SORCS3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SORCS3
Entrez Gene ID	22986
Full Name	sortilin related VPS10 domain containing receptor 3
Synonyms	SORCS
General protein information	Preferred Names sortilin related VPS10 domain containing receptor 3 Names VPS10 domain-containing receptor SorCS3 VPS10 domain receptor protein SORCS 3 (SORCS3)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q25.1
Summary	This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing. [provided by RefSeq, Dec 2014].
Disorder MIM:	606285

mRNA and Protein(s)

mRNA	Protein	Name
XM_011539542.2	XP_011537844.1	VPS10 domain-containing receptor SorCS3 isoform X1
NM_014978.3	NP_055793.1	VPS10 domain-containing receptor SorCS3 precursor
NM_014978.2	NP_055793.1	VPS10 domain-containing receptor SorCS3 precursor

Pathways from BioSystems

Homologies

	SORCS3	XP_001082205.1
Canis lupus familiaris (dog)	SORCS3	XP_544009.3
Bos taurus (cattle)	SORCS3	NP_001192915.1
Mus musculus (house mouse)	Sorcs3	NP_079972.1
Danio rerio (zebrafish)	sorcs3	XP_003197764.1
Xenopus tropicalis (tropical clawed frog)	LOC100498333	XP_002942188.2
Homo sapiens (human)	SORCS3	NP_055793.1
Gallus gallus (chicken)	SORCS3	XP_004942328.1
Pan troglodytes (chimpanzee)	SORCS3	XP_508024.4
Rattus norvegicus (Norway rat)	Sorcs3	NP_001099837.2

Gene Ontology
Bibliography

Related articles in PubMed

Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.
Januliene D, Manavalan A, Ovesen PL, Pedersen KM, Thirup S, Nykj?r A, Moeller A
Journal of molecular biology429(19)2907-2917(2017 Sep)

Genetic analysis of the isolated Faroe Islands reveals SORCS3 as a potential multiple sclerosis risk gene.
Binzer S, Stenager E, Binzer M, Kyvik KO, Hillert J, Imrell K
Multiple sclerosis (Houndmills, Basingstoke, England)22(6)733-40(2016 May)

The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.
Reitz C
Molecular genetics and genomics : MGG290(2)413-27(2015 Apr)

Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP).
Reitz C, Tosto G, Vardarajan B, Rogaeva E, Ghani M, Rogers RS, Conrad C, Haines JL, Pericak-Vance MA, Fallin MD, Foroud T, Farrer LA, Schellenberg GD, George-Hyslop PS, Mayeux R,
Translational psychiatry3e256(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here the authors have characterized SorCS1, SorCS2 and SorCS3 using biochemical methods and electron microscopy. They found that their purified extracellular domains co-exist in stable dimeric and monomeric populations.
Title: Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

The propeptide is not a requirement for normal processing of the receptor and does not prevent ligands from binding to the SorCS3 precursor form
Title: SorCS3 does not require propeptide cleavage to bind nerve growth factor.

The following SORCS3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SORCS3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu65216	XM_011539542.2 Latest version!	Homo sapiens sortilin related VPS10 domain containing receptor 3 (SORCS3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu65217	NM_014978.3 Latest version!	Homo sapiens sortilin related VPS10 domain containing receptor 3 (SORCS3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$384.30 $549.00
View Old Accession Versions >>
OHu65217	NM_014978.2	Homo sapiens sortilin related VPS10 domain containing receptor 3 (SORCS3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$384.30 $549.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SORCS3 ( XM_011539542.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011537844.1 Homo sapiens sortilin related VPS10 domain containing receptor 3 (SORCS3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu65216
Clone ID Related Accession (Same CDS sequence)	XM_011539542.2
Accession Version	XM_011539542.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2601bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	VPS10 domain-containing receptor SorCS3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011539542.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGTGC GGACCACGGA TGGATATGCT CACTACCTCA CCTGCAGGAT CCAGGAATGT 
GCCGAGACAA CTAGAAGTGG GCCTTTTGCC CGCTCCATTG ACATCAGTTC CCTGGTTGTC 
CAGGATGAAT ATATCTTCAT TCAGGTAACA ACTAGTGGAA GAGCCAGCTA CTACGTGTCT 
TATCGAAGAG AGGCCTTTGC TCAGATAAAG CTGCCTAAGT ACTCGTTGCC AAAGGACATG 
CACATCATCA GTACAGACGA GAACCAAGTA TTTGCTGCGG TCCAAGAATG GAACCAGAAC 
GACACGTACA ACCTCTACAT CTCAGACACG CGTGGGATTT ACTTCACTCT GGCCATGGAG 
AACATCAAGA GCAGCAGAGG TCTAATGGGG AACATCATTA TTGAATTGTA TGAGGTAGCA 
GGTATCAAAG GGATATTTCT GGCAAACAAG AAGGTGGACG ACCAGGTGAA GACATACATC 
ACTTACAACA AAGGCAGGGA TTGGCGCCTG CTGCAAGCTC CGGATGTGGA CCTGAGAGGA 
AGCCCAGTGC ACTGCCTGCT GCCCTTCTGT TCCTTACATC TGCACCTGCA ACTCTCTGAA 
AATCCATATT CCTCAGGAAG AATCTCTAGC AAGGAGACAG CCCCAGGACT TGTGGTGGCT 
ACAGGCAACA TTGGCCCGGA GCTCTCATAT ACTGATATTG GTGTGTTCAT CTCCTCCGAT 
GGGGGCAACA CATGGAGACA GATCTTTGAT GAAGAGTACA ATGTCTGGTT CCTAGACTGG 
GGTGGTGCCC TCGTGGCCAT GAAACACACA CCTCTGCCAG TCAGGCATTT GTGGGTGAGT 
TTTGATGAGG GCCACTCTTG GGACAAGTAT GGTTTCACTT CGGTTCCTCT CTTTGTTGAC 
GGGGCTCTGG TGGAGGCAGG AATGGAGACC CACATCATGA CAGTTTTTGG CCACTTCAGC 
CTCCGCTCCG AATGGCAATT GGTGAAAGTG GACTACAAAT CTATCTTCAG CCGGCATTGC 
ACCAAGGAGG ACTATCAGAC CTGGCACCTG CTCAATCAGG GAGAGCCTTG TGTCATGGGA 
GAAAGGAAAA TATTCAAGAA ACGTAAGCCA GGAGCTCAGT GTGCCCTGGG CCGAGACCAC 
TCAGGATCAG TGGTCTCAGA ACCCTGTGTC TGTGCCAATT GGGACTTCGA GTGTGACTAT 
GGGTATGAGA GACATGGGGA GAGCCAGTGT GTCCCAGCTT TCTGGTACAA TCCAGCATCC 
CCATCAAAGG ACTGCAGCCT TGGTCAAAGC TACCTTAACA GCACTGGGTA TCGGCGGATT 
GTGTCCAACA ACTGCACAGA TGGGCTAAGG GAGAAGTACA CCGCCAAGGC CCAGATGTGC 
CCTGGAAAAG CCCCTCGGGG CCTCCATGTG GTGACGACCG ATGGGCGGCT GGTGGCAGAG 
CAGGGGCACA ATGCAACTTT CATCATCCTC ATGGAGGAGG GTGATCTACA AAGGACAAAC 
ATCCAGCTTG ACTTTGGGGA TGGGATTGCT GTGTCCTACG CAAACTTCAG CCCCATCGAG 
GACGGCATCA AGCACGTGTA TAAGAGTGCG GGGATCTTCC AGGTGACAGC CTATGCAGAG 
AACAACCTTG GCTCAGACAC AGCTGTCCTC TTCCTGCATG TGGTTTGTCC TGTGGAGCAT 
GTTCATCTCC GAGTTCCATT TGTTGCCATA AGAAATAAGG AGGTCAACAT CAGTGCAGTC 
GTGTGGCCCA GTCAACTGGG GACCCTTACC TATTTCTGGT GGTTCGGCAA TAGCACAAAG 
CCTCTCATCA CTTTGGACAG CAGCATTTCC TTCACATTCC TTGCAGAAGG AACCGACACC 
ATCACAGTCC AGGTGGCTGC TGGGAATGCC CTCATCCAGG ACACAAAAGA GATTGCAGTT 
CATGAATATT TCCAGTCCCA GCTTTTATCA TTCTCTCCTA ATCTGGATTA CCACAATCCT 
GACATTCCTG AGTGGAGAAA AGATATTGGC AATGTCATCA AGCGAGCTCT GGTTAAAGTA 
ACCAGTGTCC CAGAGGACCA GATCCTCATT GCCGTGTTTC CTGGTCTCCC CACTTCAGCA 
GAGCTTTTCA TTCTTCCACC CAAGAACCTG ACAGAGAGGA GGAAAGGCAA TGAAGGGGAC 
CTGGAACAAA TTGTAGAAAC ACTGTTTAAT GCTCTCAACC AAAATTTGGT CCAGTTTGAG 
CTGAAGCCGG GGGTACAAGT CATTGTGTAT GTCACACAGC TGACGTTAGC TCCATTGGTG 
GACTCCAGTG CTGGGCACAG CAGCTCAGCC ATGCTTATGC TATTATCAGT GGTATTTGTT 
GGCCTGGCTG TGTTTTTGAT CTACAAGTTT AAAAGGAAAA TCCCTTGGAT TAACATCTAT 
GCTCAAGTCC AACACGACAA GGAGCAGGAG ATGATTGGGT CAGTGAGCCA AAGTGAAAAC 
GCCCCCAAAA TCACACTCAG TGACTTTACG GAGCCTGAGG AGCTGCTGGA CAAAGAGCTG 
GACACGCGGG TCATAGGAGG CATTGCCACT ATTGCAAACA GCGAAAGCAC AAAGGAGATC 
CCCAACTGCA CTAGTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011537844.1
CDS	47..2647
Translation	MEVRTTDGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEYIFIQVTTSGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQLSENPYSSGRISSKETAPGLVVATGNIGPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTSVPLFVDGALVEAGMETHIMTVFGHFSLRSEWQLVKVDYKSIFSRHCTKEDYQTWHLLNQGEPCVMGERKIFKKRKPGAQCALGRDHSGSVVSEPCVCANWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNNCTDGLREKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTNIQLDFGDGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAENNLGSDTAVLFLHVVCPVEHVHLRVPFVAIRNKEVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTDTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRKDIGNVIKRALVKVTSVPEDQILIAVFPGLPTSAELFILPPKNLTERRKGNEGDLEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRVIGGIATIANSESTKEIPNCTSV

Target ORF information:

RefSeq Version	XM_011539542.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sortilin related VPS10 domain containing receptor 3 (SORCS3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011539542.2

ORF Insert Sequence:

ATGGAGGTGC GGACCACGGA TGGATATGCT CACTACCTCA CCTGCAGGAT CCAGGAATGT 
GCCGAGACAA CTAGAAGTGG GCCTTTTGCC CGCTCCATTG ACATCAGTTC CCTGGTTGTC 
CAGGATGAAT ATATCTTCAT TCAGGTAACA ACTAGTGGAA GAGCCAGCTA CTACGTGTCT 
TATCGAAGAG AGGCCTTTGC TCAGATAAAG CTGCCTAAGT ACTCGTTGCC AAAGGACATG 
CACATCATCA GTACAGACGA GAACCAAGTA TTTGCTGCGG TCCAAGAATG GAACCAGAAC 
GACACGTACA ACCTCTACAT CTCAGACACG CGTGGGATTT ACTTCACTCT GGCCATGGAG 
AACATCAAGA GCAGCAGAGG TCTAATGGGG AACATCATTA TTGAATTGTA TGAGGTAGCA 
GGTATCAAAG GGATATTTCT GGCAAACAAG AAGGTGGACG ACCAGGTGAA GACATACATC 
ACTTACAACA AAGGCAGGGA TTGGCGCCTG CTGCAAGCTC CGGATGTGGA CCTGAGAGGA 
AGCCCAGTGC ACTGCCTGCT GCCCTTCTGT TCCTTACATC TGCACCTGCA ACTCTCTGAA 
AATCCATATT CCTCAGGAAG AATCTCTAGC AAGGAGACAG CCCCAGGACT TGTGGTGGCT 
ACAGGCAACA TTGGCCCGGA GCTCTCATAT ACTGATATTG GTGTGTTCAT CTCCTCCGAT 
GGGGGCAACA CATGGAGACA GATCTTTGAT GAAGAGTACA ATGTCTGGTT CCTAGACTGG 
GGTGGTGCCC TCGTGGCCAT GAAACACACA CCTCTGCCAG TCAGGCATTT GTGGGTGAGT 
TTTGATGAGG GCCACTCTTG GGACAAGTAT GGTTTCACTT CGGTTCCTCT CTTTGTTGAC 
GGGGCTCTGG TGGAGGCAGG AATGGAGACC CACATCATGA CAGTTTTTGG CCACTTCAGC 
CTCCGCTCCG AATGGCAATT GGTGAAAGTG GACTACAAAT CTATCTTCAG CCGGCATTGC 
ACCAAGGAGG ACTATCAGAC CTGGCACCTG CTCAATCAGG GAGAGCCTTG TGTCATGGGA 
GAAAGGAAAA TATTCAAGAA ACGTAAGCCA GGAGCTCAGT GTGCCCTGGG CCGAGACCAC 
TCAGGATCAG TGGTCTCAGA ACCCTGTGTC TGTGCCAATT GGGACTTCGA GTGTGACTAT 
GGGTATGAGA GACATGGGGA GAGCCAGTGT GTCCCAGCTT TCTGGTACAA TCCAGCATCC 
CCATCAAAGG ACTGCAGCCT TGGTCAAAGC TACCTTAACA GCACTGGGTA TCGGCGGATT 
GTGTCCAACA ACTGCACAGA TGGGCTAAGG GAGAAGTACA CCGCCAAGGC CCAGATGTGC 
CCTGGAAAAG CCCCTCGGGG CCTCCATGTG GTGACGACCG ATGGGCGGCT GGTGGCAGAG 
CAGGGGCACA ATGCAACTTT CATCATCCTC ATGGAGGAGG GTGATCTACA AAGGACAAAC 
ATCCAGCTTG ACTTTGGGGA TGGGATTGCT GTGTCCTACG CAAACTTCAG CCCCATCGAG 
GACGGCATCA AGCACGTGTA TAAGAGTGCG GGGATCTTCC AGGTGACAGC CTATGCAGAG 
AACAACCTTG GCTCAGACAC AGCTGTCCTC TTCCTGCATG TGGTTTGTCC TGTGGAGCAT 
GTTCATCTCC GAGTTCCATT TGTTGCCATA AGAAATAAGG AGGTCAACAT CAGTGCAGTC 
GTGTGGCCCA GTCAACTGGG GACCCTTACC TATTTCTGGT GGTTCGGCAA TAGCACAAAG 
CCTCTCATCA CTTTGGACAG CAGCATTTCC TTCACATTCC TTGCAGAAGG AACCGACACC 
ATCACAGTCC AGGTGGCTGC TGGGAATGCC CTCATCCAGG ACACAAAAGA GATTGCAGTT 
CATGAATATT TCCAGTCCCA GCTTTTATCA TTCTCTCCTA ATCTGGATTA CCACAATCCT 
GACATTCCTG AGTGGAGAAA AGATATTGGC AATGTCATCA AGCGAGCTCT GGTTAAAGTA 
ACCAGTGTCC CAGAGGACCA GATCCTCATT GCCGTGTTTC CTGGTCTCCC CACTTCAGCA 
GAGCTTTTCA TTCTTCCACC CAAGAACCTG ACAGAGAGGA GGAAAGGCAA TGAAGGGGAC 
CTGGAACAAA TTGTAGAAAC ACTGTTTAAT GCTCTCAACC AAAATTTGGT CCAGTTTGAG 
CTGAAGCCGG GGGTACAAGT CATTGTGTAT GTCACACAGC TGACGTTAGC TCCATTGGTG 
GACTCCAGTG CTGGGCACAG CAGCTCAGCC ATGCTTATGC TATTATCAGT GGTATTTGTT 
GGCCTGGCTG TGTTTTTGAT CTACAAGTTT AAAAGGAAAA TCCCTTGGAT TAACATCTAT 
GCTCAAGTCC AACACGACAA GGAGCAGGAG ATGATTGGGT CAGTGAGCCA AAGTGAAAAC 
GCCCCCAAAA TCACACTCAG TGACTTTACG GAGCCTGAGG AGCTGCTGGA CAAAGAGCTG 
GACACGCGGG TCATAGGAGG CATTGCCACT ATTGCAAACA GCGAAAGCAC AAAGGAGATC 
CCCAACTGCA CTAGTGTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SORCS3 ( NM_014978.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055793.1 Homo sapiens sortilin related VPS10 domain containing receptor 3 (SORCS3), mRNA.

Price & Availability↑

CloneID	OHu65217
Clone ID Related Accession (Same CDS sequence)	NM_014978.3 , NM_014978.2
Accession Version	NM_014978.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	VPS10 domain-containing receptor SorCS3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB028982.1, AL353900.14 and BC045754.1. On Nov 22, 2018 this sequence version replaced NM_014978.2. ##Evidence-Data-START## Transcript exon combination :: AB028982.1, SRR1660807.56305.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369701.8/ ENSP00000358715.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGCGG CGCGCACGGA GCGCCCCGCA GGCAGGCCGG GGGCGCCGCT TGTCCGGACG 
GGGCTCCTAC TCTTGTCGAC GTGGGTCCTG GCCGGCGCCG AGATCACTTG GGACGCGACA 
GGCGGTCCCG GACGCCCGGC GGCCCCGGCT TCGCGGCCAC CGGCGTTGTC TCCACTCTCG 
CCGCGGGCAG TGGCCAGCCA GTGGCCGGAG GAGCTGGCGT CGGCGCGGAG AGCCGCCGTG 
CTGGGGCGCC GGGCCGGACC AGAGCTGCTG CCCCAGCAGG GCGGCGGCAG AGGCGGTGAG 
ATGCAGGTGG AAGCCGGAGG GACATCACCG GCAGGCGAGC GGCGGGGCCG GGGCATCCCA 
GCTCCTGCCA AGCTTGGCGG CGCGAGGAGG AGTCGCCGGG CGCAGCCCCC AATCACCCAG 
GAACGCGGGG ACGCCTGGGC CACTGCTCCG GCCGATGGTT CCAGAGGAAG CCGTCCCCTT 
GCTAAGGGTT CCCGGGAGGA GGTGAAGGCG CCGCGGGCTG GGGGGTCGGC GGCTGAAGAC 
CTCCGGCTGC CCAGCACCTC CTTCGCGCTG ACCGGGGACT CGGCCCACAA CCAAGCCATG 
GTGCACTGGT CGGGACACAA CAGCAGCGTC ATACTTATCC TGACGAAGCT GTATGACTTC 
AACCTGGGCA GCGTGACTGA GAGTTCACTA TGGAGGTCGA CAGATTATGG CACCACCTAT 
GAAAAGCTGA ATGACAAAGT GGGTTTGAAG ACTGTCCTCA GTTACCTCTA TGTCAATCCA 
ACCAACAAAA GGAAGATTAT GCTTCTCAGT GATCCTGAGA TGGAGAGCAG CATATTGATC 
AGCTCAGACG AAGGGGCGAC CTATCAGAAG TATCGGCTCA CCTTCTATAT CCAGAGCCTG 
CTCTTTCATC CCAAGCAAGA GGACTGGGTG CTGGCCTACA GTTTGGATCA AAAGCTCTAC 
AGCTCCATGG ACTTTGGAAG ACGGTGGCAA CTCATGCATG AACGCATCAC ACCCAACAGG 
TTTTATTGGT CGGTGGCCGG ATTGGATAAG GAGGCGGACC TGGTGCACAT GGAGGTGCGG 
ACCACGGATG GATATGCTCA CTACCTCACC TGCAGGATCC AGGAATGTGC CGAGACAACT 
AGAAGTGGGC CTTTTGCCCG CTCCATTGAC ATCAGTTCCC TGGTTGTCCA GGATGAATAT 
ATCTTCATTC AGGTAACAAC TAGTGGAAGA GCCAGCTACT ACGTGTCTTA TCGAAGAGAG 
GCCTTTGCTC AGATAAAGCT GCCTAAGTAC TCGTTGCCAA AGGACATGCA CATCATCAGT 
ACAGACGAGA ACCAAGTATT TGCTGCGGTC CAAGAATGGA ACCAGAACGA CACGTACAAC 
CTCTACATCT CAGACACGCG TGGGATTTAC TTCACTCTGG CCATGGAGAA CATCAAGAGC 
AGCAGAGGTC TAATGGGGAA CATCATTATT GAATTGTATG AGGTAGCAGG TATCAAAGGG 
ATATTTCTGG CAAACAAGAA GGTGGACGAC CAGGTGAAGA CATACATCAC TTACAACAAA 
GGCAGGGATT GGCGCCTGCT GCAAGCTCCG GATGTGGACC TGAGAGGAAG CCCAGTGCAC 
TGCCTGCTGC CCTTCTGTTC CTTACATCTG CACCTGCAAC TCTCTGAAAA TCCATATTCC 
TCAGGAAGAA TCTCTAGCAA GGAGACAGCC CCAGGACTTG TGGTGGCTAC AGGCAACATT 
GGCCCGGAGC TCTCATATAC TGATATTGGT GTGTTCATCT CCTCCGATGG GGGCAACACA 
TGGAGACAGA TCTTTGATGA AGAGTACAAT GTCTGGTTCC TAGACTGGGG TGGTGCCCTC 
GTGGCCATGA AACACACACC TCTGCCAGTC AGGCATTTGT GGGTGAGTTT TGATGAGGGC 
CACTCTTGGG ACAAGTATGG TTTCACTTCG GTTCCTCTCT TTGTTGACGG GGCTCTGGTG 
GAGGCAGGAA TGGAGACCCA CATCATGACA GTTTTTGGCC ACTTCAGCCT CCGCTCCGAA 
TGGCAATTGG TGAAAGTGGA CTACAAATCT ATCTTCAGCC GGCATTGCAC CAAGGAGGAC 
TATCAGACCT GGCACCTGCT CAATCAGGGA GAGCCTTGTG TCATGGGAGA AAGGAAAATA 
TTCAAGAAAC GTAAGCCAGG AGCTCAGTGT GCCCTGGGCC GAGACCACTC AGGATCAGTG 
GTCTCAGAAC CCTGTGTCTG TGCCAATTGG GACTTCGAGT GTGACTATGG GTATGAGAGA 
CATGGGGAGA GCCAGTGTGT CCCAGCTTTC TGGTACAATC CAGCATCCCC ATCAAAGGAC 
TGCAGCCTTG GTCAAAGCTA CCTTAACAGC ACTGGGTATC GGCGGATTGT GTCCAACAAC 
TGCACAGATG GGCTAAGGGA GAAGTACACC GCCAAGGCCC AGATGTGCCC TGGAAAAGCC 
CCTCGGGGCC TCCATGTGGT GACGACCGAT GGGCGGCTGG TGGCAGAGCA GGGGCACAAT 
GCAACTTTCA TCATCCTCAT GGAGGAGGGT GATCTACAAA GGACAAACAT CCAGCTTGAC 
TTTGGGGATG GGATTGCTGT GTCCTACGCA AACTTCAGCC CCATCGAGGA CGGCATCAAG 
CACGTGTATA AGAGTGCGGG GATCTTCCAG GTGACAGCCT ATGCAGAGAA CAACCTTGGC 
TCAGACACAG CTGTCCTCTT CCTGCATGTG GTTTGTCCTG TGGAGCATGT TCATCTCCGA 
GTTCCATTTG TTGCCATAAG AAATAAGGAG GTCAACATCA GTGCAGTCGT GTGGCCCAGT 
CAACTGGGGA CCCTTACCTA TTTCTGGTGG TTCGGCAATA GCACAAAGCC TCTCATCACT 
TTGGACAGCA GCATTTCCTT CACATTCCTT GCAGAAGGAA CCGACACCAT CACAGTCCAG 
GTGGCTGCTG GGAATGCCCT CATCCAGGAC ACAAAAGAGA TTGCAGTTCA TGAATATTTC 
CAGTCCCAGC TTTTATCATT CTCTCCTAAT CTGGATTACC ACAATCCTGA CATTCCTGAG 
TGGAGAAAAG ATATTGGCAA TGTCATCAAG CGAGCTCTGG TTAAAGTAAC CAGTGTCCCA 
GAGGACCAGA TCCTCATTGC CGTGTTTCCT GGTCTCCCCA CTTCAGCAGA GCTTTTCATT 
CTTCCACCCA AGAACCTGAC AGAGAGGAGG AAAGGCAATG AAGGGGACCT GGAACAAATT 
GTAGAAACAC TGTTTAATGC TCTCAACCAA AATTTGGTCC AGTTTGAGCT GAAGCCGGGG 
GTACAAGTCA TTGTGTATGT CACACAGCTG ACGTTAGCTC CATTGGTGGA CTCCAGTGCT 
GGGCACAGCA GCTCAGCCAT GCTTATGCTA TTATCAGTGG TATTTGTTGG CCTGGCTGTG 
TTTTTGATCT ACAAGTTTAA AAGGAAAATC CCTTGGATTA ACATCTATGC TCAAGTCCAA 
CACGACAAGG AGCAGGAGAT GATTGGGTCA GTGAGCCAAA GTGAAAACGC CCCCAAAATC 
ACACTCAGTG ACTTTACGGA GCCTGAGGAG CTGCTGGACA AAGAGCTGGA CACGCGGGTC 
ATAGGAGGCA TTGCCACTAT TGCAAACAGC GAAAGCACAA AGGAGATCCC CAACTGCACT 
AGTGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055793.1
CDS	39..3707
Translation	MEAARTERPAGRPGAPLVRTGLLLLSTWVLAGAEITWDATGGPGRPAAPASRPPALSPLSPRAVASQWPEELASARRAAVLGRRAGPELLPQQGGGRGGEMQVEAGGTSPAGERRGRGIPAPAKLGGARRSRRAQPPITQERGDAWATAPADGSRGSRPLAKGSREEVKAPRAGGSAAEDLRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLYDFNLGSVTESSLWRSTDYGTTYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSILISSDEGATYQKYRLTFYIQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNRFYWSVAGLDKEADLVHMEVRTTDGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEYIFIQVTTSGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQLSENPYSSGRISSKETAPGLVVATGNIGPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTSVPLFVDGALVEAGMETHIMTVFGHFSLRSEWQLVKVDYKSIFSRHCTKEDYQTWHLLNQGEPCVMGERKIFKKRKPGAQCALGRDHSGSVVSEPCVCANWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNNCTDGLREKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTNIQLDFGDGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAENNLGSDTAVLFLHVVCPVEHVHLRVPFVAIRNKEVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTDTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRKDIGNVIKRALVKVTSVPEDQILIAVFPGLPTSAELFILPPKNLTERRKGNEGDLEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRVIGGIATIANSESTKEIPNCTSV

Target ORF information:

RefSeq Version	NM_014978.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sortilin related VPS10 domain containing receptor 3 (SORCS3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014978.3

ORF Insert Sequence:

ATGGAGGCGG CGCGCACGGA GCGCCCCGCA GGCAGGCCGG GGGCGCCGCT TGTCCGGACG 
GGGCTCCTAC TCTTGTCGAC GTGGGTCCTG GCCGGCGCCG AGATCACTTG GGACGCGACA 
GGCGGTCCCG GACGCCCGGC GGCCCCGGCT TCGCGGCCAC CGGCGTTGTC TCCACTCTCG 
CCGCGGGCAG TGGCCAGCCA GTGGCCGGAG GAGCTGGCGT CGGCGCGGAG AGCCGCCGTG 
CTGGGGCGCC GGGCCGGACC AGAGCTGCTG CCCCAGCAGG GCGGCGGCAG AGGCGGTGAG 
ATGCAGGTGG AAGCCGGAGG GACATCACCG GCAGGCGAGC GGCGGGGCCG GGGCATCCCA 
GCTCCTGCCA AGCTTGGCGG CGCGAGGAGG AGTCGCCGGG CGCAGCCCCC AATCACCCAG 
GAACGCGGGG ACGCCTGGGC CACTGCTCCG GCCGATGGTT CCAGAGGAAG CCGTCCCCTT 
GCTAAGGGTT CCCGGGAGGA GGTGAAGGCG CCGCGGGCTG GGGGGTCGGC GGCTGAAGAC 
CTCCGGCTGC CCAGCACCTC CTTCGCGCTG ACCGGGGACT CGGCCCACAA CCAAGCCATG 
GTGCACTGGT CGGGACACAA CAGCAGCGTC ATACTTATCC TGACGAAGCT GTATGACTTC 
AACCTGGGCA GCGTGACTGA GAGTTCACTA TGGAGGTCGA CAGATTATGG CACCACCTAT 
GAAAAGCTGA ATGACAAAGT GGGTTTGAAG ACTGTCCTCA GTTACCTCTA TGTCAATCCA 
ACCAACAAAA GGAAGATTAT GCTTCTCAGT GATCCTGAGA TGGAGAGCAG CATATTGATC 
AGCTCAGACG AAGGGGCGAC CTATCAGAAG TATCGGCTCA CCTTCTATAT CCAGAGCCTG 
CTCTTTCATC CCAAGCAAGA GGACTGGGTG CTGGCCTACA GTTTGGATCA AAAGCTCTAC 
AGCTCCATGG ACTTTGGAAG ACGGTGGCAA CTCATGCATG AACGCATCAC ACCCAACAGG 
TTTTATTGGT CGGTGGCCGG ATTGGATAAG GAGGCGGACC TGGTGCACAT GGAGGTGCGG 
ACCACGGATG GATATGCTCA CTACCTCACC TGCAGGATCC AGGAATGTGC CGAGACAACT 
AGAAGTGGGC CTTTTGCCCG CTCCATTGAC ATCAGTTCCC TGGTTGTCCA GGATGAATAT 
ATCTTCATTC AGGTAACAAC TAGTGGAAGA GCCAGCTACT ACGTGTCTTA TCGAAGAGAG 
GCCTTTGCTC AGATAAAGCT GCCTAAGTAC TCGTTGCCAA AGGACATGCA CATCATCAGT 
ACAGACGAGA ACCAAGTATT TGCTGCGGTC CAAGAATGGA ACCAGAACGA CACGTACAAC 
CTCTACATCT CAGACACGCG TGGGATTTAC TTCACTCTGG CCATGGAGAA CATCAAGAGC 
AGCAGAGGTC TAATGGGGAA CATCATTATT GAATTGTATG AGGTAGCAGG TATCAAAGGG 
ATATTTCTGG CAAACAAGAA GGTGGACGAC CAGGTGAAGA CATACATCAC TTACAACAAA 
GGCAGGGATT GGCGCCTGCT GCAAGCTCCG GATGTGGACC TGAGAGGAAG CCCAGTGCAC 
TGCCTGCTGC CCTTCTGTTC CTTACATCTG CACCTGCAAC TCTCTGAAAA TCCATATTCC 
TCAGGAAGAA TCTCTAGCAA GGAGACAGCC CCAGGACTTG TGGTGGCTAC AGGCAACATT 
GGCCCGGAGC TCTCATATAC TGATATTGGT GTGTTCATCT CCTCCGATGG GGGCAACACA 
TGGAGACAGA TCTTTGATGA AGAGTACAAT GTCTGGTTCC TAGACTGGGG TGGTGCCCTC 
GTGGCCATGA AACACACACC TCTGCCAGTC AGGCATTTGT GGGTGAGTTT TGATGAGGGC 
CACTCTTGGG ACAAGTATGG TTTCACTTCG GTTCCTCTCT TTGTTGACGG GGCTCTGGTG 
GAGGCAGGAA TGGAGACCCA CATCATGACA GTTTTTGGCC ACTTCAGCCT CCGCTCCGAA 
TGGCAATTGG TGAAAGTGGA CTACAAATCT ATCTTCAGCC GGCATTGCAC CAAGGAGGAC 
TATCAGACCT GGCACCTGCT CAATCAGGGA GAGCCTTGTG TCATGGGAGA AAGGAAAATA 
TTCAAGAAAC GTAAGCCAGG AGCTCAGTGT GCCCTGGGCC GAGACCACTC AGGATCAGTG 
GTCTCAGAAC CCTGTGTCTG TGCCAATTGG GACTTCGAGT GTGACTATGG GTATGAGAGA 
CATGGGGAGA GCCAGTGTGT CCCAGCTTTC TGGTACAATC CAGCATCCCC ATCAAAGGAC 
TGCAGCCTTG GTCAAAGCTA CCTTAACAGC ACTGGGTATC GGCGGATTGT GTCCAACAAC 
TGCACAGATG GGCTAAGGGA GAAGTACACC GCCAAGGCCC AGATGTGCCC TGGAAAAGCC 
CCTCGGGGCC TCCATGTGGT GACGACCGAT GGGCGGCTGG TGGCAGAGCA GGGGCACAAT 
GCAACTTTCA TCATCCTCAT GGAGGAGGGT GATCTACAAA GGACAAACAT CCAGCTTGAC 
TTTGGGGATG GGATTGCTGT GTCCTACGCA AACTTCAGCC CCATCGAGGA CGGCATCAAG 
CACGTGTATA AGAGTGCGGG GATCTTCCAG GTGACAGCCT ATGCAGAGAA CAACCTTGGC 
TCAGACACAG CTGTCCTCTT CCTGCATGTG GTTTGTCCTG TGGAGCATGT TCATCTCCGA 
GTTCCATTTG TTGCCATAAG AAATAAGGAG GTCAACATCA GTGCAGTCGT GTGGCCCAGT 
CAACTGGGGA CCCTTACCTA TTTCTGGTGG TTCGGCAATA GCACAAAGCC TCTCATCACT 
TTGGACAGCA GCATTTCCTT CACATTCCTT GCAGAAGGAA CCGACACCAT CACAGTCCAG 
GTGGCTGCTG GGAATGCCCT CATCCAGGAC ACAAAAGAGA TTGCAGTTCA TGAATATTTC 
CAGTCCCAGC TTTTATCATT CTCTCCTAAT CTGGATTACC ACAATCCTGA CATTCCTGAG 
TGGAGAAAAG ATATTGGCAA TGTCATCAAG CGAGCTCTGG TTAAAGTAAC CAGTGTCCCA 
GAGGACCAGA TCCTCATTGC CGTGTTTCCT GGTCTCCCCA CTTCAGCAGA GCTTTTCATT 
CTTCCACCCA AGAACCTGAC AGAGAGGAGG AAAGGCAATG AAGGGGACCT GGAACAAATT 
GTAGAAACAC TGTTTAATGC TCTCAACCAA AATTTGGTCC AGTTTGAGCT GAAGCCGGGG 
GTACAAGTCA TTGTGTATGT CACACAGCTG ACGTTAGCTC CATTGGTGGA CTCCAGTGCT 
GGGCACAGCA GCTCAGCCAT GCTTATGCTA TTATCAGTGG TATTTGTTGG CCTGGCTGTG 
TTTTTGATCT ACAAGTTTAA AAGGAAAATC CCTTGGATTA ACATCTATGC TCAAGTCCAA 
CACGACAAGG AGCAGGAGAT GATTGGGTCA GTGAGCCAAA GTGAAAACGC CCCCAAAATC 
ACACTCAGTG ACTTTACGGA GCCTGAGGAG CTGCTGGACA AAGAGCTGGA CACGCGGGTC 
ATAGGAGGCA TTGCCACTAT TGCAAACAGC GAAAGCACAA AGGAGATCCC CAACTGCACT 
AGTGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SORCS3 ( NM_014978.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055793.1 Homo sapiens sortilin related VPS10 domain containing receptor 3 (SORCS3), mRNA.

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CloneID	OHu65217
Clone ID Related Accession (Same CDS sequence)	NM_014978.3 , NM_014978.2
Accession Version	NM_014978.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-08
Organism	Homo sapiens(human)
Product	VPS10 domain-containing receptor SorCS3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB028982.1, AL353900.14 and BC045754.1. On Dec 24, 2014 this sequence version replaced NM_014978.1. ##Evidence-Data-START## Transcript exon combination :: AB028982.1, SRR1660807.56305.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCGG CGCGCACGGA GCGCCCCGCA GGCAGGCCGG GGGCGCCGCT TGTCCGGACG 
GGGCTCCTAC TCTTGTCGAC GTGGGTCCTG GCCGGCGCCG AGATCACTTG GGACGCGACA 
GGCGGTCCCG GACGCCCGGC GGCCCCGGCT TCGCGGCCAC CGGCGTTGTC TCCACTCTCG 
CCGCGGGCAG TGGCCAGCCA GTGGCCGGAG GAGCTGGCGT CGGCGCGGAG AGCCGCCGTG 
CTGGGGCGCC GGGCCGGACC AGAGCTGCTG CCCCAGCAGG GCGGCGGCAG AGGCGGTGAG 
ATGCAGGTGG AAGCCGGAGG GACATCACCG GCAGGCGAGC GGCGGGGCCG GGGCATCCCA 
GCTCCTGCCA AGCTTGGCGG CGCGAGGAGG AGTCGCCGGG CGCAGCCCCC AATCACCCAG 
GAACGCGGGG ACGCCTGGGC CACTGCTCCG GCCGATGGTT CCAGAGGAAG CCGTCCCCTT 
GCTAAGGGTT CCCGGGAGGA GGTGAAGGCG CCGCGGGCTG GGGGGTCGGC GGCTGAAGAC 
CTCCGGCTGC CCAGCACCTC CTTCGCGCTG ACCGGGGACT CGGCCCACAA CCAAGCCATG 
GTGCACTGGT CGGGACACAA CAGCAGCGTC ATACTTATCC TGACGAAGCT GTATGACTTC 
AACCTGGGCA GCGTGACTGA GAGTTCACTA TGGAGGTCGA CAGATTATGG CACCACCTAT 
GAAAAGCTGA ATGACAAAGT GGGTTTGAAG ACTGTCCTCA GTTACCTCTA TGTCAATCCA 
ACCAACAAAA GGAAGATTAT GCTTCTCAGT GATCCTGAGA TGGAGAGCAG CATATTGATC 
AGCTCAGACG AAGGGGCGAC CTATCAGAAG TATCGGCTCA CCTTCTATAT CCAGAGCCTG 
CTCTTTCATC CCAAGCAAGA GGACTGGGTG CTGGCCTACA GTTTGGATCA AAAGCTCTAC 
AGCTCCATGG ACTTTGGAAG ACGGTGGCAA CTCATGCATG AACGCATCAC ACCCAACAGG 
TTTTATTGGT CGGTGGCCGG ATTGGATAAG GAGGCGGACC TGGTGCACAT GGAGGTGCGG 
ACCACGGATG GATATGCTCA CTACCTCACC TGCAGGATCC AGGAATGTGC CGAGACAACT 
AGAAGTGGGC CTTTTGCCCG CTCCATTGAC ATCAGTTCCC TGGTTGTCCA GGATGAATAT 
ATCTTCATTC AGGTAACAAC TAGTGGAAGA GCCAGCTACT ACGTGTCTTA TCGAAGAGAG 
GCCTTTGCTC AGATAAAGCT GCCTAAGTAC TCGTTGCCAA AGGACATGCA CATCATCAGT 
ACAGACGAGA ACCAAGTATT TGCTGCGGTC CAAGAATGGA ACCAGAACGA CACGTACAAC 
CTCTACATCT CAGACACGCG TGGGATTTAC TTCACTCTGG CCATGGAGAA CATCAAGAGC 
AGCAGAGGTC TAATGGGGAA CATCATTATT GAATTGTATG AGGTAGCAGG TATCAAAGGG 
ATATTTCTGG CAAACAAGAA GGTGGACGAC CAGGTGAAGA CATACATCAC TTACAACAAA 
GGCAGGGATT GGCGCCTGCT GCAAGCTCCG GATGTGGACC TGAGAGGAAG CCCAGTGCAC 
TGCCTGCTGC CCTTCTGTTC CTTACATCTG CACCTGCAAC TCTCTGAAAA TCCATATTCC 
TCAGGAAGAA TCTCTAGCAA GGAGACAGCC CCAGGACTTG TGGTGGCTAC AGGCAACATT 
GGCCCGGAGC TCTCATATAC TGATATTGGT GTGTTCATCT CCTCCGATGG GGGCAACACA 
TGGAGACAGA TCTTTGATGA AGAGTACAAT GTCTGGTTCC TAGACTGGGG TGGTGCCCTC 
GTGGCCATGA AACACACACC TCTGCCAGTC AGGCATTTGT GGGTGAGTTT TGATGAGGGC 
CACTCTTGGG ACAAGTATGG TTTCACTTCG GTTCCTCTCT TTGTTGACGG GGCTCTGGTG 
GAGGCAGGAA TGGAGACCCA CATCATGACA GTTTTTGGCC ACTTCAGCCT CCGCTCCGAA 
TGGCAATTGG TGAAAGTGGA CTACAAATCT ATCTTCAGCC GGCATTGCAC CAAGGAGGAC 
TATCAGACCT GGCACCTGCT CAATCAGGGA GAGCCTTGTG TCATGGGAGA AAGGAAAATA 
TTCAAGAAAC GTAAGCCAGG AGCTCAGTGT GCCCTGGGCC GAGACCACTC AGGATCAGTG 
GTCTCAGAAC CCTGTGTCTG TGCCAATTGG GACTTCGAGT GTGACTATGG GTATGAGAGA 
CATGGGGAGA GCCAGTGTGT CCCAGCTTTC TGGTACAATC CAGCATCCCC ATCAAAGGAC 
TGCAGCCTTG GTCAAAGCTA CCTTAACAGC ACTGGGTATC GGCGGATTGT GTCCAACAAC 
TGCACAGATG GGCTAAGGGA GAAGTACACC GCCAAGGCCC AGATGTGCCC TGGAAAAGCC 
CCTCGGGGCC TCCATGTGGT GACGACCGAT GGGCGGCTGG TGGCAGAGCA GGGGCACAAT 
GCAACTTTCA TCATCCTCAT GGAGGAGGGT GATCTACAAA GGACAAACAT CCAGCTTGAC 
TTTGGGGATG GGATTGCTGT GTCCTACGCA AACTTCAGCC CCATCGAGGA CGGCATCAAG 
CACGTGTATA AGAGTGCGGG GATCTTCCAG GTGACAGCCT ATGCAGAGAA CAACCTTGGC 
TCAGACACAG CTGTCCTCTT CCTGCATGTG GTTTGTCCTG TGGAGCATGT TCATCTCCGA 
GTTCCATTTG TTGCCATAAG AAATAAGGAG GTCAACATCA GTGCAGTCGT GTGGCCCAGT 
CAACTGGGGA CCCTTACCTA TTTCTGGTGG TTCGGCAATA GCACAAAGCC TCTCATCACT 
TTGGACAGCA GCATTTCCTT CACATTCCTT GCAGAAGGAA CCGACACCAT CACAGTCCAG 
GTGGCTGCTG GGAATGCCCT CATCCAGGAC ACAAAAGAGA TTGCAGTTCA TGAATATTTC 
CAGTCCCAGC TTTTATCATT CTCTCCTAAT CTGGATTACC ACAATCCTGA CATTCCTGAG 
TGGAGAAAAG ATATTGGCAA TGTCATCAAG CGAGCTCTGG TTAAAGTAAC CAGTGTCCCA 
GAGGACCAGA TCCTCATTGC CGTGTTTCCT GGTCTCCCCA CTTCAGCAGA GCTTTTCATT 
CTTCCACCCA AGAACCTGAC AGAGAGGAGG AAAGGCAATG AAGGGGACCT GGAACAAATT 
GTAGAAACAC TGTTTAATGC TCTCAACCAA AATTTGGTCC AGTTTGAGCT GAAGCCGGGG 
GTACAAGTCA TTGTGTATGT CACACAGCTG ACGTTAGCTC CATTGGTGGA CTCCAGTGCT 
GGGCACAGCA GCTCAGCCAT GCTTATGCTA TTATCAGTGG TATTTGTTGG CCTGGCTGTG 
TTTTTGATCT ACAAGTTTAA AAGGAAAATC CCTTGGATTA ACATCTATGC TCAAGTCCAA 
CACGACAAGG AGCAGGAGAT GATTGGGTCA GTGAGCCAAA GTGAAAACGC CCCCAAAATC 
ACACTCAGTG ACTTTACGGA GCCTGAGGAG CTGCTGGACA AAGAGCTGGA CACGCGGGTC 
ATAGGAGGCA TTGCCACTAT TGCAAACAGC GAAAGCACAA AGGAGATCCC CAACTGCACT 
AGTGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055793.1
CDS	228..3896
Translation	MEAARTERPAGRPGAPLVRTGLLLLSTWVLAGAEITWDATGGPGRPAAPASRPPALSPLSPRAVASQWPEELASARRAAVLGRRAGPELLPQQGGGRGGEMQVEAGGTSPAGERRGRGIPAPAKLGGARRSRRAQPPITQERGDAWATAPADGSRGSRPLAKGSREEVKAPRAGGSAAEDLRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLYDFNLGSVTESSLWRSTDYGTTYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSILISSDEGATYQKYRLTFYIQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNRFYWSVAGLDKEADLVHMEVRTTDGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEYIFIQVTTSGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQLSENPYSSGRISSKETAPGLVVATGNIGPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTSVPLFVDGALVEAGMETHIMTVFGHFSLRSEWQLVKVDYKSIFSRHCTKEDYQTWHLLNQGEPCVMGERKIFKKRKPGAQCALGRDHSGSVVSEPCVCANWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNNCTDGLREKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTNIQLDFGDGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAENNLGSDTAVLFLHVVCPVEHVHLRVPFVAIRNKEVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTDTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRKDIGNVIKRALVKVTSVPEDQILIAVFPGLPTSAELFILPPKNLTERRKGNEGDLEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRVIGGIATIANSESTKEIPNCTSV

Target ORF information:

RefSeq Version	NM_014978.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sortilin related VPS10 domain containing receptor 3 (SORCS3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014978.2

ORF Insert Sequence:

ATGGAGGCGG CGCGCACGGA GCGCCCCGCA GGCAGGCCGG GGGCGCCGCT TGTCCGGACG 
GGGCTCCTAC TCTTGTCGAC GTGGGTCCTG GCCGGCGCCG AGATCACTTG GGACGCGACA 
GGCGGTCCCG GACGCCCGGC GGCCCCGGCT TCGCGGCCAC CGGCGTTGTC TCCACTCTCG 
CCGCGGGCAG TGGCCAGCCA GTGGCCGGAG GAGCTGGCGT CGGCGCGGAG AGCCGCCGTG 
CTGGGGCGCC GGGCCGGACC AGAGCTGCTG CCCCAGCAGG GCGGCGGCAG AGGCGGTGAG 
ATGCAGGTGG AAGCCGGAGG GACATCACCG GCAGGCGAGC GGCGGGGCCG GGGCATCCCA 
GCTCCTGCCA AGCTTGGCGG CGCGAGGAGG AGTCGCCGGG CGCAGCCCCC AATCACCCAG 
GAACGCGGGG ACGCCTGGGC CACTGCTCCG GCCGATGGTT CCAGAGGAAG CCGTCCCCTT 
GCTAAGGGTT CCCGGGAGGA GGTGAAGGCG CCGCGGGCTG GGGGGTCGGC GGCTGAAGAC 
CTCCGGCTGC CCAGCACCTC CTTCGCGCTG ACCGGGGACT CGGCCCACAA CCAAGCCATG 
GTGCACTGGT CGGGACACAA CAGCAGCGTC ATACTTATCC TGACGAAGCT GTATGACTTC 
AACCTGGGCA GCGTGACTGA GAGTTCACTA TGGAGGTCGA CAGATTATGG CACCACCTAT 
GAAAAGCTGA ATGACAAAGT GGGTTTGAAG ACTGTCCTCA GTTACCTCTA TGTCAATCCA 
ACCAACAAAA GGAAGATTAT GCTTCTCAGT GATCCTGAGA TGGAGAGCAG CATATTGATC 
AGCTCAGACG AAGGGGCGAC CTATCAGAAG TATCGGCTCA CCTTCTATAT CCAGAGCCTG 
CTCTTTCATC CCAAGCAAGA GGACTGGGTG CTGGCCTACA GTTTGGATCA AAAGCTCTAC 
AGCTCCATGG ACTTTGGAAG ACGGTGGCAA CTCATGCATG AACGCATCAC ACCCAACAGG 
TTTTATTGGT CGGTGGCCGG ATTGGATAAG GAGGCGGACC TGGTGCACAT GGAGGTGCGG 
ACCACGGATG GATATGCTCA CTACCTCACC TGCAGGATCC AGGAATGTGC CGAGACAACT 
AGAAGTGGGC CTTTTGCCCG CTCCATTGAC ATCAGTTCCC TGGTTGTCCA GGATGAATAT 
ATCTTCATTC AGGTAACAAC TAGTGGAAGA GCCAGCTACT ACGTGTCTTA TCGAAGAGAG 
GCCTTTGCTC AGATAAAGCT GCCTAAGTAC TCGTTGCCAA AGGACATGCA CATCATCAGT 
ACAGACGAGA ACCAAGTATT TGCTGCGGTC CAAGAATGGA ACCAGAACGA CACGTACAAC 
CTCTACATCT CAGACACGCG TGGGATTTAC TTCACTCTGG CCATGGAGAA CATCAAGAGC 
AGCAGAGGTC TAATGGGGAA CATCATTATT GAATTGTATG AGGTAGCAGG TATCAAAGGG 
ATATTTCTGG CAAACAAGAA GGTGGACGAC CAGGTGAAGA CATACATCAC TTACAACAAA 
GGCAGGGATT GGCGCCTGCT GCAAGCTCCG GATGTGGACC TGAGAGGAAG CCCAGTGCAC 
TGCCTGCTGC CCTTCTGTTC CTTACATCTG CACCTGCAAC TCTCTGAAAA TCCATATTCC 
TCAGGAAGAA TCTCTAGCAA GGAGACAGCC CCAGGACTTG TGGTGGCTAC AGGCAACATT 
GGCCCGGAGC TCTCATATAC TGATATTGGT GTGTTCATCT CCTCCGATGG GGGCAACACA 
TGGAGACAGA TCTTTGATGA AGAGTACAAT GTCTGGTTCC TAGACTGGGG TGGTGCCCTC 
GTGGCCATGA AACACACACC TCTGCCAGTC AGGCATTTGT GGGTGAGTTT TGATGAGGGC 
CACTCTTGGG ACAAGTATGG TTTCACTTCG GTTCCTCTCT TTGTTGACGG GGCTCTGGTG 
GAGGCAGGAA TGGAGACCCA CATCATGACA GTTTTTGGCC ACTTCAGCCT CCGCTCCGAA 
TGGCAATTGG TGAAAGTGGA CTACAAATCT ATCTTCAGCC GGCATTGCAC CAAGGAGGAC 
TATCAGACCT GGCACCTGCT CAATCAGGGA GAGCCTTGTG TCATGGGAGA AAGGAAAATA 
TTCAAGAAAC GTAAGCCAGG AGCTCAGTGT GCCCTGGGCC GAGACCACTC AGGATCAGTG 
GTCTCAGAAC CCTGTGTCTG TGCCAATTGG GACTTCGAGT GTGACTATGG GTATGAGAGA 
CATGGGGAGA GCCAGTGTGT CCCAGCTTTC TGGTACAATC CAGCATCCCC ATCAAAGGAC 
TGCAGCCTTG GTCAAAGCTA CCTTAACAGC ACTGGGTATC GGCGGATTGT GTCCAACAAC 
TGCACAGATG GGCTAAGGGA GAAGTACACC GCCAAGGCCC AGATGTGCCC TGGAAAAGCC 
CCTCGGGGCC TCCATGTGGT GACGACCGAT GGGCGGCTGG TGGCAGAGCA GGGGCACAAT 
GCAACTTTCA TCATCCTCAT GGAGGAGGGT GATCTACAAA GGACAAACAT CCAGCTTGAC 
TTTGGGGATG GGATTGCTGT GTCCTACGCA AACTTCAGCC CCATCGAGGA CGGCATCAAG 
CACGTGTATA AGAGTGCGGG GATCTTCCAG GTGACAGCCT ATGCAGAGAA CAACCTTGGC 
TCAGACACAG CTGTCCTCTT CCTGCATGTG GTTTGTCCTG TGGAGCATGT TCATCTCCGA 
GTTCCATTTG TTGCCATAAG AAATAAGGAG GTCAACATCA GTGCAGTCGT GTGGCCCAGT 
CAACTGGGGA CCCTTACCTA TTTCTGGTGG TTCGGCAATA GCACAAAGCC TCTCATCACT 
TTGGACAGCA GCATTTCCTT CACATTCCTT GCAGAAGGAA CCGACACCAT CACAGTCCAG 
GTGGCTGCTG GGAATGCCCT CATCCAGGAC ACAAAAGAGA TTGCAGTTCA TGAATATTTC 
CAGTCCCAGC TTTTATCATT CTCTCCTAAT CTGGATTACC ACAATCCTGA CATTCCTGAG 
TGGAGAAAAG ATATTGGCAA TGTCATCAAG CGAGCTCTGG TTAAAGTAAC CAGTGTCCCA 
GAGGACCAGA TCCTCATTGC CGTGTTTCCT GGTCTCCCCA CTTCAGCAGA GCTTTTCATT 
CTTCCACCCA AGAACCTGAC AGAGAGGAGG AAAGGCAATG AAGGGGACCT GGAACAAATT 
GTAGAAACAC TGTTTAATGC TCTCAACCAA AATTTGGTCC AGTTTGAGCT GAAGCCGGGG 
GTACAAGTCA TTGTGTATGT CACACAGCTG ACGTTAGCTC CATTGGTGGA CTCCAGTGCT 
GGGCACAGCA GCTCAGCCAT GCTTATGCTA TTATCAGTGG TATTTGTTGG CCTGGCTGTG 
TTTTTGATCT ACAAGTTTAA AAGGAAAATC CCTTGGATTA ACATCTATGC TCAAGTCCAA 
CACGACAAGG AGCAGGAGAT GATTGGGTCA GTGAGCCAAA GTGAAAACGC CCCCAAAATC 
ACACTCAGTG ACTTTACGGA GCCTGAGGAG CTGCTGGACA AAGAGCTGGA CACGCGGGTC 
ATAGGAGGCA TTGCCACTAT TGCAAACAGC GAAAGCACAA AGGAGATCCC CAACTGCACT 
AGTGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.
Journal of molecular biology429(19)2907-2917(2017 Sep)
Januliene D,Manavalan A,Ovesen PL,Pedersen KM,Thirup S,Nykj?r A,Moeller A

Genetic analysis of the isolated Faroe Islands reveals SORCS3 as a potential multiple sclerosis risk gene.
Multiple sclerosis (Houndmills, Basingstoke, England)22(6)733-40(2016 May)
Binzer S,Stenager E,Binzer M,Kyvik KO,Hillert J,Imrell K

The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.
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Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP).
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SORCS3 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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