ANP32C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ANP32C
Entrez Gene ID	23520
Full Name	acidic nuclear phosphoprotein 32 family member C
Synonyms	PP32R1
General protein information	Preferred Names acidic nuclear phosphoprotein 32 family member C Names acidic leucine-rich nuclear phosphoprotein 32 family member C acidic (leucine-rich) nuclear phosphoprotein 32 family, member C phosphoprotein 32-related protein 1 pp32 related 1 tumorigenic protein pp32r1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q32.3
Summary	Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008].
Disorder MIM:	606877

mRNA and Protein(s)

mRNA	Protein	Name
NM_012403.1	NP_036535.1	acidic leucine-rich nuclear phosphoprotein 32 family member C

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ANP32C	XP_517520.1
Homo sapiens (human)	ANP32C	NP_036535.1

Gene Ontology
Bibliography

Related articles in PubMed

Oncogenic acidic nuclear phosphoproteins ANP32C/D are novel clients of heat shock protein 90.
Yuzefovych Y, Blasczyk R, Huyton T
Biochimica et biophysica acta1853(10 Pt A)2338-48(2015 Oct)

Overexpression of the pp32r1 (ANP32C) oncogene or its functional mutant pp32r1Y140H confers enhanced resistance to FTY720 (Finguimod).
Buddaseth S, G?ttmann W, Blasczyk R, Huyton T
Cancer biology & therapy15(3)289-96(2014 Mar)

pp32r1 controls the decay of the RNA-binding protein HuR.
Imamachi K, Higashino F, Kitamura T, Kakuguchi W, Yanagawa-Matsuda A, Ishikawa M, Kitagawa Y, Totsuka Y, Shindoh M
Oncology reports31(3)1103-8(2014 Mar)

Dysregulation of cell cycle control caused by overexpression of the oncogene pp32r1 (ANP32C) and the Tyr>His mutant pp32r1Y140H.
Buddaseth S, G?ttmann W, Blasczyk R, Huyton T
Biochimica et biophysica acta1833(5)1212-21(2013 May)

The Anp32 family of proteins containing leucine-rich repeats.
Matilla A, Radrizzani M
Cerebellum (London, England)4(1)7-18(2005)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results highlight that certain malignancies with ANP32C/D overexpression or mutation might be specifically targeted using Hsp90 inhibitors.
Title: Oncogenic acidic nuclear phosphoproteins ANP32C/D are novel clients of heat shock protein 90.

These findings highlight that certain cancers overexpressing pp32r1 or pp32r1 mutants are likely to demonstrate enhanced resistance to FTY720 treatment.
Title: Overexpression of the pp32r1 (ANP32C) oncogene or its functional mutant pp32r1Y140H confers enhanced resistance to FTY720 (Finguimod).

pp32r1 binds to HuR to avoid the caspase-mediated decay of HuR in the cytoplasm of cells.
Title: pp32r1 controls the decay of the RNA-binding protein HuR.

CHD4 were significantly upregulated by pp32r1 and pp32r1Y140H overexpression which influence a number of cell cycle regulator genes including p53, p21 and cyclinD1
Title: Dysregulation of cell cycle control caused by overexpression of the oncogene pp32r1 (ANP32C) and the Tyr>His mutant pp32r1Y140H.

expression levels vary among human tumor cell lines, with the highest levels found in prostatic adenocarcinoma cell lines
Title: Identification of a functional mutation in pp32r1 (ANP32C).

The following ANP32C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ANP32C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29457	NM_012403.1 Latest version!	Homo sapiens acidic nuclear phosphoprotein 32 family member C (ANP32C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ANP32C ( NM_012403.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_036535.1 Homo sapiens acidic nuclear phosphoprotein 32 family member C (ANP32C), mRNA.

Price & Availability↑

CloneID	OHu29457
Clone ID Related Accession (Same CDS sequence)	NM_012403.1
Accession Version	NM_012403.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	acidic leucine-rich nuclear phosphoprotein 32 family member C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF008216.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGAGATGG GCAGACGGAT TCATTCAGAG CTGCGGAACA GGGCGCCCTC TGATGTGAAA 
GAACTTGCCC TGGACAACAG TCGGTCGAAT GAAGGCAAAC TCGAAGCCCT CACAGATGAA 
TTTGAAGAAC TGGAATTCTT AAGTAAAATC AACGGAGGCC TCACCTCAAT CTCAGACTTA 
CCAAAGTTAA AGTTGAGAAA GCTTGAACTA AGAGTCTCAG GGGGCCTGGA AGTATTGGCA 
GAAAAGTGTC CAAACCTCAC GCATCTATAT TTAAGTGGCA ACAAAATTAA AGACCTCAGC 
ACAATAGAGC CACTGAAACA GTTAGAAAAC CTCAAGAGCT TAGACCTTTT CAATTGCGAG 
GTAACCAACC TGAACGACTA CGGAGAAAAC GTGTTCAAGC TTCTCCTGCA ACTCACATAT 
CTCGACAGCT GTTACTGGGA CCACAAGGAG GCCCCTTACT CAGATATTGA GGACCACGTG 
GAGGGCCTGG ATGACGAGGA GGAGGGTGAG CATGAGGAGG AGTATGATGA AGATGCTCAG 
GTAGTGGAAG ATGAGGAGGG CGAGGAGGAG GAGGAGGAAG GTGAAGAGGA GGACGTGAGT 
GGAGGGGACG AGGAGGATGA AGAAGGTTAT AACGATGGAG AGGTAGATGG CGAGGAAGAT 
GAAGAAGAGC TTGGTGAAGA AGAAAGGGGT CAGAAGCGAA AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036535.1
CDS	1..705
Translation	MEMGRRIHSELRNRAPSDVKELALDNSRSNEGKLEALTDEFEELEFLSKINGGLTSISDLPKLKLRKLELRVSGGLEVLAEKCPNLTHLYLSGNKIKDLSTIEPLKQLENLKSLDLFNCEVTNLNDYGENVFKLLLQLTYLDSCYWDHKEAPYSDIEDHVEGLDDEEEGEHEEEYDEDAQVVEDEEGEEEEEEGEEEDVSGGDEEDEEGYNDGEVDGEEDEEELGEEERGQKRK

Target ORF information:

RefSeq Version	NM_012403.1
Organism	Homo sapiens(human)
Definition	Homo sapiens acidic nuclear phosphoprotein 32 family member C (ANP32C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012403.1

ORF Insert Sequence:

ATGGAGATGG GCAGACGGAT TCATTCAGAG CTGCGGAACA GGGCGCCCTC TGATGTGAAA 
GAACTTGCCC TGGACAACAG TCGGTCGAAT GAAGGCAAAC TCGAAGCCCT CACAGATGAA 
TTTGAAGAAC TGGAATTCTT AAGTAAAATC AACGGAGGCC TCACCTCAAT CTCAGACTTA 
CCAAAGTTAA AGTTGAGAAA GCTTGAACTA AGAGTCTCAG GGGGCCTGGA AGTATTGGCA 
GAAAAGTGTC CAAACCTCAC GCATCTATAT TTAAGTGGCA ACAAAATTAA AGACCTCAGC 
ACAATAGAGC CACTGAAACA GTTAGAAAAC CTCAAGAGCT TAGACCTTTT CAATTGCGAG 
GTAACCAACC TGAACGACTA CGGAGAAAAC GTGTTCAAGC TTCTCCTGCA ACTCACATAT 
CTCGACAGCT GTTACTGGGA CCACAAGGAG GCCCCTTACT CAGATATTGA GGACCACGTG 
GAGGGCCTGG ATGACGAGGA GGAGGGTGAG CATGAGGAGG AGTATGATGA AGATGCTCAG 
GTAGTGGAAG ATGAGGAGGG CGAGGAGGAG GAGGAGGAAG GTGAAGAGGA GGACGTGAGT 
GGAGGGGACG AGGAGGATGA AGAAGGTTAT AACGATGGAG AGGTAGATGG CGAGGAAGAT 
GAAGAAGAGC TTGGTGAAGA AGAAAGGGGT CAGAAGCGAA AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Oncogenic acidic nuclear phosphoproteins ANP32C/D are novel clients of heat shock protein 90.
Biochimica et biophysica acta1853(10 Pt A)2338-48(2015 Oct)
Yuzefovych Y,Blasczyk R,Huyton T

Overexpression of the pp32r1 (ANP32C) oncogene or its functional mutant pp32r1Y140H confers enhanced resistance to FTY720 (Finguimod).
Cancer biology & therapy15(3)289-96(2014 Mar)
Buddaseth S,G?ttmann W,Blasczyk R,Huyton T

pp32r1 controls the decay of the RNA-binding protein HuR.
Oncology reports31(3)1103-8(2014 Mar)
Imamachi K,Higashino F,Kitamura T,Kakuguchi W,Yanagawa-Matsuda A,Ishikawa M,Kitagawa Y,Totsuka Y,Shindoh M

Dysregulation of cell cycle control caused by overexpression of the oncogene pp32r1 (ANP32C) and the Tyr>His mutant pp32r1Y140H.
Biochimica et biophysica acta1833(5)1212-21(2013 May)
Buddaseth S,G?ttmann W,Blasczyk R,Huyton T

The Anp32 family of proteins containing leucine-rich repeats.
Cerebellum (London, England)4(1)7-18(2005)
Matilla A,Radrizzani M

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ANP32C cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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