CYP3A7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYP3A7
Entrez Gene ID	1551
Full Name	cytochrome P450 family 3 subfamily A member 7
Synonyms	CP37,CYPIIIA7,P-450(HFL33),P-450111A7,P450-HFLA
General protein information	Preferred Names cytochrome P450 family 3 subfamily A member 7 Names cytochrome P450 3A7 aryl hydrocarbon hydroxylase cytochrome P450, family 3, subfamily A, polypeptide 7 cytochrome P450, subfamily IIIA, polypeptide 7 cytochrome P450-HFLA flavoprotein-linked monooxygenase microsomal monooxygenase xenobiotic monooxygenase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q22.1
Summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015].
Disorder MIM:	605340

mRNA and Protein(s)

mRNA	Protein	Name
NM_000765.4	NP_000756.3	cytochrome P450 3A7
NM_000765.5	NP_000756.3	cytochrome P450 3A7

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cyp3a9	NP_671739.2
Xenopus tropicalis (tropical clawed frog)	cyp3a4	NP_001015786.1
Xenopus tropicalis (tropical clawed frog)	LOC100494419	XP_002943949.2
Gallus gallus (chicken)	CYP3A7	NP_001001751.1
Danio rerio (zebrafish)	cyp3a65	NP_001032515.1
Homo sapiens (human)	CYP3A7	NP_000756.2
Pan troglodytes (chimpanzee)	LOC100608616	XP_003318674.1
Mus musculus (house mouse)	Cyp3a13	NP_031845.1
Xenopus tropicalis (tropical clawed frog)	LOC100487665	XP_002933962.1
Oryza sativa (rice)	Os02g0221900	NP_001046325.1

Gene Ontology
Bibliography

Related articles in PubMed

Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7.
Kandel SE, Han LW, Mao Q, Lampe JN
Drug metabolism and disposition: the biological fate of chemicals45(12)1266-1275(2017 Dec)

The use of a unique co-culture model of fetoplacental steroidogenesis as a screening tool for endocrine disruptors: The effects of neonicotinoids on aromatase activity and hormone production.
Caron-Beaudoin E, Viau R, Hudon-Thibeault AA, Vaillancourt C, Sanderson JT
Toxicology and applied pharmacology33215-24(2017 10)

CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites.
Sood D, Johnson N, Jain P, Siskos AP, Bennett M, Gilham C, Busana MC, Peto J, Dos-Santos-Silva I, Keun HC, Fletcher O
British journal of cancer116(3)382-388(2017 Jan)

Developmental regulation of CYP3A4 and CYP3A7 in Chinese Han population.
He H, Nie YL, Li JF, Meng XG, Yang WH, Chen YL, Wang SJ, Ma X, Kan QC, Zhang LR
Drug metabolism and pharmacokinetics31(6)433-444(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

All three neonicotinoid pesticides induced the expression of CYP3A7 in H295R cells; induction was reversed by co-treatment of H295R cells with exogenous estriol. CYP3A7 is normally expressed in fetal liver and is a key enzyme involved in estriol synthesis.
Title: The use of a unique co-culture model of fetoplacental steroidogenesis as a screening tool for endocrine disruptors: The effects of neonicotinoids on aromatase activity and hormone production.

The CYP3A7*1C allele is associated with a lower urinary estrone levels, a more pronounced reduction in 2-hydroxylation pathway estrone metabolites (EMs) and a lower ratio of 2-hydroxylation:16alpha-hydroxylation EMs in premenopausal women.
Title: CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites.

data suggested that hepatocyte nuclear factor 4 alpha and glucocorticoid receptor, and epigenetic changes of H3K4me2 and H3K27me3 are associated with the ontogenic expressions of CYP3A4/3A7 in the livers of the Chinese Han population.
Title: Developmental regulation of CYP3A4 and CYP3A7 in Chinese Han population.

These results suggest the existence of a marked inter-individual variability regarding the presence of the isoforms of CYP3A. In addition, since sorafenib is metabolized by CYP3A4, but not by CYP3A7, an overexpression of CYP3A4 may lead to an increase in the degradation of the drug and then to clinical ineffectiveness.
Title: Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma.

CYP3A7*1C influences outcome are required.
Title: Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.

The following CYP3A7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYP3A7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23433	NM_000765.5 Latest version!	Homo sapiens cytochrome P450 family 3 subfamily A member 7 (CYP3A7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu23433	NM_000765.4	Homo sapiens cytochrome P450 family 3 subfamily A member 7 (CYP3A7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYP3A7 ( NM_000765.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000756.3 Homo sapiens cytochrome P450 family 3 subfamily A member 7 (CYP3A7), mRNA.

Price & Availability↑

CloneID	OHu23433
Clone ID Related Accession (Same CDS sequence)	NM_000765.4 , NM_000765.5
Accession Version	NM_000765.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1512bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	cytochrome P450 3A7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC069294.5, BX643367.1, D00408.1 and BX647143.1. This sequence is a reference standard in the RefSeqGene project. On Apr 10, 2014 this sequence version replaced NM_000765.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC069780.1, D00408.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGATCTCA TCCCAAACTT GGCCGTGGAA ACCTGGCTTC TCCTGGCTGT CAGCCTGATA 
CTCCTCTATC TATATGGAAC CCGTACACAT GGACTTTTTA AGAAGCTTGG AATTCCAGGG 
CCCACACCTC TGCCTTTTTT GGGAAATGCT TTGTCCTTCC GTAAGGGCTA TTGGACGTTT 
GACATGGAAT GTTATAAAAA GTATAGAAAA GTCTGGGGTA TTTATGACTG TCAACAGCCT 
ATGCTGGCTA TCACAGATCC CGACATGATC AAAACAGTGC TAGTGAAAGA ATGTTATTCT 
GTCTTCACAA ACCGGAGGCC TTTCGGGCCA GTGGGATTTA TGAAAAATGC CATCTCTATA 
GCTGAGGATG AAGAATGGAA GAGAATACGA TCATTGCTGT CTCCAACATT CACCAGCGGA 
AAACTCAAGG AGATGGTCCC TATCATTGCC CAGTATGGAG ATGTGTTGGT GAGAAATCTG 
AGGCGGGAAG CAGAGACAGG CAAGCCTGTC ACCTTGAAAC ACGTCTTTGG GGCCTACAGC 
ATGGATGTGA TCACTAGCAC ATCATTTGGA GTGAGCATCG ACTCTCTCAA CAATCCACAA 
GACCCCTTTG TGGAAAACAC CAAGAAGCTT TTAAGATTTA ATCCATTAGA TCCATTCGTT 
CTCTCAATAA AAGTCTTTCC ATTCCTTACC CCAATTCTTG AAGCATTAAA TATCACTGTG 
TTTCCAAGAA AAGTTATAAG TTTTCTAACA AAATCTGTAA AACAGATAAA AGAAGGTCGC 
CTCAAAGAGA CACAAAAGCA CCGAGTGGAT TTCCTTCAGC TGATGATTGA CTCTCAGAAT 
TCAAAAGACT CTGAGACCCA CAAAGCTCTG TCTGATCTGG AGCTCATGGC CCAATCAATT 
ATCTTTATTT TTGCTGGCTA TGAAACCACG AGCAGTGTTC TCTCCTTCAT TATATATGAA 
CTGGCCACTC ACCCTGATGT CCAGCAGAAA GTGCAGAAGG AAATTGATAC AGTTTTACCC 
AATAAGGCAC CACCCACCTA TGATACTGTG CTACAGTTGG AGTATCTTGA CATGGTGGTG 
AATGAAACAC TCAGATTATT CCCAGTTGCT ATGAGACTTG AGAGGGTCTG CAAAAAAGAT 
GTTGAAATCA ATGGGATGTT TATTCCCAAA GGGGTGGTGG TGATGATTCC AAGCTATGTT 
CTTCATCATG ACCCAAAGTA CTGGACAGAG CCTGAGAAGT TCCTCCCTGA AAGGTTCAGT 
AAAAAGAACA AGGACAACAT AGATCCTTAC ATATACACAC CCTTTGGAAG TGGACCCAGA 
AACTGCATTG GCATGAGGTT TGCTCTCGTG AACATGAAAC TTGCTCTAGT CAGAGTCCTT 
CAGAACTTCT CCTTCAAACC TTGTAAAGAA ACACAGATCC CCCTGAAATT ACGCTTTGGA 
GGACTTCTTC TAACAGAAAA ACCCATTGTT CTAAAGGCTG AGTCAAGGGA TGAGACCGTA 
AGTGGAGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000756.3
CDS	108..1619
Translation	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA

Target ORF information:

RefSeq Version	NM_000765.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 3 subfamily A member 7 (CYP3A7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000765.4

ORF Insert Sequence:

ATGGATCTCA TCCCAAACTT GGCCGTGGAA ACCTGGCTTC TCCTGGCTGT CAGCCTGATA 
CTCCTCTATC TATATGGAAC CCGTACACAT GGACTTTTTA AGAAGCTTGG AATTCCAGGG 
CCCACACCTC TGCCTTTTTT GGGAAATGCT TTGTCCTTCC GTAAGGGCTA TTGGACGTTT 
GACATGGAAT GTTATAAAAA GTATAGAAAA GTCTGGGGTA TTTATGACTG TCAACAGCCT 
ATGCTGGCTA TCACAGATCC CGACATGATC AAAACAGTGC TAGTGAAAGA ATGTTATTCT 
GTCTTCACAA ACCGGAGGCC TTTCGGGCCA GTGGGATTTA TGAAAAATGC CATCTCTATA 
GCTGAGGATG AAGAATGGAA GAGAATACGA TCATTGCTGT CTCCAACATT CACCAGCGGA 
AAACTCAAGG AGATGGTCCC TATCATTGCC CAGTATGGAG ATGTGTTGGT GAGAAATCTG 
AGGCGGGAAG CAGAGACAGG CAAGCCTGTC ACCTTGAAAC ACGTCTTTGG GGCCTACAGC 
ATGGATGTGA TCACTAGCAC ATCATTTGGA GTGAGCATCG ACTCTCTCAA CAATCCACAA 
GACCCCTTTG TGGAAAACAC CAAGAAGCTT TTAAGATTTA ATCCATTAGA TCCATTCGTT 
CTCTCAATAA AAGTCTTTCC ATTCCTTACC CCAATTCTTG AAGCATTAAA TATCACTGTG 
TTTCCAAGAA AAGTTATAAG TTTTCTAACA AAATCTGTAA AACAGATAAA AGAAGGTCGC 
CTCAAAGAGA CACAAAAGCA CCGAGTGGAT TTCCTTCAGC TGATGATTGA CTCTCAGAAT 
TCAAAAGACT CTGAGACCCA CAAAGCTCTG TCTGATCTGG AGCTCATGGC CCAATCAATT 
ATCTTTATTT TTGCTGGCTA TGAAACCACG AGCAGTGTTC TCTCCTTCAT TATATATGAA 
CTGGCCACTC ACCCTGATGT CCAGCAGAAA GTGCAGAAGG AAATTGATAC AGTTTTACCC 
AATAAGGCAC CACCCACCTA TGATACTGTG CTACAGTTGG AGTATCTTGA CATGGTGGTG 
AATGAAACAC TCAGATTATT CCCAGTTGCT ATGAGACTTG AGAGGGTCTG CAAAAAAGAT 
GTTGAAATCA ATGGGATGTT TATTCCCAAA GGGGTGGTGG TGATGATTCC AAGCTATGTT 
CTTCATCATG ACCCAAAGTA CTGGACAGAG CCTGAGAAGT TCCTCCCTGA AAGGTTCAGT 
AAAAAGAACA AGGACAACAT AGATCCTTAC ATATACACAC CCTTTGGAAG TGGACCCAGA 
AACTGCATTG GCATGAGGTT TGCTCTCGTG AACATGAAAC TTGCTCTAGT CAGAGTCCTT 
CAGAACTTCT CCTTCAAACC TTGTAAAGAA ACACAGATCC CCCTGAAATT ACGCTTTGGA 
GGACTTCTTC TAACAGAAAA ACCCATTGTT CTAAAGGCTG AGTCAAGGGA TGAGACCGTA 
AGTGGAGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CYP3A7 ( NM_000765.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000756.3 Homo sapiens cytochrome P450 family 3 subfamily A member 7 (CYP3A7), mRNA.

Price & Availability↑

CloneID	OHu23433
Clone ID Related Accession (Same CDS sequence)	NM_000765.4 , NM_000765.5
Accession Version	NM_000765.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1512bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	cytochrome P450 3A7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX643367.1, D00408.1, BX647143.1 and AC069294.5. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_000765.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.56658.1, SRR5189664.131595.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000336374.4/ ENSP00000337450.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATCTCA TCCCAAACTT GGCCGTGGAA ACCTGGCTTC TCCTGGCTGT CAGCCTGATA 
CTCCTCTATC TATATGGAAC CCGTACACAT GGACTTTTTA AGAAGCTTGG AATTCCAGGG 
CCCACACCTC TGCCTTTTTT GGGAAATGCT TTGTCCTTCC GTAAGGGCTA TTGGACGTTT 
GACATGGAAT GTTATAAAAA GTATAGAAAA GTCTGGGGTA TTTATGACTG TCAACAGCCT 
ATGCTGGCTA TCACAGATCC CGACATGATC AAAACAGTGC TAGTGAAAGA ATGTTATTCT 
GTCTTCACAA ACCGGAGGCC TTTCGGGCCA GTGGGATTTA TGAAAAATGC CATCTCTATA 
GCTGAGGATG AAGAATGGAA GAGAATACGA TCATTGCTGT CTCCAACATT CACCAGCGGA 
AAACTCAAGG AGATGGTCCC TATCATTGCC CAGTATGGAG ATGTGTTGGT GAGAAATCTG 
AGGCGGGAAG CAGAGACAGG CAAGCCTGTC ACCTTGAAAC ACGTCTTTGG GGCCTACAGC 
ATGGATGTGA TCACTAGCAC ATCATTTGGA GTGAGCATCG ACTCTCTCAA CAATCCACAA 
GACCCCTTTG TGGAAAACAC CAAGAAGCTT TTAAGATTTA ATCCATTAGA TCCATTCGTT 
CTCTCAATAA AAGTCTTTCC ATTCCTTACC CCAATTCTTG AAGCATTAAA TATCACTGTG 
TTTCCAAGAA AAGTTATAAG TTTTCTAACA AAATCTGTAA AACAGATAAA AGAAGGTCGC 
CTCAAAGAGA CACAAAAGCA CCGAGTGGAT TTCCTTCAGC TGATGATTGA CTCTCAGAAT 
TCAAAAGACT CTGAGACCCA CAAAGCTCTG TCTGATCTGG AGCTCATGGC CCAATCAATT 
ATCTTTATTT TTGCTGGCTA TGAAACCACG AGCAGTGTTC TCTCCTTCAT TATATATGAA 
CTGGCCACTC ACCCTGATGT CCAGCAGAAA GTGCAGAAGG AAATTGATAC AGTTTTACCC 
AATAAGGCAC CACCCACCTA TGATACTGTG CTACAGTTGG AGTATCTTGA CATGGTGGTG 
AATGAAACAC TCAGATTATT CCCAGTTGCT ATGAGACTTG AGAGGGTCTG CAAAAAAGAT 
GTTGAAATCA ATGGGATGTT TATTCCCAAA GGGGTGGTGG TGATGATTCC AAGCTATGTT 
CTTCATCATG ACCCAAAGTA CTGGACAGAG CCTGAGAAGT TCCTCCCTGA AAGGTTCAGT 
AAAAAGAACA AGGACAACAT AGATCCTTAC ATATACACAC CCTTTGGAAG TGGACCCAGA 
AACTGCATTG GCATGAGGTT TGCTCTCGTG AACATGAAAC TTGCTCTAGT CAGAGTCCTT 
CAGAACTTCT CCTTCAAACC TTGTAAAGAA ACACAGATCC CCCTGAAATT ACGCTTTGGA 
GGACTTCTTC TAACAGAAAA ACCCATTGTT CTAAAGGCTG AGTCAAGGGA TGAGACCGTA 
AGTGGAGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000756.3
CDS	104..1615
Translation	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA

Target ORF information:

RefSeq Version	NM_000765.5
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome P450 family 3 subfamily A member 7 (CYP3A7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000765.5

ORF Insert Sequence:

ATGGATCTCA TCCCAAACTT GGCCGTGGAA ACCTGGCTTC TCCTGGCTGT CAGCCTGATA 
CTCCTCTATC TATATGGAAC CCGTACACAT GGACTTTTTA AGAAGCTTGG AATTCCAGGG 
CCCACACCTC TGCCTTTTTT GGGAAATGCT TTGTCCTTCC GTAAGGGCTA TTGGACGTTT 
GACATGGAAT GTTATAAAAA GTATAGAAAA GTCTGGGGTA TTTATGACTG TCAACAGCCT 
ATGCTGGCTA TCACAGATCC CGACATGATC AAAACAGTGC TAGTGAAAGA ATGTTATTCT 
GTCTTCACAA ACCGGAGGCC TTTCGGGCCA GTGGGATTTA TGAAAAATGC CATCTCTATA 
GCTGAGGATG AAGAATGGAA GAGAATACGA TCATTGCTGT CTCCAACATT CACCAGCGGA 
AAACTCAAGG AGATGGTCCC TATCATTGCC CAGTATGGAG ATGTGTTGGT GAGAAATCTG 
AGGCGGGAAG CAGAGACAGG CAAGCCTGTC ACCTTGAAAC ACGTCTTTGG GGCCTACAGC 
ATGGATGTGA TCACTAGCAC ATCATTTGGA GTGAGCATCG ACTCTCTCAA CAATCCACAA 
GACCCCTTTG TGGAAAACAC CAAGAAGCTT TTAAGATTTA ATCCATTAGA TCCATTCGTT 
CTCTCAATAA AAGTCTTTCC ATTCCTTACC CCAATTCTTG AAGCATTAAA TATCACTGTG 
TTTCCAAGAA AAGTTATAAG TTTTCTAACA AAATCTGTAA AACAGATAAA AGAAGGTCGC 
CTCAAAGAGA CACAAAAGCA CCGAGTGGAT TTCCTTCAGC TGATGATTGA CTCTCAGAAT 
TCAAAAGACT CTGAGACCCA CAAAGCTCTG TCTGATCTGG AGCTCATGGC CCAATCAATT 
ATCTTTATTT TTGCTGGCTA TGAAACCACG AGCAGTGTTC TCTCCTTCAT TATATATGAA 
CTGGCCACTC ACCCTGATGT CCAGCAGAAA GTGCAGAAGG AAATTGATAC AGTTTTACCC 
AATAAGGCAC CACCCACCTA TGATACTGTG CTACAGTTGG AGTATCTTGA CATGGTGGTG 
AATGAAACAC TCAGATTATT CCCAGTTGCT ATGAGACTTG AGAGGGTCTG CAAAAAAGAT 
GTTGAAATCA ATGGGATGTT TATTCCCAAA GGGGTGGTGG TGATGATTCC AAGCTATGTT 
CTTCATCATG ACCCAAAGTA CTGGACAGAG CCTGAGAAGT TCCTCCCTGA AAGGTTCAGT 
AAAAAGAACA AGGACAACAT AGATCCTTAC ATATACACAC CCTTTGGAAG TGGACCCAGA 
AACTGCATTG GCATGAGGTT TGCTCTCGTG AACATGAAAC TTGCTCTAGT CAGAGTCCTT 
CAGAACTTCT CCTTCAAACC TTGTAAAGAA ACACAGATCC CCCTGAAATT ACGCTTTGGA 
GGACTTCTTC TAACAGAAAA ACCCATTGTT CTAAAGGCTG AGTCAAGGGA TGAGACCGTA 
AGTGGAGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7.
Drug metabolism and disposition: the biological fate of chemicals45(12)1266-1275(2017 Dec)
Kandel SE,Han LW,Mao Q,Lampe JN

The use of a unique co-culture model of fetoplacental steroidogenesis as a screening tool for endocrine disruptors: The effects of neonicotinoids on aromatase activity and hormone production.
Toxicology and applied pharmacology33215-24(2017 10)
Caron-Beaudoin E,Viau R,Hudon-Thibeault AA,Vaillancourt C,Sanderson JT

CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites.
British journal of cancer116(3)382-388(2017 Jan)
Sood D,Johnson N,Jain P,Siskos AP,Bennett M,Gilham C,Busana MC,Peto J,Dos-Santos-Silva I,Keun HC,Fletcher O

Developmental regulation of CYP3A4 and CYP3A7 in Chinese Han population.
Drug metabolism and pharmacokinetics31(6)433-444(2016 Dec)
He H,Nie YL,Li JF,Meng XG,Yang WH,Chen YL,Wang SJ,Ma X,Kan QC,Zhang LR

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CYP3A7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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