Ccr8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccr8
Entrez Gene ID	12776
Full Name	chemokine (C-C motif) receptor 8
Synonyms	C-C,C-C CKR-8,CC-CKR-8,CCR-8,CKR-8,Cmkbr8,mCCR8
General protein information	Preferred Names chemokine (C-C motif) receptor 8 Names C-C chemokine receptor type 8 C-C motif chemokine receptor 8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 F4

mRNA and Protein(s)

mRNA	Protein	Name
NM_007720.2	NP_031746.1	C-C chemokine receptor type 8

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CCR8	XP_542719.1
Pan troglodytes (chimpanzee)	CCR8	XP_526178.2
Mus musculus (house mouse)	Ccr8	NP_031746.1
Bos taurus (cattle)	CCR8	NP_001181891.1
Rattus norvegicus (Norway rat)	Ccr8	XP_236704.1
Gallus gallus (chicken)	CCR8L	NP_001074363.1
Homo sapiens (human)	CCR8	NP_005192.1
	CCR8	XP_001084047.1
Gallus gallus (chicken)	CCR8	NP_001026162.1

Gene Ontology
Bibliography

Related articles in PubMed

CCR8
Barsheshet Y, Wildbaum G, Levy E, Vitenshtein A, Akinseye C, Griggs J, Lira SA, Karin N
Proceedings of the National Academy of Sciences of the United States of America114(23)6086-6091(2017 Jun)

DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft-versus-host disease.
Nishikii H, Kim BS, Yokoyama Y, Chen Y, Baker J, Pierini A, Alvarez M, Mavers M, Maas-Bauer K, Pan Y, Chiba S, Negrin RS
Blood128(24)2846-2858(2016 12)

Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation.
Collins N, Jiang X, Zaid A, Macleod BL, Li J, Park CO, Haque A, Bedoui S, Heath WR, Mueller SN, Kupper TS, Gebhardt T, Carbone FR
Nature communications711514(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CCR8 negatively regulates migration of cutaneous dendritic cells from the skin to the draining lymph nodes in contact hypersensitivity by keeping these cells in the skin.
Title: CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes.

Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages.
Title: Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages.

A sustained donor Treg presence is critical for their beneficial properties, and that their survival depends on CCR8 and donor but not host CD11c(+) Aantigen presenting cells.
Title: CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease.

Expression of CCR-8 in microglia was upregulated in the presence of CCL-1.
Title: Effects of chemokine (C-C motif) ligand 1 on microglial function.

C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity
Title: C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity.

The following Ccr8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccr8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18502	NM_007720.2 Latest version!	Mus musculus chemokine (C-C motif) receptor 8 (Ccr8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccr8 ( NM_007720.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031746.1 Mus musculus chemokine (C-C motif) receptor 8 (Ccr8), mRNA.

Price & Availability↑

CloneID	OMu18502
Clone ID Related Accession (Same CDS sequence)	NM_007720.2
Accession Version	NM_007720.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	C-C chemokine receptor type 8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from Z98205.1 and AC117245.3. On or before Dec 7, 2005 this sequence version replaced XM_913831.1, NM_007720.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z98205.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGATTACA CGATGGAGCC CAACGTCACG ATGACCGACT ACTACCCTGA TTTCTTCACC 
GCCCCCTGTG ACGCAGAGTT CCTCCTCAGG GGCAGCATGC TGTATCTGGC CATCTTGTAC 
TGCGTCTTGT TTGTGCTGGG CCTTCTGGGG AACAGCCTGG TCATCTTAGT CCTCGTGGGC 
TGCAAGAAAC TGAGGAGCAT CACAGATATC TACCTCCTGA ACCTGGCCGC ATCCGACCTG 
CTCTTTGTCC TCTCTATTCC TTTTCAGACC CACAACCTGC TGGACCAGTG GGTGTTTGGG 
ACTGCGATGT GTAAGGTGGT CTCTGGCCTT TATTACATTG GTTTTTTCAG CAGTATGTTC 
TTCATCACCC TAATGAGTGT GGACAGGTAT CTGGCTATTG TCCACGCTGT CTATGCCATC 
AAGGTGAGGA CGGCCAGCGT GGGCACAGCC CTGAGTCTGA CAGTGTGGCT GGCTGCTGTC 
ACAGCCACCA TCCCCTTGAT GGTTTTTTAC CAAGTGGCCT CTGAAGACGG CATGCTACAA 
TGTTTCCAGT TTTATGAAGA GCAGTCTTTG AGGTGGAAGC TCTTTACCCA CTTTGAAATC 
AACGCCTTGG GTCTGCTGCT CCCCTTTGCC ATCCTCCTGT TCTGCTATGT CAGGATCCTG 
CAGCAGCTGC GGGGCTGCCT GAACCACAAC AGGACCAGAG CCATCAAGCT GGTGCTCACC 
GTAGTCATTG TGTCTTTACT CTTCTGGGTC CCATTCAACG TGGCCCTTTT CCTCACGTCC 
CTGCACGACC TGCACATCTT GGATGGATGT GCCACGAGGC AGAGGCTGGC TCTGGCCATC 
CATGTCACAG AGGTCATCTC TTTTACCCAC TGCTGCGTGA ACCCCGTCAT CTACGCGTTC 
ATAGGAGAGA AGTTTAAGAA ACACCTCATG GATGTGTTTC AAAAGAGCTG CAGCCACATC 
TTCCTCTACT TAGGGAGACA AATGCCCGTG GGGGCGTTGG AAAGGCAGCT GTCCTCGAAC 
CAGCGATCTT CCCATTCTTC CACCCTGGAT GACATCTTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031746.1
CDS	71..1132
Translation	MDYTMEPNVTMTDYYPDFFTAPCDAEFLLRGSMLYLAILYCVLFVLGLLGNSLVILVLVGCKKLRSITDIYLLNLAASDLLFVLSIPFQTHNLLDQWVFGTAMCKVVSGLYYIGFFSSMFFITLMSVDRYLAIVHAVYAIKVRTASVGTALSLTVWLAAVTATIPLMVFYQVASEDGMLQCFQFYEEQSLRWKLFTHFEINALGLLLPFAILLFCYVRILQQLRGCLNHNRTRAIKLVLTVVIVSLLFWVPFNVALFLTSLHDLHILDGCATRQRLALAIHVTEVISFTHCCVNPVIYAFIGEKFKKHLMDVFQKSCSHIFLYLGRQMPVGALERQLSSNQRSSHSSTLDDIL

Target ORF information:

RefSeq Version	NM_007720.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C-C motif) receptor 8 (Ccr8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007720.2

ORF Insert Sequence:

ATGGATTACA CGATGGAGCC CAACGTCACG ATGACCGACT ACTACCCTGA TTTCTTCACC 
GCCCCCTGTG ACGCAGAGTT CCTCCTCAGG GGCAGCATGC TGTATCTGGC CATCTTGTAC 
TGCGTCTTGT TTGTGCTGGG CCTTCTGGGG AACAGCCTGG TCATCTTAGT CCTCGTGGGC 
TGCAAGAAAC TGAGGAGCAT CACAGATATC TACCTCCTGA ACCTGGCCGC ATCCGACCTG 
CTCTTTGTCC TCTCTATTCC TTTTCAGACC CACAACCTGC TGGACCAGTG GGTGTTTGGG 
ACTGCGATGT GTAAGGTGGT CTCTGGCCTT TATTACATTG GTTTTTTCAG CAGTATGTTC 
TTCATCACCC TAATGAGTGT GGACAGGTAT CTGGCTATTG TCCACGCTGT CTATGCCATC 
AAGGTGAGGA CGGCCAGCGT GGGCACAGCC CTGAGTCTGA CAGTGTGGCT GGCTGCTGTC 
ACAGCCACCA TCCCCTTGAT GGTTTTTTAC CAAGTGGCCT CTGAAGACGG CATGCTACAA 
TGTTTCCAGT TTTATGAAGA GCAGTCTTTG AGGTGGAAGC TCTTTACCCA CTTTGAAATC 
AACGCCTTGG GTCTGCTGCT CCCCTTTGCC ATCCTCCTGT TCTGCTATGT CAGGATCCTG 
CAGCAGCTGC GGGGCTGCCT GAACCACAAC AGGACCAGAG CCATCAAGCT GGTGCTCACC 
GTAGTCATTG TGTCTTTACT CTTCTGGGTC CCATTCAACG TGGCCCTTTT CCTCACGTCC 
CTGCACGACC TGCACATCTT GGATGGATGT GCCACGAGGC AGAGGCTGGC TCTGGCCATC 
CATGTCACAG AGGTCATCTC TTTTACCCAC TGCTGCGTGA ACCCCGTCAT CTACGCGTTC 
ATAGGAGAGA AGTTTAAGAA ACACCTCATG GATGTGTTTC AAAAGAGCTG CAGCCACATC 
TTCCTCTACT TAGGGAGACA AATGCCCGTG GGGGCGTTGG AAAGGCAGCT GTCCTCGAAC 
CAGCGATCTT CCCATTCTTC CACCCTGGAT GACATCTTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CCR8
Proceedings of the National Academy of Sciences of the United States of America114(23)6086-6091(2017 Jun)
Barsheshet Y,Wildbaum G,Levy E,Vitenshtein A,Akinseye C,Griggs J,Lira SA,Karin N

DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft-versus-host disease.
Blood128(24)2846-2858(2016 12)
Nishikii H,Kim BS,Yokoyama Y,Chen Y,Baker J,Pierini A,Alvarez M,Mavers M,Maas-Bauer K,Pan Y,Chiba S,Negrin RS

Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation.
Nature communications711514(2016 May)
Collins N,Jiang X,Zaid A,Macleod BL,Li J,Park CO,Haque A,Bedoui S,Heath WR,Mueller SN,Kupper TS,Gebhardt T,Carbone FR

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Ccr8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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