C8orf37 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	C8orf37
Entrez Gene ID	157657
Full Name	chromosome 8 open reading frame 37
Synonyms	BBS21,CORD16,RP64,smalltalk
General protein information	Preferred Names chromosome 8 open reading frame 37 Names protein C8orf37
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q22.1
Summary	This gene encodes a ubiquitously expressed protein of unknown function. It has high levels of mRNA expression in the brain, heart, and retina and the protein co-localizes with polyglutamylated tubulin at the base of the primary cilium in human retinal pigment epithelial cells. Mutations in this gene have been associated with autosomal recessive cone-rod dystrophy (arCRD) and retinitis pigmentosa (arRP). [provided by RefSeq, Mar 2012].
Disorder MIM:	614477
Disorder Html:	Retinitis pigmentosa 64, 614500 (3); Cone-rod dystrophy 16, 614500 (3); Bardet-Biedl syndrome 21, 617406 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005250799.3	XP_005250856.2	protein C8orf37 isoform X1
NM_177965.4	NP_808880.1	protein C8orf37 isoform 1
NM_001363260.1	NP_001350189.1	protein C8orf37 isoform 2
NM_177965.3	NP_808880.1	protein C8orf37

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	2610301B20Rik	NP_080281.3
Rattus norvegicus (Norway rat)	MGC94199	NP_001007747.1
Rattus norvegicus (Norway rat)	LOC102554232	XP_006237928.1
Homo sapiens (human)	C8orf37	NP_808880.1
Bos taurus (cattle)	C14H8orf37	XP_002692859.1
Danio rerio (zebrafish)	LOC100534958	XP_003200284.2
	C8H8orf37	XP_001090711.1
Pan troglodytes (chimpanzee)	C8H8orf37	XP_001144875.1
Canis lupus familiaris (dog)	C29H8orf37	XP_005638217.1
Gallus gallus (chicken)	C2H8ORF37	XP_004940012.1
Xenopus tropicalis (tropical clawed frog)	LOC100489713	XP_002931575.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel C8orf37 splice mutation and genotype-phenotype correlation for cone-rod dystrophy.
Rahner N, Nuernberg G, Finis D, Nuernberg P, Royer-Pokora B
Ophthalmic genetics37(3)294-300(2016 09)

C8orf37 is mutated in Bardet-Biedl syndrome and constitutes a locus allelic to non-syndromic retinal dystrophies.
Khan AO, Decker E, Bachmann N, Bolz HJ, Bergmann C
Ophthalmic genetics37(3)290-3(2016 09)

Mutations in C8ORF37 cause Bardet Biedl syndrome (BBS21).
Heon E, Kim G, Qin S, Garrison JE, Tavares E, Vincent A, Nuangchamnong N, Scott CA, Slusarski DC, Sheffield VC
Human molecular genetics25(11)2283-2294(2016 06)

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This report extends the genotypic spectrum of C8orf37-associated retinal dystrophies and demonstrates for the first time a genotype-phenotype correlation between an arCRD-polydactyly-association and truncating germline mutations affecting the N-terminal region of the protein.
Title: A novel C8orf37 splice mutation and genotype-phenotype correlation for cone-rod dystrophy.

We conclude that C8orf37 should be added to Bardet-Biedl syndrome (BBS) screening panels as a probable rare cause of the disease and that individuals with C8orf37-related retinal dystrophy should be screened for BBS features.
Title: C8orf37 is mutated in Bardet-Biedl syndrome and constitutes a locus allelic to non-syndromic retinal dystrophies.

This is the first functional validation and association of C8ORF37 mutations with the BBS phenotype, which identifies BBS21. The zebrafish studies hereby show that C8ORF37 variants underlie clinically diagnosed BBS-related phenotypes as well as isolated retinal degeneration
Title: Mutations in C8ORF37 cause Bardet Biedl syndrome (BBS21).

Our study identified two novel truncating mutations of the C8orf37 gene in siblings with early-onset retinal dystrophy, macular atrophy, cataracts, and high myopia.
Title: Novel C8orf37 Mutations in Patients with Early-onset Retinal Dystrophy, Macular Atrophy, Cataracts, and High Myopia.

Novel C8orf37 mutations cause retinitis pigmentosa in two consanguineous families of Pakistani origin.
Title: Novel C8orf37 mutations cause retinitis pigmentosa in consanguineous families of Pakistani origin.

The following C8orf37 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C8orf37 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22584	NM_177965.4 Latest version!	Homo sapiens chromosome 8 open reading frame 37 (C8orf37), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu76886	XM_005250799.3 Latest version!	Homo sapiens chromosome 8 open reading frame 37 (C8orf37), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu106943	NM_001363260.1 Latest version!	Homo sapiens chromosome 8 open reading frame 37 (C8orf37), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu22584	NM_177965.3	Homo sapiens chromosome 8 open reading frame 37 (C8orf37), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C8orf37 ( NM_177965.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_808880.1 Homo sapiens chromosome 8 open reading frame 37 (C8orf37), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22584
Clone ID Related Accession (Same CDS sequence)	NM_177965.4 , NM_177965.3
Accession Version	NM_177965.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	protein C8orf37 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA473498.1, DB205618.1, AP003466.2 and AA897574.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_177965.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC150301.1, SRR1803614.155999.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000286688.6/ ENSP00000286688.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGAGG ACCTGGACGA GCTCTTGGAT GAAGTCGAGT CCAAGTTTTG CACACCTGAC 
CTTCTAAGAC GGGGTATGGT CGAGCAGCCC AAAGGCTGCG GCGGCGGCAC CCACAGTAGC 
GACCGGAACC AAGCCAAGGC GAAAGAGACG CTCAGATCAA CAGAAACATT TAAAAAAGAA 
GATGATCTTG ACAGTCTTAT TAATGAAATA CTTGAAGAGC CCAACTTGGA CAAAAAACCC 
TCTAAATTAA AATCTAAATC TTCAGGTAAC ACATCTGTCA GAGCTTCCAT TGAAGGCCTT 
GGTAAAAGTT GCAGTCCGGT GTACCTTGGT GGAAGCTCTA TTCCATGTGG GATTGGAACA 
AATATTTCAT GGAGAGCATG TGACCATCTG CGTTGTATAG CCTGTGATTT CTTGGTAGTC 
AGCTATGATG ACTATATGTG GGACAAATCG TGTGATTATC TGTTTTTCAG GAACAACATG 
CCAGAATTTC ACAAATTAAA AGCAAAGTTG ATAAAGAAGA AAGGAACACG GGCATATGCC 
TGCCAGTGTA GCTGGAGAAC TATTGAAGAA GTGACTGACC TTCAGACAGA TCATCAGCTT 
CGCTGGGTTT GTGGTAAACA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808880.1
CDS	13..636
Translation	MAEDLDELLDEVESKFCTPDLLRRGMVEQPKGCGGGTHSSDRNQAKAKETLRSTETFKKEDDLDSLINEILEEPNLDKKPSKLKSKSSGNTSVRASIEGLGKSCSPVYLGGSSIPCGIGTNISWRACDHLRCIACDFLVVSYDDYMWDKSCDYLFFRNNMPEFHKLKAKLIKKKGTRAYACQCSWRTIEEVTDLQTDHQLRWVCGKH

Target ORF information:

RefSeq Version	NM_177965.4
Organism	Homo sapiens(human)
Definition	Homo sapiens chromosome 8 open reading frame 37 (C8orf37), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177965.4

ORF Insert Sequence:

ATGGCGGAGG ACCTGGACGA GCTCTTGGAT GAAGTCGAGT CCAAGTTTTG CACACCTGAC 
CTTCTAAGAC GGGGTATGGT CGAGCAGCCC AAAGGCTGCG GCGGCGGCAC CCACAGTAGC 
GACCGGAACC AAGCCAAGGC GAAAGAGACG CTCAGATCAA CAGAAACATT TAAAAAAGAA 
GATGATCTTG ACAGTCTTAT TAATGAAATA CTTGAAGAGC CCAACTTGGA CAAAAAACCC 
TCTAAATTAA AATCTAAATC TTCAGGTAAC ACATCTGTCA GAGCTTCCAT TGAAGGCCTT 
GGTAAAAGTT GCAGTCCGGT GTACCTTGGT GGAAGCTCTA TTCCATGTGG GATTGGAACA 
AATATTTCAT GGAGAGCATG TGACCATCTG CGTTGTATAG CCTGTGATTT CTTGGTAGTC 
AGCTATGATG ACTATATGTG GGACAAATCG TGTGATTATC TGTTTTTCAG GAACAACATG 
CCAGAATTTC ACAAATTAAA AGCAAAGTTG ATAAAGAAGA AAGGAACACG GGCATATGCC 
TGCCAGTGTA GCTGGAGAAC TATTGAAGAA GTGACTGACC TTCAGACAGA TCATCAGCTT 
CGCTGGGTTT GTGGTAAACA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C8orf37 ( NM_177965.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_808880.1 Homo sapiens chromosome 8 open reading frame 37 (C8orf37), mRNA.

Price & Availability↑

CloneID	OHu22584
Clone ID Related Accession (Same CDS sequence)	NM_177965.4 , NM_177965.3
Accession Version	NM_177965.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-12
Organism	Homo sapiens(human)
Product	protein C8orf37
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA473498.1, DB205618.1, AP003466.2 and AA897574.1. This sequence is a reference standard in the RefSeqGene project. On Sep 24, 2010 this sequence version replaced NM_177965.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: DA473498.1, BC150301.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGAGG ACCTGGACGA GCTCTTGGAT GAAGTCGAGT CCAAGTTTTG CACACCTGAC 
CTTCTAAGAC GGGGTATGGT CGAGCAGCCC AAAGGCTGCG GCGGCGGCAC CCACAGTAGC 
GACCGGAACC AAGCCAAGGC GAAAGAGACG CTCAGATCAA CAGAAACATT TAAAAAAGAA 
GATGATCTTG ACAGTCTTAT TAATGAAATA CTTGAAGAGC CCAACTTGGA CAAAAAACCC 
TCTAAATTAA AATCTAAATC TTCAGGTAAC ACATCTGTCA GAGCTTCCAT TGAAGGCCTT 
GGTAAAAGTT GCAGTCCGGT GTACCTTGGT GGAAGCTCTA TTCCATGTGG GATTGGAACA 
AATATTTCAT GGAGAGCATG TGACCATCTG CGTTGTATAG CCTGTGATTT CTTGGTAGTC 
AGCTATGATG ACTATATGTG GGACAAATCG TGTGATTATC TGTTTTTCAG GAACAACATG 
CCAGAATTTC ACAAATTAAA AGCAAAGTTG ATAAAGAAGA AAGGAACACG GGCATATGCC 
TGCCAGTGTA GCTGGAGAAC TATTGAAGAA GTGACTGACC TTCAGACAGA TCATCAGCTT 
CGCTGGGTTT GTGGTAAACA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808880.1
CDS	46..669
Translation	MAEDLDELLDEVESKFCTPDLLRRGMVEQPKGCGGGTHSSDRNQAKAKETLRSTETFKKEDDLDSLINEILEEPNLDKKPSKLKSKSSGNTSVRASIEGLGKSCSPVYLGGSSIPCGIGTNISWRACDHLRCIACDFLVVSYDDYMWDKSCDYLFFRNNMPEFHKLKAKLIKKKGTRAYACQCSWRTIEEVTDLQTDHQLRWVCGKH

Target ORF information:

RefSeq Version	NM_177965.3
Organism	Homo sapiens(human)
Definition	Homo sapiens chromosome 8 open reading frame 37 (C8orf37), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177965.3

ORF Insert Sequence:

ATGGCGGAGG ACCTGGACGA GCTCTTGGAT GAAGTCGAGT CCAAGTTTTG CACACCTGAC 
CTTCTAAGAC GGGGTATGGT CGAGCAGCCC AAAGGCTGCG GCGGCGGCAC CCACAGTAGC 
GACCGGAACC AAGCCAAGGC GAAAGAGACG CTCAGATCAA CAGAAACATT TAAAAAAGAA 
GATGATCTTG ACAGTCTTAT TAATGAAATA CTTGAAGAGC CCAACTTGGA CAAAAAACCC 
TCTAAATTAA AATCTAAATC TTCAGGTAAC ACATCTGTCA GAGCTTCCAT TGAAGGCCTT 
GGTAAAAGTT GCAGTCCGGT GTACCTTGGT GGAAGCTCTA TTCCATGTGG GATTGGAACA 
AATATTTCAT GGAGAGCATG TGACCATCTG CGTTGTATAG CCTGTGATTT CTTGGTAGTC 
AGCTATGATG ACTATATGTG GGACAAATCG TGTGATTATC TGTTTTTCAG GAACAACATG 
CCAGAATTTC ACAAATTAAA AGCAAAGTTG ATAAAGAAGA AAGGAACACG GGCATATGCC 
TGCCAGTGTA GCTGGAGAAC TATTGAAGAA GTGACTGACC TTCAGACAGA TCATCAGCTT 
CGCTGGGTTT GTGGTAAACA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C8orf37 ( XM_005250799.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005250856.2 Homo sapiens chromosome 8 open reading frame 37 (C8orf37), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu76886
Clone ID Related Accession (Same CDS sequence)	XM_005250799.3
Accession Version	XM_005250799.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	protein C8orf37 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005250799.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGGGC GAGAATGCGT GCTTGTGGTT ACAACGTGGG CCCGGGAGGG GGAGACGGGA 
GGAACCACGC CAGACATGCT GAAAGGAAGA AACGCAAAGC ATCGCGAGTC ACACAGACAC 
ACTGCAGAGA CAGCTCCGAA CTCTGTCCCT GCATACGCCC GCCCCTCACG AACCCACCGC 
GTTCTCTGCC GCGAGCCCTC GTGGGCGCCG GGTTGCCACG GGAAGCGGTG CGCATGCGCG 
GGGACGCCTA ACGGGGCAGG AGCCCGCCAG GTCCCCTCGT TACTCCTGGA AACCACCGGA 
GCCTTGGCGA TTGGAGGGGA AAAGGCCAGG CGATTCAAGA TGGCGGAGGA CCTGGACGAG 
CTCTTGGATG AAGTCGAGTC CAAGTTTTGC ACACCTGACC TTCTAAGACG GGGTATGGTC 
GAGCAGCCCA AAGGCTGCGG CGGCGGCACC CACAGTAGCG ACCGGAACCA AGCCAAGGCG 
AAAGAGACGC TCAGATCAAC AGAAACATTT AAAAAAGAAG ATGATCTTGA CAGTCTTATT 
AATGAAATAC TTGAAGAGCC CAACTTGGAC AAAAAACCCT CTAAATTAAA ATCTAAATCT 
TCAGGTAACA CATCTGTCAG AGCTTCCATT GAAGGCCTTG GTAAAAGTTG CAGTCCGGTG 
TACCTTGGTG GAAGCTCTAT TCCATGTGGG ATTGGAACAA ATATTTCATG GAGGAACAAC 
ATGCCAGAAT TTCACAAATT AAAAGCAAAG TTGATAAAGA AGAAAGGAAC ACGGGCATAT 
GCCTGCCAGT GTAGCTGGAG AACTATTGAA GAAGTGACTG ACCTTCAGAC AGATCATCAG 
CTTCGCTGGG TTTGTGGTAA ACATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005250856.2
CDS	1075..1941
Translation	MKGRECVLVVTTWAREGETGGTTPDMLKGRNAKHRESHRHTAETAPNSVPAYARPSRTHRVLCREPSWAPGCHGKRCACAGTPNGAGARQVPSLLLETTGALAIGGEKARRFKMAEDLDELLDEVESKFCTPDLLRRGMVEQPKGCGGGTHSSDRNQAKAKETLRSTETFKKEDDLDSLINEILEEPNLDKKPSKLKSKSSGNTSVRASIEGLGKSCSPVYLGGSSIPCGIGTNISWRNNMPEFHKLKAKLIKKKGTRAYACQCSWRTIEEVTDLQTDHQLRWVCGKH

Target ORF information:

RefSeq Version	XM_005250799.3
Organism	Homo sapiens(human)
Definition	Homo sapiens chromosome 8 open reading frame 37 (C8orf37), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005250799.3

ORF Insert Sequence:

ATGAAGGGGC GAGAATGCGT GCTTGTGGTT ACAACGTGGG CCCGGGAGGG GGAGACGGGA 
GGAACCACGC CAGACATGCT GAAAGGAAGA AACGCAAAGC ATCGCGAGTC ACACAGACAC 
ACTGCAGAGA CAGCTCCGAA CTCTGTCCCT GCATACGCCC GCCCCTCACG AACCCACCGC 
GTTCTCTGCC GCGAGCCCTC GTGGGCGCCG GGTTGCCACG GGAAGCGGTG CGCATGCGCG 
GGGACGCCTA ACGGGGCAGG AGCCCGCCAG GTCCCCTCGT TACTCCTGGA AACCACCGGA 
GCCTTGGCGA TTGGAGGGGA AAAGGCCAGG CGATTCAAGA TGGCGGAGGA CCTGGACGAG 
CTCTTGGATG AAGTCGAGTC CAAGTTTTGC ACACCTGACC TTCTAAGACG GGGTATGGTC 
GAGCAGCCCA AAGGCTGCGG CGGCGGCACC CACAGTAGCG ACCGGAACCA AGCCAAGGCG 
AAAGAGACGC TCAGATCAAC AGAAACATTT AAAAAAGAAG ATGATCTTGA CAGTCTTATT 
AATGAAATAC TTGAAGAGCC CAACTTGGAC AAAAAACCCT CTAAATTAAA ATCTAAATCT 
TCAGGTAACA CATCTGTCAG AGCTTCCATT GAAGGCCTTG GTAAAAGTTG CAGTCCGGTG 
TACCTTGGTG GAAGCTCTAT TCCATGTGGG ATTGGAACAA ATATTTCATG GAGGAACAAC 
ATGCCAGAAT TTCACAAATT AAAAGCAAAG TTGATAAAGA AGAAAGGAAC ACGGGCATAT 
GCCTGCCAGT GTAGCTGGAG AACTATTGAA GAAGTGACTG ACCTTCAGAC AGATCATCAG 
CTTCGCTGGG TTTGTGGTAA ACATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C8orf37 ( NM_001363260.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001350189.1 Homo sapiens chromosome 8 open reading frame 37 (C8orf37), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu106943
Clone ID Related Accession (Same CDS sequence)	NM_001363260.1
Accession Version	NM_001363260.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	protein C8orf37 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA473498.1, DB205618.1, AP003466.2 and AA897574.1. On May 12, 2018 this sequence version replaced XM_005250799.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.194231.1, SRR1803613.18182.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGG ACCTGGACGA GCTCTTGGAT GAAGTCGAGT CCAAGTTTTG CACACCTGAC 
CTTCTAAGAC GGGGTATGGT CGAGCAGCCC AAAGGCTGCG GCGGCGGCAC CCACAGTAGC 
GACCGGAACC AAGCCAAGGC GAAAGAGACG CTCAGATCAA CAGAAACATT TAAAAAAGAA 
GATGATCTTG ACAGTCTTAT TAATGAAATA CTTGAAGAGC CCAACTTGGA CAAAAAACCC 
TCTAAATTAA AATCTAAATC TTCAGGTAAC ACATCTGTCA GAGCTTCCAT TGAAGGCCTT 
GGTAAAAGTT GCAGTCCGGT GTACCTTGGT GGAAGCTCTA TTCCATGTGG GATTGGAACA 
AATATTTCAT GGAGGAACAA CATGCCAGAA TTTCACAAAT TAAAAGCAAA GTTGATAAAG 
AAGAAAGGAA CACGGGCATA TGCCTGCCAG TGTAGCTGGA GAACTATTGA AGAAGTGACT 
GACCTTCAGA CAGATCATCA GCTTCGCTGG GTTTGTGGTA AACATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350189.1
CDS	13..540
Translation	MAEDLDELLDEVESKFCTPDLLRRGMVEQPKGCGGGTHSSDRNQAKAKETLRSTETFKKEDDLDSLINEILEEPNLDKKPSKLKSKSSGNTSVRASIEGLGKSCSPVYLGGSSIPCGIGTNISWRNNMPEFHKLKAKLIKKKGTRAYACQCSWRTIEEVTDLQTDHQLRWVCGKH

Target ORF information:

RefSeq Version	NM_001363260.1
Organism	Homo sapiens(human)
Definition	Homo sapiens chromosome 8 open reading frame 37 (C8orf37), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363260.1

ORF Insert Sequence:

ATGGCGGAGG ACCTGGACGA GCTCTTGGAT GAAGTCGAGT CCAAGTTTTG CACACCTGAC 
CTTCTAAGAC GGGGTATGGT CGAGCAGCCC AAAGGCTGCG GCGGCGGCAC CCACAGTAGC 
GACCGGAACC AAGCCAAGGC GAAAGAGACG CTCAGATCAA CAGAAACATT TAAAAAAGAA 
GATGATCTTG ACAGTCTTAT TAATGAAATA CTTGAAGAGC CCAACTTGGA CAAAAAACCC 
TCTAAATTAA AATCTAAATC TTCAGGTAAC ACATCTGTCA GAGCTTCCAT TGAAGGCCTT 
GGTAAAAGTT GCAGTCCGGT GTACCTTGGT GGAAGCTCTA TTCCATGTGG GATTGGAACA 
AATATTTCAT GGAGGAACAA CATGCCAGAA TTTCACAAAT TAAAAGCAAA GTTGATAAAG 
AAGAAAGGAA CACGGGCATA TGCCTGCCAG TGTAGCTGGA GAACTATTGA AGAAGTGACT 
GACCTTCAGA CAGATCATCA GCTTCGCTGG GTTTGTGGTA AACATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel C8orf37 splice mutation and genotype-phenotype correlation for cone-rod dystrophy.
Ophthalmic genetics37(3)294-300(2016 09)
Rahner N,Nuernberg G,Finis D,Nuernberg P,Royer-Pokora B

C8orf37 is mutated in Bardet-Biedl syndrome and constitutes a locus allelic to non-syndromic retinal dystrophies.
Ophthalmic genetics37(3)290-3(2016 09)
Khan AO,Decker E,Bachmann N,Bolz HJ,Bergmann C

Mutations in C8ORF37 cause Bardet Biedl syndrome (BBS21).
Human molecular genetics25(11)2283-2294(2016 06)
Heon E,Kim G,Qin S,Garrison JE,Tavares E,Vincent A,Nuangchamnong N,Scott CA,Slusarski DC,Sheffield VC

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Nature communications711491(2016 May)
Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R,

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C8orf37 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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