NKAPL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NKAPL
Entrez Gene ID	222698
Full Name	NFKB activating protein like
Synonyms	C6orf194,bA424I5.1
General protein information	Preferred Names NFKB activating protein like Names NKAP-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001007531.2	NP_001007532.1	NKAP-like protein
NM_001007531.3	NP_001007532.1	NKAP-like protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NKAPL	XP_518308.2
Mus musculus (house mouse)	Nkapl	NP_079995.2
Gallus gallus (chicken)	NKAP	NP_001006437.1
Homo sapiens (human)	NKAPL	NP_001007532.1
	NKAPL	XP_001099236.1
Canis lupus familiaris (dog)	NKAPL	XP_003434255.1
Rattus norvegicus (Norway rat)	Nkapl	NP_001025084.1

Gene Ontology
Bibliography

Related articles in PubMed

Association between NF-?B Pathway Gene Variants and sICAM1 Levels in Taiwanese.
Wu S, Teng MS, Er LK, Hsiao WY, Hsu LA, Yeh CH, Lin JF, Lin YY, Su CW, Ko YL
PloS one12(1)e0169516(2017)

Further evidence supporting the association of NKAPL with schizophrenia.
Wang Z, Yang B, Liu Y, Shugart YY, Cheng Z, Jin C, Yuan J, Zhu W, Wang G, Zhang F
Neuroscience letters60549-52(2015 Sep)

A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis.
Okuda H, Kiuchi H, Takao T, Miyagawa Y, Tsujimura A, Nonomura N, Miyata H, Okabe M, Ikawa M, Kawakami Y, Goshima N, Wada M, Tanaka H
PloS one10(4)e0124293(2015)

Resequencing and association study of the NFKB activating protein-like gene (NKAPL) in schizophrenia.
Chen SF, Chao YL, Shen YC, Chen CH, Weng CF
Schizophrenia research157(1-3)169-74(2014 Aug)

Identification of the NF-?B activating protein-like locus as a risk locus for rheumatoid arthritis.
Xie G, Lu Y, Sun Y, Zhang SS, Keystone EC, Gregersen PK, Plenge RM, Amos CI, Siminovitch KA
Annals of the rheumatic diseases72(7)1249-54(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Single nucleotide polymorphism in NKAPL is associated with atherosclerosis.
Title: Association between NF-?B Pathway Gene Variants and sICAM1 Levels in Taiwanese.

further evidence for the involvement of NKAPL polymorphisms in the development of schizophrenia.
Title: Further evidence supporting the association of NKAPL with schizophrenia.

Overexpression of NKAPL in germline stem cells demonstrated that Nkapl induced changes in spermatogonial stem cell (SSC) markers and the reduction of differentiation factors through the Notch signaling pathway.
Title: A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis.

Study suggested that rs1635 in the NKAPL gene appeared to play a role in conferring susceptibility to schizophrenia
Title: Resequencing and association study of the NFKB activating protein-like gene (NKAPL) in schizophrenia.

Fine-mapping analyses identified six NKAPL locus variants in a single haplotype block showing association with rheumatoid arthritis.
Title: Identification of the NF-?B activating protein-like locus as a risk locus for rheumatoid arthritis.

The following NKAPL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NKAPL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00594	NM_001007531.3 Latest version!	Homo sapiens NFKB activating protein like (NKAPL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu00594	NM_001007531.2	Homo sapiens NFKB activating protein like (NKAPL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NKAPL ( NM_001007531.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001007532.1 Homo sapiens NFKB activating protein like (NKAPL), mRNA.

Price & Availability↑

CloneID	OHu00594
Clone ID Related Accession (Same CDS sequence)	NM_001007531.2 , NM_001007531.3
Accession Version	NM_001007531.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1209bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	NKAP-like protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB471905.1, BC101681.1, AI240405.1 and BC038240.1. On Feb 6, 2013 this sequence version replaced NM_001007531.1.

ATGCCCCCAG TATCCCGGTC CAGCTATTCC GAGGACATCG TGGGCTCTCG GAGAAGGCGA 
CGCAGCTCCT CGGGGAGCCC ACCATCCCCG CAGAGCAGAT GTTCCTCTTG GGATGGCTGT 
TCCCGCTCTC ACTCCCGCGG CCGTGAGGGC CTCAGGCCTC CTTGGAGTGA GTTGGACGTG 
GGCGCTCTTT ACCCCTTTAG TCGCTCTGGG TCGCGAGGGC GGCTCCCAAG ATTCCGCAAC 
TACGCCTTCG CGTCCTCCTG GTCGACCTCG TATAGTGGAT ATCGCTACCA TCGTCACTGC 
TATGCAGAAG AACGGCAGTC AGCGGAAGAC TACGAGAAGG AAGAGAGCCA TCGGCAGAGG 
AGGCTGAAGG AGAGAGAGAG GATTGGGGAA TTGGGAGCGC CTGAAGTGTG GGGGCCGTCT 
CCAAAGTTCC CTCAGCTAGA TTCTGACGAA CATACCCCAG TTGAGGATGA AGAAGAGGTA 
ACGCATCAGA AAAGCAGCAG TTCAGATTCC AACTCGGAAG AACATAGGAA AAAGAAGACC 
AGTCGTTCAA GAAACAAGAA AAAAAGAAAG AATAAGTCGT CTAAAAGAAA GCATAGGAAA 
TATTCTGATA GTGACAGTAA CTCAGAGTCT GACACAAATT CTGACTCTGA TGATGATAAA 
AAGAGAGTTA AAGCCAAGAA GAAAAAGAAG AAAAAGAAAC ACAAAACAAA GAAAAAGAAG 
AATAAGAAAA CCAAAAAAGA ATCCAGTGAC TCAAGCTGTA AAGACTCAGA AGAGGACTTG 
TCAGAAGCTA CCTGGATGGA GCAGCCAAAT GTGGCAGATA CTATGGATTT AATAGGGCCA 
GAAGCACCTA TAATACATAC CTCTCAAGAT GAAAAACCTT TGAAGTATGG CCATGCTTTG 
CTTCCCGGTG AAGGTGCAGC TATGGCTGAG TATGTAAAAG CTGGAAAGCG AATCCCACGA 
AGAGGTGAAA TTGGGTTGAC AAGTGAAGAG ATCGGTTCTT TTGAATGCTC AGGTTATGTC 
ATGAGTGGTA GCAGGCATCG CAGAATGGAG GCTGTACGAC TGCGTAAGGA GAACCAGATC 
TACAGTGCTG ATGAGAAGAG AGCTCTTGCA TCCTTTAACC AAGAAGAGAG ACGAAAGAGA 
GAAAGTAAGA TTTTAGCCAG TTTCCGAGAG ATGGTGCACA AAAAGACAAA AGAGAAAGAT 
GACAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007532.1
CDS	76..1284
Translation	MPPVSRSSYSEDIVGSRRRRRSSSGSPPSPQSRCSSWDGCSRSHSRGREGLRPPWSELDVGALYPFSRSGSRGRLPRFRNYAFASSWSTSYSGYRYHRHCYAEERQSAEDYEKEESHRQRRLKERERIGELGAPEVWGPSPKFPQLDSDEHTPVEDEEEVTHQKSSSSDSNSEEHRKKKTSRSRNKKKRKNKSSKRKHRKYSDSDSNSESDTNSDSDDDKKRVKAKKKKKKKKHKTKKKKNKKTKKESSDSSCKDSEEDLSEATWMEQPNVADTMDLIGPEAPIIHTSQDEKPLKYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIGSFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRESKILASFREMVHKKTKEKDDK

Target ORF information:

RefSeq Version	NM_001007531.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NFKB activating protein like (NKAPL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007531.2

ORF Insert Sequence:

ATGCCCCCAG TATCCCGGTC CAGCTATTCC GAGGACATCG TGGGCTCTCG GAGAAGGCGA 
CGCAGCTCCT CGGGGAGCCC ACCATCCCCG CAGAGCAGAT GTTCCTCTTG GGATGGCTGT 
TCCCGCTCTC ACTCCCGCGG CCGTGAGGGC CTCAGGCCTC CTTGGAGTGA GTTGGACGTG 
GGCGCTCTTT ACCCCTTTAG TCGCTCTGGG TCGCGAGGGC GGCTCCCAAG ATTCCGCAAC 
TACGCCTTCG CGTCCTCCTG GTCGACCTCG TATAGTGGAT ATCGCTACCA TCGTCACTGC 
TATGCAGAAG AACGGCAGTC AGCGGAAGAC TACGAGAAGG AAGAGAGCCA TCGGCAGAGG 
AGGCTGAAGG AGAGAGAGAG GATTGGGGAA TTGGGAGCGC CTGAAGTGTG GGGGCCGTCT 
CCAAAGTTCC CTCAGCTAGA TTCTGACGAA CATACCCCAG TTGAGGATGA AGAAGAGGTA 
ACGCATCAGA AAAGCAGCAG TTCAGATTCC AACTCGGAAG AACATAGGAA AAAGAAGACC 
AGTCGTTCAA GAAACAAGAA AAAAAGAAAG AATAAGTCGT CTAAAAGAAA GCATAGGAAA 
TATTCTGATA GTGACAGTAA CTCAGAGTCT GACACAAATT CTGACTCTGA TGATGATAAA 
AAGAGAGTTA AAGCCAAGAA GAAAAAGAAG AAAAAGAAAC ACAAAACAAA GAAAAAGAAG 
AATAAGAAAA CCAAAAAAGA ATCCAGTGAC TCAAGCTGTA AAGACTCAGA AGAGGACTTG 
TCAGAAGCTA CCTGGATGGA GCAGCCAAAT GTGGCAGATA CTATGGATTT AATAGGGCCA 
GAAGCACCTA TAATACATAC CTCTCAAGAT GAAAAACCTT TGAAGTATGG CCATGCTTTG 
CTTCCCGGTG AAGGTGCAGC TATGGCTGAG TATGTAAAAG CTGGAAAGCG AATCCCACGA 
AGAGGTGAAA TTGGGTTGAC AAGTGAAGAG ATCGGTTCTT TTGAATGCTC AGGTTATGTC 
ATGAGTGGTA GCAGGCATCG CAGAATGGAG GCTGTACGAC TGCGTAAGGA GAACCAGATC 
TACAGTGCTG ATGAGAAGAG AGCTCTTGCA TCCTTTAACC AAGAAGAGAG ACGAAAGAGA 
GAAAGTAAGA TTTTAGCCAG TTTCCGAGAG ATGGTGCACA AAAAGACAAA AGAGAAAGAT 
GACAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NKAPL ( NM_001007531.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001007532.1 Homo sapiens NFKB activating protein like (NKAPL), mRNA.

Price & Availability↑

CloneID	OHu00594
Clone ID Related Accession (Same CDS sequence)	NM_001007531.2 , NM_001007531.3
Accession Version	NM_001007531.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1209bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	NKAP-like protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB471905.1, BC101681.1, AI240405.1 and BC038240.1. On May 17, 2019 this sequence version replaced NM_001007531.2. ##Evidence-Data-START## Transcript is intronless :: BC038240.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000343684.4/ ENSP00000345716.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCCCCCAG TATCCCGGTC CAGCTATTCC GAGGACATCG TGGGCTCTCG GAGAAGGCGA 
CGCAGCTCCT CGGGGAGCCC ACCATCCCCG CAGAGCAGAT GTTCCTCTTG GGATGGCTGT 
TCCCGCTCTC ACTCCCGCGG CCGTGAGGGC CTCAGGCCTC CTTGGAGTGA GTTGGACGTG 
GGCGCTCTTT ACCCCTTTAG TCGCTCTGGG TCGCGAGGGC GGCTCCCAAG ATTCCGCAAC 
TACGCCTTCG CGTCCTCCTG GTCGACCTCG TATAGTGGAT ATCGCTACCA TCGTCACTGC 
TATGCAGAAG AACGGCAGTC AGCGGAAGAC TACGAGAAGG AAGAGAGCCA TCGGCAGAGG 
AGGCTGAAGG AGAGAGAGAG GATTGGGGAA TTGGGAGCGC CTGAAGTGTG GGGGCCGTCT 
CCAAAGTTCC CTCAGCTAGA TTCTGACGAA CATACCCCAG TTGAGGATGA AGAAGAGGTA 
ACGCATCAGA AAAGCAGCAG TTCAGATTCC AACTCGGAAG AACATAGGAA AAAGAAGACC 
AGTCGTTCAA GAAACAAGAA AAAAAGAAAG AATAAGTCGT CTAAAAGAAA GCATAGGAAA 
TATTCTGATA GTGACAGTAA CTCAGAGTCT GACACAAATT CTGACTCTGA TGATGATAAA 
AAGAGAGTTA AAGCCAAGAA GAAAAAGAAG AAAAAGAAAC ACAAAACAAA GAAAAAGAAG 
AATAAGAAAA CCAAAAAAGA ATCCAGTGAC TCAAGCTGTA AAGACTCAGA AGAGGACTTG 
TCAGAAGCTA CCTGGATGGA GCAGCCAAAT GTGGCAGATA CTATGGATTT AATAGGGCCA 
GAAGCACCTA TAATACATAC CTCTCAAGAT GAAAAACCTT TGAAGTATGG CCATGCTTTG 
CTTCCCGGTG AAGGTGCAGC TATGGCTGAG TATGTAAAAG CTGGAAAGCG AATCCCACGA 
AGAGGTGAAA TTGGGTTGAC AAGTGAAGAG ATCGGTTCTT TTGAATGCTC AGGTTATGTC 
ATGAGTGGTA GCAGGCATCG CAGAATGGAG GCTGTACGAC TGCGTAAGGA GAACCAGATC 
TACAGTGCTG ATGAGAAGAG AGCTCTTGCA TCCTTTAACC AAGAAGAGAG ACGAAAGAGA 
GAAAGTAAGA TTTTAGCCAG TTTCCGAGAG ATGGTGCACA AAAAGACAAA AGAGAAAGAT 
GACAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007532.1
CDS	76..1284
Translation	MPPVSRSSYSEDIVGSRRRRRSSSGSPPSPQSRCSSWDGCSRSHSRGREGLRPPWSELDVGALYPFSRSGSRGRLPRFRNYAFASSWSTSYSGYRYHRHCYAEERQSAEDYEKEESHRQRRLKERERIGELGAPEVWGPSPKFPQLDSDEHTPVEDEEEVTHQKSSSSDSNSEEHRKKKTSRSRNKKKRKNKSSKRKHRKYSDSDSNSESDTNSDSDDDKKRVKAKKKKKKKKHKTKKKKNKKTKKESSDSSCKDSEEDLSEATWMEQPNVADTMDLIGPEAPIIHTSQDEKPLKYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIGSFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRESKILASFREMVHKKTKEKDDK

Target ORF information:

RefSeq Version	NM_001007531.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NFKB activating protein like (NKAPL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007531.3

ORF Insert Sequence:

ATGCCCCCAG TATCCCGGTC CAGCTATTCC GAGGACATCG TGGGCTCTCG GAGAAGGCGA 
CGCAGCTCCT CGGGGAGCCC ACCATCCCCG CAGAGCAGAT GTTCCTCTTG GGATGGCTGT 
TCCCGCTCTC ACTCCCGCGG CCGTGAGGGC CTCAGGCCTC CTTGGAGTGA GTTGGACGTG 
GGCGCTCTTT ACCCCTTTAG TCGCTCTGGG TCGCGAGGGC GGCTCCCAAG ATTCCGCAAC 
TACGCCTTCG CGTCCTCCTG GTCGACCTCG TATAGTGGAT ATCGCTACCA TCGTCACTGC 
TATGCAGAAG AACGGCAGTC AGCGGAAGAC TACGAGAAGG AAGAGAGCCA TCGGCAGAGG 
AGGCTGAAGG AGAGAGAGAG GATTGGGGAA TTGGGAGCGC CTGAAGTGTG GGGGCCGTCT 
CCAAAGTTCC CTCAGCTAGA TTCTGACGAA CATACCCCAG TTGAGGATGA AGAAGAGGTA 
ACGCATCAGA AAAGCAGCAG TTCAGATTCC AACTCGGAAG AACATAGGAA AAAGAAGACC 
AGTCGTTCAA GAAACAAGAA AAAAAGAAAG AATAAGTCGT CTAAAAGAAA GCATAGGAAA 
TATTCTGATA GTGACAGTAA CTCAGAGTCT GACACAAATT CTGACTCTGA TGATGATAAA 
AAGAGAGTTA AAGCCAAGAA GAAAAAGAAG AAAAAGAAAC ACAAAACAAA GAAAAAGAAG 
AATAAGAAAA CCAAAAAAGA ATCCAGTGAC TCAAGCTGTA AAGACTCAGA AGAGGACTTG 
TCAGAAGCTA CCTGGATGGA GCAGCCAAAT GTGGCAGATA CTATGGATTT AATAGGGCCA 
GAAGCACCTA TAATACATAC CTCTCAAGAT GAAAAACCTT TGAAGTATGG CCATGCTTTG 
CTTCCCGGTG AAGGTGCAGC TATGGCTGAG TATGTAAAAG CTGGAAAGCG AATCCCACGA 
AGAGGTGAAA TTGGGTTGAC AAGTGAAGAG ATCGGTTCTT TTGAATGCTC AGGTTATGTC 
ATGAGTGGTA GCAGGCATCG CAGAATGGAG GCTGTACGAC TGCGTAAGGA GAACCAGATC 
TACAGTGCTG ATGAGAAGAG AGCTCTTGCA TCCTTTAACC AAGAAGAGAG ACGAAAGAGA 
GAAAGTAAGA TTTTAGCCAG TTTCCGAGAG ATGGTGCACA AAAAGACAAA AGAGAAAGAT 
GACAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association between NF-?B Pathway Gene Variants and sICAM1 Levels in Taiwanese.
PloS one12(1)e0169516(2017)
Wu S,Teng MS,Er LK,Hsiao WY,Hsu LA,Yeh CH,Lin JF,Lin YY,Su CW,Ko YL

Further evidence supporting the association of NKAPL with schizophrenia.
Neuroscience letters60549-52(2015 Sep)
Wang Z,Yang B,Liu Y,Shugart YY,Cheng Z,Jin C,Yuan J,Zhu W,Wang G,Zhang F

A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis.
PloS one10(4)e0124293(2015)
Okuda H,Kiuchi H,Takao T,Miyagawa Y,Tsujimura A,Nonomura N,Miyata H,Okabe M,Ikawa M,Kawakami Y,Goshima N,Wada M,Tanaka H

Resequencing and association study of the NFKB activating protein-like gene (NKAPL) in schizophrenia.
Schizophrenia research157(1-3)169-74(2014 Aug)
Chen SF,Chao YL,Shen YC,Chen CH,Weng CF

Identification of the NF-?B activating protein-like locus as a risk locus for rheumatoid arthritis.
Annals of the rheumatic diseases72(7)1249-54(2013 Jul)
Xie G,Lu Y,Sun Y,Zhang SS,Keystone EC,Gregersen PK,Plenge RM,Amos CI,Siminovitch KA

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NKAPL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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