PLK3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PLK3
Entrez Gene ID	1263
Full Name	polo like kinase 3
Synonyms	CNK,FNK,PLK-3,PRK
General protein information	Preferred Names polo like kinase 3 Names serine/threonine-protein kinase PLK3 FGF-inducible kinase cytokine-inducible serine/threonine-protein kinase proliferation-related kinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p34.1
Summary	The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. [provided by RefSeq, Sep 2015].
Disorder MIM:	602913

mRNA and Protein(s)

mRNA	Protein	Name
NM_004073.3	NP_004064.2	serine/threonine-protein kinase PLK3
NM_004073.4	NP_004064.2	serine/threonine-protein kinase PLK3

Pathways from BioSystems

Homologies

	PLK3	XP_001099497.1
Mus musculus (house mouse)	Plk3	NP_038835.2
Gallus gallus (chicken)	PLK3	XP_004936781.1
Homo sapiens (human)	PLK3	NP_004064.2
Canis lupus familiaris (dog)	PLK3	XP_532604.2
Bos taurus (cattle)	PLK3	NP_001068621.1
Xenopus tropicalis (tropical clawed frog)	plk3	NP_001006766.1
Rattus norvegicus (Norway rat)	Plk3	NP_071523.1
Danio rerio (zebrafish)	plk3	NP_958465.1

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated Autophagy.
Wang H, Tian C, Sun J, Chen LN, Lv Y, Yang XD, Xiao K, Wang J, Chen C, Shi Q, Shao QX, Dong XP
Molecular neurobiology54(6)4401-4413(2017 Aug)

Mutual regulation between Polo-like kinase 3 and SIAH2 E3 ubiquitin ligase defines a regulatory network that fine-tunes the cellular response to hypoxia and nickel.
Li C, Park S, Zhang X, Dai W, Xu D
The Journal of biological chemistry292(27)11431-11444(2017 07)

Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy.
R?del F, Martin D, Helmke C, Balermpas P, Fokas E, Wieland U, Rave-Fr?nk M, Kitz J, Matthess Y, Raab M, Strebhardt K, R?del C
Oncotarget7(33)53339-53349(2016 08)

Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.
Barton O, Naumann SC, Diemer-Biehs R, K?nzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, L?brich M
The Journal of cell biology206(7)877-94(2014 Sep)

Investigation on PLK2 and PLK3 substrate recognition.
Salvi M, Trashi E, Cozza G, Franchin C, Arrigoni G, Pinna LA
Biochimica et biophysica acta1824(12)1366-73(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study revealed an interesting mutual regulation between Plk3 and SIAH2 and uncovered a regulatory network that functions to fine-tune the cellular hypoxic response.
Title: Mutual regulation between Polo-like kinase 3 and SIAH2 E3 ubiquitin ligase defines a regulatory network that fine-tunes the cellular response to hypoxia and nickel.

the differential effects of hypoxic stress on Plk3 activity in Human Limbal Stem and HCE cells. Instead of apoptosis, hypoxic stress suppresses Plk3 activity to protect limbal stem cells from death and to allow the process of Human Limbal Stem cell differentiation.
Title: Effect of Hypoxia-regulated Polo-like Kinase 3 (Plk3) on Human Limbal Stem Cell Differentiation.

Knockout (KO) or knockdown of caspase-8, CD95 or FADD prevents activation of Plk3 upon CD95 stimulation, suggesting a requirement of a functional death-inducing signaling complex for Plk3 activation.
Title: Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8.

Plk3 is involved in the inhibition of cell proliferation and tumorigenesis, which may occur via interactions with p21.
Title: Polo?like kinase 3 inhibits osteosarcoma cell proliferation and tumorigenesis via cooperative interaction with p21.

Data suggest that HOXA-AS2 could be an oncogene for gastric cancer partly through suppressing P21, PLK3, and DDIT3 expression.
Title: Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression.

The following PLK3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLK3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04267	NM_004073.4 Latest version!	Homo sapiens polo like kinase 3 (PLK3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu04267	NM_004073.3	Homo sapiens polo like kinase 3 (PLK3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLK3 ( NM_004073.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004064.2 Homo sapiens polo like kinase 3 (PLK3), mRNA.

Price & Availability↑

CloneID	OHu04267
Clone ID Related Accession (Same CDS sequence)	NM_004073.3 , NM_004073.4
Accession Version	NM_004073.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1941bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PLK3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC013899.2 and BC013960.2. On Nov 22, 2018 this sequence version replaced NM_004073.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013899.2, AJ293866.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372201.5/ ENSP00000361275.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCCTG CCGCCGGTTT CCTGTCTCCG CGCCCCTTCC AGCGTGCGGC CGCCGCGCCC 
GCTCCCCCGG CCGGGCCCGG GCCGCCTCCG AGTGCCTTGC GCGGACCTGA GCTGGAGATG 
CTGGCCGGGC TACCGACGTC AGACCCCGGG CGCCTCATCA CGGACCCGCG CAGCGGCCGC 
ACCTACCTCA AAGGCCGCTT GTTGGGCAAG GGGGGCTTCG CCCGCTGCTA CGAGGCCACT 
GACACAGAGA CTGGCAGCGC CTACGCTGTC AAAGTCATCC CGCAGAGCCG CGTCGCCAAG 
CCGCATCAGC GCGAGAAGAT CCTAAATGAG ATTGAGCTGC ACCGAGACCT GCAGCACCGC 
CACATCGTGC GTTTTTCGCA CCACTTTGAG GACGCTGACA ACATCTACAT TTTCTTGGAG 
CTCTGCAGCC GAAAGTCCCT GGCCCACATC TGGAAGGCCC GGCACACCCT GTTGGAGCCA 
GAAGTGCGCT ACTACCTGCG GCAGATCCTT TCTGGCCTCA AGTACTTGCA CCAGCGCGGC 
ATCTTGCACC GGGACCTCAA GTTGGGAAAT TTTTTCATCA CTGAGAACAT GGAACTGAAG 
GTGGGGGATT TTGGGCTGGC AGCCCGGTTG GAGCCTCCGG AGCAGAGGAA GAAGACCATC 
TGTGGCACCC CCAACTATGT GGCTCCAGAA GTGCTGCTGA GACAGGGCCA CGGCCCTGAG 
GCGGATGTAT GGTCACTGGG CTGTGTCATG TACACGCTGC TCTGCGGGAG CCCTCCCTTT 
GAGACGGCTG ACCTGAAGGA GACGTACCGC TGCATCAAGC AGGTTCACTA CACGCTGCCT 
GCCAGCCTCT CACTGCCTGC CCGGCAGCTC CTGGCCGCCA TCCTTCGGGC CTCACCCCGA 
GACCGCCCCT CTATTGACCA GATCCTGCGC CATGACTTCT TTACCAAGGG CTACACCCCC 
GATCGACTCC CTATCAGCAG CTGCGTGACA GTCCCAGACC TGACACCCCC CAACCCAGCT 
AGGAGTCTGT TTGCCAAAGT TACCAAGAGC CTCTTTGGCA GAAAGAAGAA GAGTAAGAAT 
CATGCCCAGG AGAGGGATGA GGTCTCCGGT TTGGTGAGCG GCCTCATGCG CACATCCGTT 
GGCCATCAGG ATGCCAGGCC AGAGGCTCCA GCAGCTTCTG GCCCAGCCCC TGTCAGCCTG 
GTAGAGACAG CACCTGAAGA CAGCTCACCC CGTGGGACAC TGGCAAGCAG TGGAGATGGA 
TTTGAAGAAG GTCTGACTGT GGCCACAGTA GTGGAGTCAG CCCTTTGTGC TCTGAGAAAT 
TGTATAGCCT TCATGCCCCC AGCGGAACAG AACCCGGCCC CCCTGGCCCA GCCAGAGCCT 
CTGGTGTGGG TCAGCAAGTG GGTTGACTAC TCCAATAAGT TCGGCTTTGG GTATCAACTG 
TCCAGCCGCC GTGTGGCTGT GCTCTTCAAC GATGGCACAC ATATGGCCCT GTCGGCCAAC 
AGAAAGACTG TGCACTACAA TCCCACCAGC ACAAAGCACT TCTCCTTCTC CGTGGGTGCT 
GTGCCCCGGG CCCTGCAGCC TCAGCTGGGT ATCCTGCGGT ACTTCGCCTC CTACATGGAG 
CAGCACCTCA TGAAGGGTGG AGATCTGCCC AGTGTGGAAG AGGTAGAGGT ACCTGCTCCG 
CCCTTGCTGC TGCAGTGGGT CAAGACGGAT CAGGCTCTCC TCATGCTGTT TAGTGATGGC 
ACTGTCCAGG TGAACTTCTA CGGGGACCAC ACCAAGCTGA TTCTCAGTGG CTGGGAGCCC 
CTCCTTGTGA CTTTTGTGGC CCGAAATCGT AGTGCTTGTA CTTACCTCGC TTCCCACCTT 
CGGCAGCTGG GCTGCTCTCC AGACCTGCGG CAGCGACTCC GCTATGCTCT GCGCCTGCTC 
CGGGACCGCA GCCCAGCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004064.2
CDS	88..2028
Translation	MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKNHAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA

Target ORF information:

RefSeq Version	NM_004073.4
Organism	Homo sapiens(human)
Definition	Homo sapiens polo like kinase 3 (PLK3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004073.4

ORF Insert Sequence:

ATGGAGCCTG CCGCCGGTTT CCTGTCTCCG CGCCCCTTCC AGCGTGCGGC CGCCGCGCCC 
GCTCCCCCGG CCGGGCCCGG GCCGCCTCCG AGTGCCTTGC GCGGACCTGA GCTGGAGATG 
CTGGCCGGGC TACCGACGTC AGACCCCGGG CGCCTCATCA CGGACCCGCG CAGCGGCCGC 
ACCTACCTCA AAGGCCGCTT GTTGGGCAAG GGGGGCTTCG CCCGCTGCTA CGAGGCCACT 
GACACAGAGA CTGGCAGCGC CTACGCTGTC AAAGTCATCC CGCAGAGCCG CGTCGCCAAG 
CCGCATCAGC GCGAGAAGAT CCTAAATGAG ATTGAGCTGC ACCGAGACCT GCAGCACCGC 
CACATCGTGC GTTTTTCGCA CCACTTTGAG GACGCTGACA ACATCTACAT TTTCTTGGAG 
CTCTGCAGCC GAAAGTCCCT GGCCCACATC TGGAAGGCCC GGCACACCCT GTTGGAGCCA 
GAAGTGCGCT ACTACCTGCG GCAGATCCTT TCTGGCCTCA AGTACTTGCA CCAGCGCGGC 
ATCTTGCACC GGGACCTCAA GTTGGGAAAT TTTTTCATCA CTGAGAACAT GGAACTGAAG 
GTGGGGGATT TTGGGCTGGC AGCCCGGTTG GAGCCTCCGG AGCAGAGGAA GAAGACCATC 
TGTGGCACCC CCAACTATGT GGCTCCAGAA GTGCTGCTGA GACAGGGCCA CGGCCCTGAG 
GCGGATGTAT GGTCACTGGG CTGTGTCATG TACACGCTGC TCTGCGGGAG CCCTCCCTTT 
GAGACGGCTG ACCTGAAGGA GACGTACCGC TGCATCAAGC AGGTTCACTA CACGCTGCCT 
GCCAGCCTCT CACTGCCTGC CCGGCAGCTC CTGGCCGCCA TCCTTCGGGC CTCACCCCGA 
GACCGCCCCT CTATTGACCA GATCCTGCGC CATGACTTCT TTACCAAGGG CTACACCCCC 
GATCGACTCC CTATCAGCAG CTGCGTGACA GTCCCAGACC TGACACCCCC CAACCCAGCT 
AGGAGTCTGT TTGCCAAAGT TACCAAGAGC CTCTTTGGCA GAAAGAAGAA GAGTAAGAAT 
CATGCCCAGG AGAGGGATGA GGTCTCCGGT TTGGTGAGCG GCCTCATGCG CACATCCGTT 
GGCCATCAGG ATGCCAGGCC AGAGGCTCCA GCAGCTTCTG GCCCAGCCCC TGTCAGCCTG 
GTAGAGACAG CACCTGAAGA CAGCTCACCC CGTGGGACAC TGGCAAGCAG TGGAGATGGA 
TTTGAAGAAG GTCTGACTGT GGCCACAGTA GTGGAGTCAG CCCTTTGTGC TCTGAGAAAT 
TGTATAGCCT TCATGCCCCC AGCGGAACAG AACCCGGCCC CCCTGGCCCA GCCAGAGCCT 
CTGGTGTGGG TCAGCAAGTG GGTTGACTAC TCCAATAAGT TCGGCTTTGG GTATCAACTG 
TCCAGCCGCC GTGTGGCTGT GCTCTTCAAC GATGGCACAC ATATGGCCCT GTCGGCCAAC 
AGAAAGACTG TGCACTACAA TCCCACCAGC ACAAAGCACT TCTCCTTCTC CGTGGGTGCT 
GTGCCCCGGG CCCTGCAGCC TCAGCTGGGT ATCCTGCGGT ACTTCGCCTC CTACATGGAG 
CAGCACCTCA TGAAGGGTGG AGATCTGCCC AGTGTGGAAG AGGTAGAGGT ACCTGCTCCG 
CCCTTGCTGC TGCAGTGGGT CAAGACGGAT CAGGCTCTCC TCATGCTGTT TAGTGATGGC 
ACTGTCCAGG TGAACTTCTA CGGGGACCAC ACCAAGCTGA TTCTCAGTGG CTGGGAGCCC 
CTCCTTGTGA CTTTTGTGGC CCGAAATCGT AGTGCTTGTA CTTACCTCGC TTCCCACCTT 
CGGCAGCTGG GCTGCTCTCC AGACCTGCGG CAGCGACTCC GCTATGCTCT GCGCCTGCTC 
CGGGACCGCA GCCCAGCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLK3 ( NM_004073.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004064.2 Homo sapiens polo like kinase 3 (PLK3), mRNA.

Price & Availability↑

CloneID	OHu04267
Clone ID Related Accession (Same CDS sequence)	NM_004073.3 , NM_004073.4
Accession Version	NM_004073.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1941bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PLK3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL592166.16, AJ293866.1, BC013899.2, BC013960.2 and AL157684.1. On Sep 12, 2015 this sequence version replaced NM_004073.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ293866.1, BC013899.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCTG CCGCCGGTTT CCTGTCTCCG CGCCCCTTCC AGCGTGCGGC CGCCGCGCCC 
GCTCCCCCGG CCGGGCCCGG GCCGCCTCCG AGTGCCTTGC GCGGACCTGA GCTGGAGATG 
CTGGCCGGGC TACCGACGTC AGACCCCGGG CGCCTCATCA CGGACCCGCG CAGCGGCCGC 
ACCTACCTCA AAGGCCGCTT GTTGGGCAAG GGGGGCTTCG CCCGCTGCTA CGAGGCCACT 
GACACAGAGA CTGGCAGCGC CTACGCTGTC AAAGTCATCC CGCAGAGCCG CGTCGCCAAG 
CCGCATCAGC GCGAGAAGAT CCTAAATGAG ATTGAGCTGC ACCGAGACCT GCAGCACCGC 
CACATCGTGC GTTTTTCGCA CCACTTTGAG GACGCTGACA ACATCTACAT TTTCTTGGAG 
CTCTGCAGCC GAAAGTCCCT GGCCCACATC TGGAAGGCCC GGCACACCCT GTTGGAGCCA 
GAAGTGCGCT ACTACCTGCG GCAGATCCTT TCTGGCCTCA AGTACTTGCA CCAGCGCGGC 
ATCTTGCACC GGGACCTCAA GTTGGGAAAT TTTTTCATCA CTGAGAACAT GGAACTGAAG 
GTGGGGGATT TTGGGCTGGC AGCCCGGTTG GAGCCTCCGG AGCAGAGGAA GAAGACCATC 
TGTGGCACCC CCAACTATGT GGCTCCAGAA GTGCTGCTGA GACAGGGCCA CGGCCCTGAG 
GCGGATGTAT GGTCACTGGG CTGTGTCATG TACACGCTGC TCTGCGGGAG CCCTCCCTTT 
GAGACGGCTG ACCTGAAGGA GACGTACCGC TGCATCAAGC AGGTTCACTA CACGCTGCCT 
GCCAGCCTCT CACTGCCTGC CCGGCAGCTC CTGGCCGCCA TCCTTCGGGC CTCACCCCGA 
GACCGCCCCT CTATTGACCA GATCCTGCGC CATGACTTCT TTACCAAGGG CTACACCCCC 
GATCGACTCC CTATCAGCAG CTGCGTGACA GTCCCAGACC TGACACCCCC CAACCCAGCT 
AGGAGTCTGT TTGCCAAAGT TACCAAGAGC CTCTTTGGCA GAAAGAAGAA GAGTAAGAAT 
CATGCCCAGG AGAGGGATGA GGTCTCCGGT TTGGTGAGCG GCCTCATGCG CACATCCGTT 
GGCCATCAGG ATGCCAGGCC AGAGGCTCCA GCAGCTTCTG GCCCAGCCCC TGTCAGCCTG 
GTAGAGACAG CACCTGAAGA CAGCTCACCC CGTGGGACAC TGGCAAGCAG TGGAGATGGA 
TTTGAAGAAG GTCTGACTGT GGCCACAGTA GTGGAGTCAG CCCTTTGTGC TCTGAGAAAT 
TGTATAGCCT TCATGCCCCC AGCGGAACAG AACCCGGCCC CCCTGGCCCA GCCAGAGCCT 
CTGGTGTGGG TCAGCAAGTG GGTTGACTAC TCCAATAAGT TCGGCTTTGG GTATCAACTG 
TCCAGCCGCC GTGTGGCTGT GCTCTTCAAC GATGGCACAC ATATGGCCCT GTCGGCCAAC 
AGAAAGACTG TGCACTACAA TCCCACCAGC ACAAAGCACT TCTCCTTCTC CGTGGGTGCT 
GTGCCCCGGG CCCTGCAGCC TCAGCTGGGT ATCCTGCGGT ACTTCGCCTC CTACATGGAG 
CAGCACCTCA TGAAGGGTGG AGATCTGCCC AGTGTGGAAG AGGTAGAGGT ACCTGCTCCG 
CCCTTGCTGC TGCAGTGGGT CAAGACGGAT CAGGCTCTCC TCATGCTGTT TAGTGATGGC 
ACTGTCCAGG TGAACTTCTA CGGGGACCAC ACCAAGCTGA TTCTCAGTGG CTGGGAGCCC 
CTCCTTGTGA CTTTTGTGGC CCGAAATCGT AGTGCTTGTA CTTACCTCGC TTCCCACCTT 
CGGCAGCTGG GCTGCTCTCC AGACCTGCGG CAGCGACTCC GCTATGCTCT GCGCCTGCTC 
CGGGACCGCA GCCCAGCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004064.2
CDS	240..2180
Translation	MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKNHAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA

Target ORF information:

RefSeq Version	NM_004073.3
Organism	Homo sapiens(human)
Definition	Homo sapiens polo like kinase 3 (PLK3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004073.3

ORF Insert Sequence:

ATGGAGCCTG CCGCCGGTTT CCTGTCTCCG CGCCCCTTCC AGCGTGCGGC CGCCGCGCCC 
GCTCCCCCGG CCGGGCCCGG GCCGCCTCCG AGTGCCTTGC GCGGACCTGA GCTGGAGATG 
CTGGCCGGGC TACCGACGTC AGACCCCGGG CGCCTCATCA CGGACCCGCG CAGCGGCCGC 
ACCTACCTCA AAGGCCGCTT GTTGGGCAAG GGGGGCTTCG CCCGCTGCTA CGAGGCCACT 
GACACAGAGA CTGGCAGCGC CTACGCTGTC AAAGTCATCC CGCAGAGCCG CGTCGCCAAG 
CCGCATCAGC GCGAGAAGAT CCTAAATGAG ATTGAGCTGC ACCGAGACCT GCAGCACCGC 
CACATCGTGC GTTTTTCGCA CCACTTTGAG GACGCTGACA ACATCTACAT TTTCTTGGAG 
CTCTGCAGCC GAAAGTCCCT GGCCCACATC TGGAAGGCCC GGCACACCCT GTTGGAGCCA 
GAAGTGCGCT ACTACCTGCG GCAGATCCTT TCTGGCCTCA AGTACTTGCA CCAGCGCGGC 
ATCTTGCACC GGGACCTCAA GTTGGGAAAT TTTTTCATCA CTGAGAACAT GGAACTGAAG 
GTGGGGGATT TTGGGCTGGC AGCCCGGTTG GAGCCTCCGG AGCAGAGGAA GAAGACCATC 
TGTGGCACCC CCAACTATGT GGCTCCAGAA GTGCTGCTGA GACAGGGCCA CGGCCCTGAG 
GCGGATGTAT GGTCACTGGG CTGTGTCATG TACACGCTGC TCTGCGGGAG CCCTCCCTTT 
GAGACGGCTG ACCTGAAGGA GACGTACCGC TGCATCAAGC AGGTTCACTA CACGCTGCCT 
GCCAGCCTCT CACTGCCTGC CCGGCAGCTC CTGGCCGCCA TCCTTCGGGC CTCACCCCGA 
GACCGCCCCT CTATTGACCA GATCCTGCGC CATGACTTCT TTACCAAGGG CTACACCCCC 
GATCGACTCC CTATCAGCAG CTGCGTGACA GTCCCAGACC TGACACCCCC CAACCCAGCT 
AGGAGTCTGT TTGCCAAAGT TACCAAGAGC CTCTTTGGCA GAAAGAAGAA GAGTAAGAAT 
CATGCCCAGG AGAGGGATGA GGTCTCCGGT TTGGTGAGCG GCCTCATGCG CACATCCGTT 
GGCCATCAGG ATGCCAGGCC AGAGGCTCCA GCAGCTTCTG GCCCAGCCCC TGTCAGCCTG 
GTAGAGACAG CACCTGAAGA CAGCTCACCC CGTGGGACAC TGGCAAGCAG TGGAGATGGA 
TTTGAAGAAG GTCTGACTGT GGCCACAGTA GTGGAGTCAG CCCTTTGTGC TCTGAGAAAT 
TGTATAGCCT TCATGCCCCC AGCGGAACAG AACCCGGCCC CCCTGGCCCA GCCAGAGCCT 
CTGGTGTGGG TCAGCAAGTG GGTTGACTAC TCCAATAAGT TCGGCTTTGG GTATCAACTG 
TCCAGCCGCC GTGTGGCTGT GCTCTTCAAC GATGGCACAC ATATGGCCCT GTCGGCCAAC 
AGAAAGACTG TGCACTACAA TCCCACCAGC ACAAAGCACT TCTCCTTCTC CGTGGGTGCT 
GTGCCCCGGG CCCTGCAGCC TCAGCTGGGT ATCCTGCGGT ACTTCGCCTC CTACATGGAG 
CAGCACCTCA TGAAGGGTGG AGATCTGCCC AGTGTGGAAG AGGTAGAGGT ACCTGCTCCG 
CCCTTGCTGC TGCAGTGGGT CAAGACGGAT CAGGCTCTCC TCATGCTGTT TAGTGATGGC 
ACTGTCCAGG TGAACTTCTA CGGGGACCAC ACCAAGCTGA TTCTCAGTGG CTGGGAGCCC 
CTCCTTGTGA CTTTTGTGGC CCGAAATCGT AGTGCTTGTA CTTACCTCGC TTCCCACCTT 
CGGCAGCTGG GCTGCTCTCC AGACCTGCGG CAGCGACTCC GCTATGCTCT GCGCCTGCTC 
CGGGACCGCA GCCCAGCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated Autophagy.
Molecular neurobiology54(6)4401-4413(2017 Aug)
Wang H,Tian C,Sun J,Chen LN,Lv Y,Yang XD,Xiao K,Wang J,Chen C,Shi Q,Shao QX,Dong XP

Mutual regulation between Polo-like kinase 3 and SIAH2 E3 ubiquitin ligase defines a regulatory network that fine-tunes the cellular response to hypoxia and nickel.
The Journal of biological chemistry292(27)11431-11444(2017 07)
Li C,Park S,Zhang X,Dai W,Xu D

Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy.
Oncotarget7(33)53339-53349(2016 08)
R?del F,Martin D,Helmke C,Balermpas P,Fokas E,Wieland U,Rave-Fr?nk M,Kitz J,Matthess Y,Raab M,Strebhardt K,R?del C

Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.
The Journal of cell biology206(7)877-94(2014 Sep)
Barton O,Naumann SC,Diemer-Biehs R,K?nzel J,Steinlage M,Conrad S,Makharashvili N,Wang J,Feng L,Lopez BS,Paull TT,Chen J,Jeggo PA,L?brich M

Investigation on PLK2 and PLK3 substrate recognition.
Biochimica et biophysica acta1824(12)1366-73(2012 Dec)
Salvi M,Trashi E,Cozza G,Franchin C,Arrigoni G,Pinna LA

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PLK3 cDNA ORF clone, Homo sapiens(human)

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