CELA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CELA1
Entrez Gene ID	1990
Full Name	chymotrypsin like elastase family member 1
Synonyms	ELA1
General protein information	Preferred Names chymotrypsin like elastase family member 1 Names chymotrypsin-like elastase family member 1 elastase 1, pancreatic elastase-1 pancreatic elastase 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Summary	Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B. [provided by RefSeq, May 2009].
Disorder MIM:	130120

mRNA and Protein(s)

mRNA	Protein	Name
NM_001971.6	NP_001962.3	chymotrypsin-like elastase family member 1
NM_001971.5	NP_001962.3	chymotrypsin-like elastase family member 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CELA1	NP_001962.3
Canis lupus familiaris (dog)	CELA1	NP_001003007.1
Rattus norvegicus (Norway rat)	Cela1	NP_036684.1
Xenopus tropicalis (tropical clawed frog)	LOC496972	NP_001011481.1
Xenopus tropicalis (tropical clawed frog)	ela1	NP_001025669.1
	LOC695507	XP_001088682.1
Xenopus tropicalis (tropical clawed frog)	cela1	NP_001011493.1
Xenopus tropicalis (tropical clawed frog)	LOC101730694	XP_004911959.1
Xenopus tropicalis (tropical clawed frog)	cela1	XP_002933738.2
Pan troglodytes (chimpanzee)	CELA1	XP_001142473.2
Mus musculus (house mouse)	Cela1	NP_291090.2
Xenopus tropicalis (tropical clawed frog)	LOC100135144	XP_002933737.2
Bos taurus (cattle)	CELA1	NP_776473.1
Gallus gallus (chicken)	CELA1	NP_001096672.1

Gene Ontology
Bibliography

Related articles in PubMed

[Molecular genetic study of a family affected with punctate palmoplantar keratoderma].
Jia Y, Wang S, Zhu Y, Luo D
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics34(3)369-372(2017 Jun)

Inverse association of HbA1c with faecal elastase 1 in people without diabetes.
Rathmann W, Haastert B, Oscarsson J, Berglind N, Wareham NJ
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]15(6)620-5(2015 Nov-Dec)

Extract of the mycelium of T. matsutake inhibits elastase activity and TPA-induced MMP-1 expression in human fibroblasts.
Kim SY, Go KC, Song YS, Jeong YS, Kim EJ, Kim BJ
International journal of molecular medicine34(6)1613-21(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A heterozygous frameshift variant c.419delC in exons of the CELA1 gene identified in all punctate palmoplantar keratoderma patients.
Title: [Molecular genetic study of a family affected with punctate palmoplantar keratoderma].

Inverse association of HbA1c with faecal elastase 1 in people without diabetes suggests that pancreatic exocrine dysfunction might be an early disturbance that develops in parallel with hyperglycemia.
Title: Inverse association of HbA1c with faecal elastase 1 in people without diabetes.

Results indicate that the extract of the mycelium of Tricholoma matsutake decreased elastase activity in a dose-dependent manner and reduced the levels of matrix metalloproteinase 1 (MMP-1).
Title: Extract of the mycelium of T. matsutake inhibits elastase activity and TPA-induced MMP-1 expression in human fibroblasts.

Data indicate that fecal elastase-1 was lower in the pancreaticoduodenectomy (PD) group.
Title: Nutritional status, fecal elastase-1, and 13C-labeled mixed triglyceride breath test in the long-term after pancreaticoduodenectomy.

Mutant genes (CELA1, HSPG2, and KCNK5) in Balkan endemic nephropathy patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis.
Title: NGS nominated CELA1, HSPG2, and KCNK5 as candidate genes for predisposition to Balkan endemic nephropathy.

The following CELA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CELA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31854	NM_001971.6 Latest version!	Homo sapiens chymotrypsin like elastase 1 (CELA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31854	NM_001971.5	Homo sapiens chymotrypsin like elastase 1 (CELA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CELA1 ( NM_001971.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_001962.3 Homo sapiens chymotrypsin like elastase 1 (CELA1), mRNA.

Price & Availability↑

CloneID	OHu31854
Clone ID Related Accession (Same CDS sequence)	NM_001971.6 , NM_001971.5
Accession Version	NM_001971.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	chymotrypsin-like elastase family member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069454.1, AC046135.15 and AF120493.1. On May 17, 2019 this sequence version replaced NM_001971.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF120493.1, BC069454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2153347 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000293636.2/ ENSP00000293636.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGGTCC TTTATGGACA CAGCACCCAG GACCTTCCGG AAACCAATGC CCGCGTAGTC 
GGAGGGACTG AGGCCGGGAG GAATTCCTGG CCCTCTCAGA TTTCCCTCCA GTACCGGTCT 
GGAGGTTCCC GGTATCACAC CTGTGGAGGG ACCCTTATCA GACAGAACTG GGTGATGACA 
GCTGCTCACT GCGTGGATTA CCAGAAGACT TTCCGCGTGG TGGCTGGAGA CCATAACCTG 
AGCCAGAATG ATGGCACTGA GCAGTACGTG AGTGTGCAGA AGATCGTGGT GCATCCATAC 
TGGAACAGCG ATAACGTGGC TGCCGGCTAT GACATCGCCC TGCTGCGCCT GGCCCAGAGC 
GTTACCCTCA ATAGCTATGT CCAGCTGGGT GTTCTGCCCC AGGAGGGAGC CATCCTGGCT 
AACAACAGTC CCTGCTACAT CACAGGCTGG GGCAAGACCA AGACCAATGG GCAGCTGGCC 
CAGACCCTGC AGCAGGCTTA CCTGCCCTCT GTGGACTACG CCATCTGCTC CAGCTCCTCC 
TACTGGGGCT CCACTGTGAA GAACACCATG GTGTGTGCTG GTGGAGATGG AGTTCGCTCT 
GGATGCCAGG GTGACTCTGG GGGCCCCCTC CATTGCTTGG TGAATGGCAA GTATTCTGTC 
CATGGAGTGA CCAGCTTTGT GTCCAGCCGG GGCTGTAATG TCTCCAGGAA GCCTACAGTC 
TTCACCCAGG TCTCTGCTTA CATCTCCTGG ATAAATAATG TCATCGCCTC CAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001962.3
CDS	42..818
Translation	MLVLYGHSTQDLPETNARVVGGTEAGRNSWPSQISLQYRSGGSRYHTCGGTLIRQNWVMTAAHCVDYQKTFRVVAGDHNLSQNDGTEQYVSVQKIVVHPYWNSDNVAAGYDIALLRLAQSVTLNSYVQLGVLPQEGAILANNSPCYITGWGKTKTNGQLAQTLQQAYLPSVDYAICSSSSYWGSTVKNTMVCAGGDGVRSGCQGDSGGPLHCLVNGKYSVHGVTSFVSSRGCNVSRKPTVFTQVSAYISWINNVIASN

Target ORF information:

RefSeq Version	NM_001971.6
Organism	Homo sapiens(human)
Definition	Homo sapiens chymotrypsin like elastase 1 (CELA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001971.6

ORF Insert Sequence:

ATGCTGGTCC TTTATGGACA CAGCACCCAG GACCTTCCGG AAACCAATGC CCGCGTAGTC 
GGAGGGACTG AGGCCGGGAG GAATTCCTGG CCCTCTCAGA TTTCCCTCCA GTACCGGTCT 
GGAGGTTCCC GGTATCACAC CTGTGGAGGG ACCCTTATCA GACAGAACTG GGTGATGACA 
GCTGCTCACT GCGTGGATTA CCAGAAGACT TTCCGCGTGG TGGCTGGAGA CCATAACCTG 
AGCCAGAATG ATGGCACTGA GCAGTACGTG AGTGTGCAGA AGATCGTGGT GCATCCATAC 
TGGAACAGCG ATAACGTGGC TGCCGGCTAT GACATCGCCC TGCTGCGCCT GGCCCAGAGC 
GTTACCCTCA ATAGCTATGT CCAGCTGGGT GTTCTGCCCC AGGAGGGAGC CATCCTGGCT 
AACAACAGTC CCTGCTACAT CACAGGCTGG GGCAAGACCA AGACCAATGG GCAGCTGGCC 
CAGACCCTGC AGCAGGCTTA CCTGCCCTCT GTGGACTACG CCATCTGCTC CAGCTCCTCC 
TACTGGGGCT CCACTGTGAA GAACACCATG GTGTGTGCTG GTGGAGATGG AGTTCGCTCT 
GGATGCCAGG GTGACTCTGG GGGCCCCCTC CATTGCTTGG TGAATGGCAA GTATTCTGTC 
CATGGAGTGA CCAGCTTTGT GTCCAGCCGG GGCTGTAATG TCTCCAGGAA GCCTACAGTC 
TTCACCCAGG TCTCTGCTTA CATCTCCTGG ATAAATAATG TCATCGCCTC CAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CELA1 ( NM_001971.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001962.3 Homo sapiens chymotrypsin like elastase 1 (CELA1), mRNA.

Price & Availability↑

CloneID	OHu31854
Clone ID Related Accession (Same CDS sequence)	NM_001971.6 , NM_001971.5
Accession Version	NM_001971.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-10
Organism	Homo sapiens(human)
Product	chymotrypsin-like elastase family member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069454.1, AC046135.15 and AF120493.1. On May 13, 2009 this sequence version replaced NM_001971.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF120493.1, BC075091.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2153347 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGGTCC TTTATGGACA CAGCACCCAG GACCTTCCGG AAACCAATGC CCGCGTAGTC 
GGAGGGACTG AGGCCGGGAG GAATTCCTGG CCCTCTCAGA TTTCCCTCCA GTACCGGTCT 
GGAGGTTCCC GGTATCACAC CTGTGGAGGG ACCCTTATCA GACAGAACTG GGTGATGACA 
GCTGCTCACT GCGTGGATTA CCAGAAGACT TTCCGCGTGG TGGCTGGAGA CCATAACCTG 
AGCCAGAATG ATGGCACTGA GCAGTACGTG AGTGTGCAGA AGATCGTGGT GCATCCATAC 
TGGAACAGCG ATAACGTGGC TGCCGGCTAT GACATCGCCC TGCTGCGCCT GGCCCAGAGC 
GTTACCCTCA ATAGCTATGT CCAGCTGGGT GTTCTGCCCC AGGAGGGAGC CATCCTGGCT 
AACAACAGTC CCTGCTACAT CACAGGCTGG GGCAAGACCA AGACCAATGG GCAGCTGGCC 
CAGACCCTGC AGCAGGCTTA CCTGCCCTCT GTGGACTACG CCATCTGCTC CAGCTCCTCC 
TACTGGGGCT CCACTGTGAA GAACACCATG GTGTGTGCTG GTGGAGATGG AGTTCGCTCT 
GGATGCCAGG GTGACTCTGG GGGCCCCCTC CATTGCTTGG TGAATGGCAA GTATTCTGTC 
CATGGAGTGA CCAGCTTTGT GTCCAGCCGG GGCTGTAATG TCTCCAGGAA GCCTACAGTC 
TTCACCCAGG TCTCTGCTTA CATCTCCTGG ATAAATAATG TCATCGCCTC CAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001962.3
CDS	42..818
Translation	MLVLYGHSTQDLPETNARVVGGTEAGRNSWPSQISLQYRSGGSRYHTCGGTLIRQNWVMTAAHCVDYQKTFRVVAGDHNLSQNDGTEQYVSVQKIVVHPYWNSDNVAAGYDIALLRLAQSVTLNSYVQLGVLPQEGAILANNSPCYITGWGKTKTNGQLAQTLQQAYLPSVDYAICSSSSYWGSTVKNTMVCAGGDGVRSGCQGDSGGPLHCLVNGKYSVHGVTSFVSSRGCNVSRKPTVFTQVSAYISWINNVIASN

Target ORF information:

RefSeq Version	NM_001971.5
Organism	Homo sapiens(human)
Definition	Homo sapiens chymotrypsin like elastase 1 (CELA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001971.5

ORF Insert Sequence:

ATGCTGGTCC TTTATGGACA CAGCACCCAG GACCTTCCGG AAACCAATGC CCGCGTAGTC 
GGAGGGACTG AGGCCGGGAG GAATTCCTGG CCCTCTCAGA TTTCCCTCCA GTACCGGTCT 
GGAGGTTCCC GGTATCACAC CTGTGGAGGG ACCCTTATCA GACAGAACTG GGTGATGACA 
GCTGCTCACT GCGTGGATTA CCAGAAGACT TTCCGCGTGG TGGCTGGAGA CCATAACCTG 
AGCCAGAATG ATGGCACTGA GCAGTACGTG AGTGTGCAGA AGATCGTGGT GCATCCATAC 
TGGAACAGCG ATAACGTGGC TGCCGGCTAT GACATCGCCC TGCTGCGCCT GGCCCAGAGC 
GTTACCCTCA ATAGCTATGT CCAGCTGGGT GTTCTGCCCC AGGAGGGAGC CATCCTGGCT 
AACAACAGTC CCTGCTACAT CACAGGCTGG GGCAAGACCA AGACCAATGG GCAGCTGGCC 
CAGACCCTGC AGCAGGCTTA CCTGCCCTCT GTGGACTACG CCATCTGCTC CAGCTCCTCC 
TACTGGGGCT CCACTGTGAA GAACACCATG GTGTGTGCTG GTGGAGATGG AGTTCGCTCT 
GGATGCCAGG GTGACTCTGG GGGCCCCCTC CATTGCTTGG TGAATGGCAA GTATTCTGTC 
CATGGAGTGA CCAGCTTTGT GTCCAGCCGG GGCTGTAATG TCTCCAGGAA GCCTACAGTC 
TTCACCCAGG TCTCTGCTTA CATCTCCTGG ATAAATAATG TCATCGCCTC CAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[Molecular genetic study of a family affected with punctate palmoplantar keratoderma].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics34(3)369-372(2017 Jun)
Jia Y,Wang S,Zhu Y,Luo D

Inverse association of HbA1c with faecal elastase 1 in people without diabetes.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]15(6)620-5(2015 Nov-Dec)
Rathmann W,Haastert B,Oscarsson J,Berglind N,Wareham NJ

Extract of the mycelium of T. matsutake inhibits elastase activity and TPA-induced MMP-1 expression in human fibroblasts.
International journal of molecular medicine34(6)1613-21(2014 Dec)
Kim SY,Go KC,Song YS,Jeong YS,Kim EJ,Kim BJ

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CELA1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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