COX7B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX7B
Entrez Gene ID	1349
Full Name	cytochrome c oxidase subunit 7B
Synonyms	APLCC,LSDMCA2
General protein information	Preferred Names cytochrome c oxidase subunit 7B Names cytochrome c oxidase subunit 7B, mitochondrial cytochrome c oxidase polypeptide VIIb cytochrome c oxidase subunit VIIb cytochrome-c oxidase chain VIIb
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq21.1
Summary	Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011].
Disorder MIM:	300885
Disorder Html:	Linear skin defects with multiple congenital anomalies 2, 300887 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001866.2	NP_001857.1	cytochrome c oxidase subunit 7B, mitochondrial precursor
NM_001866.3	NP_001857.1	cytochrome c oxidase subunit 7B, mitochondrial precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	COX7B	NP_001857.1
Pan troglodytes (chimpanzee)	COX7B	XP_003954072.1
Bos taurus (cattle)	COX7B	NP_786989.3
Mus musculus (house mouse)	Cox7b	NP_079655.1
Xenopus tropicalis (tropical clawed frog)	cox7b	NP_001165069.1
	COX7B	XP_001100150.1
Rattus norvegicus (Norway rat)	Cox7b	NP_877971.2

Gene Ontology
Bibliography

Related articles in PubMed

Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway.
Hadife N, Nemos C, Frippiat JP, Hamad? T, Perrot A, Dalloul A
Leukemia & lymphoma54(3)587-97(2013 Mar)

Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease.
Indrieri A, van Rahden VA, Tiranti V, Morleo M, Iaconis D, Tammaro R, D'Amato I, Conte I, Maystadt I, Demuth S, Zvulunov A, Kutsche K, Zeviani M, Franco B
American journal of human genetics91(5)942-9(2012 Nov)

Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b.
Fornuskova D, Stiburek L, Wenchich L, Vinsova K, Hansikova H, Zeman J
The Biochemical journal428(3)363-74(2010 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that recombinant (r)IL-24 stimulated the mitochondrial apoptotic pathway genes Bax, Bid, Casp8, COX6C, COX7B after 36 h.
Title: Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway.

study analyzed the X-linked COX7B and found deleterious de novo mutations in two simplex cases of microphthalmia with linear skin lesions and a nonsense mutation, which segregates with the disease, in a familial case
Title: Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease.

Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 7b
Title: Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b.

The following COX7B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX7B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19273	NM_001866.3 Latest version!	Homo sapiens cytochrome c oxidase subunit 7B (COX7B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19273	NM_001866.2	Homo sapiens cytochrome c oxidase subunit 7B (COX7B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX7B ( NM_001866.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001857.1 Homo sapiens cytochrome c oxidase subunit 7B (COX7B), mRNA.

Price & Availability↑

CloneID	OHu19273
Clone ID Related Accession (Same CDS sequence)	NM_001866.2 , NM_001866.3
Accession Version	NM_001866.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 7B, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z14244.1. This sequence is a reference standard in the RefSeqGene project. On Jan 10, 2002 this sequence version replaced NM_001866.1. ##Evidence-Data-START## Transcript exon combination :: Z14244.1, SRR1163658.336943.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTCCCT TGGTCAAAAG CGCACTAAAT CGTCTCCAAG TTCGAAGCAT TCAGCAAACA 
ATGGCAAGGC AGAGCCACCA GAAACGTACA CCTGATTTTC ATGACAAATA CGGTAATGCT 
GTATTAGCTA GTGGAGCCAC TTTCTGTATT GTTACATGGA CATATGTAGC AACACAAGTC 
GGAATAGAAT GGAACCTGTC CCCTGTTGGC AGAGTTACCC CAAAGGAATG GAGGAATCAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001857.1
CDS	91..333
Translation	MFPLVKSALNRLQVRSIQQTMARQSHQKRTPDFHDKYGNAVLASGATFCIVTWTYVATQVGIEWNLSPVGRVTPKEWRNQ

Target ORF information:

RefSeq Version	NM_001866.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 7B (COX7B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001866.2

ORF Insert Sequence:

ATGTTTCCCT TGGTCAAAAG CGCACTAAAT CGTCTCCAAG TTCGAAGCAT TCAGCAAACA 
ATGGCAAGGC AGAGCCACCA GAAACGTACA CCTGATTTTC ATGACAAATA CGGTAATGCT 
GTATTAGCTA GTGGAGCCAC TTTCTGTATT GTTACATGGA CATATGTAGC AACACAAGTC 
GGAATAGAAT GGAACCTGTC CCCTGTTGGC AGAGTTACCC CAAAGGAATG GAGGAATCAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX7B ( NM_001866.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001857.1 Homo sapiens cytochrome c oxidase subunit 7B (COX7B), mRNA.

Price & Availability↑

CloneID	OHu19273
Clone ID Related Accession (Same CDS sequence)	NM_001866.2 , NM_001866.3
Accession Version	NM_001866.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 243bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 7B, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z14244.1 and AL356235.22. This sequence is a reference standard in the RefSeqGene project. On Jul 13, 2018 this sequence version replaced NM_001866.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA173495.1, SRR3476690.694958.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000650309.2/ ENSP00000497474.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTTCCCT TGGTCAAAAG CGCACTAAAT CGTCTCCAAG TTCGAAGCAT TCAGCAAACA 
ATGGCAAGGC AGAGCCACCA GAAACGTACA CCTGATTTTC ATGACAAATA CGGTAATGCT 
GTATTAGCTA GTGGAGCCAC TTTCTGTATT GTTACATGGA CATATGTAGC AACACAAGTC 
GGAATAGAAT GGAACCTGTC CCCTGTTGGC AGAGTTACCC CAAAGGAATG GAGGAATCAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001857.1
CDS	87..329
Translation	MFPLVKSALNRLQVRSIQQTMARQSHQKRTPDFHDKYGNAVLASGATFCIVTWTYVATQVGIEWNLSPVGRVTPKEWRNQ

Target ORF information:

RefSeq Version	NM_001866.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 7B (COX7B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001866.3

ORF Insert Sequence:

ATGTTTCCCT TGGTCAAAAG CGCACTAAAT CGTCTCCAAG TTCGAAGCAT TCAGCAAACA 
ATGGCAAGGC AGAGCCACCA GAAACGTACA CCTGATTTTC ATGACAAATA CGGTAATGCT 
GTATTAGCTA GTGGAGCCAC TTTCTGTATT GTTACATGGA CATATGTAGC AACACAAGTC 
GGAATAGAAT GGAACCTGTC CCCTGTTGGC AGAGTTACCC CAAAGGAATG GAGGAATCAG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway.
Leukemia & lymphoma54(3)587-97(2013 Mar)
Hadife N,Nemos C,Frippiat JP,Hamad? T,Perrot A,Dalloul A

Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease.
American journal of human genetics91(5)942-9(2012 Nov)
Indrieri A,van Rahden VA,Tiranti V,Morleo M,Iaconis D,Tammaro R,D'Amato I,Conte I,Maystadt I,Demuth S,Zvulunov A,Kutsche K,Zeviani M,Franco B

Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b.
The Biochemical journal428(3)363-74(2010 May)
Fornuskova D,Stiburek L,Wenchich L,Vinsova K,Hansikova H,Zeman J

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COX7B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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