SOSTDC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SOSTDC1
Entrez Gene ID	25928
Full Name	sclerostin domain containing 1
Synonyms	CDA019,DAND7,ECTODIN,USAG1
General protein information	Preferred Names sclerostin domain containing 1 Names sclerostin domain-containing protein 1 cystine-knot containing secreted protein ectodermal BMP inhibitor uterine sensitization-associated protein-1 wise
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p21.2
Summary	This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008].
Disorder MIM:	609675

mRNA and Protein(s)

mRNA	Protein	Name
NM_015464.3	NP_056279.1	sclerostin domain-containing protein 1 precursor
XM_017011943.1	XP_016867432.1	sclerostin domain-containing protein 1 isoform X1
NM_015464.2	NP_056279.1	sclerostin domain-containing protein 1 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SOSTDC1	NP_001039730.1
Gallus gallus (chicken)	SOSTDC1	NP_989704.1
Danio rerio (zebrafish)	sostdc1a	NP_001017598.1
Xenopus tropicalis (tropical clawed frog)	sostdc1	NP_001093740.1
Pan troglodytes (chimpanzee)	SOSTDC1	XP_001149186.2
	SOSTDC1	XP_001105428.2
Canis lupus familiaris (dog)	SOSTDC1	XP_003639529.1
Homo sapiens (human)	SOSTDC1	NP_056279.1
Mus musculus (house mouse)	Sostdc1	NP_079588.1
Rattus norvegicus (Norway rat)	Sostdc1	NP_714959.1

Gene Ontology
Bibliography

Related articles in PubMed

SOSTDC1 inhibits follicular thyroid cancer cell proliferation, migration, and EMT via suppressing PI3K/Akt and MAPK/Erk signaling pathways.
Zhou Q, Chen J, Feng J, Xu Y, Zheng W, Wang J
Molecular and cellular biochemistry435(1-2)87-95(2017 Nov)

Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2.
Liang W, Guan H, He X, Ke W, Xu L, Liu L, Xiao H, Li Y
Oncotarget6(31)31780-91(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2.
Title: Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2.

Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer and is associated with accelerated disease progression in patients with prostate cancer
Title: Hepcidin regulation in prostate and its disruption in prostate cancer.

Results conclude that the transcriptional repressor E4BP4 plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 silencing.
Title: E4BP4 is a repressor of epigenetically regulated SOSTDC1 expression in breast cancer cells.

Unliganded VDR upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1.
Title: Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes.

DNA methylation is involved in the down-regulation of SOSTDC1 expression in gastric cancer.
Title: SOSTDC1 down-regulation of expression involves CpG methylation and is a potential prognostic marker in gastric cancer.

The following SOSTDC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOSTDC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10444	NM_015464.3 Latest version!	Homo sapiens sclerostin domain containing 1 (SOSTDC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10444	XM_017011943.1 Latest version!	Homo sapiens sclerostin domain containing 1 (SOSTDC1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu10444	NM_015464.2	Homo sapiens sclerostin domain containing 1 (SOSTDC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SOSTDC1 ( NM_015464.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_056279.1 Homo sapiens sclerostin domain containing 1 (SOSTDC1), mRNA.

Price & Availability↑

CloneID	OHu10444
Clone ID Related Accession (Same CDS sequence)	NM_015464.3 , XM_017011943.1 , NM_015464.2
Accession Version	NM_015464.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	sclerostin domain-containing protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF361494.1, AI927000.1 and AI540640.1. On Nov 22, 2018 this sequence version replaced NM_015464.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF361494.1, SRR1660803.121045.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307068.5/ ENSP00000304930.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTTCCTC CTGCCATTCA TTTCTATCTC CTTCCCCTTG CATGCATCCT AATGAAAAGC 
TGTTTGGCTT TTAAAAATGA TGCCACAGAA ATCCTTTATT CACATGTGGT TAAACCTGTT 
CCAGCACACC CCAGCAGCAA CAGCACGTTG AATCAAGCCA GAAATGGAGG CAGGCATTTC 
AGTAACACTG GACTGGATCG GAACACTCGG GTTCAAGTGG GTTGCCGGGA ACTGCGTTCC 
ACCAAATACA TCTCTGATGG CCAGTGCACC AGCATCAGCC CTCTGAAGGA GCTGGTGTGT 
GCTGGCGAGT GCTTGCCCCT GCCAGTGCTC CCTAACTGGA TTGGAGGAGG CTATGGAACA 
AAGTACTGGA GCAGGAGGAG CTCCCAGGAG TGGCGGTGTG TCAATGACAA AACCCGTACC 
CAGAGAATCC AGCTGCAGTG CCAAGATGGC AGCACACGCA CCTACAAAAT CACAGTAGTC 
ACTGCCTGCA AGTGCAAGAG GTACACCCGG CAGCACAACG AGTCCAGTCA CAACTTTGAG 
AGCATGTCAC CTGCCAAGCC AGTCCAGCAT CACAGAGAGC GGAAAAGAGC CAGCAAATCC 
AGCAAGCACA GCATGAGTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056279.1
CDS	71..691
Translation	MLPPAIHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS

Target ORF information:

RefSeq Version	NM_015464.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sclerostin domain containing 1 (SOSTDC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015464.3

ORF Insert Sequence:

ATGCTTCCTC CTGCCATTCA TTTCTATCTC CTTCCCCTTG CATGCATCCT AATGAAAAGC 
TGTTTGGCTT TTAAAAATGA TGCCACAGAA ATCCTTTATT CACATGTGGT TAAACCTGTT 
CCAGCACACC CCAGCAGCAA CAGCACGTTG AATCAAGCCA GAAATGGAGG CAGGCATTTC 
AGTAACACTG GACTGGATCG GAACACTCGG GTTCAAGTGG GTTGCCGGGA ACTGCGTTCC 
ACCAAATACA TCTCTGATGG CCAGTGCACC AGCATCAGCC CTCTGAAGGA GCTGGTGTGT 
GCTGGCGAGT GCTTGCCCCT GCCAGTGCTC CCTAACTGGA TTGGAGGAGG CTATGGAACA 
AAGTACTGGA GCAGGAGGAG CTCCCAGGAG TGGCGGTGTG TCAATGACAA AACCCGTACC 
CAGAGAATCC AGCTGCAGTG CCAAGATGGC AGCACACGCA CCTACAAAAT CACAGTAGTC 
ACTGCCTGCA AGTGCAAGAG GTACACCCGG CAGCACAACG AGTCCAGTCA CAACTTTGAG 
AGCATGTCAC CTGCCAAGCC AGTCCAGCAT CACAGAGAGC GGAAAAGAGC CAGCAAATCC 
AGCAAGCACA GCATGAGTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOSTDC1 ( NM_015464.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_056279.1 Homo sapiens sclerostin domain containing 1 (SOSTDC1), mRNA.

Price & Availability↑

CloneID	OHu10444
Clone ID Related Accession (Same CDS sequence)	NM_015464.3 , XM_017011943.1 , NM_015464.2
Accession Version	NM_015464.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	sclerostin domain-containing protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF361494.1, AI927000.1 and AI540640.1. On May 25, 2006 this sequence version replaced NM_015464.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF361494.1, SRR1803613.182523.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTTCCTC CTGCCATTCA TTTCTATCTC CTTCCCCTTG CATGCATCCT AATGAAAAGC 
TGTTTGGCTT TTAAAAATGA TGCCACAGAA ATCCTTTATT CACATGTGGT TAAACCTGTT 
CCAGCACACC CCAGCAGCAA CAGCACGTTG AATCAAGCCA GAAATGGAGG CAGGCATTTC 
AGTAACACTG GACTGGATCG GAACACTCGG GTTCAAGTGG GTTGCCGGGA ACTGCGTTCC 
ACCAAATACA TCTCTGATGG CCAGTGCACC AGCATCAGCC CTCTGAAGGA GCTGGTGTGT 
GCTGGCGAGT GCTTGCCCCT GCCAGTGCTC CCTAACTGGA TTGGAGGAGG CTATGGAACA 
AAGTACTGGA GCAGGAGGAG CTCCCAGGAG TGGCGGTGTG TCAATGACAA AACCCGTACC 
CAGAGAATCC AGCTGCAGTG CCAAGATGGC AGCACACGCA CCTACAAAAT CACAGTAGTC 
ACTGCCTGCA AGTGCAAGAG GTACACCCGG CAGCACAACG AGTCCAGTCA CAACTTTGAG 
AGCATGTCAC CTGCCAAGCC AGTCCAGCAT CACAGAGAGC GGAAAAGAGC CAGCAAATCC 
AGCAAGCACA GCATGAGTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056279.1
CDS	182..802
Translation	MLPPAIHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS

Target ORF information:

RefSeq Version	NM_015464.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sclerostin domain containing 1 (SOSTDC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015464.2

ORF Insert Sequence:

ATGCTTCCTC CTGCCATTCA TTTCTATCTC CTTCCCCTTG CATGCATCCT AATGAAAAGC 
TGTTTGGCTT TTAAAAATGA TGCCACAGAA ATCCTTTATT CACATGTGGT TAAACCTGTT 
CCAGCACACC CCAGCAGCAA CAGCACGTTG AATCAAGCCA GAAATGGAGG CAGGCATTTC 
AGTAACACTG GACTGGATCG GAACACTCGG GTTCAAGTGG GTTGCCGGGA ACTGCGTTCC 
ACCAAATACA TCTCTGATGG CCAGTGCACC AGCATCAGCC CTCTGAAGGA GCTGGTGTGT 
GCTGGCGAGT GCTTGCCCCT GCCAGTGCTC CCTAACTGGA TTGGAGGAGG CTATGGAACA 
AAGTACTGGA GCAGGAGGAG CTCCCAGGAG TGGCGGTGTG TCAATGACAA AACCCGTACC 
CAGAGAATCC AGCTGCAGTG CCAAGATGGC AGCACACGCA CCTACAAAAT CACAGTAGTC 
ACTGCCTGCA AGTGCAAGAG GTACACCCGG CAGCACAACG AGTCCAGTCA CAACTTTGAG 
AGCATGTCAC CTGCCAAGCC AGTCCAGCAT CACAGAGAGC GGAAAAGAGC CAGCAAATCC 
AGCAAGCACA GCATGAGTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOSTDC1 ( XM_017011943.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016867432.1 Homo sapiens sclerostin domain containing 1 (SOSTDC1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu10444
Clone ID Related Accession (Same CDS sequence)	NM_015464.3 , XM_017011943.1 , NM_015464.2
Accession Version	XM_017011943.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	sclerostin domain-containing protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTTCCTC CTGCCATTCA TTTCTATCTC CTTCCCCTTG CATGCATCCT AATGAAAAGC 
TGTTTGGCTT TTAAAAATGA TGCCACAGAA ATCCTTTATT CACATGTGGT TAAACCTGTT 
CCAGCACACC CCAGCAGCAA CAGCACGTTG AATCAAGCCA GAAATGGAGG CAGGCATTTC 
AGTAACACTG GACTGGATCG GAACACTCGG GTTCAAGTGG GTTGCCGGGA ACTGCGTTCC 
ACCAAATACA TCTCTGATGG CCAGTGCACC AGCATCAGCC CTCTGAAGGA GCTGGTGTGT 
GCTGGCGAGT GCTTGCCCCT GCCAGTGCTC CCTAACTGGA TTGGAGGAGG CTATGGAACA 
AAGTACTGGA GCAGGAGGAG CTCCCAGGAG TGGCGGTGTG TCAATGACAA AACCCGTACC 
CAGAGAATCC AGCTGCAGTG CCAAGATGGC AGCACACGCA CCTACAAAAT CACAGTAGTC 
ACTGCCTGCA AGTGCAAGAG GTACACCCGG CAGCACAACG AGTCCAGTCA CAACTTTGAG 
AGCATGTCAC CTGCCAAGCC AGTCCAGCAT CACAGAGAGC GGAAAAGAGC CAGCAAATCC 
AGCAAGCACA GCATGAGTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016867432.1
CDS	324..944
Translation	MLPPAIHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS

Target ORF information:

RefSeq Version	XM_017011943.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sclerostin domain containing 1 (SOSTDC1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011943.1

ORF Insert Sequence:

ATGCTTCCTC CTGCCATTCA TTTCTATCTC CTTCCCCTTG CATGCATCCT AATGAAAAGC 
TGTTTGGCTT TTAAAAATGA TGCCACAGAA ATCCTTTATT CACATGTGGT TAAACCTGTT 
CCAGCACACC CCAGCAGCAA CAGCACGTTG AATCAAGCCA GAAATGGAGG CAGGCATTTC 
AGTAACACTG GACTGGATCG GAACACTCGG GTTCAAGTGG GTTGCCGGGA ACTGCGTTCC 
ACCAAATACA TCTCTGATGG CCAGTGCACC AGCATCAGCC CTCTGAAGGA GCTGGTGTGT 
GCTGGCGAGT GCTTGCCCCT GCCAGTGCTC CCTAACTGGA TTGGAGGAGG CTATGGAACA 
AAGTACTGGA GCAGGAGGAG CTCCCAGGAG TGGCGGTGTG TCAATGACAA AACCCGTACC 
CAGAGAATCC AGCTGCAGTG CCAAGATGGC AGCACACGCA CCTACAAAAT CACAGTAGTC 
ACTGCCTGCA AGTGCAAGAG GTACACCCGG CAGCACAACG AGTCCAGTCA CAACTTTGAG 
AGCATGTCAC CTGCCAAGCC AGTCCAGCAT CACAGAGAGC GGAAAAGAGC CAGCAAATCC 
AGCAAGCACA GCATGAGTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SOSTDC1 inhibits follicular thyroid cancer cell proliferation, migration, and EMT via suppressing PI3K/Akt and MAPK/Erk signaling pathways.
Molecular and cellular biochemistry435(1-2)87-95(2017 Nov)
Zhou Q,Chen J,Feng J,Xu Y,Zheng W,Wang J

Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2.
Oncotarget6(31)31780-91(2015 Oct)
Liang W,Guan H,He X,Ke W,Xu L,Liu L,Xiao H,Li Y

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SOSTDC1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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