CST2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CST2
Entrez Gene ID	1470
Full Name	cystatin SA
General protein information	Preferred Names cystatin SA Names cystatin-SA cystatin 2 cystatin S5 cysteine-proteinase inhibitor salivary cysteine (thiol) protease inhibitor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p11.21
Summary	The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. [provided by RefSeq, Jul 2008].
Disorder MIM:	123856

mRNA and Protein(s)

mRNA	Protein	Name
NM_001322.2	NP_001313.1	cystatin-SA precursor
NM_001322.3	NP_001313.1	cystatin-SA precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Structural Dynamics Investigation of Human Family 1 & 2 Cystatin-Cathepsin L1 Interaction: A Comparison of Binding Modes.
Nandy SK, Seal A
PloS one11(10)e0164970(2016)

Salivary protein profiles are linked to bitter taste acceptance in infants.
Morzel M, Chabanet C, Schwartz C, Lucchi G, Ducoroy P, Nicklaus S
European journal of pediatrics173(5)575-82(2014 May)

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma na?ve to therapy.
Pieragostino D, Agnifili L, Fasanella V, D'Aguanno S, Mastropasqua R, Di Ilio C, Sacchetta P, Urbani A, Del Boccio P
Molecular bioSystems9(6)1108-16(2013 Jun)

Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1.
Lindh E, Br?nnstr?m J, Jones P, Wermeling F, H?ssler S, Betterle C, Garty BZ, Stridsberg M, Herrmann B, Karlsson MC, Winqvist O
Journal of autoimmunity421-6(2013 May)

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
B?hm D, Keller K, Pieter J, Boehm N, Wolters D, Siggelkow W, Lebrecht A, Schmidt M, K?lbl H, Pfeiffer N, Grus FH
Oncology reports28(2)429-38(2012 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

interactions of human family 1 & 2 cystatins with cathepsin L1
Title: Structural Dynamics Investigation of Human Family 1 & 2 Cystatin-Cathepsin L1 Interaction: A Comparison of Binding Modes.

This data suggests an autoimmune mechanism behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type I and provides rationale for evaluating cystatin SA1 in antifungal therapy.
Title: Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1.

Identification of cystatin SA as a novel inhibitor of acid ceramidase.
Title: Identification of cystatin SA as a novel inhibitor of acid ceramidase.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.

Observational study of gene-disease association. (HuGE Navigator)
Title: Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

The following CST2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CST2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31113	NM_001322.3 Latest version!	Homo sapiens cystatin SA (CST2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31113	NM_001322.2	Homo sapiens cystatin SA (CST2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CST2 ( NM_001322.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001313.1 Homo sapiens cystatin SA (CST2), mRNA.

Price & Availability↑

CloneID	OHu31113
Clone ID Related Accession (Same CDS sequence)	NM_001322.2 , NM_001322.3
Accession Version	NM_001322.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	cystatin-SA precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF319564.1. On Apr 2, 2002 this sequence version replaced NM_001322.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI521546.1, BC062679.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2151887 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTGGC CCCTGTGCAC CCTGCTGCTC CTGCTGGCCA CCCAGGCTGT GGCCCTGGCC 
TGGAGCCCCC AGGAGGAGGA CAGGATAATC GAGGGTGGCA TCTATGATGC AGACCTCAAT 
GATGAGCGGG TACAGCGTGC CCTTCACTTT GTCATCAGCG AGTATAACAA GGCCACTGAA 
GATGAGTACT ACAGACGCCT GCTGCGGGTG CTACGAGCCA GGGAGCAGAT CGTGGGCGGG 
GTGAATTACT TCTTCGACAT AGAGGTGGGC CGAACCATAT GTACCAAGTC CCAGCCCAAC 
TTGGACACCT GTGCCTTCCA TGAACAGCCA GAACTGCAGA AGAAACAGTT GTGCTCTTTC 
CAGATCTACG AAGTTCCCTG GGAGGACAGA ATGTCCCTGG TGAATTCCAG GTGTCAAGAA 
GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001313.1
CDS	16..441
Translation	MAWPLCTLLLLLATQAVALAWSPQEEDRIIEGGIYDADLNDERVQRALHFVISEYNKATEDEYYRRLLRVLRAREQIVGGVNYFFDIEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFQIYEVPWEDRMSLVNSRCQEA

Target ORF information:

RefSeq Version	NM_001322.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cystatin SA (CST2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001322.2

ORF Insert Sequence:

ATGGCCTGGC CCCTGTGCAC CCTGCTGCTC CTGCTGGCCA CCCAGGCTGT GGCCCTGGCC 
TGGAGCCCCC AGGAGGAGGA CAGGATAATC GAGGGTGGCA TCTATGATGC AGACCTCAAT 
GATGAGCGGG TACAGCGTGC CCTTCACTTT GTCATCAGCG AGTATAACAA GGCCACTGAA 
GATGAGTACT ACAGACGCCT GCTGCGGGTG CTACGAGCCA GGGAGCAGAT CGTGGGCGGG 
GTGAATTACT TCTTCGACAT AGAGGTGGGC CGAACCATAT GTACCAAGTC CCAGCCCAAC 
TTGGACACCT GTGCCTTCCA TGAACAGCCA GAACTGCAGA AGAAACAGTT GTGCTCTTTC 
CAGATCTACG AAGTTCCCTG GGAGGACAGA ATGTCCCTGG TGAATTCCAG GTGTCAAGAA 
GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CST2 ( NM_001322.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001313.1 Homo sapiens cystatin SA (CST2), mRNA.

Price & Availability↑

CloneID	OHu31113
Clone ID Related Accession (Same CDS sequence)	NM_001322.2 , NM_001322.3
Accession Version	NM_001322.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	cystatin-SA precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL591074.10. On Nov 26, 2018 this sequence version replaced NM_001322.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CK905410.1, BC062679.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2151887 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000304725.3/ ENSP00000307540.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCTGGC CCCTGTGCAC CCTGCTGCTC CTGCTGGCCA CCCAGGCTGT GGCCCTGGCC 
TGGAGCCCCC AGGAGGAGGA CAGGATAATC GAGGGTGGCA TCTATGATGC AGACCTCAAT 
GATGAGCGGG TACAGCGTGC CCTTCACTTT GTCATCAGCG AGTATAACAA GGCCACTGAA 
GATGAGTACT ACAGACGCCT GCTGCGGGTG CTACGAGCCA GGGAGCAGAT CGTGGGCGGG 
GTGAATTACT TCTTCGACAT AGAGGTGGGC CGAACCATAT GTACCAAGTC CCAGCCCAAC 
TTGGACACCT GTGCCTTCCA TGAACAGCCA GAACTGCAGA AGAAACAGTT GTGCTCTTTC 
CAGATCTACG AAGTTCCCTG GGAGGACAGA ATGTCCCTGG TGAATTCCAG GTGTCAAGAA 
GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001313.1
CDS	70..495
Translation	MAWPLCTLLLLLATQAVALAWSPQEEDRIIEGGIYDADLNDERVQRALHFVISEYNKATEDEYYRRLLRVLRAREQIVGGVNYFFDIEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFQIYEVPWEDRMSLVNSRCQEA

Target ORF information:

RefSeq Version	NM_001322.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cystatin SA (CST2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001322.3

ORF Insert Sequence:

ATGGCCTGGC CCCTGTGCAC CCTGCTGCTC CTGCTGGCCA CCCAGGCTGT GGCCCTGGCC 
TGGAGCCCCC AGGAGGAGGA CAGGATAATC GAGGGTGGCA TCTATGATGC AGACCTCAAT 
GATGAGCGGG TACAGCGTGC CCTTCACTTT GTCATCAGCG AGTATAACAA GGCCACTGAA 
GATGAGTACT ACAGACGCCT GCTGCGGGTG CTACGAGCCA GGGAGCAGAT CGTGGGCGGG 
GTGAATTACT TCTTCGACAT AGAGGTGGGC CGAACCATAT GTACCAAGTC CCAGCCCAAC 
TTGGACACCT GTGCCTTCCA TGAACAGCCA GAACTGCAGA AGAAACAGTT GTGCTCTTTC 
CAGATCTACG AAGTTCCCTG GGAGGACAGA ATGTCCCTGG TGAATTCCAG GTGTCAAGAA 
GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural Dynamics Investigation of Human Family 1 & 2 Cystatin-Cathepsin L1 Interaction: A Comparison of Binding Modes.
PloS one11(10)e0164970(2016)
Nandy SK,Seal A

Salivary protein profiles are linked to bitter taste acceptance in infants.
European journal of pediatrics173(5)575-82(2014 May)
Morzel M,Chabanet C,Schwartz C,Lucchi G,Ducoroy P,Nicklaus S

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma na?ve to therapy.
Molecular bioSystems9(6)1108-16(2013 Jun)
Pieragostino D,Agnifili L,Fasanella V,D'Aguanno S,Mastropasqua R,Di Ilio C,Sacchetta P,Urbani A,Del Boccio P

Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1.
Journal of autoimmunity421-6(2013 May)
Lindh E,Br?nnstr?m J,Jones P,Wermeling F,H?ssler S,Betterle C,Garty BZ,Stridsberg M,Herrmann B,Karlsson MC,Winqvist O

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
Oncology reports28(2)429-38(2012 Aug)
B?hm D,Keller K,Pieter J,Boehm N,Wolters D,Siggelkow W,Lebrecht A,Schmidt M,K?lbl H,Pfeiffer N,Grus FH

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CST2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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