TAC4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAC4
Entrez Gene ID	255061
Full Name	tachykinin 4
Synonyms	EK,HK-1,HK1,PPT-C
General protein information	Preferred Names tachykinin 4 Names tachykinin-4 endokinin preprotachykinin-C tachykinin 4 (hemokinin)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.33
Summary	This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	607833

mRNA and Protein(s)

mRNA	Protein	Name
NM_001077506.1	NP_001070974.1	tachykinin-4 isoform alpha-2 precursor
NM_170685.2	NP_733786.2	tachykinin-4 isoform alpha precursor
NM_001077505.1	NP_001070973.1	tachykinin-4 isoform delta precursor
NM_001077503.1	NP_001070971.1	tachykinin-4 isoform beta precursor
NM_001077504.1	NP_001070972.1	tachykinin-4 isoform gamma precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	TAC4	NP_001070974.1
Pan troglodytes (chimpanzee)	TAC4	XP_001168543.1

Gene Ontology
Bibliography

Related articles in PubMed

Altered expression of the tachykinins substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors in uterine leiomyomata.
Gonz?lez-Santana A, Marrero-Hern?ndez S, Dorta I, Hern?ndez M, Pinto FM, B?ez D, Bello AR, Candenas L, Almeida TA
Fertility and sterility106(6)1521-1529(2016 Nov)

Human hemokinin-1 promotes migration of melanoma cells and increases MMP-2 and MT1-MMP expression by activating tumor cell NK1 receptors.
Zhang Y, Li X, Li J, Hu H, Miao X, Song X, Yang W, Zeng Q, Mou L, Wang R
Peptides838-15(2016 Sep)

Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells.
Garc?a-Ortega J, Pinto FM, Prados N, Bello AR, Almeida TA, Fern?ndez-S?nchez M, Candenas L
Biology of reproduction94(6)124(2016 06)

Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor.
Song H, Yin W, Zeng Q, Jia H, Lin L, Liu X, Mu L, Wang R
The international journal of biochemistry & cell biology44(9)1410-21(2012 Sep)

The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1?, IL-23, and TNF-like 1A expression by monocytes.
Cunin P, Caillon A, Corvaisier M, Garo E, Scotet M, Blanchard S, Delneste Y, Jeannin P
Journal of immunology (Baltimore, Md. : 1950)186(7)4175-82(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expression substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors are dysregulated in uterine leiomyomata.
Title: Altered expression of the tachykinins substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors in uterine leiomyomata.

Kinase activation led to increased MMP-2 and MT1-MMP expression and melanoma cell migration induced by hHK-1. Thus, hHK-1 and the NK1 receptor are critical to melanoma cell migration and each may be a promising chemotherapeutic target
Title: Human hemokinin-1 promotes migration of melanoma cells and increases MMP-2 and MT1-MMP expression by activating tumor cell NK1 receptors.

expressed in mural granulosa and cumulus cells
Title: Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells.

HKs emerge as pivotal endogenous regulators of angiogenesis through neurokinin-1 receptor
Title: Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor.

HK-1 and substance P are novel T helper (Th)17 cell-inducing factors that may act locally on memory T cells to amplify inflammatory responses.
Title: The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1?, IL-23, and TNF-like 1A expression by monocytes.

The following TAC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30466	NM_001077505.1 Latest version!	Homo sapiens tachykinin precursor 4 (TAC4), transcript variant delta, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu19119	NM_170685.2 Latest version!	Homo sapiens tachykinin precursor 4 (TAC4), transcript variant alpha, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu30045	NM_001077503.1 Latest version!	Homo sapiens tachykinin precursor 4 (TAC4), transcript variant beta, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu30169	NM_001077504.1 Latest version!	Homo sapiens tachykinin precursor 4 (TAC4), transcript variant gamma, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu30273	NM_001077506.1 Latest version!	Homo sapiens tachykinin precursor 4 (TAC4), transcript variant alpha-2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAC4 ( NM_001077505.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001070973.1 Homo sapiens tachykinin precursor 4 (TAC4), transcript variant delta, mRNA.

Price & Availability↑

CloneID	OHu30466
Clone ID Related Accession (Same CDS sequence)	NM_001077505.1
Accession Version	NM_001077505.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 231bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-13
Organism	Homo sapiens(human)
Product	tachykinin-4 isoform delta precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF515831.1. Transcript Variant: This variant (delta) uses an alternate in-frame splice site in the 5' coding region and skips two alternate in-frame exons in the 3' coding region, compared to variant alpha. The resulting protein (isoform delta) is shorter than isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF515831.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCTT GCCTCGCCCT GCTTCTCCTG ATGGAGCTGT CCGTGTGCAC TGTGGCAGGT 
GATGGTGGAG AGGAACAGAC ACTCAGCACT GAAGCAGAGA CCTGGGAAGG CGCTGGCCCC 
AGCATTCAGC TCCAGCTGCA GGAGGTGAAG ACGGGCAAGG CAAGCCAGTT CTTTGGGCTG 
ATGGGGAAGC GAGTGGGAGG CAGAGAGGAT GAGGCCCAAG GTTCAGAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001070973.1
CDS	1..231
Translation	MLPCLALLLLMELSVCTVAGDGGEEQTLSTEAETWEGAGPSIQLQLQEVKTGKASQFFGLMGKRVGGREDEAQGSE

Target ORF information:

RefSeq Version	NM_001077505.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tachykinin precursor 4 (TAC4), transcript variant delta, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077505.1

ORF Insert Sequence:

ATGCTGCCTT GCCTCGCCCT GCTTCTCCTG ATGGAGCTGT CCGTGTGCAC TGTGGCAGGT 
GATGGTGGAG AGGAACAGAC ACTCAGCACT GAAGCAGAGA CCTGGGAAGG CGCTGGCCCC 
AGCATTCAGC TCCAGCTGCA GGAGGTGAAG ACGGGCAAGG CAAGCCAGTT CTTTGGGCTG 
ATGGGGAAGC GAGTGGGAGG CAGAGAGGAT GAGGCCCAAG GTTCAGAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAC4 ( NM_170685.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_733786.2 Homo sapiens tachykinin precursor 4 (TAC4), transcript variant alpha, mRNA.

Price & Availability↑

CloneID	OHu19119
Clone ID Related Accession (Same CDS sequence)	NM_170685.2
Accession Version	NM_170685.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-13
Organism	Homo sapiens(human)
Product	tachykinin-4 isoform alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF515828.1. This sequence is a reference standard in the RefSeqGene project. On Nov 13, 2006 this sequence version replaced NM_170685.1. Transcript Variant: This variant (alpha) represents the longest transcript and encodes the longest isoform (alpha). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF515828.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2153031, SAMEA2157437 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCTT GCCTCGCCCT GCTTCTCCTG ATGGAGCTGT CCGTGTGCAC TGTGGCAGGT 
GATGGTGGAG AGGAACAGAC ACTCAGCACT GAAGCAGAGA CCTGGGTAAT TGTGGCCTTG 
GAGGAAGGCG CTGGCCCCAG CATTCAGCTC CAGCTGCAGG AGGTGAAGAC GGGCAAGGCA 
AGCCAGTTCT TTGGGCTGAT GGGGAAGCGA GTGGGAGGAA GACCTCTGAT CCAGCCAAGG 
AGAAAAAAAG CATATCAGCT GGAACACACG TTCCAGGGCC TCCTGGGCAA GAGAAGCCTG 
TTCACAGAAG GCAGAGAGGA TGAGGCCCAA GGTTCAGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_733786.2
CDS	1..342
Translation	MLPCLALLLLMELSVCTVAGDGGEEQTLSTEAETWVIVALEEGAGPSIQLQLQEVKTGKASQFFGLMGKRVGGRPLIQPRRKKAYQLEHTFQGLLGKRSLFTEGREDEAQGSE

Target ORF information:

RefSeq Version	NM_170685.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tachykinin precursor 4 (TAC4), transcript variant alpha, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_170685.2

ORF Insert Sequence:

ATGCTGCCTT GCCTCGCCCT GCTTCTCCTG ATGGAGCTGT CCGTGTGCAC TGTGGCAGGT 
GATGGTGGAG AGGAACAGAC ACTCAGCACT GAAGCAGAGA CCTGGGTAAT TGTGGCCTTG 
GAGGAAGGCG CTGGCCCCAG CATTCAGCTC CAGCTGCAGG AGGTGAAGAC GGGCAAGGCA 
AGCCAGTTCT TTGGGCTGAT GGGGAAGCGA GTGGGAGGAA GACCTCTGAT CCAGCCAAGG 
AGAAAAAAAG CATATCAGCT GGAACACACG TTCCAGGGCC TCCTGGGCAA GAGAAGCCTG 
TTCACAGAAG GCAGAGAGGA TGAGGCCCAA GGTTCAGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAC4 ( NM_001077503.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001070971.1 Homo sapiens tachykinin precursor 4 (TAC4), transcript variant beta, mRNA.

Price & Availability↑

CloneID	OHu30045
Clone ID Related Accession (Same CDS sequence)	NM_001077503.1
Accession Version	NM_001077503.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 291bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-13
Organism	Homo sapiens(human)
Product	tachykinin-4 isoform beta precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF515829.1. Transcript Variant: This variant (beta) uses an alternate in-frame splice site in the 5' coding region and skips an alternate in-frame exon in the 3' coding region, compared to variant alpha. The resulting protein (isoform beta) is shorter than isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF515829.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2151741, SAMEA2153031 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCTT GCCTCGCCCT GCTTCTCCTG ATGGAGCTGT CCGTGTGCAC TGTGGCAGGT 
GATGGTGGAG AGGAACAGAC ACTCAGCACT GAAGCAGAGA CCTGGGAAGG CGCTGGCCCC 
AGCATTCAGC TCCAGCTGCA GGAGGTGAAG ACGGGCAAGG CAAGCCAGTT CTTTGGGCTG 
ATGGGGAAGC GAGTGGGAGC ATATCAGCTG GAACACACGT TCCAGGGCCT CCTGGGCAAG 
AGAAGCCTGT TCACAGAAGG CAGAGAGGAT GAGGCCCAAG GTTCAGAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001070971.1
CDS	1..291
Translation	MLPCLALLLLMELSVCTVAGDGGEEQTLSTEAETWEGAGPSIQLQLQEVKTGKASQFFGLMGKRVGAYQLEHTFQGLLGKRSLFTEGREDEAQGSE

Target ORF information:

RefSeq Version	NM_001077503.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tachykinin precursor 4 (TAC4), transcript variant beta, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077503.1

ORF Insert Sequence:

ATGCTGCCTT GCCTCGCCCT GCTTCTCCTG ATGGAGCTGT CCGTGTGCAC TGTGGCAGGT 
GATGGTGGAG AGGAACAGAC ACTCAGCACT GAAGCAGAGA CCTGGGAAGG CGCTGGCCCC 
AGCATTCAGC TCCAGCTGCA GGAGGTGAAG ACGGGCAAGG CAAGCCAGTT CTTTGGGCTG 
ATGGGGAAGC GAGTGGGAGC ATATCAGCTG GAACACACGT TCCAGGGCCT CCTGGGCAAG 
AGAAGCCTGT TCACAGAAGG CAGAGAGGAT GAGGCCCAAG GTTCAGAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAC4 ( NM_001077504.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001070972.1 Homo sapiens tachykinin precursor 4 (TAC4), transcript variant gamma, mRNA.

Price & Availability↑

CloneID	OHu30169
Clone ID Related Accession (Same CDS sequence)	NM_001077504.1
Accession Version	NM_001077504.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 264bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-13
Organism	Homo sapiens(human)
Product	tachykinin-4 isoform gamma precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF515830.1. Transcript Variant: This variant (gamma) uses an alternate in-frame splice site in the 5' coding region and skips an alternate in-frame exon in the 3' coding region, compared to variant alpha. The resulting protein (isoform gamma) is shorter than isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF515830.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCTT GCCTCGCCCT GCTTCTCCTG ATGGAGCTGT CCGTGTGCAC TGTGGCAGGT 
GATGGTGGAG AGGAACAGAC ACTCAGCACT GAAGCAGAGA CCTGGGAAGG CGCTGGCCCC 
AGCATTCAGC TCCAGCTGCA GGAGGTGAAG ACGGGCAAGG CAAGCCAGTT CTTTGGGCTG 
ATGGGGAAGC GAGTGGGAGG AAGACCTCTG ATCCAGCCAA GGAGAAAAAA AGGCAGAGAG 
GATGAGGCCC AAGGTTCAGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001070972.1
CDS	1..264
Translation	MLPCLALLLLMELSVCTVAGDGGEEQTLSTEAETWEGAGPSIQLQLQEVKTGKASQFFGLMGKRVGGRPLIQPRRKKGREDEAQGSE

Target ORF information:

RefSeq Version	NM_001077504.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tachykinin precursor 4 (TAC4), transcript variant gamma, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077504.1

ORF Insert Sequence:

ATGCTGCCTT GCCTCGCCCT GCTTCTCCTG ATGGAGCTGT CCGTGTGCAC TGTGGCAGGT 
GATGGTGGAG AGGAACAGAC ACTCAGCACT GAAGCAGAGA CCTGGGAAGG CGCTGGCCCC 
AGCATTCAGC TCCAGCTGCA GGAGGTGAAG ACGGGCAAGG CAAGCCAGTT CTTTGGGCTG 
ATGGGGAAGC GAGTGGGAGG AAGACCTCTG ATCCAGCCAA GGAGAAAAAA AGGCAGAGAG 
GATGAGGCCC AAGGTTCAGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAC4 ( NM_001077506.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001070974.1 Homo sapiens tachykinin precursor 4 (TAC4), transcript variant alpha-2, mRNA.

Price & Availability↑

CloneID	OHu30273
Clone ID Related Accession (Same CDS sequence)	NM_001077506.1
Accession Version	NM_001077506.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-13
Organism	Homo sapiens(human)
Product	tachykinin-4 isoform alpha-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY471574.1. Transcript Variant: This variant (alpha-2) uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha. The resulting protein (isoform alpha-2) is shorter than isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY471574.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA2142363 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCCTT GCCTCGCCCT GCTTCTCCTG ATGGAGCTGT CCGTGTGCAC TGTGGCAGGT 
GATGGTGGAG AGGAACAGAC ACTCAGCACT GAAGCAGAGA CCTGGGAAGG CGCTGGCCCC 
AGCATTCAGC TCCAGCTGCA GGAGGTGAAG ACGGGCAAGG CAAGCCAGTT CTTTGGGCTG 
ATGGGGAAGC GAGTGGGAGG AAGACCTCTG ATCCAGCCAA GGAGAAAAAA AGCATATCAG 
CTGGAACACA CGTTCCAGGG CCTCCTGGGC AAGAGAAGCC TGTTCACAGA AGGCAGAGAG 
GATGAGGCCC AAGGTTCAGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001070974.1
CDS	1..324
Translation	MLPCLALLLLMELSVCTVAGDGGEEQTLSTEAETWEGAGPSIQLQLQEVKTGKASQFFGLMGKRVGGRPLIQPRRKKAYQLEHTFQGLLGKRSLFTEGREDEAQGSE

Target ORF information:

RefSeq Version	NM_001077506.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tachykinin precursor 4 (TAC4), transcript variant alpha-2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077506.1

ORF Insert Sequence:

ATGCTGCCTT GCCTCGCCCT GCTTCTCCTG ATGGAGCTGT CCGTGTGCAC TGTGGCAGGT 
GATGGTGGAG AGGAACAGAC ACTCAGCACT GAAGCAGAGA CCTGGGAAGG CGCTGGCCCC 
AGCATTCAGC TCCAGCTGCA GGAGGTGAAG ACGGGCAAGG CAAGCCAGTT CTTTGGGCTG 
ATGGGGAAGC GAGTGGGAGG AAGACCTCTG ATCCAGCCAA GGAGAAAAAA AGCATATCAG 
CTGGAACACA CGTTCCAGGG CCTCCTGGGC AAGAGAAGCC TGTTCACAGA AGGCAGAGAG 
GATGAGGCCC AAGGTTCAGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Altered expression of the tachykinins substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors in uterine leiomyomata.
Fertility and sterility106(6)1521-1529(2016 Nov)
Gonz?lez-Santana A,Marrero-Hern?ndez S,Dorta I,Hern?ndez M,Pinto FM,B?ez D,Bello AR,Candenas L,Almeida TA

Human hemokinin-1 promotes migration of melanoma cells and increases MMP-2 and MT1-MMP expression by activating tumor cell NK1 receptors.
Peptides838-15(2016 Sep)
Zhang Y,Li X,Li J,Hu H,Miao X,Song X,Yang W,Zeng Q,Mou L,Wang R

Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells.
Biology of reproduction94(6)124(2016 06)
Garc?a-Ortega J,Pinto FM,Prados N,Bello AR,Almeida TA,Fern?ndez-S?nchez M,Candenas L

Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor.
The international journal of biochemistry & cell biology44(9)1410-21(2012 Sep)
Song H,Yin W,Zeng Q,Jia H,Lin L,Liu X,Mu L,Wang R

The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1?, IL-23, and TNF-like 1A expression by monocytes.
Journal of immunology (Baltimore, Md. : 1950)186(7)4175-82(2011 Apr)
Cunin P,Caillon A,Corvaisier M,Garo E,Scotet M,Blanchard S,Delneste Y,Jeannin P

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TAC4 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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