F, Yang SR, Kato T, Zhang L, Ishida A, Ohta N, Jin XM, Kakehata S, Geng JS, Yamakawa M
Translational research : the journal of laboratory and clinical medicine166(3)281-91(2015 Sep)

Osteogenic differentiation of human periodontal ligament cells after transfection with recombinant lentiviral vector containing follicular dendritic cell secreted protein.
Xiang L, Ma L, He Y, Wei N, Gong P
Journal of periodontal research49(5)554-62(2014 Oct)

Transfection with follicular dendritic cell secreted protein to affect phenotype expression of human periodontal ligament cells.
Xiang L, Ma L, He Y, Wei N, Gong P
Journal of cellular biochemistry115(5)940-8(2014 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LPS-induced upregulation of FDC-SP expression in human periodontal ligament cells may enhance osteoclastogenesis in periodontal disease.
Title: Follicular dendritic cell-secreted protein may enhance osteoclastogenesis in periodontal disease.

FDC-SP may be involved in IgA production in the tonsils of Immunoglobulin A nephropathy patients.
Title: Decreased expression of follicular dendritic cell-secreted protein correlates with increased immunoglobulin A production in the tonsils of individuals with immunoglobulin A nephropathy.

FDC-SP overexpression inhibits osteogenic differentiation of hPDLCs. study contributes to a better understanding of biological functions governing FDC-SP-induced hPDLC differentiation.
Title: Osteogenic differentiation of human periodontal ligament cells after transfection with recombinant lentiviral vector containing follicular dendritic cell secreted protein.

Our findings demonstrate that transfection with FDC-SP has negligible adverse effect on proliferation of hPDLCs and imply the biological function of FDC-SP as a fibroblastic phenotype stabilizer
Title: Transfection with follicular dendritic cell secreted protein to affect phenotype expression of human periodontal ligament cells.

The role of C4orf7 in ovarian cancer cell morphology, motility and invasion was demonstrated.
Title: C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion.

The following FDCSP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FDCSP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55973	NM_152997.4 Latest version!	Homo sapiens follicular dendritic cell secreted protein (FDCSP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu55973	NM_152997.3	Homo sapiens follicular dendritic cell secreted protein (FDCSP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FDCSP ( NM_152997.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_694542.1 Homo sapiens follicular dendritic cell secreted protein (FDCSP), mRNA.

Price & Availability↑

CloneID	OHu55973
Clone ID Related Accession (Same CDS sequence)	NM_152997.4 , NM_152997.3
Accession Version	NM_152997.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 258bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	follicular dendritic cell secreted peptide precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY190326.1. On May 17, 2019 this sequence version replaced NM_152997.3. ##Evidence-Data-START## Transcript exon combination :: AY190326.1, AF086120.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000317987.6/ ENSP00000318437.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGAAAG TTCTCCTCCT GATCACAGCC ATCTTGGCAG TGGCTGTTGG TTTCCCAGTC 
TCTCAAGACC AGGAACGAGA AAAAAGAAGT ATCAGTGACA GCGATGAATT AGCTTCAGGG 
TTTTTTGTGT TCCCTTACCC ATATCCATTT CGCCCACTTC CACCAATTCC ATTTCCAAGA 
TTTCCATGGT TTAGACGTAA TTTTCCTATT CCAATACCTG AATCTGCCCC TACAACTCCC 
CTTCCTAGCG AAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694542.1
CDS	60..317
Translation	MKKVLLLITAILAVAVGFPVSQDQEREKRSISDSDELASGFFVFPYPYPFRPLPPIPFPRFPWFRRNFPIPIPESAPTTPLPSEK

Target ORF information:

RefSeq Version	NM_152997.4
Organism	Homo sapiens(human)
Definition	Homo sapiens follicular dendritic cell secreted protein (FDCSP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152997.4

ORF Insert Sequence:

ATGAAGAAAG TTCTCCTCCT GATCACAGCC ATCTTGGCAG TGGCTGTTGG TTTCCCAGTC 
TCTCAAGACC AGGAACGAGA AAAAAGAAGT ATCAGTGACA GCGATGAATT AGCTTCAGGG 
TTTTTTGTGT TCCCTTACCC ATATCCATTT CGCCCACTTC CACCAATTCC ATTTCCAAGA 
TTTCCATGGT TTAGACGTAA TTTTCCTATT CCAATACCTG AATCTGCCCC TACAACTCCC 
CTTCCTAGCG AAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FDCSP ( NM_152997.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_694542.1 Homo sapiens follicular dendritic cell secreted protein (FDCSP), mRNA.

Price & Availability↑

CloneID	OHu55973
Clone ID Related Accession (Same CDS sequence)	NM_152997.4 , NM_152997.3
Accession Version	NM_152997.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 258bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-29
Organism	Homo sapiens(human)
Product	follicular dendritic cell secreted peptide precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY190326.1. On Dec 2, 2011 this sequence version replaced NM_152997.2. ##Evidence-Data-START## Transcript exon combination :: AY190326.1, AY358958.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAAAG TTCTCCTCCT GATCACAGCC ATCTTGGCAG TGGCTGTTGG TTTCCCAGTC 
TCTCAAGACC AGGAACGAGA AAAAAGAAGT ATCAGTGACA GCGATGAATT AGCTTCAGGG 
TTTTTTGTGT TCCCTTACCC ATATCCATTT CGCCCACTTC CACCAATTCC ATTTCCAAGA 
TTTCCATGGT TTAGACGTAA TTTTCCTATT CCAATACCTG AATCTGCCCC TACAACTCCC 
CTTCCTAGCG AAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694542.1
CDS	113..370
Translation	MKKVLLLITAILAVAVGFPVSQDQEREKRSISDSDELASGFFVFPYPYPFRPLPPIPFPRFPWFRRNFPIPIPESAPTTPLPSEK

Target ORF information:

RefSeq Version	NM_152997.3
Organism	Homo sapiens(human)
Definition	Homo sapiens follicular dendritic cell secreted protein (FDCSP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152997.3

ORF Insert Sequence:

ATGAAGAAAG TTCTCCTCCT GATCACAGCC ATCTTGGCAG TGGCTGTTGG TTTCCCAGTC 
TCTCAAGACC AGGAACGAGA AAAAAGAAGT ATCAGTGACA GCGATGAATT AGCTTCAGGG 
TTTTTTGTGT TCCCTTACCC ATATCCATTT CGCCCACTTC CACCAATTCC ATTTCCAAGA 
TTTCCATGGT TTAGACGTAA TTTTCCTATT CCAATACCTG AATCTGCCCC TACAACTCCC 
CTTCCTAGCG AAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tumor necrosis factor-? regulates human follicular dendritic cell-secreted protein gene transcription in gingival epithelial cells.
Genes to cells : devoted to molecular & cellular mechanisms(2018 Jan)
Iwai Y,Noda K,Yamazaki M,Kato A,Mezawa M,Takai H,Nakayama Y,Ogata Y

Follicular dendritic cell-secreted protein may enhance osteoclastogenesis in periodontal disease.
Connective tissue research57(1)38-43(2016)
Liu J,Bian H,Ding R,Chi X,Wang Y

Decreased expression of follicular dendritic cell-secreted protein correlates with increased immunoglobulin A production in the tonsils of individuals with immunoglobulin A nephropathy.
Translational research : the journal of laboratory and clinical medicine166(3)281-91(2015 Sep)
Meng HX,Li HN,Geng JS,Ohe R,Yu XY,E XQ,Ye F,Yang SR,Kato T,Zhang L,Ishida A,Ohta N,Jin XM,Kakehata S,Geng JS,Yamakawa M

Osteogenic differentiation of human periodontal ligament cells after transfection with recombinant lentiviral vector containing follicular dendritic cell secreted protein.
Journal of periodontal research49(5)554-62(2014 Oct)
Xiang L,Ma L,He Y,Wei N,Gong P

Transfection with follicular dendritic cell secreted protein to affect phenotype expression of human periodontal ligament cells.
Journal of cellular biochemistry115(5)940-8(2014 May)
Xiang L,Ma L,He Y,Wei N,Gong P

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FDCSP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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