Gene Symbol | PRAME |
Entrez Gene ID | 23532 |
Full Name | preferentially expressed antigen in melanoma |
Synonyms | CT130,MAPE,OIP-4,OIP4 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. |
Disorder MIM: |