DUSP4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DUSP4
Entrez Gene ID	1846
Full Name	dual specificity phosphatase 4
Synonyms	HVH2,MKP-2,MKP2,TYP
General protein information	Preferred Names dual specificity phosphatase 4 Names dual specificity protein phosphatase 4 MAP kinase phosphatase 2 VH1 homologous phosphatase 2 dual specificity protein phosphatase hVH2 mitogen-activated protein kinase phosphatase 2 serine/threonine specific protein phosphatase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p12
Summary	The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008].
Disorder MIM:	602747

mRNA and Protein(s)

mRNA	Protein	Name
XM_011544428.1	XP_011542730.1	dual specificity protein phosphatase 4 isoform X1
NM_057158.3	NP_476499.1	dual specificity protein phosphatase 4 isoform 2
XM_011544428.3	XP_011542730.1	dual specificity protein phosphatase 4 isoform X1
XM_011544428.2	XP_011542730.1	dual specificity protein phosphatase 4 isoform X1
NM_001394.7	NP_001385.1	dual specificity protein phosphatase 4 isoform 1
NM_001394.6	NP_001385.1	dual specificity protein phosphatase 4 isoform 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Dusp4	NP_071535.1
Canis lupus familiaris (dog)	LOC482880	XP_539995.3
Oryza sativa (rice)	Os02g0720300	NP_001047951.1
	DUSP4	XP_001110903.1
Arabidopsis thaliana (thale cress)	IBR5	NP_178534.2
Oryza sativa (rice)	Os06g0308100	NP_001057473.1
Xenopus tropicalis (tropical clawed frog)	dusp4	NP_001016109.1
Pan troglodytes (chimpanzee)	DUSP4	XP_520046.2
Bos taurus (cattle)	DUSP4	NP_001193882.1
Homo sapiens (human)	DUSP4	NP_001385.1
Mus musculus (house mouse)	Dusp4	NP_795907.1
Gallus gallus (chicken)	DUSP4	NP_990169.1
Danio rerio (zebrafish)	dusp4	NP_957465.1

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas.
Ichimanda M, Hijiya N, Tsukamoto Y, Uchida T, Nakada C, Akagi T, Etoh T, Iha H, Inomata M, Takekawa M, Moriyama M
Cancer science109(1)250-258(2018 Jan)

Sanguinarine inhibits growth and invasion of gastric cancer cells via regulation of the DUSP4/ERK pathway.
Zhang R, Wang G, Zhang PF, Zhang J, Huang YX, Lu YM, Da W, Sun Q, Zhu JS
Journal of cellular and molecular medicine21(6)1117-1127(2017 Jun)

Impaired Dual-Specificity Protein Phosphatase DUSP4 Reduces Corticosteroid Sensitivity.
Kobayashi Y, Ito K, Kanda A, Tomoda K, Mercado N, Barnes PJ
Molecular pharmacology91(5)475-481(2017 May)

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.
Mazumdar A, Poage GM, Shepherd J, Tsimelzon A, Hartman ZC, Den Hollander P, Hill J, Zhang Y, Chang J, Hilsenbeck SG, Fuqua S, Kent Osborne C, Mills GB, Brown PH
Breast cancer research and treatment158(3)441-54(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DUSP4 is crucial in regulating corticosteroid sensitivity.
Title: Impaired Dual-Specificity Protein Phosphatase DUSP4 Reduces Corticosteroid Sensitivity.

Results show that DUSP4 gene is under-expressed in ER-negative breast cancer and is deleted in approximately 50 % of breast cancers. Induced DUSP4 expression suppresses both in vitro and in vivo growths of breast cancer cells suggesting that DUSP4 is a critical regulator of the growth and invasion of triple-negative breast cancer cells.
Title: Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.

Our findings demonstrate a genetic mechanism by which pancreatic precursor lesions progress to invasive carcinomas and highlight DUSP4 as a novel invasion suppressor
Title: Genomic Loss of DUSP4 Contributes to the Progression of Intraepithelial Neoplasm of Pancreas to Invasive Carcinoma.

Ectopic expression of wild-type DUSP4, but not of a phosphatase-deficient mutant, dephosphorylates c-JUN N-terminal kinase (JNK) and induces apoptosis in DLBCL cells.
Title: DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma.

Data indicate that normalization of dual-specific phosphatase 4 (DUSP4) expression using a specific siRNA improved CD4(+) T-cell activity in idiopathic CD4 lymphopenia (ICL).
Title: DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia.

The following DUSP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DUSP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23480	NM_001394.7 Latest version!	Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu23661	NM_057158.3 Latest version!	Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu23661	XM_011544428.3 Latest version!	Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu23661	XM_011544428.1	Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu23661	XM_011544428.2	Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu23480	NM_001394.6	Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DUSP4 ( NM_001394.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_001385.1 Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23480
Clone ID Related Accession (Same CDS sequence)	NM_001394.7 , NM_001394.6
Accession Version	NM_001394.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-25
Organism	Homo sapiens(human)
Product	dual specificity protein phosphatase 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA645190.1, AK314820.1, AL137704.1, AC084262.6 and BC012900.1. On Nov 22, 2018 this sequence version replaced NM_001394.6. Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.76161.1, U48807.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146411, SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000240100.7/ ENSP00000240100.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGACGA TGGAGGAGCT GCGGGAGATG GACTGCAGTG TGCTCAAAAG GCTGATGAAC 
CGGGACGAGA ATGGCGGCGG CGCGGGCGGC AGCGGCAGCC ACGGCACCCT GGGGCTGCCG 
AGCGGCGGCA AGTGCCTGCT GCTGGACTGC AGACCGTTCC TGGCGCACAG CGCGGGCTAC 
ATCCTAGGTT CGGTCAACGT GCGCTGTAAC ACCATCGTGC GGCGGCGGGC TAAGGGCTCC 
GTGAGCCTGG AGCAGATCCT GCCCGCCGAG GAGGAGGTAC GCGCCCGCTT GCGCTCCGGC 
CTCTACTCGG CGGTCATCGT CTACGACGAG CGCAGCCCGC GCGCCGAGAG CCTCCGCGAG 
GACAGCACCG TGTCGCTGGT GGTGCAGGCG CTGCGCCGCA ACGCCGAGCG CACCGACATC 
TGCCTGCTCA AAGGCGGCTA TGAGAGGTTT TCCTCCGAGT ACCCAGAATT CTGTTCTAAA 
ACCAAGGCCC TGGCAGCCAT CCCACCCCCG GTTCCCCCCA GTGCCACAGA GCCCTTGGAC 
CTGGGCTGCA GCTCCTGTGG GACCCCACTA CACGACCAGG GGGGTCCTGT GGAGATCCTT 
CCCTTCCTCT ACCTCGGCAG TGCCTACCAT GCTGCCCGGA GAGACATGCT GGACGCCCTG 
GGCATCACGG CTCTGTTGAA TGTCTCCTCG GACTGCCCAA ACCACTTTGA AGGACACTAT 
CAGTACAAGT GCATCCCAGT GGAAGATAAC CACAAGGCCG ACATCAGCTC CTGGTTCATG 
GAAGCCATAG AGTACATCGA TGCCGTGAAG GACTGCCGTG GGCGCGTGCT GGTGCACTGC 
CAGGCGGGCA TCTCGCGGTC GGCCACCATC TGCCTGGCCT ACCTGATGAT GAAGAAACGG 
GTGAGGCTGG AGGAGGCCTT CGAGTTCGTT AAGCAGCGCC GCAGCATCAT CTCGCCCAAC 
TTCAGCTTCA TGGGGCAGCT GCTGCAGTTC GAGTCCCAGG TGCTGGCCAC GTCCTGTGCT 
GCGGAGGCTG CTAGCCCCTC GGGACCCCTG CGGGAGCGGG GCAAGACCCC CGCCACCCCC 
ACCTCGCAGT TCGTCTTCAG CTTTCCGGTC TCCGTGGGCG TGCACTCGGC CCCCAGCAGC 
CTGCCCTACC TGCACAGCCC CATCACCACC TCTCCCAGCT GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001385.1
CDS	407..1591
Translation	MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC

Target ORF information:

RefSeq Version	NM_001394.7
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001394.7

ORF Insert Sequence:

ATGGTGACGA TGGAGGAGCT GCGGGAGATG GACTGCAGTG TGCTCAAAAG GCTGATGAAC 
CGGGACGAGA ATGGCGGCGG CGCGGGCGGC AGCGGCAGCC ACGGCACCCT GGGGCTGCCG 
AGCGGCGGCA AGTGCCTGCT GCTGGACTGC AGACCGTTCC TGGCGCACAG CGCGGGCTAC 
ATCCTAGGTT CGGTCAACGT GCGCTGTAAC ACCATCGTGC GGCGGCGGGC TAAGGGCTCC 
GTGAGCCTGG AGCAGATCCT GCCCGCCGAG GAGGAGGTAC GCGCCCGCTT GCGCTCCGGC 
CTCTACTCGG CGGTCATCGT CTACGACGAG CGCAGCCCGC GCGCCGAGAG CCTCCGCGAG 
GACAGCACCG TGTCGCTGGT GGTGCAGGCG CTGCGCCGCA ACGCCGAGCG CACCGACATC 
TGCCTGCTCA AAGGCGGCTA TGAGAGGTTT TCCTCCGAGT ACCCAGAATT CTGTTCTAAA 
ACCAAGGCCC TGGCAGCCAT CCCACCCCCG GTTCCCCCCA GTGCCACAGA GCCCTTGGAC 
CTGGGCTGCA GCTCCTGTGG GACCCCACTA CACGACCAGG GGGGTCCTGT GGAGATCCTT 
CCCTTCCTCT ACCTCGGCAG TGCCTACCAT GCTGCCCGGA GAGACATGCT GGACGCCCTG 
GGCATCACGG CTCTGTTGAA TGTCTCCTCG GACTGCCCAA ACCACTTTGA AGGACACTAT 
CAGTACAAGT GCATCCCAGT GGAAGATAAC CACAAGGCCG ACATCAGCTC CTGGTTCATG 
GAAGCCATAG AGTACATCGA TGCCGTGAAG GACTGCCGTG GGCGCGTGCT GGTGCACTGC 
CAGGCGGGCA TCTCGCGGTC GGCCACCATC TGCCTGGCCT ACCTGATGAT GAAGAAACGG 
GTGAGGCTGG AGGAGGCCTT CGAGTTCGTT AAGCAGCGCC GCAGCATCAT CTCGCCCAAC 
TTCAGCTTCA TGGGGCAGCT GCTGCAGTTC GAGTCCCAGG TGCTGGCCAC GTCCTGTGCT 
GCGGAGGCTG CTAGCCCCTC GGGACCCCTG CGGGAGCGGG GCAAGACCCC CGCCACCCCC 
ACCTCGCAGT TCGTCTTCAG CTTTCCGGTC TCCGTGGGCG TGCACTCGGC CCCCAGCAGC 
CTGCCCTACC TGCACAGCCC CATCACCACC TCTCCCAGCT GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DUSP4 ( NM_001394.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_001385.1 Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23480
Clone ID Related Accession (Same CDS sequence)	NM_001394.7 , NM_001394.6
Accession Version	NM_001394.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	dual specificity protein phosphatase 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA645190.1, AK314820.1, AL137704.1, AC084262.6, BC012900.1 and AI123616.1. On Mar 10, 2011 this sequence version replaced NM_001394.5. Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.76161.1, U48807.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146411, SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGACGA TGGAGGAGCT GCGGGAGATG GACTGCAGTG TGCTCAAAAG GCTGATGAAC 
CGGGACGAGA ATGGCGGCGG CGCGGGCGGC AGCGGCAGCC ACGGCACCCT GGGGCTGCCG 
AGCGGCGGCA AGTGCCTGCT GCTGGACTGC AGACCGTTCC TGGCGCACAG CGCGGGCTAC 
ATCCTAGGTT CGGTCAACGT GCGCTGTAAC ACCATCGTGC GGCGGCGGGC TAAGGGCTCC 
GTGAGCCTGG AGCAGATCCT GCCCGCCGAG GAGGAGGTAC GCGCCCGCTT GCGCTCCGGC 
CTCTACTCGG CGGTCATCGT CTACGACGAG CGCAGCCCGC GCGCCGAGAG CCTCCGCGAG 
GACAGCACCG TGTCGCTGGT GGTGCAGGCG CTGCGCCGCA ACGCCGAGCG CACCGACATC 
TGCCTGCTCA AAGGCGGCTA TGAGAGGTTT TCCTCCGAGT ACCCAGAATT CTGTTCTAAA 
ACCAAGGCCC TGGCAGCCAT CCCACCCCCG GTTCCCCCCA GTGCCACAGA GCCCTTGGAC 
CTGGGCTGCA GCTCCTGTGG GACCCCACTA CACGACCAGG GGGGTCCTGT GGAGATCCTT 
CCCTTCCTCT ACCTCGGCAG TGCCTACCAT GCTGCCCGGA GAGACATGCT GGACGCCCTG 
GGCATCACGG CTCTGTTGAA TGTCTCCTCG GACTGCCCAA ACCACTTTGA AGGACACTAT 
CAGTACAAGT GCATCCCAGT GGAAGATAAC CACAAGGCCG ACATCAGCTC CTGGTTCATG 
GAAGCCATAG AGTACATCGA TGCCGTGAAG GACTGCCGTG GGCGCGTGCT GGTGCACTGC 
CAGGCGGGCA TCTCGCGGTC GGCCACCATC TGCCTGGCCT ACCTGATGAT GAAGAAACGG 
GTGAGGCTGG AGGAGGCCTT CGAGTTCGTT AAGCAGCGCC GCAGCATCAT CTCGCCCAAC 
TTCAGCTTCA TGGGGCAGCT GCTGCAGTTC GAGTCCCAGG TGCTGGCCAC GTCCTGTGCT 
GCGGAGGCTG CTAGCCCCTC GGGACCCCTG CGGGAGCGGG GCAAGACCCC CGCCACCCCC 
ACCTCGCAGT TCGTCTTCAG CTTTCCGGTC TCCGTGGGCG TGCACTCGGC CCCCAGCAGC 
CTGCCCTACC TGCACAGCCC CATCACCACC TCTCCCAGCT GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001385.1
CDS	473..1657
Translation	MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC

Target ORF information:

RefSeq Version	NM_001394.6
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001394.6

ORF Insert Sequence:

ATGGTGACGA TGGAGGAGCT GCGGGAGATG GACTGCAGTG TGCTCAAAAG GCTGATGAAC 
CGGGACGAGA ATGGCGGCGG CGCGGGCGGC AGCGGCAGCC ACGGCACCCT GGGGCTGCCG 
AGCGGCGGCA AGTGCCTGCT GCTGGACTGC AGACCGTTCC TGGCGCACAG CGCGGGCTAC 
ATCCTAGGTT CGGTCAACGT GCGCTGTAAC ACCATCGTGC GGCGGCGGGC TAAGGGCTCC 
GTGAGCCTGG AGCAGATCCT GCCCGCCGAG GAGGAGGTAC GCGCCCGCTT GCGCTCCGGC 
CTCTACTCGG CGGTCATCGT CTACGACGAG CGCAGCCCGC GCGCCGAGAG CCTCCGCGAG 
GACAGCACCG TGTCGCTGGT GGTGCAGGCG CTGCGCCGCA ACGCCGAGCG CACCGACATC 
TGCCTGCTCA AAGGCGGCTA TGAGAGGTTT TCCTCCGAGT ACCCAGAATT CTGTTCTAAA 
ACCAAGGCCC TGGCAGCCAT CCCACCCCCG GTTCCCCCCA GTGCCACAGA GCCCTTGGAC 
CTGGGCTGCA GCTCCTGTGG GACCCCACTA CACGACCAGG GGGGTCCTGT GGAGATCCTT 
CCCTTCCTCT ACCTCGGCAG TGCCTACCAT GCTGCCCGGA GAGACATGCT GGACGCCCTG 
GGCATCACGG CTCTGTTGAA TGTCTCCTCG GACTGCCCAA ACCACTTTGA AGGACACTAT 
CAGTACAAGT GCATCCCAGT GGAAGATAAC CACAAGGCCG ACATCAGCTC CTGGTTCATG 
GAAGCCATAG AGTACATCGA TGCCGTGAAG GACTGCCGTG GGCGCGTGCT GGTGCACTGC 
CAGGCGGGCA TCTCGCGGTC GGCCACCATC TGCCTGGCCT ACCTGATGAT GAAGAAACGG 
GTGAGGCTGG AGGAGGCCTT CGAGTTCGTT AAGCAGCGCC GCAGCATCAT CTCGCCCAAC 
TTCAGCTTCA TGGGGCAGCT GCTGCAGTTC GAGTCCCAGG TGCTGGCCAC GTCCTGTGCT 
GCGGAGGCTG CTAGCCCCTC GGGACCCCTG CGGGAGCGGG GCAAGACCCC CGCCACCCCC 
ACCTCGCAGT TCGTCTTCAG CTTTCCGGTC TCCGTGGGCG TGCACTCGGC CCCCAGCAGC 
CTGCCCTACC TGCACAGCCC CATCACCACC TCTCCCAGCT GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DUSP4 ( NM_057158.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_476499.1 Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23661
Clone ID Related Accession (Same CDS sequence)	XM_011544428.1 , NM_057158.3 , XM_011544428.3 , XM_011544428.2
Accession Version	NM_057158.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-25
Organism	Homo sapiens(human)
Product	dual specificity protein phosphatase 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL137704.1, AC084262.6, BC012900.1 and AI123616.1. On Mar 10, 2011 this sequence version replaced NM_057158.2. Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL137704.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAAGAA AAGTTCACTC CAACGGAAGC CAGTTTGCTG AACATAGCAG ATCGCCCAGG 
AGGACTGGGA GAGACTGCAA ACCAGTTCGA GCCCCCAGCA TGGCGTTAGG TGTCAGCCAG 
CTGGCAGGAA GGTCCAGGTG TCTGTGTTCA GAGTCTCAAG GCGGCTATGA GAGGTTTTCC 
TCCGAGTACC CAGAATTCTG TTCTAAAACC AAGGCCCTGG CAGCCATCCC ACCCCCGGTT 
CCCCCCAGTG CCACAGAGCC CTTGGACCTG GGCTGCAGCT CCTGTGGGAC CCCACTACAC 
GACCAGGGGG GTCCTGTGGA GATCCTTCCC TTCCTCTACC TCGGCAGTGC CTACCATGCT 
GCCCGGAGAG ACATGCTGGA CGCCCTGGGC ATCACGGCTC TGTTGAATGT CTCCTCGGAC 
TGCCCAAACC ACTTTGAAGG ACACTATCAG TACAAGTGCA TCCCAGTGGA AGATAACCAC 
AAGGCCGACA TCAGCTCCTG GTTCATGGAA GCCATAGAGT ACATCGATGC CGTGAAGGAC 
TGCCGTGGGC GCGTGCTGGT GCACTGCCAG GCGGGCATCT CGCGGTCGGC CACCATCTGC 
CTGGCCTACC TGATGATGAA GAAACGGGTG AGGCTGGAGG AGGCCTTCGA GTTCGTTAAG 
CAGCGCCGCA GCATCATCTC GCCCAACTTC AGCTTCATGG GGCAGCTGCT GCAGTTCGAG 
TCCCAGGTGC TGGCCACGTC CTGTGCTGCG GAGGCTGCTA GCCCCTCGGG ACCCCTGCGG 
GAGCGGGGCA AGACCCCCGC CACCCCCACC TCGCAGTTCG TCTTCAGCTT TCCGGTCTCC 
GTGGGCGTGC ACTCGGCCCC CAGCAGCCTG CCCTACCTGC ACAGCCCCAT CACCACCTCT 
CCCAGCTGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476499.1
CDS	1561..2472
Translation	MGRKVHSNGSQFAEHSRSPRRTGRDCKPVRAPSMALGVSQLAGRSRCLCSESQGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC

Target ORF information:

RefSeq Version	NM_057158.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057158.3

ORF Insert Sequence:

ATGGGAAGAA AAGTTCACTC CAACGGAAGC CAGTTTGCTG AACATAGCAG ATCGCCCAGG 
AGGACTGGGA GAGACTGCAA ACCAGTTCGA GCCCCCAGCA TGGCGTTAGG TGTCAGCCAG 
CTGGCAGGAA GGTCCAGGTG TCTGTGTTCA GAGTCTCAAG GCGGCTATGA GAGGTTTTCC 
TCCGAGTACC CAGAATTCTG TTCTAAAACC AAGGCCCTGG CAGCCATCCC ACCCCCGGTT 
CCCCCCAGTG CCACAGAGCC CTTGGACCTG GGCTGCAGCT CCTGTGGGAC CCCACTACAC 
GACCAGGGGG GTCCTGTGGA GATCCTTCCC TTCCTCTACC TCGGCAGTGC CTACCATGCT 
GCCCGGAGAG ACATGCTGGA CGCCCTGGGC ATCACGGCTC TGTTGAATGT CTCCTCGGAC 
TGCCCAAACC ACTTTGAAGG ACACTATCAG TACAAGTGCA TCCCAGTGGA AGATAACCAC 
AAGGCCGACA TCAGCTCCTG GTTCATGGAA GCCATAGAGT ACATCGATGC CGTGAAGGAC 
TGCCGTGGGC GCGTGCTGGT GCACTGCCAG GCGGGCATCT CGCGGTCGGC CACCATCTGC 
CTGGCCTACC TGATGATGAA GAAACGGGTG AGGCTGGAGG AGGCCTTCGA GTTCGTTAAG 
CAGCGCCGCA GCATCATCTC GCCCAACTTC AGCTTCATGG GGCAGCTGCT GCAGTTCGAG 
TCCCAGGTGC TGGCCACGTC CTGTGCTGCG GAGGCTGCTA GCCCCTCGGG ACCCCTGCGG 
GAGCGGGGCA AGACCCCCGC CACCCCCACC TCGCAGTTCG TCTTCAGCTT TCCGGTCTCC 
GTGGGCGTGC ACTCGGCCCC CAGCAGCCTG CCCTACCTGC ACAGCCCCAT CACCACCTCT 
CCCAGCTGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DUSP4 ( XM_011544428.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542730.1 Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant X1, mRNA.

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CloneID	OHu23661
Clone ID Related Accession (Same CDS sequence)	XM_011544428.1 , NM_057158.3 , XM_011544428.3 , XM_011544428.2
Accession Version	XM_011544428.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	dual specificity protein phosphatase 4 isoform X1
Comment

ATGGGAAGAA AAGTTCACTC CAACGGAAGC CAGTTTGCTG AACATAGCAG ATCGCCCAGG 
AGGACTGGGA GAGACTGCAA ACCAGTTCGA GCCCCCAGCA TGGCGTTAGG TGTCAGCCAG 
CTGGCAGGAA GGTCCAGGTG TCTGTGTTCA GAGTCTCAAG GCGGCTATGA GAGGTTTTCC 
TCCGAGTACC CAGAATTCTG TTCTAAAACC AAGGCCCTGG CAGCCATCCC ACCCCCGGTT 
CCCCCCAGTG CCACAGAGCC CTTGGACCTG GGCTGCAGCT CCTGTGGGAC CCCACTACAC 
GACCAGGGGG GTCCTGTGGA GATCCTTCCC TTCCTCTACC TCGGCAGTGC CTACCATGCT 
GCCCGGAGAG ACATGCTGGA CGCCCTGGGC ATCACGGCTC TGTTGAATGT CTCCTCGGAC 
TGCCCAAACC ACTTTGAAGG ACACTATCAG TACAAGTGCA TCCCAGTGGA AGATAACCAC 
AAGGCCGACA TCAGCTCCTG GTTCATGGAA GCCATAGAGT ACATCGATGC CGTGAAGGAC 
TGCCGTGGGC GCGTGCTGGT GCACTGCCAG GCGGGCATCT CGCGGTCGGC CACCATCTGC 
CTGGCCTACC TGATGATGAA GAAACGGGTG AGGCTGGAGG AGGCCTTCGA GTTCGTTAAG 
CAGCGCCGCA GCATCATCTC GCCCAACTTC AGCTTCATGG GGCAGCTGCT GCAGTTCGAG 
TCCCAGGTGC TGGCCACGTC CTGTGCTGCG GAGGCTGCTA GCCCCTCGGG ACCCCTGCGG 
GAGCGGGGCA AGACCCCCGC CACCCCCACC TCGCAGTTCG TCTTCAGCTT TCCGGTCTCC 
GTGGGCGTGC ACTCGGCCCC CAGCAGCCTG CCCTACCTGC ACAGCCCCAT CACCACCTCT 
CCCAGCTGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542730.1
Translation	MGRKVHSNGSQFAEHSRSPRRTGRDCKPVRAPSMALGVSQLAGRSRCLCSESQGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC

Target ORF information:

RefSeq Version	XM_011544428.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544428.1

ORF Insert Sequence:

ATGGGAAGAA AAGTTCACTC CAACGGAAGC CAGTTTGCTG AACATAGCAG ATCGCCCAGG 
AGGACTGGGA GAGACTGCAA ACCAGTTCGA GCCCCCAGCA TGGCGTTAGG TGTCAGCCAG 
CTGGCAGGAA GGTCCAGGTG TCTGTGTTCA GAGTCTCAAG GCGGCTATGA GAGGTTTTCC 
TCCGAGTACC CAGAATTCTG TTCTAAAACC AAGGCCCTGG CAGCCATCCC ACCCCCGGTT 
CCCCCCAGTG CCACAGAGCC CTTGGACCTG GGCTGCAGCT CCTGTGGGAC CCCACTACAC 
GACCAGGGGG GTCCTGTGGA GATCCTTCCC TTCCTCTACC TCGGCAGTGC CTACCATGCT 
GCCCGGAGAG ACATGCTGGA CGCCCTGGGC ATCACGGCTC TGTTGAATGT CTCCTCGGAC 
TGCCCAAACC ACTTTGAAGG ACACTATCAG TACAAGTGCA TCCCAGTGGA AGATAACCAC 
AAGGCCGACA TCAGCTCCTG GTTCATGGAA GCCATAGAGT ACATCGATGC CGTGAAGGAC 
TGCCGTGGGC GCGTGCTGGT GCACTGCCAG GCGGGCATCT CGCGGTCGGC CACCATCTGC 
CTGGCCTACC TGATGATGAA GAAACGGGTG AGGCTGGAGG AGGCCTTCGA GTTCGTTAAG 
CAGCGCCGCA GCATCATCTC GCCCAACTTC AGCTTCATGG GGCAGCTGCT GCAGTTCGAG 
TCCCAGGTGC TGGCCACGTC CTGTGCTGCG GAGGCTGCTA GCCCCTCGGG ACCCCTGCGG 
GAGCGGGGCA AGACCCCCGC CACCCCCACC TCGCAGTTCG TCTTCAGCTT TCCGGTCTCC 
GTGGGCGTGC ACTCGGCCCC CAGCAGCCTG CCCTACCTGC ACAGCCCCAT CACCACCTCT 
CCCAGCTGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DUSP4 ( XM_011544428.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542730.1 Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu23661
Clone ID Related Accession (Same CDS sequence)	XM_011544428.1 , NM_057158.3 , XM_011544428.3 , XM_011544428.2
Accession Version	XM_011544428.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	dual specificity protein phosphatase 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011544428.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAAGAA AAGTTCACTC CAACGGAAGC CAGTTTGCTG AACATAGCAG ATCGCCCAGG 
AGGACTGGGA GAGACTGCAA ACCAGTTCGA GCCCCCAGCA TGGCGTTAGG TGTCAGCCAG 
CTGGCAGGAA GGTCCAGGTG TCTGTGTTCA GAGTCTCAAG GCGGCTATGA GAGGTTTTCC 
TCCGAGTACC CAGAATTCTG TTCTAAAACC AAGGCCCTGG CAGCCATCCC ACCCCCGGTT 
CCCCCCAGTG CCACAGAGCC CTTGGACCTG GGCTGCAGCT CCTGTGGGAC CCCACTACAC 
GACCAGGGGG GTCCTGTGGA GATCCTTCCC TTCCTCTACC TCGGCAGTGC CTACCATGCT 
GCCCGGAGAG ACATGCTGGA CGCCCTGGGC ATCACGGCTC TGTTGAATGT CTCCTCGGAC 
TGCCCAAACC ACTTTGAAGG ACACTATCAG TACAAGTGCA TCCCAGTGGA AGATAACCAC 
AAGGCCGACA TCAGCTCCTG GTTCATGGAA GCCATAGAGT ACATCGATGC CGTGAAGGAC 
TGCCGTGGGC GCGTGCTGGT GCACTGCCAG GCGGGCATCT CGCGGTCGGC CACCATCTGC 
CTGGCCTACC TGATGATGAA GAAACGGGTG AGGCTGGAGG AGGCCTTCGA GTTCGTTAAG 
CAGCGCCGCA GCATCATCTC GCCCAACTTC AGCTTCATGG GGCAGCTGCT GCAGTTCGAG 
TCCCAGGTGC TGGCCACGTC CTGTGCTGCG GAGGCTGCTA GCCCCTCGGG ACCCCTGCGG 
GAGCGGGGCA AGACCCCCGC CACCCCCACC TCGCAGTTCG TCTTCAGCTT TCCGGTCTCC 
GTGGGCGTGC ACTCGGCCCC CAGCAGCCTG CCCTACCTGC ACAGCCCCAT CACCACCTCT 
CCCAGCTGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542730.1
CDS	3303..4214
Translation	MGRKVHSNGSQFAEHSRSPRRTGRDCKPVRAPSMALGVSQLAGRSRCLCSESQGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC

Target ORF information:

RefSeq Version	XM_011544428.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544428.3

ORF Insert Sequence:

ATGGGAAGAA AAGTTCACTC CAACGGAAGC CAGTTTGCTG AACATAGCAG ATCGCCCAGG 
AGGACTGGGA GAGACTGCAA ACCAGTTCGA GCCCCCAGCA TGGCGTTAGG TGTCAGCCAG 
CTGGCAGGAA GGTCCAGGTG TCTGTGTTCA GAGTCTCAAG GCGGCTATGA GAGGTTTTCC 
TCCGAGTACC CAGAATTCTG TTCTAAAACC AAGGCCCTGG CAGCCATCCC ACCCCCGGTT 
CCCCCCAGTG CCACAGAGCC CTTGGACCTG GGCTGCAGCT CCTGTGGGAC CCCACTACAC 
GACCAGGGGG GTCCTGTGGA GATCCTTCCC TTCCTCTACC TCGGCAGTGC CTACCATGCT 
GCCCGGAGAG ACATGCTGGA CGCCCTGGGC ATCACGGCTC TGTTGAATGT CTCCTCGGAC 
TGCCCAAACC ACTTTGAAGG ACACTATCAG TACAAGTGCA TCCCAGTGGA AGATAACCAC 
AAGGCCGACA TCAGCTCCTG GTTCATGGAA GCCATAGAGT ACATCGATGC CGTGAAGGAC 
TGCCGTGGGC GCGTGCTGGT GCACTGCCAG GCGGGCATCT CGCGGTCGGC CACCATCTGC 
CTGGCCTACC TGATGATGAA GAAACGGGTG AGGCTGGAGG AGGCCTTCGA GTTCGTTAAG 
CAGCGCCGCA GCATCATCTC GCCCAACTTC AGCTTCATGG GGCAGCTGCT GCAGTTCGAG 
TCCCAGGTGC TGGCCACGTC CTGTGCTGCG GAGGCTGCTA GCCCCTCGGG ACCCCTGCGG 
GAGCGGGGCA AGACCCCCGC CACCCCCACC TCGCAGTTCG TCTTCAGCTT TCCGGTCTCC 
GTGGGCGTGC ACTCGGCCCC CAGCAGCCTG CCCTACCTGC ACAGCCCCAT CACCACCTCT 
CCCAGCTGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DUSP4 ( XM_011544428.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011542730.1 Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu23661
Clone ID Related Accession (Same CDS sequence)	XM_011544428.1 , NM_057158.3 , XM_011544428.3 , XM_011544428.2
Accession Version	XM_011544428.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	dual specificity protein phosphatase 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011544428.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAAGAA AAGTTCACTC CAACGGAAGC CAGTTTGCTG AACATAGCAG ATCGCCCAGG 
AGGACTGGGA GAGACTGCAA ACCAGTTCGA GCCCCCAGCA TGGCGTTAGG TGTCAGCCAG 
CTGGCAGGAA GGTCCAGGTG TCTGTGTTCA GAGTCTCAAG GCGGCTATGA GAGGTTTTCC 
TCCGAGTACC CAGAATTCTG TTCTAAAACC AAGGCCCTGG CAGCCATCCC ACCCCCGGTT 
CCCCCCAGTG CCACAGAGCC CTTGGACCTG GGCTGCAGCT CCTGTGGGAC CCCACTACAC 
GACCAGGGGG GTCCTGTGGA GATCCTTCCC TTCCTCTACC TCGGCAGTGC CTACCATGCT 
GCCCGGAGAG ACATGCTGGA CGCCCTGGGC ATCACGGCTC TGTTGAATGT CTCCTCGGAC 
TGCCCAAACC ACTTTGAAGG ACACTATCAG TACAAGTGCA TCCCAGTGGA AGATAACCAC 
AAGGCCGACA TCAGCTCCTG GTTCATGGAA GCCATAGAGT ACATCGATGC CGTGAAGGAC 
TGCCGTGGGC GCGTGCTGGT GCACTGCCAG GCGGGCATCT CGCGGTCGGC CACCATCTGC 
CTGGCCTACC TGATGATGAA GAAACGGGTG AGGCTGGAGG AGGCCTTCGA GTTCGTTAAG 
CAGCGCCGCA GCATCATCTC GCCCAACTTC AGCTTCATGG GGCAGCTGCT GCAGTTCGAG 
TCCCAGGTGC TGGCCACGTC CTGTGCTGCG GAGGCTGCTA GCCCCTCGGG ACCCCTGCGG 
GAGCGGGGCA AGACCCCCGC CACCCCCACC TCGCAGTTCG TCTTCAGCTT TCCGGTCTCC 
GTGGGCGTGC ACTCGGCCCC CAGCAGCCTG CCCTACCTGC ACAGCCCCAT CACCACCTCT 
CCCAGCTGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011542730.1
CDS	3306..4217
Translation	MGRKVHSNGSQFAEHSRSPRRTGRDCKPVRAPSMALGVSQLAGRSRCLCSESQGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC

Target ORF information:

RefSeq Version	XM_011544428.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011544428.2

ORF Insert Sequence:

ATGGGAAGAA AAGTTCACTC CAACGGAAGC CAGTTTGCTG AACATAGCAG ATCGCCCAGG 
AGGACTGGGA GAGACTGCAA ACCAGTTCGA GCCCCCAGCA TGGCGTTAGG TGTCAGCCAG 
CTGGCAGGAA GGTCCAGGTG TCTGTGTTCA GAGTCTCAAG GCGGCTATGA GAGGTTTTCC 
TCCGAGTACC CAGAATTCTG TTCTAAAACC AAGGCCCTGG CAGCCATCCC ACCCCCGGTT 
CCCCCCAGTG CCACAGAGCC CTTGGACCTG GGCTGCAGCT CCTGTGGGAC CCCACTACAC 
GACCAGGGGG GTCCTGTGGA GATCCTTCCC TTCCTCTACC TCGGCAGTGC CTACCATGCT 
GCCCGGAGAG ACATGCTGGA CGCCCTGGGC ATCACGGCTC TGTTGAATGT CTCCTCGGAC 
TGCCCAAACC ACTTTGAAGG ACACTATCAG TACAAGTGCA TCCCAGTGGA AGATAACCAC 
AAGGCCGACA TCAGCTCCTG GTTCATGGAA GCCATAGAGT ACATCGATGC CGTGAAGGAC 
TGCCGTGGGC GCGTGCTGGT GCACTGCCAG GCGGGCATCT CGCGGTCGGC CACCATCTGC 
CTGGCCTACC TGATGATGAA GAAACGGGTG AGGCTGGAGG AGGCCTTCGA GTTCGTTAAG 
CAGCGCCGCA GCATCATCTC GCCCAACTTC AGCTTCATGG GGCAGCTGCT GCAGTTCGAG 
TCCCAGGTGC TGGCCACGTC CTGTGCTGCG GAGGCTGCTA GCCCCTCGGG ACCCCTGCGG 
GAGCGGGGCA AGACCCCCGC CACCCCCACC TCGCAGTTCG TCTTCAGCTT TCCGGTCTCC 
GTGGGCGTGC ACTCGGCCCC CAGCAGCCTG CCCTACCTGC ACAGCCCCAT CACCACCTCT 
CCCAGCTGTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas.
Cancer science109(1)250-258(2018 Jan)
Ichimanda M,Hijiya N,Tsukamoto Y,Uchida T,Nakada C,Akagi T,Etoh T,Iha H,Inomata M,Takekawa M,Moriyama M

Sanguinarine inhibits growth and invasion of gastric cancer cells via regulation of the DUSP4/ERK pathway.
Journal of cellular and molecular medicine21(6)1117-1127(2017 Jun)
Zhang R,Wang G,Zhang PF,Zhang J,Huang YX,Lu YM,Da W,Sun Q,Zhu JS

Impaired Dual-Specificity Protein Phosphatase DUSP4 Reduces Corticosteroid Sensitivity.
Molecular pharmacology91(5)475-481(2017 May)
Kobayashi Y,Ito K,Kanda A,Tomoda K,Mercado N,Barnes PJ

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.
Breast cancer research and treatment158(3)441-54(2016 08)
Mazumdar A,Poage GM,Shepherd J,Tsimelzon A,Hartman ZC,Den Hollander P,Hill J,Zhang Y,Chang J,Hilsenbeck SG,Fuqua S,Kent Osborne C,Mills GB,Brown PH

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DUSP4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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