DAZL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DAZL
Entrez Gene ID	1618
Full Name	deleted in azoospermia like
Synonyms	DAZH,DAZL1,DAZLA,SPGYLA
General protein information	Preferred Names deleted in azoospermia like Names deleted in azoospermia-like DAZ homolog DAZ-like autosomal SPGY-like-autosomal deleted in azoospermia-like 1 germline specific RNA binding protein spermatogenesis gene on the Y-like autosomal testis secretory sperm-binding protein Li 204a
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p24.3
Summary	The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Disorder MIM:	601486
Disorder Html:	{Spermatogenic failure, susceptibility to} (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001351.3	NP_001342.2	deleted in azoospermia-like isoform 2
NM_001190811.1	NP_001177740.1	deleted in azoospermia-like isoform 1
NM_001351.4	NP_001342.2	deleted in azoospermia-like isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	DAZL	NP_001177740.1
Pan troglodytes (chimpanzee)	DAZL	XP_516314.3
Canis lupus familiaris (dog)	DAZL	XP_534251.3
Bos taurus (cattle)	DAZL	NP_001075194.1

Gene Ontology
Bibliography

Related articles in PubMed

In silico analysis of non-synonymous single nucleotide polymorphisms in human DAZL gene associated with male infertility.
Nailwal M, Chauhan JB
Systems biology in reproductive medicine63(4)248-258(2017 Aug)

RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary.
Rosario R, Smith RW, Adams IR, Anderson RA
Molecular human reproduction23(3)177-186(2017 Mar)

Highly conserved epigenetic regulation of BOULE and DAZL is associated with human fertility.
Zhang C, Xue P, Gao L, Chen X, Lin K, Yang X, Dai Y, Xu EY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(10)3424-3440(2016 10)

Is there a role for DAZL in human female fertility?
Rosario R, Adams IR, Anderson RA
Molecular human reproduction22(6)377-83(2016 Jun)

Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells.
Panula S, Reda A, Stukenborg JB, Ramathal C, Sukhwani M, Albalushi H, Edsg?rd D, Nakamura M, S?der O, Orwig KE, Yamanaka S, Reijo Pera RA, Hovatta O
PloS one11(10)e0165268(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Through the translational regulation of novel RNA targets SMC1B and TEX11, DAZL may have a key role in regulating chromosome cohesion and DNA recombination; two processes fundamental in determining oocyte quality and whose establishment in foetal life may support lifelong fertility.
Title: RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary.

hypermethylation of DAZL and BOULE promoters in human sperm is associated with human infertility
Title: Highly conserved epigenetic regulation of BOULE and DAZL is associated with human fertility.

analysis demonstrated that SNP260 of DAZL did not contribute to oligo/azoospermia while SNP386 was correlated to male infertility
Title: Association of polymorphisms of A260G and A386G in DAZL gene with male infertility: a meta-analysis and systemic review.

data can be used to further elucidate the role of NANOS3 and DAZL in germ cell development both in vitro and in vivo
Title: Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells.

DAZL was not expressed either in normal cultures or lesions from cervixes with papillomavirus infections and cervical intraepithelial neoplasia.
Title: OCT-4 and DAZL expression in precancerous lesions of the human uterine cervix.

The following DAZL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DAZL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26820	NM_001190811.1 Latest version!	Homo sapiens deleted in azoospermia like (DAZL), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu27425	NM_001351.4 Latest version!	Homo sapiens deleted in azoospermia like (DAZL), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu27425	NM_001351.3	Homo sapiens deleted in azoospermia like (DAZL), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DAZL ( NM_001190811.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001177740.1 Homo sapiens deleted in azoospermia like (DAZL), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26820
Clone ID Related Accession (Same CDS sequence)	NM_001190811.1
Accession Version	NM_001190811.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	deleted in azoospermia-like isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK303026.1, AK310341.1 and BX648638.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX648638.1, AK310341.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCTC CCTCGTGTGG CGGCGACAGA AAAGCTCGCC TGACGCCATC TTTGCCGCAC 
GAGTCTACTG CAAATCCTGA AACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCCTCATCAG CTGCAACCAG CCAAGGCTAT ATTTTACCAG AAGGCAAAAT CATGCCAAAC 
ACTGTTTTTG TTGGAGGAAT TGATGTTAGG ATGGATGAAA CTGAGATTAG AAGCTTCTTT 
GCTAGATATG GTTCAGTGAA AGAAGTGAAG ATAATCACTG ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCATT TTTTAATGAC GTGGATGTGC AGAAGATAGT AGAATCACAG 
ATAAATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAATTTATGT 
GCTTATCATG TGCAGCCACG TCCTTTGGTT TTTAATCATC CTCCTCCACC ACAGTTTCAG 
AATGTCTGGA CTAATCCAAA CACTGAAACT TATATGCAGC CCACAACCAC GATGAATCCT 
ATAACTCAGT ATGTTCAGGC ATATCCTACT TACCCAAATT CACCAGTTCA GGTCATCACT 
GGATATCAGT TGCCTGTATA TAATTATCAG ATGCCACCAC AGTGGCCTGT TGGGGAGCAA 
AGGAGCTATG TTGTACCTCC GGCTTATTCA GCTGTTAACT ACCACTGTAA TGAAGTTGAT 
CCAGGAGCTG AAGTTGTGCC AAATGAATGT TCAGTTCATG AAGCTACTCC ACCCTCTGGA 
AATGGCCCAC AAAAGAAATC TGTGGACCGA AGCATACAAA CGGTGGTATC TTGTCTGTTT 
AATCCAGAGA ACAGACTGAG AAACTCTGTT GTTACTCAAG ATGACTACTT CAAGGATAAA 
AGAGTGCATC ACTTTAGAAG AAGTCGGGCA ATGCTTAAAT CTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177740.1
CDS	289..1236
Translation	MAAPSCGGDRKARLTPSLPHESTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPPSGNGPQKKSVDRSIQTVVSCLFNPENRLRNSVVTQDDYFKDKRVHHFRRSRAMLKSV

Target ORF information:

RefSeq Version	NM_001190811.1
Organism	Homo sapiens(human)
Definition	Homo sapiens deleted in azoospermia like (DAZL), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001190811.1

ORF Insert Sequence:

ATGGCGGCTC CCTCGTGTGG CGGCGACAGA AAAGCTCGCC TGACGCCATC TTTGCCGCAC 
GAGTCTACTG CAAATCCTGA AACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCCTCATCAG CTGCAACCAG CCAAGGCTAT ATTTTACCAG AAGGCAAAAT CATGCCAAAC 
ACTGTTTTTG TTGGAGGAAT TGATGTTAGG ATGGATGAAA CTGAGATTAG AAGCTTCTTT 
GCTAGATATG GTTCAGTGAA AGAAGTGAAG ATAATCACTG ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCATT TTTTAATGAC GTGGATGTGC AGAAGATAGT AGAATCACAG 
ATAAATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAATTTATGT 
GCTTATCATG TGCAGCCACG TCCTTTGGTT TTTAATCATC CTCCTCCACC ACAGTTTCAG 
AATGTCTGGA CTAATCCAAA CACTGAAACT TATATGCAGC CCACAACCAC GATGAATCCT 
ATAACTCAGT ATGTTCAGGC ATATCCTACT TACCCAAATT CACCAGTTCA GGTCATCACT 
GGATATCAGT TGCCTGTATA TAATTATCAG ATGCCACCAC AGTGGCCTGT TGGGGAGCAA 
AGGAGCTATG TTGTACCTCC GGCTTATTCA GCTGTTAACT ACCACTGTAA TGAAGTTGAT 
CCAGGAGCTG AAGTTGTGCC AAATGAATGT TCAGTTCATG AAGCTACTCC ACCCTCTGGA 
AATGGCCCAC AAAAGAAATC TGTGGACCGA AGCATACAAA CGGTGGTATC TTGTCTGTTT 
AATCCAGAGA ACAGACTGAG AAACTCTGTT GTTACTCAAG ATGACTACTT CAAGGATAAA 
AGAGTGCATC ACTTTAGAAG AAGTCGGGCA ATGCTTAAAT CTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DAZL ( NM_001351.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001342.2 Homo sapiens deleted in azoospermia like (DAZL), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27425
Clone ID Related Accession (Same CDS sequence)	NM_001351.3 , NM_001351.4
Accession Version	NM_001351.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	deleted in azoospermia-like isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB080081.1, BC027595.2 and BX648638.1. This sequence is a reference standard in the RefSeqGene project. On Jun 30, 2010 this sequence version replaced NM_001351.2. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005617.1, U65918.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTACTG CAAATCCTGA AACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCCTCATCAG CTGCAACCAG CCAAGGCTAT ATTTTACCAG AAGGCAAAAT CATGCCAAAC 
ACTGTTTTTG TTGGAGGAAT TGATGTTAGG ATGGATGAAA CTGAGATTAG AAGCTTCTTT 
GCTAGATATG GTTCAGTGAA AGAAGTGAAG ATAATCACTG ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCATT TTTTAATGAC GTGGATGTGC AGAAGATAGT AGAATCACAG 
ATAAATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAATTTATGT 
GCTTATCATG TGCAGCCACG TCCTTTGGTT TTTAATCATC CTCCTCCACC ACAGTTTCAG 
AATGTCTGGA CTAATCCAAA CACTGAAACT TATATGCAGC CCACAACCAC GATGAATCCT 
ATAACTCAGT ATGTTCAGGC ATATCCTACT TACCCAAATT CACCAGTTCA GGTCATCACT 
GGATATCAGT TGCCTGTATA TAATTATCAG ATGCCACCAC AGTGGCCTGT TGGGGAGCAA 
AGGAGCTATG TTGTACCTCC GGCTTATTCA GCTGTTAACT ACCACTGTAA TGAAGTTGAT 
CCAGGAGCTG AAGTTGTGCC AAATGAATGT TCAGTTCATG AAGCTACTCC ACCCTCTGGA 
AATGGCCCAC AAAAGAAATC TGTGGACCGA AGCATACAAA CGGTGGTATC TTGTCTGTTT 
AATCCAGAGA ACAGACTGAG AAACTCTGTT GTTACTCAAG ATGACTACTT CAAGGATAAA 
AGAGTGCATC ACTTTAGAAG AAGTCGGGCA ATGCTTAAAT CTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001342.2
CDS	295..1182
Translation	MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPPSGNGPQKKSVDRSIQTVVSCLFNPENRLRNSVVTQDDYFKDKRVHHFRRSRAMLKSV

Target ORF information:

RefSeq Version	NM_001351.3
Organism	Homo sapiens(human)
Definition	Homo sapiens deleted in azoospermia like (DAZL), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001351.3

ORF Insert Sequence:

ATGTCTACTG CAAATCCTGA AACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCCTCATCAG CTGCAACCAG CCAAGGCTAT ATTTTACCAG AAGGCAAAAT CATGCCAAAC 
ACTGTTTTTG TTGGAGGAAT TGATGTTAGG ATGGATGAAA CTGAGATTAG AAGCTTCTTT 
GCTAGATATG GTTCAGTGAA AGAAGTGAAG ATAATCACTG ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCATT TTTTAATGAC GTGGATGTGC AGAAGATAGT AGAATCACAG 
ATAAATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAATTTATGT 
GCTTATCATG TGCAGCCACG TCCTTTGGTT TTTAATCATC CTCCTCCACC ACAGTTTCAG 
AATGTCTGGA CTAATCCAAA CACTGAAACT TATATGCAGC CCACAACCAC GATGAATCCT 
ATAACTCAGT ATGTTCAGGC ATATCCTACT TACCCAAATT CACCAGTTCA GGTCATCACT 
GGATATCAGT TGCCTGTATA TAATTATCAG ATGCCACCAC AGTGGCCTGT TGGGGAGCAA 
AGGAGCTATG TTGTACCTCC GGCTTATTCA GCTGTTAACT ACCACTGTAA TGAAGTTGAT 
CCAGGAGCTG AAGTTGTGCC AAATGAATGT TCAGTTCATG AAGCTACTCC ACCCTCTGGA 
AATGGCCCAC AAAAGAAATC TGTGGACCGA AGCATACAAA CGGTGGTATC TTGTCTGTTT 
AATCCAGAGA ACAGACTGAG AAACTCTGTT GTTACTCAAG ATGACTACTT CAAGGATAAA 
AGAGTGCATC ACTTTAGAAG AAGTCGGGCA ATGCTTAAAT CTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DAZL ( NM_001351.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001342.2 Homo sapiens deleted in azoospermia like (DAZL), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27425
Clone ID Related Accession (Same CDS sequence)	NM_001351.3 , NM_001351.4
Accession Version	NM_001351.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	deleted in azoospermia-like isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB080081.1, BC027595.2 and BX648638.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_001351.3. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005617.1, U66726.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTACTG CAAATCCTGA AACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCCTCATCAG CTGCAACCAG CCAAGGCTAT ATTTTACCAG AAGGCAAAAT CATGCCAAAC 
ACTGTTTTTG TTGGAGGAAT TGATGTTAGG ATGGATGAAA CTGAGATTAG AAGCTTCTTT 
GCTAGATATG GTTCAGTGAA AGAAGTGAAG ATAATCACTG ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCATT TTTTAATGAC GTGGATGTGC AGAAGATAGT AGAATCACAG 
ATAAATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAATTTATGT 
GCTTATCATG TGCAGCCACG TCCTTTGGTT TTTAATCATC CTCCTCCACC ACAGTTTCAG 
AATGTCTGGA CTAATCCAAA CACTGAAACT TATATGCAGC CCACAACCAC GATGAATCCT 
ATAACTCAGT ATGTTCAGGC ATATCCTACT TACCCAAATT CACCAGTTCA GGTCATCACT 
GGATATCAGT TGCCTGTATA TAATTATCAG ATGCCACCAC AGTGGCCTGT TGGGGAGCAA 
AGGAGCTATG TTGTACCTCC GGCTTATTCA GCTGTTAACT ACCACTGTAA TGAAGTTGAT 
CCAGGAGCTG AAGTTGTGCC AAATGAATGT TCAGTTCATG AAGCTACTCC ACCCTCTGGA 
AATGGCCCAC AAAAGAAATC TGTGGACCGA AGCATACAAA CGGTGGTATC TTGTCTGTTT 
AATCCAGAGA ACAGACTGAG AAACTCTGTT GTTACTCAAG ATGACTACTT CAAGGATAAA 
AGAGTGCATC ACTTTAGAAG AAGTCGGGCA ATGCTTAAAT CTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001342.2
CDS	219..1106
Translation	MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPPSGNGPQKKSVDRSIQTVVSCLFNPENRLRNSVVTQDDYFKDKRVHHFRRSRAMLKSV

Target ORF information:

RefSeq Version	NM_001351.4
Organism	Homo sapiens(human)
Definition	Homo sapiens deleted in azoospermia like (DAZL), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001351.4

ORF Insert Sequence:

ATGTCTACTG CAAATCCTGA AACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCCTCATCAG CTGCAACCAG CCAAGGCTAT ATTTTACCAG AAGGCAAAAT CATGCCAAAC 
ACTGTTTTTG TTGGAGGAAT TGATGTTAGG ATGGATGAAA CTGAGATTAG AAGCTTCTTT 
GCTAGATATG GTTCAGTGAA AGAAGTGAAG ATAATCACTG ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCATT TTTTAATGAC GTGGATGTGC AGAAGATAGT AGAATCACAG 
ATAAATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAATTTATGT 
GCTTATCATG TGCAGCCACG TCCTTTGGTT TTTAATCATC CTCCTCCACC ACAGTTTCAG 
AATGTCTGGA CTAATCCAAA CACTGAAACT TATATGCAGC CCACAACCAC GATGAATCCT 
ATAACTCAGT ATGTTCAGGC ATATCCTACT TACCCAAATT CACCAGTTCA GGTCATCACT 
GGATATCAGT TGCCTGTATA TAATTATCAG ATGCCACCAC AGTGGCCTGT TGGGGAGCAA 
AGGAGCTATG TTGTACCTCC GGCTTATTCA GCTGTTAACT ACCACTGTAA TGAAGTTGAT 
CCAGGAGCTG AAGTTGTGCC AAATGAATGT TCAGTTCATG AAGCTACTCC ACCCTCTGGA 
AATGGCCCAC AAAAGAAATC TGTGGACCGA AGCATACAAA CGGTGGTATC TTGTCTGTTT 
AATCCAGAGA ACAGACTGAG AAACTCTGTT GTTACTCAAG ATGACTACTT CAAGGATAAA 
AGAGTGCATC ACTTTAGAAG AAGTCGGGCA ATGCTTAAAT CTGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

In silico analysis of non-synonymous single nucleotide polymorphisms in human DAZL gene associated with male infertility.
Systems biology in reproductive medicine63(4)248-258(2017 Aug)
Nailwal M,Chauhan JB

RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary.
Molecular human reproduction23(3)177-186(2017 Mar)
Rosario R,Smith RW,Adams IR,Anderson RA

Highly conserved epigenetic regulation of BOULE and DAZL is associated with human fertility.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(10)3424-3440(2016 10)
Zhang C,Xue P,Gao L,Chen X,Lin K,Yang X,Dai Y,Xu EY

Is there a role for DAZL in human female fertility?
Molecular human reproduction22(6)377-83(2016 Jun)
Rosario R,Adams IR,Anderson RA

Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells.
PloS one11(10)e0165268(2016)
Panula S,Reda A,Stukenborg JB,Ramathal C,Sukhwani M,Albalushi H,Edsg?rd D,Nakamura M,S?der O,Orwig KE,Yamanaka S,Reijo Pera RA,Hovatta O

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DAZL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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