CCR8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCR8
Entrez Gene ID	1237
Full Name	C-C motif chemokine receptor 8
Synonyms	CC-CKR-8,CCR-8,CDw198,CKRL1,CMKBR8,CMKBRL2,CY6,GPRCY6,TER1
General protein information	Preferred Names C-C motif chemokine receptor 8 Names C-C chemokine receptor type 8 CC chemokine receptor 8 CC chemokine receptor CHEMR1 CC-chemokine receptor chemr1 chemokine (C-C motif) receptor 8 chemokine (C-C) receptor 8 chemokine (C-C) receptor-like 2 chemokine receptor-like 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p22.1
Summary	This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008].
Disorder MIM:	601834

mRNA and Protein(s)

mRNA	Protein	Name
NM_005201.4	NP_005192.1	C-C chemokine receptor type 8
NM_005201.3	NP_005192.1	C-C chemokine receptor type 8

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CCR8	XP_542719.1
Pan troglodytes (chimpanzee)	CCR8	XP_526178.2
Mus musculus (house mouse)	Ccr8	NP_031746.1
Bos taurus (cattle)	CCR8	NP_001181891.1
Rattus norvegicus (Norway rat)	Ccr8	XP_236704.1
Gallus gallus (chicken)	CCR8L	NP_001074363.1
Homo sapiens (human)	CCR8	NP_005192.1
	CCR8	XP_001084047.1
Gallus gallus (chicken)	CCR8	NP_001026162.1

Gene Ontology
Bibliography

Related articles in PubMed

CCR8
Barsheshet Y, Wildbaum G, Levy E, Vitenshtein A, Akinseye C, Griggs J, Lira SA, Karin N
Proceedings of the National Academy of Sciences of the United States of America114(23)6086-6091(2017 Jun)

Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding.
Barington L, Rummel PC, L?ckmann M, Pihl H, Larsen O, Daugvilaite V, Johnsen AH, Frimurer TM, Karlsh?j S, Rosenkilde MM
The Journal of biological chemistry291(31)16208-20(2016 07)

Positive intratumoral chemokine (C-C motif) receptor 8 expression predicts high recurrence risk of post-operation clear-cell renal cell carcinoma patients.
Fu Q, Chang Y, Zhou L, An H, Zhu Y, Xu L, Zhang W, Xu J
Oncotarget7(7)8413-21(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding.
Title: Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding.

High CCR8 expression is associated with high recurrence in kidney cancer.
Title: Positive intratumoral chemokine (C-C motif) receptor 8 expression predicts high recurrence risk of post-operation clear-cell renal cell carcinoma patients.

findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease
Title: Expression of the chemokine receptor gene, CCR8, is associated With DUSP22 rearrangements in anaplastic large cell lymphoma.

Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin.
Title: Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells.

Identification of human CCR8 as a CCL18 receptor.
Title: Identification of human CCR8 as a CCL18 receptor.

The following CCR8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCR8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17577	NM_005201.4 Latest version!	Homo sapiens C-C motif chemokine receptor 8 (CCR8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu17577	NM_005201.3	Homo sapiens C-C motif chemokine receptor 8 (CCR8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCR8 ( NM_005201.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005192.1 Homo sapiens C-C motif chemokine receptor 8 (CCR8), mRNA.

Price & Availability↑

CloneID	OHu17577
Clone ID Related Accession (Same CDS sequence)	NM_005201.4 , NM_005201.3
Accession Version	NM_005201.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	C-C chemokine receptor type 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314957.1, BC107159.1 and AC104850.2. On May 17, 2019 this sequence version replaced NM_005201.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC107159.1, D49919.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000326306.5/ ENSP00000326432.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGATTATA CACTTGACCT CAGTGTGACA ACAGTGACCG ACTACTACTA CCCTGATATC 
TTCTCAAGCC CCTGTGATGC GGAACTTATT CAGACAAATG GCAAGTTGCT CCTTGCTGTC 
TTTTATTGCC TCCTGTTTGT ATTCAGTCTT CTGGGAAACA GCCTGGTCAT CCTGGTCCTT 
GTGGTCTGCA AGAAGCTGAG GAGCATCACA GATGTATACC TCTTGAACCT GGCCCTGTCT 
GACCTGCTTT TTGTCTTCTC CTTCCCCTTT CAGACCTACT ATCTGCTGGA CCAGTGGGTG 
TTTGGGACTG TAATGTGCAA AGTGGTGTCT GGCTTTTATT ACATTGGCTT CTACAGCAGC 
ATGTTTTTCA TCACCCTCAT GAGTGTGGAC AGGTACCTGG CTGTTGTCCA TGCCGTGTAT 
GCCCTAAAGG TGAGGACGAT CAGGATGGGC ACAACGCTGT GCCTGGCAGT ATGGCTAACC 
GCCATTATGG CTACCATCCC ATTGCTAGTG TTTTACCAAG TGGCCTCTGA AGATGGTGTT 
CTACAGTGTT ATTCATTTTA CAATCAACAG ACTTTGAAGT GGAAGATCTT CACCAACTTC 
AAAATGAACA TTTTAGGCTT GTTGATCCCA TTCACCATCT TTATGTTCTG CTACATTAAA 
ATCCTGCACC AGCTGAAGAG GTGTCAAAAC CACAACAAGA CCAAGGCCAT CAGGTTGGTG 
CTCATTGTGG TCATTGCATC TTTACTTTTC TGGGTCCCAT TCAACGTGGT TCTTTTCCTC 
ACTTCCTTGC ACAGTATGCA CATCTTGGAT GGATGTAGCA TAAGCCAACA GCTGACTTAT 
GCCACCCATG TCACAGAAAT CATTTCCTTT ACTCACTGCT GTGTGAACCC TGTTATCTAT 
GCTTTTGTTG GGGAGAAGTT CAAGAAACAC CTCTCAGAAA TATTTCAGAA AAGTTGCAGC 
CAAATCTTCA ACTACCTAGG AAGACAAATG CCTAGGGAGA GCTGTGAAAA GTCATCATCC 
TGCCAGCAGC ACTCCTCCCG TTCCTCCAGC GTAGACTACA TTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005192.1
CDS	136..1203
Translation	MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL

Target ORF information:

RefSeq Version	NM_005201.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine receptor 8 (CCR8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005201.4

ORF Insert Sequence:

ATGGATTATA CACTTGACCT CAGTGTGACA ACAGTGACCG ACTACTACTA CCCTGATATC 
TTCTCAAGCC CCTGTGATGC GGAACTTATT CAGACAAATG GCAAGTTGCT CCTTGCTGTC 
TTTTATTGCC TCCTGTTTGT ATTCAGTCTT CTGGGAAACA GCCTGGTCAT CCTGGTCCTT 
GTGGTCTGCA AGAAGCTGAG GAGCATCACA GATGTATACC TCTTGAACCT GGCCCTGTCT 
GACCTGCTTT TTGTCTTCTC CTTCCCCTTT CAGACCTACT ATCTGCTGGA CCAGTGGGTG 
TTTGGGACTG TAATGTGCAA AGTGGTGTCT GGCTTTTATT ACATTGGCTT CTACAGCAGC 
ATGTTTTTCA TCACCCTCAT GAGTGTGGAC AGGTACCTGG CTGTTGTCCA TGCCGTGTAT 
GCCCTAAAGG TGAGGACGAT CAGGATGGGC ACAACGCTGT GCCTGGCAGT ATGGCTAACC 
GCCATTATGG CTACCATCCC ATTGCTAGTG TTTTACCAAG TGGCCTCTGA AGATGGTGTT 
CTACAGTGTT ATTCATTTTA CAATCAACAG ACTTTGAAGT GGAAGATCTT CACCAACTTC 
AAAATGAACA TTTTAGGCTT GTTGATCCCA TTCACCATCT TTATGTTCTG CTACATTAAA 
ATCCTGCACC AGCTGAAGAG GTGTCAAAAC CACAACAAGA CCAAGGCCAT CAGGTTGGTG 
CTCATTGTGG TCATTGCATC TTTACTTTTC TGGGTCCCAT TCAACGTGGT TCTTTTCCTC 
ACTTCCTTGC ACAGTATGCA CATCTTGGAT GGATGTAGCA TAAGCCAACA GCTGACTTAT 
GCCACCCATG TCACAGAAAT CATTTCCTTT ACTCACTGCT GTGTGAACCC TGTTATCTAT 
GCTTTTGTTG GGGAGAAGTT CAAGAAACAC CTCTCAGAAA TATTTCAGAA AAGTTGCAGC 
CAAATCTTCA ACTACCTAGG AAGACAAATG CCTAGGGAGA GCTGTGAAAA GTCATCATCC 
TGCCAGCAGC ACTCCTCCCG TTCCTCCAGC GTAGACTACA TTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCR8 ( NM_005201.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005192.1 Homo sapiens C-C motif chemokine receptor 8 (CCR8), mRNA.

Price & Availability↑

CloneID	OHu17577
Clone ID Related Accession (Same CDS sequence)	NM_005201.4 , NM_005201.3
Accession Version	NM_005201.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	C-C chemokine receptor type 8
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314957.1, BC107159.1 and AC104850.2. On Aug 12, 2008 this sequence version replaced NM_005201.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC107159.1, SRR1163658.247939.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGATTATA CACTTGACCT CAGTGTGACA ACAGTGACCG ACTACTACTA CCCTGATATC 
TTCTCAAGCC CCTGTGATGC GGAACTTATT CAGACAAATG GCAAGTTGCT CCTTGCTGTC 
TTTTATTGCC TCCTGTTTGT ATTCAGTCTT CTGGGAAACA GCCTGGTCAT CCTGGTCCTT 
GTGGTCTGCA AGAAGCTGAG GAGCATCACA GATGTATACC TCTTGAACCT GGCCCTGTCT 
GACCTGCTTT TTGTCTTCTC CTTCCCCTTT CAGACCTACT ATCTGCTGGA CCAGTGGGTG 
TTTGGGACTG TAATGTGCAA AGTGGTGTCT GGCTTTTATT ACATTGGCTT CTACAGCAGC 
ATGTTTTTCA TCACCCTCAT GAGTGTGGAC AGGTACCTGG CTGTTGTCCA TGCCGTGTAT 
GCCCTAAAGG TGAGGACGAT CAGGATGGGC ACAACGCTGT GCCTGGCAGT ATGGCTAACC 
GCCATTATGG CTACCATCCC ATTGCTAGTG TTTTACCAAG TGGCCTCTGA AGATGGTGTT 
CTACAGTGTT ATTCATTTTA CAATCAACAG ACTTTGAAGT GGAAGATCTT CACCAACTTC 
AAAATGAACA TTTTAGGCTT GTTGATCCCA TTCACCATCT TTATGTTCTG CTACATTAAA 
ATCCTGCACC AGCTGAAGAG GTGTCAAAAC CACAACAAGA CCAAGGCCAT CAGGTTGGTG 
CTCATTGTGG TCATTGCATC TTTACTTTTC TGGGTCCCAT TCAACGTGGT TCTTTTCCTC 
ACTTCCTTGC ACAGTATGCA CATCTTGGAT GGATGTAGCA TAAGCCAACA GCTGACTTAT 
GCCACCCATG TCACAGAAAT CATTTCCTTT ACTCACTGCT GTGTGAACCC TGTTATCTAT 
GCTTTTGTTG GGGAGAAGTT CAAGAAACAC CTCTCAGAAA TATTTCAGAA AAGTTGCAGC 
CAAATCTTCA ACTACCTAGG AAGACAAATG CCTAGGGAGA GCTGTGAAAA GTCATCATCC 
TGCCAGCAGC ACTCCTCCCG TTCCTCCAGC GTAGACTACA TTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005192.1
CDS	139..1206
Translation	MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL

Target ORF information:

RefSeq Version	NM_005201.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine receptor 8 (CCR8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005201.3

ORF Insert Sequence:

ATGGATTATA CACTTGACCT CAGTGTGACA ACAGTGACCG ACTACTACTA CCCTGATATC 
TTCTCAAGCC CCTGTGATGC GGAACTTATT CAGACAAATG GCAAGTTGCT CCTTGCTGTC 
TTTTATTGCC TCCTGTTTGT ATTCAGTCTT CTGGGAAACA GCCTGGTCAT CCTGGTCCTT 
GTGGTCTGCA AGAAGCTGAG GAGCATCACA GATGTATACC TCTTGAACCT GGCCCTGTCT 
GACCTGCTTT TTGTCTTCTC CTTCCCCTTT CAGACCTACT ATCTGCTGGA CCAGTGGGTG 
TTTGGGACTG TAATGTGCAA AGTGGTGTCT GGCTTTTATT ACATTGGCTT CTACAGCAGC 
ATGTTTTTCA TCACCCTCAT GAGTGTGGAC AGGTACCTGG CTGTTGTCCA TGCCGTGTAT 
GCCCTAAAGG TGAGGACGAT CAGGATGGGC ACAACGCTGT GCCTGGCAGT ATGGCTAACC 
GCCATTATGG CTACCATCCC ATTGCTAGTG TTTTACCAAG TGGCCTCTGA AGATGGTGTT 
CTACAGTGTT ATTCATTTTA CAATCAACAG ACTTTGAAGT GGAAGATCTT CACCAACTTC 
AAAATGAACA TTTTAGGCTT GTTGATCCCA TTCACCATCT TTATGTTCTG CTACATTAAA 
ATCCTGCACC AGCTGAAGAG GTGTCAAAAC CACAACAAGA CCAAGGCCAT CAGGTTGGTG 
CTCATTGTGG TCATTGCATC TTTACTTTTC TGGGTCCCAT TCAACGTGGT TCTTTTCCTC 
ACTTCCTTGC ACAGTATGCA CATCTTGGAT GGATGTAGCA TAAGCCAACA GCTGACTTAT 
GCCACCCATG TCACAGAAAT CATTTCCTTT ACTCACTGCT GTGTGAACCC TGTTATCTAT 
GCTTTTGTTG GGGAGAAGTT CAAGAAACAC CTCTCAGAAA TATTTCAGAA AAGTTGCAGC 
CAAATCTTCA ACTACCTAGG AAGACAAATG CCTAGGGAGA GCTGTGAAAA GTCATCATCC 
TGCCAGCAGC ACTCCTCCCG TTCCTCCAGC GTAGACTACA TTTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CCR8
Proceedings of the National Academy of Sciences of the United States of America114(23)6086-6091(2017 Jun)
Barsheshet Y,Wildbaum G,Levy E,Vitenshtein A,Akinseye C,Griggs J,Lira SA,Karin N

Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding.
The Journal of biological chemistry291(31)16208-20(2016 07)
Barington L,Rummel PC,L?ckmann M,Pihl H,Larsen O,Daugvilaite V,Johnsen AH,Frimurer TM,Karlsh?j S,Rosenkilde MM

Positive intratumoral chemokine (C-C motif) receptor 8 expression predicts high recurrence risk of post-operation clear-cell renal cell carcinoma patients.
Oncotarget7(7)8413-21(2016 Feb)
Fu Q,Chang Y,Zhou L,An H,Zhu Y,Xu L,Zhang W,Xu J

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CCR8 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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