VEGFD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VEGFD
Entrez Gene ID	2277
Full Name	vascular endothelial growth factor D
Synonyms	FIGF,VEGF-D
General protein information	Preferred Names vascular endothelial growth factor D Names vascular endothelial growth factor D c-fos induced growth factor (vascular endothelial growth factor D)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp22.2
Summary	The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011].
Disorder MIM:	300091

mRNA and Protein(s)

mRNA	Protein	Name
NM_004469.4	NP_004460.1	vascular endothelial growth factor D preproprotein
NM_004469.5	NP_004460.1	vascular endothelial growth factor D preproprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FIGF	NP_001094513.1
	FIGF	XP_001101077.1
Canis lupus familiaris (dog)	FIGF	XP_548869.2
Mus musculus (house mouse)	Figf	NP_034346.1
Gallus gallus (chicken)	FIGF	NP_989899.1
Xenopus tropicalis (tropical clawed frog)	figf	XP_002942609.2
Pan troglodytes (chimpanzee)	FIGF	XP_520946.2
Homo sapiens (human)	FIGF	NP_004460.1
Rattus norvegicus (Norway rat)	Figf	NP_113949.1
Danio rerio (zebrafish)	figf	NP_001035268.1

Gene Ontology
Bibliography

Related articles in PubMed

Analysis of Angiogenesis Biomarkers for Ramucirumab Efficacy in Patients with Metastatic Colorectal Cancer from RAISE, a Global, Randomized, Double-Blind, Phase III Study.
Tabernero J, Hozak RR, Yoshino T, Cohn AL, Obermannova R, Bodoky G, Garcia-Carbonero R, Ciuleanu TE, Portnoy DC, Prausov? J, Muro K, Siegel RW, Konrad RJ, Ouyang H, Melemed SA, Ferry D, Nasroulah F, Van Cutsem E
Annals of oncology : official journal of the European Society for Medical Oncology(2017 Dec)

SPARC suppresses lymph node metastasis by regulating the expression of VEGFs in ovarian carcinoma.
Peng F, Zhong Y, Liu Y, Zhang Y, Xie Y, Lu Y, Zhang X, Li D
International journal of oncology51(6)1920-1928(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that VEGF-C, VEGF-D, and VEGFR-3 were expressed in a substantial percentage of breast carcinomas.
Title: Vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGFR-3 and D2-40 expressions in primary breast cancer: Association with lymph node metastasis.

High VEGFD expression is associated with lymphangioleiomyomatosis.
Title: Aberrant SYK Kinase Signaling Is Essential for Tumorigenesis Induced by TSC2 Inactivation.

Sulf2 facilitated lymphangiogenesis in breast cancer cells by regulating VEGF-D and that the AKT1related signaling pathway was involved.
Title: Sulfatase 2 facilitates lymphangiogenesis in breast cancer by regulating VEGF-D.

High VEGFD expression is associated with angiogenesis and lymphangiogenesis.
Title: Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D.

VEGF-D-enhanced metastasis was evidently reversed by MP. MP significantly reduced the invasion of VEGFD-SK cells, tumor volume, lymphatic metastasis rates and lymphatic vessel density compared with control groups
Title: VEGF-D-enhanced lymph node metastasis of ovarian cancer is reversed by vesicular stomatitis virus matrix protein.

The following VEGFD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VEGFD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27377	NM_004469.5 Latest version!	Homo sapiens vascular endothelial growth factor D (VEGFD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
View Old Accession Versions >>
OHu27377	NM_004469.4	Homo sapiens vascular endothelial growth factor D (VEGFD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VEGFD ( NM_004469.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004460.1 Homo sapiens vascular endothelial growth factor D (VEGFD), mRNA.

Price & Availability↑

CloneID	OHu27377
Clone ID Related Accession (Same CDS sequence)	NM_004469.4 , NM_004469.5
Accession Version	NM_004469.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	vascular endothelial growth factor D preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA587496.1, BC027948.1 and Y12863.1. This sequence is a reference standard in the RefSeqGene project. On Feb 16, 2011 this sequence version replaced NM_004469.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y12863.1, AK223160.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTACAGAG AGTGGGTAGT GGTGAATGTT TTCATGATGT TGTACGTCCA GCTGGTGCAG 
GGCTCCAGTA ATGAACATGG ACCAGTGAAG CGATCATCTC AGTCCACATT GGAACGATCT 
GAACAGCAGA TCAGGGCTGC TTCTAGTTTG GAGGAACTAC TTCGAATTAC TCACTCTGAG 
GACTGGAAGC TGTGGAGATG CAGGCTGAGG CTCAAAAGTT TTACCAGTAT GGACTCTCGC 
TCAGCATCCC ATCGGTCCAC TAGGTTTGCG GCAACTTTCT ATGACATTGA AACACTAAAA 
GTTATAGATG AAGAATGGCA AAGAACTCAG TGCAGCCCTA GAGAAACGTG CGTGGAGGTG 
GCCAGTGAGC TGGGGAAGAG TACCAACACA TTCTTCAAGC CCCCTTGTGT GAACGTGTTC 
CGATGTGGTG GCTGTTGCAA TGAAGAGAGC CTTATCTGTA TGAACACCAG CACCTCGTAC 
ATTTCCAAAC AGCTCTTTGA GATATCAGTG CCTTTGACAT CAGTACCTGA ATTAGTGCCT 
GTTAAAGTTG CCAATCATAC AGGTTGTAAG TGCTTGCCAA CAGCCCCCCG CCATCCATAC 
TCAATTATCA GAAGATCCAT CCAGATCCCT GAAGAAGATC GCTGTTCCCA TTCCAAGAAA 
CTCTGTCCTA TTGACATGCT ATGGGATAGC AACAAATGTA AATGTGTTTT GCAGGAGGAA 
AATCCACTTG CTGGAACAGA AGACCACTCT CATCTCCAGG AACCAGCTCT CTGTGGGCCA 
CACATGATGT TTGACGAAGA TCGTTGCGAG TGTGTCTGTA AAACACCATG TCCCAAAGAT 
CTAATCCAGC ACCCCAAAAA CTGCAGTTGC TTTGAGTGCA AAGAAAGTCT GGAGACCTGC 
TGCCAGAAGC ACAAGCTATT TCACCCAGAC ACCTGCAGCT GTGAGGACAG ATGCCCCTTT 
CATACCAGAC CATGTGCAAG TGGCAAAACA GCATGTGCAA AGCATTGCCG CTTTCCAAAG 
GAGAAAAGGG CTGCCCAGGG GCCCCACAGC CGAAAGAATC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004460.1
CDS	468..1532
Translation	MYREWVVVNVFMMLYVQLVQGSSNEHGPVKRSSQSTLERSEQQIRAASSLEELLRITHSEDWKLWRCRLRLKSFTSMDSRSASHRSTRFAATFYDIETLKVIDEEWQRTQCSPRETCVEVASELGKSTNTFFKPPCVNVFRCGGCCNEESLICMNTSTSYISKQLFEISVPLTSVPELVPVKVANHTGCKCLPTAPRHPYSIIRRSIQIPEEDRCSHSKKLCPIDMLWDSNKCKCVLQEENPLAGTEDHSHLQEPALCGPHMMFDEDRCECVCKTPCPKDLIQHPKNCSCFECKESLETCCQKHKLFHPDTCSCEDRCPFHTRPCASGKTACAKHCRFPKEKRAAQGPHSRKNP

Target ORF information:

RefSeq Version	NM_004469.4
Organism	Homo sapiens(human)
Definition	Homo sapiens vascular endothelial growth factor D (VEGFD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004469.4

ORF Insert Sequence:

ATGTACAGAG AGTGGGTAGT GGTGAATGTT TTCATGATGT TGTACGTCCA GCTGGTGCAG 
GGCTCCAGTA ATGAACATGG ACCAGTGAAG CGATCATCTC AGTCCACATT GGAACGATCT 
GAACAGCAGA TCAGGGCTGC TTCTAGTTTG GAGGAACTAC TTCGAATTAC TCACTCTGAG 
GACTGGAAGC TGTGGAGATG CAGGCTGAGG CTCAAAAGTT TTACCAGTAT GGACTCTCGC 
TCAGCATCCC ATCGGTCCAC TAGGTTTGCG GCAACTTTCT ATGACATTGA AACACTAAAA 
GTTATAGATG AAGAATGGCA AAGAACTCAG TGCAGCCCTA GAGAAACGTG CGTGGAGGTG 
GCCAGTGAGC TGGGGAAGAG TACCAACACA TTCTTCAAGC CCCCTTGTGT GAACGTGTTC 
CGATGTGGTG GCTGTTGCAA TGAAGAGAGC CTTATCTGTA TGAACACCAG CACCTCGTAC 
ATTTCCAAAC AGCTCTTTGA GATATCAGTG CCTTTGACAT CAGTACCTGA ATTAGTGCCT 
GTTAAAGTTG CCAATCATAC AGGTTGTAAG TGCTTGCCAA CAGCCCCCCG CCATCCATAC 
TCAATTATCA GAAGATCCAT CCAGATCCCT GAAGAAGATC GCTGTTCCCA TTCCAAGAAA 
CTCTGTCCTA TTGACATGCT ATGGGATAGC AACAAATGTA AATGTGTTTT GCAGGAGGAA 
AATCCACTTG CTGGAACAGA AGACCACTCT CATCTCCAGG AACCAGCTCT CTGTGGGCCA 
CACATGATGT TTGACGAAGA TCGTTGCGAG TGTGTCTGTA AAACACCATG TCCCAAAGAT 
CTAATCCAGC ACCCCAAAAA CTGCAGTTGC TTTGAGTGCA AAGAAAGTCT GGAGACCTGC 
TGCCAGAAGC ACAAGCTATT TCACCCAGAC ACCTGCAGCT GTGAGGACAG ATGCCCCTTT 
CATACCAGAC CATGTGCAAG TGGCAAAACA GCATGTGCAA AGCATTGCCG CTTTCCAAAG 
GAGAAAAGGG CTGCCCAGGG GCCCCACAGC CGAAAGAATC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VEGFD ( NM_004469.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004460.1 Homo sapiens vascular endothelial growth factor D (VEGFD), mRNA.

Price & Availability↑

CloneID	OHu27377
Clone ID Related Accession (Same CDS sequence)	NM_004469.4 , NM_004469.5
Accession Version	NM_004469.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	vascular endothelial growth factor D preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA587496.1 and BC027948.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004469.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.286389.1, AK223160.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000297904.4/ ENSP00000297904.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTACAGAG AGTGGGTAGT GGTGAATGTT TTCATGATGT TGTACGTCCA GCTGGTGCAG 
GGCTCCAGTA ATGAACATGG ACCAGTGAAG CGATCATCTC AGTCCACATT GGAACGATCT 
GAACAGCAGA TCAGGGCTGC TTCTAGTTTG GAGGAACTAC TTCGAATTAC TCACTCTGAG 
GACTGGAAGC TGTGGAGATG CAGGCTGAGG CTCAAAAGTT TTACCAGTAT GGACTCTCGC 
TCAGCATCCC ATCGGTCCAC TAGGTTTGCG GCAACTTTCT ATGACATTGA AACACTAAAA 
GTTATAGATG AAGAATGGCA AAGAACTCAG TGCAGCCCTA GAGAAACGTG CGTGGAGGTG 
GCCAGTGAGC TGGGGAAGAG TACCAACACA TTCTTCAAGC CCCCTTGTGT GAACGTGTTC 
CGATGTGGTG GCTGTTGCAA TGAAGAGAGC CTTATCTGTA TGAACACCAG CACCTCGTAC 
ATTTCCAAAC AGCTCTTTGA GATATCAGTG CCTTTGACAT CAGTACCTGA ATTAGTGCCT 
GTTAAAGTTG CCAATCATAC AGGTTGTAAG TGCTTGCCAA CAGCCCCCCG CCATCCATAC 
TCAATTATCA GAAGATCCAT CCAGATCCCT GAAGAAGATC GCTGTTCCCA TTCCAAGAAA 
CTCTGTCCTA TTGACATGCT ATGGGATAGC AACAAATGTA AATGTGTTTT GCAGGAGGAA 
AATCCACTTG CTGGAACAGA AGACCACTCT CATCTCCAGG AACCAGCTCT CTGTGGGCCA 
CACATGATGT TTGACGAAGA TCGTTGCGAG TGTGTCTGTA AAACACCATG TCCCAAAGAT 
CTAATCCAGC ACCCCAAAAA CTGCAGTTGC TTTGAGTGCA AAGAAAGTCT GGAGACCTGC 
TGCCAGAAGC ACAAGCTATT TCACCCAGAC ACCTGCAGCT GTGAGGACAG ATGCCCCTTT 
CATACCAGAC CATGTGCAAG TGGCAAAACA GCATGTGCAA AGCATTGCCG CTTTCCAAAG 
GAGAAAAGGG CTGCCCAGGG GCCCCACAGC CGAAAGAATC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004460.1
CDS	468..1532
Translation	MYREWVVVNVFMMLYVQLVQGSSNEHGPVKRSSQSTLERSEQQIRAASSLEELLRITHSEDWKLWRCRLRLKSFTSMDSRSASHRSTRFAATFYDIETLKVIDEEWQRTQCSPRETCVEVASELGKSTNTFFKPPCVNVFRCGGCCNEESLICMNTSTSYISKQLFEISVPLTSVPELVPVKVANHTGCKCLPTAPRHPYSIIRRSIQIPEEDRCSHSKKLCPIDMLWDSNKCKCVLQEENPLAGTEDHSHLQEPALCGPHMMFDEDRCECVCKTPCPKDLIQHPKNCSCFECKESLETCCQKHKLFHPDTCSCEDRCPFHTRPCASGKTACAKHCRFPKEKRAAQGPHSRKNP

Target ORF information:

RefSeq Version	NM_004469.5
Organism	Homo sapiens(human)
Definition	Homo sapiens vascular endothelial growth factor D (VEGFD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004469.5

ORF Insert Sequence:

ATGTACAGAG AGTGGGTAGT GGTGAATGTT TTCATGATGT TGTACGTCCA GCTGGTGCAG 
GGCTCCAGTA ATGAACATGG ACCAGTGAAG CGATCATCTC AGTCCACATT GGAACGATCT 
GAACAGCAGA TCAGGGCTGC TTCTAGTTTG GAGGAACTAC TTCGAATTAC TCACTCTGAG 
GACTGGAAGC TGTGGAGATG CAGGCTGAGG CTCAAAAGTT TTACCAGTAT GGACTCTCGC 
TCAGCATCCC ATCGGTCCAC TAGGTTTGCG GCAACTTTCT ATGACATTGA AACACTAAAA 
GTTATAGATG AAGAATGGCA AAGAACTCAG TGCAGCCCTA GAGAAACGTG CGTGGAGGTG 
GCCAGTGAGC TGGGGAAGAG TACCAACACA TTCTTCAAGC CCCCTTGTGT GAACGTGTTC 
CGATGTGGTG GCTGTTGCAA TGAAGAGAGC CTTATCTGTA TGAACACCAG CACCTCGTAC 
ATTTCCAAAC AGCTCTTTGA GATATCAGTG CCTTTGACAT CAGTACCTGA ATTAGTGCCT 
GTTAAAGTTG CCAATCATAC AGGTTGTAAG TGCTTGCCAA CAGCCCCCCG CCATCCATAC 
TCAATTATCA GAAGATCCAT CCAGATCCCT GAAGAAGATC GCTGTTCCCA TTCCAAGAAA 
CTCTGTCCTA TTGACATGCT ATGGGATAGC AACAAATGTA AATGTGTTTT GCAGGAGGAA 
AATCCACTTG CTGGAACAGA AGACCACTCT CATCTCCAGG AACCAGCTCT CTGTGGGCCA 
CACATGATGT TTGACGAAGA TCGTTGCGAG TGTGTCTGTA AAACACCATG TCCCAAAGAT 
CTAATCCAGC ACCCCAAAAA CTGCAGTTGC TTTGAGTGCA AAGAAAGTCT GGAGACCTGC 
TGCCAGAAGC ACAAGCTATT TCACCCAGAC ACCTGCAGCT GTGAGGACAG ATGCCCCTTT 
CATACCAGAC CATGTGCAAG TGGCAAAACA GCATGTGCAA AGCATTGCCG CTTTCCAAAG 
GAGAAAAGGG CTGCCCAGGG GCCCCACAGC CGAAAGAATC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Analysis of Angiogenesis Biomarkers for Ramucirumab Efficacy in Patients with Metastatic Colorectal Cancer from RAISE, a Global, Randomized, Double-Blind, Phase III Study.
Annals of oncology : official journal of the European Society for Medical Oncology(2017 Dec)
Tabernero J,Hozak RR,Yoshino T,Cohn AL,Obermannova R,Bodoky G,Garcia-Carbonero R,Ciuleanu TE,Portnoy DC,Prausov? J,Muro K,Siegel RW,Konrad RJ,Ouyang H,Melemed SA,Ferry D,Nasroulah F,Van Cutsem E

SPARC suppresses lymph node metastasis by regulating the expression of VEGFs in ovarian carcinoma.
International journal of oncology51(6)1920-1928(2017 Dec)
Peng F,Zhong Y,Liu Y,Zhang Y,Xie Y,Lu Y,Zhang X,Li D

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VEGFD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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