GPR151 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPR151
Entrez Gene ID	134391
Full Name	G protein-coupled receptor 151
Synonyms	GALR4,GALRL,GPCR,GPCR-2037,PGR7
General protein information	Preferred Names G protein-coupled receptor 151 Names probable G-protein coupled receptor 151 G-protein coupled receptor PGR7 galanin receptor 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q32
Summary	This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_194251.3	NP_919227.2	G-protein coupled receptor 151
NM_194251.2	NP_919227.2	probable G-protein coupled receptor 151

Pathways from BioSystems

Homologies

Homo sapiens (human)	GPR151	NP_919227.2
	GPR151	XP_001101607.1
Canis lupus familiaris (dog)	GPR151	XP_544329.2
Pan troglodytes (chimpanzee)	GPR151	XP_003950699.1
Rattus norvegicus (Norway rat)	Gpr151	NP_853664.1
Danio rerio (zebrafish)	LOC100538082	XP_003200026.1
Xenopus tropicalis (tropical clawed frog)	gpr151	XP_002935323.1
Danio rerio (zebrafish)	LOC565170	XP_693547.3
Mus musculus (house mouse)	Gpr151	NP_853521.1
Bos taurus (cattle)	GPR151	XP_002689346.2

Gene Ontology
Bibliography

Related articles in PubMed

Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain.
Holmes FE, Kerr N, Chen YJ, Vanderplank P, McArdle CA, Wynick D
Molecular and cellular neurosciences7835-40(2017 Jan)

Conserved expression of the GPR151 receptor in habenular axonal projections of vertebrates.
Broms J, Antolin-Fontes B, Tingstr?m A, Iba?ez-Tallon I
The Journal of comparative neurology523(3)359-80(2015 Feb)

Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors.
Kakarala KK, Jamil K
Molecular phylogenetics and evolution7466-96(2014 May)

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets.
Tang XL, Wang Y, Li DL, Luo J, Liu MY
Acta pharmacologica Sinica33(3)363-71(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Northern blot analysis reveals expression of galanin-receptor like (GalRL) in the central nervous system with minor levels in peripheral organs and tissues, such as testis, liver, kidney and stomach.
Title: Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors.

The following GPR151 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPR151 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29860	NM_194251.3 Latest version!	Homo sapiens G protein-coupled receptor 151 (GPR151), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu29860	NM_194251.2	Homo sapiens G protein-coupled receptor 151 (GPR151), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPR151 ( NM_194251.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_919227.2 Homo sapiens G protein-coupled receptor 151 (GPR151), mRNA.

Price & Availability↑

CloneID	OHu29860
Clone ID Related Accession (Same CDS sequence)	NM_194251.3 , NM_194251.2
Accession Version	NM_194251.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-11
Organism	Homo sapiens(human)
Product	G-protein coupled receptor 151
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC011375.5. On Dec 12, 2019 this sequence version replaced NM_194251.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AY351676.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCTGGCAG CTGCCTTTGC AGACTCTAAC TCCAGCAGCA TGAATGTGTC CTTTGCTCAC 
CTCCACTTTG CCGGAGGGTA CCTGCCCTCT GATTCCCAGG ACTGGAGAAC CATCATCCCG 
GCTCTCTTGG TGGCTGTCTG CCTGGTGGGC TTCGTGGGAA ACCTGTGTGT GATTGGCATC 
CTCCTTCACA ATGCTTGGAA AGGAAAGCCA TCCATGATCC ACTCCCTGAT TCTGAATCTC 
AGCCTGGCTG ATCTCTCCCT CCTGCTGTTT TCTGCACCTA TCCGAGCTAC GGCGTACTCC 
AAAAGTGTTT GGGATCTAGG CTGGTTTGTC TGCAAGTCCT CTGACTGGTT TATCCACACA 
TGCATGGCAG CCAAGAGCCT GACAATCGTT GTGGTGGCCA AAGTATGCTT CATGTATGCA 
AGTGACCCAG CCAAGCAAGT GAGTATCCAC AACTACACCA TCTGGTCAGT GCTGGTGGCC 
ATCTGGACTG TGGCTAGCCT GTTACCCCTG CCGGAATGGT TCTTTAGCAC CATCAGGCAT 
CATGAAGGTG TGGAAATGTG CCTCGTGGAT GTACCAGCTG TGGCTGAAGA GTTTATGTCG 
ATGTTTGGTA AGCTCTACCC ACTCCTGGCA TTTGGCCTTC CATTATTTTT TGCCAGCTTT 
TATTTCTGGA GAGCTTATGA CCAATGTAAA AAACGAGGAA CTAAGACTCA AAATCTTAGA 
AACCAGATAC GCTCAAAGCA AGTCACAGTG ATGCTGCTGA GCATTGCCAT CATCTCTGCT 
CTCTTGTGGC TCCCCGAATG GGTAGCTTGG CTGTGGGTAT GGCATCTGAA GGCTGCAGGC 
CCGGCCCCAC CACAAGGTTT CATAGCCCTG TCTCAAGTCT TGATGTTTTC CATCTCTTCA 
GCAAATCCTC TCATTTTTCT TGTGATGTCG GAAGAGTTCA GGGAAGGCTT GAAAGGTGTA 
TGGAAATGGA TGATAACCAA AAAACCTCCA ACTGTCTCAG AGTCTCAGGA AACACCAGCT 
GGCAACTCAG AGGGTCTTCC TGACAAGGTT CCATCTCCAG AATCCCCAGC ATCCATACCA 
GAAAAAGAGA AACCCAGCTC TCCCTCCTCT GGCAAAGGGA AAACTGAGAA GGCAGAGATT 
CCCATCCTTC CTGACGTAGA GCAGTTTTGG CATGAGAGGG ACACAGTCCC TTCTGTACAG 
GACAATGACC CTATCCCCTG GGAACATGAA GATCAAGAGA CAGGGGAAGG TGTTAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_919227.2
CDS	78..1337
Translation	MLAAAFADSNSSSMNVSFAHLHFAGGYLPSDSQDWRTIIPALLVAVCLVGFVGNLCVIGILLHNAWKGKPSMIHSLILNLSLADLSLLLFSAPIRATAYSKSVWDLGWFVCKSSDWFIHTCMAAKSLTIVVVAKVCFMYASDPAKQVSIHNYTIWSVLVAIWTVASLLPLPEWFFSTIRHHEGVEMCLVDVPAVAEEFMSMFGKLYPLLAFGLPLFFASFYFWRAYDQCKKRGTKTQNLRNQIRSKQVTVMLLSIAIISALLWLPEWVAWLWVWHLKAAGPAPPQGFIALSQVLMFSISSANPLIFLVMSEEFREGLKGVWKWMITKKPPTVSESQETPAGNSEGLPDKVPSPESPASIPEKEKPSSPSSGKGKTEKAEIPILPDVEQFWHERDTVPSVQDNDPIPWEHEDQETGEGVK

Target ORF information:

RefSeq Version	NM_194251.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 151 (GPR151), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_194251.3

ORF Insert Sequence:

ATGCTGGCAG CTGCCTTTGC AGACTCTAAC TCCAGCAGCA TGAATGTGTC CTTTGCTCAC 
CTCCACTTTG CCGGAGGGTA CCTGCCCTCT GATTCCCAGG ACTGGAGAAC CATCATCCCG 
GCTCTCTTGG TGGCTGTCTG CCTGGTGGGC TTCGTGGGAA ACCTGTGTGT GATTGGCATC 
CTCCTTCACA ATGCTTGGAA AGGAAAGCCA TCCATGATCC ACTCCCTGAT TCTGAATCTC 
AGCCTGGCTG ATCTCTCCCT CCTGCTGTTT TCTGCACCTA TCCGAGCTAC GGCGTACTCC 
AAAAGTGTTT GGGATCTAGG CTGGTTTGTC TGCAAGTCCT CTGACTGGTT TATCCACACA 
TGCATGGCAG CCAAGAGCCT GACAATCGTT GTGGTGGCCA AAGTATGCTT CATGTATGCA 
AGTGACCCAG CCAAGCAAGT GAGTATCCAC AACTACACCA TCTGGTCAGT GCTGGTGGCC 
ATCTGGACTG TGGCTAGCCT GTTACCCCTG CCGGAATGGT TCTTTAGCAC CATCAGGCAT 
CATGAAGGTG TGGAAATGTG CCTCGTGGAT GTACCAGCTG TGGCTGAAGA GTTTATGTCG 
ATGTTTGGTA AGCTCTACCC ACTCCTGGCA TTTGGCCTTC CATTATTTTT TGCCAGCTTT 
TATTTCTGGA GAGCTTATGA CCAATGTAAA AAACGAGGAA CTAAGACTCA AAATCTTAGA 
AACCAGATAC GCTCAAAGCA AGTCACAGTG ATGCTGCTGA GCATTGCCAT CATCTCTGCT 
CTCTTGTGGC TCCCCGAATG GGTAGCTTGG CTGTGGGTAT GGCATCTGAA GGCTGCAGGC 
CCGGCCCCAC CACAAGGTTT CATAGCCCTG TCTCAAGTCT TGATGTTTTC CATCTCTTCA 
GCAAATCCTC TCATTTTTCT TGTGATGTCG GAAGAGTTCA GGGAAGGCTT GAAAGGTGTA 
TGGAAATGGA TGATAACCAA AAAACCTCCA ACTGTCTCAG AGTCTCAGGA AACACCAGCT 
GGCAACTCAG AGGGTCTTCC TGACAAGGTT CCATCTCCAG AATCCCCAGC ATCCATACCA 
GAAAAAGAGA AACCCAGCTC TCCCTCCTCT GGCAAAGGGA AAACTGAGAA GGCAGAGATT 
CCCATCCTTC CTGACGTAGA GCAGTTTTGG CATGAGAGGG ACACAGTCCC TTCTGTACAG 
GACAATGACC CTATCCCCTG GGAACATGAA GATCAAGAGA CAGGGGAAGG TGTTAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPR151 ( NM_194251.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_919227.2 Homo sapiens G protein-coupled receptor 151 (GPR151), mRNA.

Price & Availability↑

CloneID	OHu29860
Clone ID Related Accession (Same CDS sequence)	NM_194251.3 , NM_194251.2
Accession Version	NM_194251.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-26
Organism	Homo sapiens(human)
Product	probable G-protein coupled receptor 151
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY351676.1. On Jan 20, 2005 this sequence version replaced NM_194251.1. ##Evidence-Data-START## Transcript is intronless :: AY351676.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCTGGCAG CTGCCTTTGC AGACTCTAAC TCCAGCAGCA TGAATGTGTC CTTTGCTCAC 
CTCCACTTTG CCGGAGGGTA CCTGCCCTCT GATTCCCAGG ACTGGAGAAC CATCATCCCG 
GCTCTCTTGG TGGCTGTCTG CCTGGTGGGC TTCGTGGGAA ACCTGTGTGT GATTGGCATC 
CTCCTTCACA ATGCTTGGAA AGGAAAGCCA TCCATGATCC ACTCCCTGAT TCTGAATCTC 
AGCCTGGCTG ATCTCTCCCT CCTGCTGTTT TCTGCACCTA TCCGAGCTAC GGCGTACTCC 
AAAAGTGTTT GGGATCTAGG CTGGTTTGTC TGCAAGTCCT CTGACTGGTT TATCCACACA 
TGCATGGCAG CCAAGAGCCT GACAATCGTT GTGGTGGCCA AAGTATGCTT CATGTATGCA 
AGTGACCCAG CCAAGCAAGT GAGTATCCAC AACTACACCA TCTGGTCAGT GCTGGTGGCC 
ATCTGGACTG TGGCTAGCCT GTTACCCCTG CCGGAATGGT TCTTTAGCAC CATCAGGCAT 
CATGAAGGTG TGGAAATGTG CCTCGTGGAT GTACCAGCTG TGGCTGAAGA GTTTATGTCG 
ATGTTTGGTA AGCTCTACCC ACTCCTGGCA TTTGGCCTTC CATTATTTTT TGCCAGCTTT 
TATTTCTGGA GAGCTTATGA CCAATGTAAA AAACGAGGAA CTAAGACTCA AAATCTTAGA 
AACCAGATAC GCTCAAAGCA AGTCACAGTG ATGCTGCTGA GCATTGCCAT CATCTCTGCT 
CTCTTGTGGC TCCCCGAATG GGTAGCTTGG CTGTGGGTAT GGCATCTGAA GGCTGCAGGC 
CCGGCCCCAC CACAAGGTTT CATAGCCCTG TCTCAAGTCT TGATGTTTTC CATCTCTTCA 
GCAAATCCTC TCATTTTTCT TGTGATGTCG GAAGAGTTCA GGGAAGGCTT GAAAGGTGTA 
TGGAAATGGA TGATAACCAA AAAACCTCCA ACTGTCTCAG AGTCTCAGGA AACACCAGCT 
GGCAACTCAG AGGGTCTTCC TGACAAGGTT CCATCTCCAG AATCCCCAGC ATCCATACCA 
GAAAAAGAGA AACCCAGCTC TCCCTCCTCT GGCAAAGGGA AAACTGAGAA GGCAGAGATT 
CCCATCCTTC CTGACGTAGA GCAGTTTTGG CATGAGAGGG ACACAGTCCC TTCTGTACAG 
GACAATGACC CTATCCCCTG GGAACATGAA GATCAAGAGA CAGGGGAAGG TGTTAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_919227.2
CDS	1..1260
Translation	MLAAAFADSNSSSMNVSFAHLHFAGGYLPSDSQDWRTIIPALLVAVCLVGFVGNLCVIGILLHNAWKGKPSMIHSLILNLSLADLSLLLFSAPIRATAYSKSVWDLGWFVCKSSDWFIHTCMAAKSLTIVVVAKVCFMYASDPAKQVSIHNYTIWSVLVAIWTVASLLPLPEWFFSTIRHHEGVEMCLVDVPAVAEEFMSMFGKLYPLLAFGLPLFFASFYFWRAYDQCKKRGTKTQNLRNQIRSKQVTVMLLSIAIISALLWLPEWVAWLWVWHLKAAGPAPPQGFIALSQVLMFSISSANPLIFLVMSEEFREGLKGVWKWMITKKPPTVSESQETPAGNSEGLPDKVPSPESPASIPEKEKPSSPSSGKGKTEKAEIPILPDVEQFWHERDTVPSVQDNDPIPWEHEDQETGEGVK

Target ORF information:

RefSeq Version	NM_194251.2
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 151 (GPR151), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_194251.2

ORF Insert Sequence:

ATGCTGGCAG CTGCCTTTGC AGACTCTAAC TCCAGCAGCA TGAATGTGTC CTTTGCTCAC 
CTCCACTTTG CCGGAGGGTA CCTGCCCTCT GATTCCCAGG ACTGGAGAAC CATCATCCCG 
GCTCTCTTGG TGGCTGTCTG CCTGGTGGGC TTCGTGGGAA ACCTGTGTGT GATTGGCATC 
CTCCTTCACA ATGCTTGGAA AGGAAAGCCA TCCATGATCC ACTCCCTGAT TCTGAATCTC 
AGCCTGGCTG ATCTCTCCCT CCTGCTGTTT TCTGCACCTA TCCGAGCTAC GGCGTACTCC 
AAAAGTGTTT GGGATCTAGG CTGGTTTGTC TGCAAGTCCT CTGACTGGTT TATCCACACA 
TGCATGGCAG CCAAGAGCCT GACAATCGTT GTGGTGGCCA AAGTATGCTT CATGTATGCA 
AGTGACCCAG CCAAGCAAGT GAGTATCCAC AACTACACCA TCTGGTCAGT GCTGGTGGCC 
ATCTGGACTG TGGCTAGCCT GTTACCCCTG CCGGAATGGT TCTTTAGCAC CATCAGGCAT 
CATGAAGGTG TGGAAATGTG CCTCGTGGAT GTACCAGCTG TGGCTGAAGA GTTTATGTCG 
ATGTTTGGTA AGCTCTACCC ACTCCTGGCA TTTGGCCTTC CATTATTTTT TGCCAGCTTT 
TATTTCTGGA GAGCTTATGA CCAATGTAAA AAACGAGGAA CTAAGACTCA AAATCTTAGA 
AACCAGATAC GCTCAAAGCA AGTCACAGTG ATGCTGCTGA GCATTGCCAT CATCTCTGCT 
CTCTTGTGGC TCCCCGAATG GGTAGCTTGG CTGTGGGTAT GGCATCTGAA GGCTGCAGGC 
CCGGCCCCAC CACAAGGTTT CATAGCCCTG TCTCAAGTCT TGATGTTTTC CATCTCTTCA 
GCAAATCCTC TCATTTTTCT TGTGATGTCG GAAGAGTTCA GGGAAGGCTT GAAAGGTGTA 
TGGAAATGGA TGATAACCAA AAAACCTCCA ACTGTCTCAG AGTCTCAGGA AACACCAGCT 
GGCAACTCAG AGGGTCTTCC TGACAAGGTT CCATCTCCAG AATCCCCAGC ATCCATACCA 
GAAAAAGAGA AACCCAGCTC TCCCTCCTCT GGCAAAGGGA AAACTGAGAA GGCAGAGATT 
CCCATCCTTC CTGACGTAGA GCAGTTTTGG CATGAGAGGG ACACAGTCCC TTCTGTACAG 
GACAATGACC CTATCCCCTG GGAACATGAA GATCAAGAGA CAGGGGAAGG TGTTAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain.
Molecular and cellular neurosciences7835-40(2017 Jan)
Holmes FE,Kerr N,Chen YJ,Vanderplank P,McArdle CA,Wynick D

Conserved expression of the GPR151 receptor in habenular axonal projections of vertebrates.
The Journal of comparative neurology523(3)359-80(2015 Feb)
Broms J,Antolin-Fontes B,Tingstr?m A,Iba?ez-Tallon I

Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors.
Molecular phylogenetics and evolution7466-96(2014 May)
Kakarala KK,Jamil K

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets.
Acta pharmacologica Sinica33(3)363-71(2012 Mar)
Tang XL,Wang Y,Li DL,Luo J,Liu MY

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GPR151 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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