COMMD6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COMMD6
Entrez Gene ID	170622
Full Name	COMM domain containing 6
Synonyms	Acrg
General protein information	Preferred Names COMM domain containing 6 Names COMM domain-containing protein 6 Acrg embryonic lethality minimal region ortholog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q22.2
Summary	COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009].
Disorder MIM:	612377

mRNA and Protein(s)

mRNA	Protein	Name
NM_203497.3	NP_987093.1	COMM domain-containing protein 6 isoform a
NM_203495.3	NP_987091.1	COMM domain-containing protein 6 isoform b
XM_011534948.2	XP_011533250.1	COMM domain-containing protein 6 isoform X1
NM_001287393.1	NP_001274322.1	COMM domain-containing protein 6 isoform c
NM_001287394.1	NP_001274323.1	COMM domain-containing protein 6 isoform c
NM_001287392.1	NP_001274321.1	COMM domain-containing protein 6 isoform c

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.
Phillips-Krawczak CA, Singla A, Starokadomskyy P, Deng Z, Osborne DG, Li H, Dick CJ, Gomez TS, Koenecke M, Zhang JS, Dai H, Sifuentes-Dominguez LF, Geng LN, Kaufmann SH, Hein MY, Wallis M, McGaughran J, Gecz J, Sluis Bv, Billadeau DD, Burstein E
Molecular biology of the cell26(1)91-103(2015 Jan)

Genome-wide association study in a Chinese population with diabetic retinopathy.
Sheu WH, Kuo JZ, Lee IT, Hung YJ, Lee WJ, Tsai HY, Wang JS, Goodarzi MO, Klein R, Klein BE, Ipp E, Lin SY, Guo X, Hsieh CH, Taylor KD, Fu CP, Rotter JI, Chen YD
Human molecular genetics22(15)3165-73(2013 Aug)

CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling.
Starokadomskyy P, Gluck N, Li H, Chen B, Wallis M, Maine GN, Mao X, Zaidi IW, Hein MY, McDonald FJ, Lenzner S, Zecha A, Ropers HH, Kuss AW, McGaughran J, Gecz J, Burstein E
The Journal of clinical investigation123(5)2244-56(2013 May)

Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation.
Kang JG, Amar MJ, Remaley AT, Kwon J, Blackshear PJ, Wang PY, Hwang PM
Journal of immunology (Baltimore, Md. : 1950)187(5)2696-701(2011 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data support the significance of COMMD protein-protein interactions and provide new mechanistic insight into the function of this protein family in NF-kappaB signalling.
Title: Characterization of COMMD protein-protein interactions in NF-kappaB signalling.

The following COMMD6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COMMD6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02982	NM_203495.3 Latest version!	Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu02992	NM_203497.3 Latest version!	Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu06097	NM_001287394.1 Latest version!	Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu06097	NM_001287392.1 Latest version!	Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu06097	NM_001287393.1 Latest version!	Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu77417	XM_011534948.2 Latest version!	Homo sapiens COMM domain containing 6 (COMMD6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COMMD6 ( NM_203495.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_987091.1 Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02982
Clone ID Related Accession (Same CDS sequence)	NM_203495.3
Accession Version	NM_203495.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 258bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	COMM domain-containing protein 6 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY105279.1, BC110837.1, DB574884.1, BX106312.1 and AA425275.1. On Dec 13, 2013 this sequence version replaced NM_203495.2. Transcript Variant: This variant (2) lacks an in-frame coding exon in the 3' region compared to variant 1. The resulting shorter isoform (b) lacks a 13 aa protein segment compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.51975.1, SRR1803615.167086.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCGT CCAGCGAGCC GCCGCTGGAT GCTAAGTCCG ATGTCACCAA CCAGCTTGTA 
GATTTTCAGT GGAAACTGGG TATGGCTGTG AGCTCAGACA CTTGCAGATC TCTTAAGTAT 
CCTTACGTTG CAGTGATGCT AAAAGTGGCA GATCATTCAG GCCAAGTAAA GACCAAGTGC 
TTTGAAATGA CGATTCCACA GTTTCAGAAT TTCTACAGAC AGTTCAAGGA AATTGCTGCA 
GTTATTGAAA CGGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_987091.1
CDS	68..325
Translation	MEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQNFYRQFKEIAAVIETV

Target ORF information:

RefSeq Version	NM_203495.3
Organism	Homo sapiens(human)
Definition	Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_203495.3

ORF Insert Sequence:

ATGGAGGCGT CCAGCGAGCC GCCGCTGGAT GCTAAGTCCG ATGTCACCAA CCAGCTTGTA 
GATTTTCAGT GGAAACTGGG TATGGCTGTG AGCTCAGACA CTTGCAGATC TCTTAAGTAT 
CCTTACGTTG CAGTGATGCT AAAAGTGGCA GATCATTCAG GCCAAGTAAA GACCAAGTGC 
TTTGAAATGA CGATTCCACA GTTTCAGAAT TTCTACAGAC AGTTCAAGGA AATTGCTGCA 
GTTATTGAAA CGGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COMMD6 ( NM_203497.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_987093.1 Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02992
Clone ID Related Accession (Same CDS sequence)	NM_203497.3
Accession Version	NM_203497.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 297bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	COMM domain-containing protein 6 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY105279.1, HY028175.1, BC110837.1, DB574884.1, BX106312.1, AA425275.1 and W94914.1. On Dec 13, 2013 this sequence version replaced NM_203497.2. Transcript Variant: This variant (1) encodes the longest isoform (a). ##Evidence-Data-START## Transcript exon combination :: SRR1803612.313128.1, HY028175.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCGT CCAGCGAGCC GCCGCTGGAT GCTAAGTCCG ATGTCACCAA CCAGCTTGTA 
GATTTTCAGT GGAAACTGGG TATGGCTGTG AGCTCAGACA CTTGCAGATC TCTTAAGTAT 
CCTTACGTTG CAGTGATGCT AAAAGTGGCA GATCATTCAG GCCAAGTAAA GACCAAGTGC 
TTTGAAATGA CGATTCCACA GTTTCAGCCT CAGCTCCTGG CAACCTCCAG TCTCCTTTCT 
GCTTCTAATT TCTACAGACA GTTCAAGGAA ATTGCTGCAG TTATTGAAAC GGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_987093.1
CDS	68..364
Translation	MEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQPQLLATSSLLSASNFYRQFKEIAAVIETV

Target ORF information:

RefSeq Version	NM_203497.3
Organism	Homo sapiens(human)
Definition	Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_203497.3

ORF Insert Sequence:

ATGGAGGCGT CCAGCGAGCC GCCGCTGGAT GCTAAGTCCG ATGTCACCAA CCAGCTTGTA 
GATTTTCAGT GGAAACTGGG TATGGCTGTG AGCTCAGACA CTTGCAGATC TCTTAAGTAT 
CCTTACGTTG CAGTGATGCT AAAAGTGGCA GATCATTCAG GCCAAGTAAA GACCAAGTGC 
TTTGAAATGA CGATTCCACA GTTTCAGCCT CAGCTCCTGG CAACCTCCAG TCTCCTTTCT 
GCTTCTAATT TCTACAGACA GTTCAAGGAA ATTGCTGCAG TTATTGAAAC GGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COMMD6 ( NM_001287393.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001274322.1 Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu06097
Clone ID Related Accession (Same CDS sequence)	NM_001287393.1 , NM_001287394.1 , NM_001287392.1
Accession Version	NM_001287393.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 177bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	COMM domain-containing protein 6 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY105279.1, HY045286.1, BC110837.1, DB574884.1, BX106312.1 and AA425275.1. Transcript Variant: This variant (4) is alternatively spliced in the 5' region (which results in translation initiation from an in-frame downstream start codon) and lacks an in-frame coding exon in the 3' region compared to variant 1. The resulting isoform (c) has a shorter N-terminus and lacks a 13 aa protein segment compared to isoform 1. Variants 3-5 encode the same isoform. ##Evidence-Data-START## Transcript exon combination :: HY045286.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGGCTGTGA GCTCAGACAC TTGCAGATCT CTTAAGTATC CTTACGTTGC AGTGATGCTA 
AAAGTGGCAG ATCATTCAGG CCAAGTAAAG ACCAAGTGCT TTGAAATGAC GATTCCACAG 
TTTCAGAATT TCTACAGACA GTTCAAGGAA ATTGCTGCAG TTATTGAAAC GGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001274322.1
CDS	314..490
Translation	MAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQNFYRQFKEIAAVIETV

Target ORF information:

RefSeq Version	NM_001287393.1
Organism	Homo sapiens(human)
Definition	Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001287393.1

ORF Insert Sequence:

1
61
121

ATGGCTGTGA GCTCAGACAC TTGCAGATCT CTTAAGTATC CTTACGTTGC AGTGATGCTA 
AAAGTGGCAG ATCATTCAGG CCAAGTAAAG ACCAAGTGCT TTGAAATGAC GATTCCACAG 
TTTCAGAATT TCTACAGACA GTTCAAGGAA ATTGCTGCAG TTATTGAAAC GGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COMMD6 ( NM_001287394.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001274323.1 Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu06097
Clone ID Related Accession (Same CDS sequence)	NM_001287393.1 , NM_001287394.1 , NM_001287392.1
Accession Version	NM_001287394.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 177bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	COMM domain-containing protein 6 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB489071.1, DB509325.2, DB574884.1, BX106312.1 and AA425275.1. Transcript Variant: This variant (5) contains a novel 5' terminal exon, lacks 2 exons in the 5' region (which result in translation initiation from an in-frame downstream start codon) and an in-frame coding exon in the 3' region compared to variant 1. The resulting isoform (c) has a shorter N-terminus and lacks a 13 aa protein segment compared to isoform 1. Variants 3-5 encode the same isoform. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.64943.1, DB509325.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2157437, SAMEA2467147 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGGCTGTGA GCTCAGACAC TTGCAGATCT CTTAAGTATC CTTACGTTGC AGTGATGCTA 
AAAGTGGCAG ATCATTCAGG CCAAGTAAAG ACCAAGTGCT TTGAAATGAC GATTCCACAG 
TTTCAGAATT TCTACAGACA GTTCAAGGAA ATTGCTGCAG TTATTGAAAC GGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001274323.1
CDS	145..321
Translation	MAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQNFYRQFKEIAAVIETV

Target ORF information:

RefSeq Version	NM_001287394.1
Organism	Homo sapiens(human)
Definition	Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001287394.1

ORF Insert Sequence:

1
61
121

ATGGCTGTGA GCTCAGACAC TTGCAGATCT CTTAAGTATC CTTACGTTGC AGTGATGCTA 
AAAGTGGCAG ATCATTCAGG CCAAGTAAAG ACCAAGTGCT TTGAAATGAC GATTCCACAG 
TTTCAGAATT TCTACAGACA GTTCAAGGAA ATTGCTGCAG TTATTGAAAC GGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COMMD6 ( NM_001287392.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001274321.1 Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu06097
Clone ID Related Accession (Same CDS sequence)	NM_001287393.1 , NM_001287394.1 , NM_001287392.1
Accession Version	NM_001287392.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 177bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	COMM domain-containing protein 6 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY105279.1, BX538116.1, DB574884.1, BX106312.1 and AA425275.1. Transcript Variant: This variant (3) is alternatively spliced in the 5' region (which results in translation initiation from an in-frame downstream start codon) and lacks an in-frame coding exon in the 3' region compared to variant 1. The resulting isoform (c) has a shorter N-terminus and lacks a 13 aa protein segment compared to isoform 1. Variants 3-5 encode the same isoform. ##Evidence-Data-START## Transcript exon combination :: BX538116.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGGCTGTGA GCTCAGACAC TTGCAGATCT CTTAAGTATC CTTACGTTGC AGTGATGCTA 
AAAGTGGCAG ATCATTCAGG CCAAGTAAAG ACCAAGTGCT TTGAAATGAC GATTCCACAG 
TTTCAGAATT TCTACAGACA GTTCAAGGAA ATTGCTGCAG TTATTGAAAC GGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001274321.1
CDS	329..505
Translation	MAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQNFYRQFKEIAAVIETV

Target ORF information:

RefSeq Version	NM_001287392.1
Organism	Homo sapiens(human)
Definition	Homo sapiens COMM domain containing 6 (COMMD6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001287392.1

ORF Insert Sequence:

1
61
121

ATGGCTGTGA GCTCAGACAC TTGCAGATCT CTTAAGTATC CTTACGTTGC AGTGATGCTA 
AAAGTGGCAG ATCATTCAGG CCAAGTAAAG ACCAAGTGCT TTGAAATGAC GATTCCACAG 
TTTCAGAATT TCTACAGACA GTTCAAGGAA ATTGCTGCAG TTATTGAAAC GGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COMMD6 ( XM_011534948.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011533250.1 Homo sapiens COMM domain containing 6 (COMMD6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu77417
Clone ID Related Accession (Same CDS sequence)	XM_011534948.2
Accession Version	XM_011534948.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	COMM domain-containing protein 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011534948.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTTCC CCTGCTACGT CCGCCCCATG CGCCAGGCCG CTAGGGGCAG GACGTGGAAG 
CGGAAGCGCT GGTCTGGGGG CGTTCTCTCG AGTCCGGGCC GCAAGTCCCA GACGCTGCCC 
ATGGAGGCGT CCAGCGAGCC GCCGCTGGAT GCTAAGTCCG ATGTCACCAA CCAGCTTGTA 
GATTTTCAGT GGAAACTGGG TATGGCTGTG AGCTCAGACA CTTGCAGATC TCTTAAGTAT 
CCTTACGTTG CAGTGATGCT AAAAGTGGCA GATCATTCAG GCCAAGTAAA GACCAAGTGC 
TTTGAAATGA CGATTCCACA GTTTCAGAAT TTCTACAGAC AGTTCAAGGA AATTGCTGCA 
GTTATTGAAA CGGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011533250.1
CDS	41..418
Translation	MGFPCYVRPMRQAARGRTWKRKRWSGGVLSSPGRKSQTLPMEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQNFYRQFKEIAAVIETV

Target ORF information:

RefSeq Version	XM_011534948.2
Organism	Homo sapiens(human)
Definition	Homo sapiens COMM domain containing 6 (COMMD6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011534948.2

ORF Insert Sequence:

ATGGGCTTCC CCTGCTACGT CCGCCCCATG CGCCAGGCCG CTAGGGGCAG GACGTGGAAG 
CGGAAGCGCT GGTCTGGGGG CGTTCTCTCG AGTCCGGGCC GCAAGTCCCA GACGCTGCCC 
ATGGAGGCGT CCAGCGAGCC GCCGCTGGAT GCTAAGTCCG ATGTCACCAA CCAGCTTGTA 
GATTTTCAGT GGAAACTGGG TATGGCTGTG AGCTCAGACA CTTGCAGATC TCTTAAGTAT 
CCTTACGTTG CAGTGATGCT AAAAGTGGCA GATCATTCAG GCCAAGTAAA GACCAAGTGC 
TTTGAAATGA CGATTCCACA GTTTCAGAAT TTCTACAGAC AGTTCAAGGA AATTGCTGCA 
GTTATTGAAA CGGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.
Molecular biology of the cell26(1)91-103(2015 Jan)
Phillips-Krawczak CA,Singla A,Starokadomskyy P,Deng Z,Osborne DG,Li H,Dick CJ,Gomez TS,Koenecke M,Zhang JS,Dai H,Sifuentes-Dominguez LF,Geng LN,Kaufmann SH,Hein MY,Wallis M,McGaughran J,Gecz J,Sluis Bv,Billadeau DD,Burstein E

Genome-wide association study in a Chinese population with diabetic retinopathy.
Human molecular genetics22(15)3165-73(2013 Aug)
Sheu WH,Kuo JZ,Lee IT,Hung YJ,Lee WJ,Tsai HY,Wang JS,Goodarzi MO,Klein R,Klein BE,Ipp E,Lin SY,Guo X,Hsieh CH,Taylor KD,Fu CP,Rotter JI,Chen YD

CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling.
The Journal of clinical investigation123(5)2244-56(2013 May)
Starokadomskyy P,Gluck N,Li H,Chen B,Wallis M,Maine GN,Mao X,Zaidi IW,Hein MY,McDonald FJ,Lenzner S,Zecha A,Ropers HH,Kuss AW,McGaughran J,Gecz J,Burstein E

Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation.
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Kang JG,Amar MJ,Remaley AT,Kwon J,Blackshear PJ,Wang PY,Hwang PM

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COMMD6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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