LSM4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LSM4
Entrez Gene ID	25804
Full Name	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms	GRP,YER112W
General protein information	Preferred Names LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated Names U6 snRNA-associated Sm-like protein LSm4 LSM4 U6 small nuclear RNA and mRNA degradation associated LSM4 homolog, U6 small nuclear RNA associated glycine-rich protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.11
Summary	This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
Disorder MIM:	607284

mRNA and Protein(s)

mRNA	Protein	Name
NM_012321.4	NP_036453.1	U6 snRNA-associated Sm-like protein LSm4 isoform 1
NM_012321.5	NP_036453.1	U6 snRNA-associated Sm-like protein LSm4 isoform 1
NM_001252129.1	NP_001239058.1	U6 snRNA-associated Sm-like protein LSm4 isoform 2
NM_001252129.2	NP_001239058.1	U6 snRNA-associated Sm-like protein LSm4 isoform 2

Pathways from BioSystems

Homologies

	LSM4	XP_001115319.2
Rattus norvegicus (Norway rat)	Lsm4	NP_001099543.1
Gallus gallus (chicken)	LSM4	XP_418245.3
Danio rerio (zebrafish)	lsm4	NP_956990.1
Xenopus tropicalis (tropical clawed frog)	lsm4	NP_989371.1
Homo sapiens (human)	LSM4	NP_036453.1
Canis lupus familiaris (dog)	LSM4	NP_001104275.1
Mus musculus (house mouse)	Lsm4	NP_056631.2
Bos taurus (cattle)	LSM4	NP_001030513.1

Gene Ontology
Bibliography

Related articles in PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, L?hrmann R, Stark H
Cell170(4)701-713.e11(2017 Aug)

The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation.
Arribas-Layton M, Dennis J, Bennett EJ, Damgaard CK, Lykke-Andersen J
Molecular and cellular biology36(17)2226-35(2016 Sep)

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Agafonov DE, Kastner B, Dybkov O, Hofele RV, Liu WT, Urlaub H, L?hrmann R, Stark H
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)

The C-terminal extension of Lsm4 interacts directly with the 3' end of the histone mRNP and is required for efficient histone mRNA degradation.
Lyons SM, Ricciardi AS, Guo AY, Kambach C, Marzluff WF
RNA (New York, N.Y.)20(1)88-102(2014 Jan)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that the RGG domain of human Lsm4 stimulates processing bodies formation. Also, a novel interaction of the Lsm4 RGG domain with HAT1 and RBBP7 was discovered, leading to the possibility of a posttranslational modifications network involved in mRNP regulation.
Title: The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation.

C-terminal extension of Lsm4 interacts directly with the histone mRNP, contacting both SLBP and 3'hExo.
Title: The C-terminal extension of Lsm4 interacts directly with the 3' end of the histone mRNP and is required for efficient histone mRNA degradation.

Observational study of gene-disease association. (HuGE Navigator)
Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

LSm4 not only acts in RNA processing, but also as a co-factor in cell volume regulation.
Title: LSm4 associates with the plasma membrane and acts as a co-factor in cell volume regulation.

Gene induces transformed phenotype when overexpressed in a cancer breast cell line.
Title: Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.

The following LSM4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LSM4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09593	NM_012321.5 Latest version!	Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09732	NM_001252129.2 Latest version!	Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu09593	NM_012321.4	Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09732	NM_001252129.1	Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LSM4 ( NM_012321.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036453.1 Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09593
Clone ID Related Accession (Same CDS sequence)	NM_012321.4 , NM_012321.5
Accession Version	NM_012321.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB493307.1, BC000387.2, BU539495.1, CF147062.1, BX096089.1 and AA722246.1. On Nov 4, 2011 this sequence version replaced NM_012321.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.198600.1, SRR1803612.366838.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTTCCCT TGTCACTGCT GAAGACGGCT CAGAATCACC CCATGTTGGT GGAGCTGAAA 
AATGGGGAGA CGTACAATGG ACACCTGGTG AGCTGCGACA ACTGGATGAA CATTAACCTG 
CGAGAAGTCA TCTGCACGTC CAGGGACGGG GACAAGTTCT GGCGGATGCC CGAGTGCTAC 
ATCCGCGGCA GCACCATCAA GTACCTGCGC ATCCCCGACG AGATCATCGA CATGGTCAAG 
GAGGAGGTGG TGGCCAAGGG CCGCGGCCGC GGAGGCCTGC AGCAGCAGAA GCAGCAGAAA 
GGCCGCGGCA TGGGCGGCGC TGGCCGAGGT GTGTTTGGTG GCCGGGGCCG AGGTGGGATC 
CCGGGCACAG GCAGAGGCCA GCCAGAGAAG AAGCCTGGCA GACAGGCGGG CAAACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036453.1
CDS	172..591
Translation	MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ

Target ORF information:

RefSeq Version	NM_012321.4
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012321.4

ORF Insert Sequence:

ATGCTTCCCT TGTCACTGCT GAAGACGGCT CAGAATCACC CCATGTTGGT GGAGCTGAAA 
AATGGGGAGA CGTACAATGG ACACCTGGTG AGCTGCGACA ACTGGATGAA CATTAACCTG 
CGAGAAGTCA TCTGCACGTC CAGGGACGGG GACAAGTTCT GGCGGATGCC CGAGTGCTAC 
ATCCGCGGCA GCACCATCAA GTACCTGCGC ATCCCCGACG AGATCATCGA CATGGTCAAG 
GAGGAGGTGG TGGCCAAGGG CCGCGGCCGC GGAGGCCTGC AGCAGCAGAA GCAGCAGAAA 
GGCCGCGGCA TGGGCGGCGC TGGCCGAGGT GTGTTTGGTG GCCGGGGCCG AGGTGGGATC 
CCGGGCACAG GCAGAGGCCA GCCAGAGAAG AAGCCTGGCA GACAGGCGGG CAAACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM4 ( NM_012321.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_036453.1 Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09593
Clone ID Related Accession (Same CDS sequence)	NM_012321.4 , NM_012321.5
Accession Version	NM_012321.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB493307.1, BC000387.2, BU539495.1, CF147062.1, BX096089.1 and AA722246.1. On Jun 2, 2019 this sequence version replaced NM_012321.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.692678.1, DRR138519.308927.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTTCCCT TGTCACTGCT GAAGACGGCT CAGAATCACC CCATGTTGGT GGAGCTGAAA 
AATGGGGAGA CGTACAATGG ACACCTGGTG AGCTGCGACA ACTGGATGAA CATTAACCTG 
CGAGAAGTCA TCTGCACGTC CAGGGACGGG GACAAGTTCT GGCGGATGCC CGAGTGCTAC 
ATCCGCGGCA GCACCATCAA GTACCTGCGC ATCCCCGACG AGATCATCGA CATGGTCAAG 
GAGGAGGTGG TGGCCAAGGG CCGCGGCCGC GGAGGCCTGC AGCAGCAGAA GCAGCAGAAA 
GGCCGCGGCA TGGGCGGCGC TGGCCGAGGT GTGTTTGGTG GCCGGGGCCG AGGTGGGATC 
CCGGGCACAG GCAGAGGCCA GCCAGAGAAG AAGCCTGGCA GACAGGCGGG CAAACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036453.1
CDS	57..476
Translation	MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ

Target ORF information:

RefSeq Version	NM_012321.5
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012321.5

ORF Insert Sequence:

ATGCTTCCCT TGTCACTGCT GAAGACGGCT CAGAATCACC CCATGTTGGT GGAGCTGAAA 
AATGGGGAGA CGTACAATGG ACACCTGGTG AGCTGCGACA ACTGGATGAA CATTAACCTG 
CGAGAAGTCA TCTGCACGTC CAGGGACGGG GACAAGTTCT GGCGGATGCC CGAGTGCTAC 
ATCCGCGGCA GCACCATCAA GTACCTGCGC ATCCCCGACG AGATCATCGA CATGGTCAAG 
GAGGAGGTGG TGGCCAAGGG CCGCGGCCGC GGAGGCCTGC AGCAGCAGAA GCAGCAGAAA 
GGCCGCGGCA TGGGCGGCGC TGGCCGAGGT GTGTTTGGTG GCCGGGGCCG AGGTGGGATC 
CCGGGCACAG GCAGAGGCCA GCCAGAGAAG AAGCCTGGCA GACAGGCGGG CAAACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM4 ( NM_001252129.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001239058.1 Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09732
Clone ID Related Accession (Same CDS sequence)	NM_001252129.1 , NM_001252129.2
Accession Version	NM_001252129.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB493307.1, BQ069184.1, BU539495.1, CF147062.1, BX096089.1 and AA722246.1. Transcript Variant: This variant (2) lacks an exon in the 5' coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.257725.1, BU855310.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGGTGG AGCTGAAAAA TGGGGAGACG TACAATGGAC ACCTGGTGAG CTGCGACAAC 
TGGATGAACA TTAACCTGCG AGAAGTCATC TGCACGTCCA GGGACGGGGA CAAGTTCTGG 
CGGATGCCCG AGTGCTACAT CCGCGGCAGC ACCATCAAGT ACCTGCGCAT CCCCGACGAG 
ATCATCGACA TGGTCAAGGA GGAGGTGGTG GCCAAGGGCC GCGGCCGCGG AGGCCTGCAG 
CAGCAGAAGC AGCAGAAAGG CCGCGGCATG GGCGGCGCTG GCCGAGGTGT GTTTGGTGGC 
CGGGGCCGAG GTGGGATCCC GGGCACAGGC AGAGGCCAGC CAGAGAAGAA GCCTGGCAGA 
CAGGCGGGCA AACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001239058.1
CDS	172..549
Translation	MLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ

Target ORF information:

RefSeq Version	NM_001252129.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001252129.1

ORF Insert Sequence:

ATGTTGGTGG AGCTGAAAAA TGGGGAGACG TACAATGGAC ACCTGGTGAG CTGCGACAAC 
TGGATGAACA TTAACCTGCG AGAAGTCATC TGCACGTCCA GGGACGGGGA CAAGTTCTGG 
CGGATGCCCG AGTGCTACAT CCGCGGCAGC ACCATCAAGT ACCTGCGCAT CCCCGACGAG 
ATCATCGACA TGGTCAAGGA GGAGGTGGTG GCCAAGGGCC GCGGCCGCGG AGGCCTGCAG 
CAGCAGAAGC AGCAGAAAGG CCGCGGCATG GGCGGCGCTG GCCGAGGTGT GTTTGGTGGC 
CGGGGCCGAG GTGGGATCCC GGGCACAGGC AGAGGCCAGC CAGAGAAGAA GCCTGGCAGA 
CAGGCGGGCA AACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LSM4 ( NM_001252129.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001239058.1 Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09732
Clone ID Related Accession (Same CDS sequence)	NM_001252129.1 , NM_001252129.2
Accession Version	NM_001252129.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-29
Organism	Homo sapiens(human)
Product	U6 snRNA-associated Sm-like protein LSm4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB493307.1, BQ069184.1, BU539495.1, CF147062.1, BX096089.1 and AA722246.1. On Jun 2, 2019 this sequence version replaced NM_001252129.1. Transcript Variant: This variant (2) lacks an exon in the 5' coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.257725.1, SRR7346977.183122.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGGTGG AGCTGAAAAA TGGGGAGACG TACAATGGAC ACCTGGTGAG CTGCGACAAC 
TGGATGAACA TTAACCTGCG AGAAGTCATC TGCACGTCCA GGGACGGGGA CAAGTTCTGG 
CGGATGCCCG AGTGCTACAT CCGCGGCAGC ACCATCAAGT ACCTGCGCAT CCCCGACGAG 
ATCATCGACA TGGTCAAGGA GGAGGTGGTG GCCAAGGGCC GCGGCCGCGG AGGCCTGCAG 
CAGCAGAAGC AGCAGAAAGG CCGCGGCATG GGCGGCGCTG GCCGAGGTGT GTTTGGTGGC 
CGGGGCCGAG GTGGGATCCC GGGCACAGGC AGAGGCCAGC CAGAGAAGAA GCCTGGCAGA 
CAGGCGGGCA AACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001239058.1
CDS	57..434
Translation	MLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ

Target ORF information:

RefSeq Version	NM_001252129.2
Organism	Homo sapiens(human)
Definition	Homo sapiens LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated (LSM4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001252129.2

ORF Insert Sequence:

ATGTTGGTGG AGCTGAAAAA TGGGGAGACG TACAATGGAC ACCTGGTGAG CTGCGACAAC 
TGGATGAACA TTAACCTGCG AGAAGTCATC TGCACGTCCA GGGACGGGGA CAAGTTCTGG 
CGGATGCCCG AGTGCTACAT CCGCGGCAGC ACCATCAAGT ACCTGCGCAT CCCCGACGAG 
ATCATCGACA TGGTCAAGGA GGAGGTGGTG GCCAAGGGCC GCGGCCGCGG AGGCCTGCAG 
CAGCAGAAGC AGCAGAAAGG CCGCGGCATG GGCGGCGCTG GCCGAGGTGT GTTTGGTGGC 
CGGGGCCGAG GTGGGATCCC GGGCACAGGC AGAGGCCAGC CAGAGAAGAA GCCTGGCAGA 
CAGGCGGGCA AACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell170(4)701-713.e11(2017 Aug)
Bertram K,Agafonov DE,Dybkov O,Haselbach D,Leelaram MN,Will CL,Urlaub H,Kastner B,L?hrmann R,Stark H

The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation.
Molecular and cellular biology36(17)2226-35(2016 Sep)
Arribas-Layton M,Dennis J,Bennett EJ,Damgaard CK,Lykke-Andersen J

Molecular architecture of the human U4/U6.U5 tri-snRNP.
Science (New York, N.Y.)351(6280)1416-20(2016 Mar)
Agafonov DE,Kastner B,Dybkov O,Hofele RV,Liu WT,Urlaub H,L?hrmann R,Stark H

The C-terminal extension of Lsm4 interacts directly with the 3' end of the histone mRNP and is required for efficient histone mRNA degradation.
RNA (New York, N.Y.)20(1)88-102(2014 Jan)
Lyons SM,Ricciardi AS,Guo AY,Kambach C,Marzluff WF

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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LSM4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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FAX

オンラインフォーム