TAS2R39 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAS2R39
Entrez Gene ID	259285
Full Name	taste 2 receptor member 39
Synonyms	T2R39,T2R57
General protein information	Preferred Names taste 2 receptor member 39 Names taste receptor type 2 member 39 taste receptor type 2 member 57 taste receptor, type 2, member 39
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q34
Summary	The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_176881.2	NP_795362.2	taste receptor type 2 member 39

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TAS2R39	NP_001138970.1
Bos taurus (cattle)	TAS2R39	XP_002687163.1
Mus musculus (house mouse)	Tas2r139	NP_851792.1
Homo sapiens (human)	TAS2R39	NP_795362.2
Pan troglodytes (chimpanzee)	TAS2R39	NP_001009130.1
	TAS2R39	NP_001074232.1
Rattus norvegicus (Norway rat)	Tas2r139	NP_001074374.1

Gene Ontology
Bibliography

Related articles in PubMed

The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins.
Yamazaki T, Sagisaka M, Ikeda R, Nakamura T, Matsuda N, Ishii T, Nakayama T, Watanabe T
Bioscience, biotechnology, and biochemistry78(10)1753-6(2014)

Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39.
Roland WS, Vincken JP, Gouka RJ, van Buren L, Gruppen H, Smit G
Journal of agricultural and food chemistry59(21)11764-71(2011 Nov)

Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39.
Narukawa M, Noga C, Ueno Y, Sato T, Misaka T, Watanabe T
Biochemical and biophysical research communications405(4)620-5(2011 Feb)

Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.
Ueno Y, Sakurai T, Okada S, Abe K, Misaka T
Bioscience, biotechnology, and biochemistry75(6)1188-90(2011)

The molecular receptive ranges of human TAS2R bitter taste receptors.
Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M
Chemical senses35(2)157-70(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hTAS2R39 is the primary receptor for the bitterness of theaflavins
Title: The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins.

TAS2R14 and TAS2R39 were activated by isoflavones and other isoflavonoids.
Title: Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39.

these results suggest the participation of hTAS2R39 in the detection of catechins in humans.
Title: Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39.

Human bitter taste receptors hTAS2R8 and hTAS2R39 display differential functions to recognize bitter peptides.
Title: Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.

The following TAS2R39 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAS2R39 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30128	NM_176881.2 Latest version!	Homo sapiens taste 2 receptor member 39 (TAS2R39), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAS2R39 ( NM_176881.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_795362.2 Homo sapiens taste 2 receptor member 39 (TAS2R39), mRNA.

Price & Availability↑

CloneID	OHu30128
Clone ID Related Accession (Same CDS sequence)	NM_176881.2
Accession Version	NM_176881.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Homo sapiens(human)
Product	taste receptor type 2 member 39
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC073342.3. On Oct 31, 2006 this sequence version replaced NM_176881.1. ##Evidence-Data-START## Transcript is intronless :: BC100947.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000446620.1/ ENSP00000405095.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCTAGGGA GATGTTTTCC TCCAGACACC AAAGAGAAGC AACAGCTCAG AATGACTAAA 
CTCTGCGATC CTGCAGAAAG TGAATTGTCG CCATTTCTCA TCACCTTAAT TTTAGCAGTT 
TTACTTGCTG AATACCTCAT TGGTATCATT GCAAATGGTT TCATCATGGC TATACATGCA 
GCTGAATGGG TTCAAAATAA GGCAGTTTCC ACAAGTGGCA GGATCCTGGT TTTCCTGAGT 
GTATCCAGAA TAGCTCTCCA AAGCCTCATG ATGTTAGAAA TTACCATCAG CTCAACCTCC 
CTAAGTTTTT ATTCTGAAGA CGCTGTATAT TATGCATTCA AAATAAGTTT TATATTCTTA 
AATTTTTGTA GCCTGTGGTT TGCTGCCTGG CTCAGTTTCT TCTACTTTGT GAAGATTGCC 
AATTTCTCCT ACCCCCTTTT CCTCAAACTG AGGTGGAGAA TTACTGGATT GATACCCTGG 
CTTCTGTGGC TGTCCGTGTT TATTTCCTTC AGTCACAGCA TGTTCTGCAT CAACATCTGC 
ACTGTGTATT GTAACAATTC TTTCCCTATC CACTCCTCCA ACTCCACTAA GAAAACATAC 
TTGTCTGAGA TCAATGTGGT CGGTCTGGCT TTTTTCTTTA ACCTGGGGAT TGTGACTCCT 
CTGATCATGT TCATCCTGAC AGCCACCCTG CTGATCCTCT CTCTCAAGAG ACACACCCTA 
CACATGGGAA GCAATGCCAC AGGGTCCAAC GACCCCAGCA TGGAGGCTCA CATGGGGGCC 
ATCAAAGCTA TCAGCTACTT TCTCATTCTC TACATTTTCA ATGCAGTTGC TCTGTTTATC 
TACCTGTCCA ACATGTTTGA CATCAACAGT CTGTGGAATA ATTTGTGCCA GATCATCATG 
GCTGCCTACC CTGCCAGCCA CTCAATTCTA CTGATTCAAG ATAACCCTGG GCTGAGAAGA 
GCCTGGAAGC GGCTTCAGCT TCGACTTCAT CTTTACCCAA AAGAGTGGAC TCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_795362.2
CDS	1..1017
Translation	MLGRCFPPDTKEKQQLRMTKLCDPAESELSPFLITLILAVLLAEYLIGIIANGFIMAIHAAEWVQNKAVSTSGRILVFLSVSRIALQSLMMLEITISSTSLSFYSEDAVYYAFKISFIFLNFCSLWFAAWLSFFYFVKIANFSYPLFLKLRWRITGLIPWLLWLSVFISFSHSMFCINICTVYCNNSFPIHSSNSTKKTYLSEINVVGLAFFFNLGIVTPLIMFILTATLLILSLKRHTLHMGSNATGSNDPSMEAHMGAIKAISYFLILYIFNAVALFIYLSNMFDINSLWNNLCQIIMAAYPASHSILLIQDNPGLRRAWKRLQLRLHLYPKEWTL

Target ORF information:

RefSeq Version	NM_176881.2
Organism	Homo sapiens(human)
Definition	Homo sapiens taste 2 receptor member 39 (TAS2R39), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176881.2

ORF Insert Sequence:

ATGCTAGGGA GATGTTTTCC TCCAGACACC AAAGAGAAGC AACAGCTCAG AATGACTAAA 
CTCTGCGATC CTGCAGAAAG TGAATTGTCG CCATTTCTCA TCACCTTAAT TTTAGCAGTT 
TTACTTGCTG AATACCTCAT TGGTATCATT GCAAATGGTT TCATCATGGC TATACATGCA 
GCTGAATGGG TTCAAAATAA GGCAGTTTCC ACAAGTGGCA GGATCCTGGT TTTCCTGAGT 
GTATCCAGAA TAGCTCTCCA AAGCCTCATG ATGTTAGAAA TTACCATCAG CTCAACCTCC 
CTAAGTTTTT ATTCTGAAGA CGCTGTATAT TATGCATTCA AAATAAGTTT TATATTCTTA 
AATTTTTGTA GCCTGTGGTT TGCTGCCTGG CTCAGTTTCT TCTACTTTGT GAAGATTGCC 
AATTTCTCCT ACCCCCTTTT CCTCAAACTG AGGTGGAGAA TTACTGGATT GATACCCTGG 
CTTCTGTGGC TGTCCGTGTT TATTTCCTTC AGTCACAGCA TGTTCTGCAT CAACATCTGC 
ACTGTGTATT GTAACAATTC TTTCCCTATC CACTCCTCCA ACTCCACTAA GAAAACATAC 
TTGTCTGAGA TCAATGTGGT CGGTCTGGCT TTTTTCTTTA ACCTGGGGAT TGTGACTCCT 
CTGATCATGT TCATCCTGAC AGCCACCCTG CTGATCCTCT CTCTCAAGAG ACACACCCTA 
CACATGGGAA GCAATGCCAC AGGGTCCAAC GACCCCAGCA TGGAGGCTCA CATGGGGGCC 
ATCAAAGCTA TCAGCTACTT TCTCATTCTC TACATTTTCA ATGCAGTTGC TCTGTTTATC 
TACCTGTCCA ACATGTTTGA CATCAACAGT CTGTGGAATA ATTTGTGCCA GATCATCATG 
GCTGCCTACC CTGCCAGCCA CTCAATTCTA CTGATTCAAG ATAACCCTGG GCTGAGAAGA 
GCCTGGAAGC GGCTTCAGCT TCGACTTCAT CTTTACCCAA AAGAGTGGAC TCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The human bitter taste receptor hTAS2R39 is the primary receptor for the bitterness of theaflavins.
Bioscience, biotechnology, and biochemistry78(10)1753-6(2014)
Yamazaki T,Sagisaka M,Ikeda R,Nakamura T,Matsuda N,Ishii T,Nakayama T,Watanabe T

Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39.
Journal of agricultural and food chemistry59(21)11764-71(2011 Nov)
Roland WS,Vincken JP,Gouka RJ,van Buren L,Gruppen H,Smit G

Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39.
Biochemical and biophysical research communications405(4)620-5(2011 Feb)
Narukawa M,Noga C,Ueno Y,Sato T,Misaka T,Watanabe T

Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.
Bioscience, biotechnology, and biochemistry75(6)1188-90(2011)
Ueno Y,Sakurai T,Okada S,Abe K,Misaka T

The molecular receptive ranges of human TAS2R bitter taste receptors.
Chemical senses35(2)157-70(2010 Feb)
Meyerhof W,Batram C,Kuhn C,Brockhoff A,Chudoba E,Bufe B,Appendino G,Behrens M

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TAS2R39 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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