COX6C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX6C
Entrez Gene ID	1345
Full Name	cytochrome c oxidase subunit 6C
General protein information	Preferred Names cytochrome c oxidase subunit 6C Names cytochrome c oxidase subunit 6C cytochrome c oxidase polypeptide VIc cytochrome c oxidase subunit VIc preprotein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q22.2
Summary	Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010].
Disorder MIM:	124090

mRNA and Protein(s)

mRNA	Protein	Name
NM_004374.4	NP_004365.1	cytochrome c oxidase subunit 6C
XM_017013020.1	XP_016868509.1	cytochrome c oxidase subunit 6C isoform X1
NM_004374.3	NP_004365.1	cytochrome c oxidase subunit 6C

Pathways from BioSystems

Homologies

Homo sapiens (human)	COX6C	NP_004365.1
	COX6C	XP_002805459.1
	LOC703685	XP_001097441.2
Rattus norvegicus (Norway rat)	LOC100365711	XP_003751831.1
Pan troglodytes (chimpanzee)	COX6C	XP_003339209.1
Mus musculus (house mouse)	LOC102640946	XP_006516484.1

Gene Ontology
Bibliography

Related articles in PubMed

Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276.
Othumpangat S, Noti JD, Beezhold DH
Virology468-470256-64(2014 Nov)

Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway.
Hadife N, Nemos C, Frippiat JP, Hamad? T, Perrot A, Dalloul A
Leukemia & lymphoma54(3)587-97(2013 Mar)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria.
Lazarou M, Smith SM, Thorburn DR, Ryan MT, McKenzie M
The FEBS journal276(22)6701-13(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Within the first 3h of infection with influenza virus, significant down-regulation of hsa-miRNA-4276 is followed by a 2-fold increase in cytochrome c oxidase VIc mRNA was found to occur in human alveolar and bronchial epithelial cells.
Title: Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276.

Data indicate that recombinant (r)IL-24 stimulated the mitochondrial apoptotic pathway genes Bax, Bid, Casp8, COX6C, COX7B after 36 h.
Title: Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Data found that subunits Cox6a, Cox6b and Cox7a assembled into pre-existing complex IV, while Cox4-1 and Cox6c subunits assembled into subcomplexes that may represent rate-limiting intermediates.
Title: Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria.

Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphisms in mitochondrial genes and prostate cancer risk.

The following COX6C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX6C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12368	NM_004374.4 Latest version!	Homo sapiens cytochrome c oxidase subunit 6C (COX6C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu12368	XM_017013020.1 Latest version!	Homo sapiens cytochrome c oxidase subunit 6C (COX6C), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu12368	NM_004374.3	Homo sapiens cytochrome c oxidase subunit 6C (COX6C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX6C ( NM_004374.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004365.1 Homo sapiens cytochrome c oxidase subunit 6C (COX6C), mRNA.

Price & Availability↑

CloneID	OHu12368
Clone ID Related Accession (Same CDS sequence)	NM_004374.4 , XM_017013020.1 , NM_004374.3
Accession Version	NM_004374.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 228bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 6C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC105328.13. On Nov 23, 2018 this sequence version replaced NM_004374.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA181749.1, SRR1660807.118684.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000520468.7/ ENSP00000428895.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCCCG AAGTTTTGCC AAAACCTCGG ATGCGTGGCC TTCTGGCCAG GCGTCTGCGA 
AATCATATGG CTGTAGCATT CGTGCTATCC CTGGGGGTTG CAGCTTTGTA TAAGTTTCGT 
GTGGCTGATC AAAGAAAGAA GGCATACGCA GATTTCTACA GAAACTACGA TGTCATGAAA 
GATTTTGAGG AGATGAGGAA GGCTGGTATC TTTCAGAGTG TAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004365.1
CDS	101..328
Translation	MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMKDFEEMRKAGIFQSVK

Target ORF information:

RefSeq Version	NM_004374.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 6C (COX6C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004374.4

ORF Insert Sequence:

ATGGCTCCCG AAGTTTTGCC AAAACCTCGG ATGCGTGGCC TTCTGGCCAG GCGTCTGCGA 
AATCATATGG CTGTAGCATT CGTGCTATCC CTGGGGGTTG CAGCTTTGTA TAAGTTTCGT 
GTGGCTGATC AAAGAAAGAA GGCATACGCA GATTTCTACA GAAACTACGA TGTCATGAAA 
GATTTTGAGG AGATGAGGAA GGCTGGTATC TTTCAGAGTG TAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX6C ( NM_004374.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004365.1 Homo sapiens cytochrome c oxidase subunit 6C (COX6C), mRNA.

Price & Availability↑

CloneID	OHu12368
Clone ID Related Accession (Same CDS sequence)	NM_004374.4 , XM_017013020.1 , NM_004374.3
Accession Version	NM_004374.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 228bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 6C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC105328.13. On Jul 22, 2010 this sequence version replaced NM_004374.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA234938.1, BQ278583.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCCG AAGTTTTGCC AAAACCTCGG ATGCGTGGCC TTCTGGCCAG GCGTCTGCGA 
AATCATATGG CTGTAGCATT CGTGCTATCC CTGGGGGTTG CAGCTTTGTA TAAGTTTCGT 
GTGGCTGATC AAAGAAAGAA GGCATACGCA GATTTCTACA GAAACTACGA TGTCATGAAA 
GATTTTGAGG AGATGAGGAA GGCTGGTATC TTTCAGAGTG TAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004365.1
CDS	408..635
Translation	MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMKDFEEMRKAGIFQSVK

Target ORF information:

RefSeq Version	NM_004374.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 6C (COX6C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004374.3

ORF Insert Sequence:

ATGGCTCCCG AAGTTTTGCC AAAACCTCGG ATGCGTGGCC TTCTGGCCAG GCGTCTGCGA 
AATCATATGG CTGTAGCATT CGTGCTATCC CTGGGGGTTG CAGCTTTGTA TAAGTTTCGT 
GTGGCTGATC AAAGAAAGAA GGCATACGCA GATTTCTACA GAAACTACGA TGTCATGAAA 
GATTTTGAGG AGATGAGGAA GGCTGGTATC TTTCAGAGTG TAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COX6C ( XM_017013020.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016868509.1 Homo sapiens cytochrome c oxidase subunit 6C (COX6C), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu12368
Clone ID Related Accession (Same CDS sequence)	NM_004374.4 , XM_017013020.1 , NM_004374.3
Accession Version	XM_017013020.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 228bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cytochrome c oxidase subunit 6C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCCCG AAGTTTTGCC AAAACCTCGG ATGCGTGGCC TTCTGGCCAG GCGTCTGCGA 
AATCATATGG CTGTAGCATT CGTGCTATCC CTGGGGGTTG CAGCTTTGTA TAAGTTTCGT 
GTGGCTGATC AAAGAAAGAA GGCATACGCA GATTTCTACA GAAACTACGA TGTCATGAAA 
GATTTTGAGG AGATGAGGAA GGCTGGTATC TTTCAGAGTG TAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016868509.1
CDS	214..441
Translation	MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMKDFEEMRKAGIFQSVK

Target ORF information:

RefSeq Version	XM_017013020.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase subunit 6C (COX6C), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017013020.1

ORF Insert Sequence:

ATGGCTCCCG AAGTTTTGCC AAAACCTCGG ATGCGTGGCC TTCTGGCCAG GCGTCTGCGA 
AATCATATGG CTGTAGCATT CGTGCTATCC CTGGGGGTTG CAGCTTTGTA TAAGTTTCGT 
GTGGCTGATC AAAGAAAGAA GGCATACGCA GATTTCTACA GAAACTACGA TGTCATGAAA 
GATTTTGAGG AGATGAGGAA GGCTGGTATC TTTCAGAGTG TAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276.
Virology468-470256-64(2014 Nov)
Othumpangat S,Noti JD,Beezhold DH

Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway.
Leukemia & lymphoma54(3)587-97(2013 Mar)
Hadife N,Nemos C,Frippiat JP,Hamad? T,Perrot A,Dalloul A

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria.
The FEBS journal276(22)6701-13(2009 Nov)
Lazarou M,Smith SM,Thorburn DR,Ryan MT,McKenzie M

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COX6C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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