PSMB11 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSMB11
Entrez Gene ID	122706
Full Name	proteasome subunit beta 11
Synonyms	BETA5T
General protein information	Preferred Names proteasome subunit beta 11 Names proteasome subunit beta type-11 proteasome (prosome, macropain) subunit, beta type, 11 proteasome subunit beta 5T proteasome subunit beta-5t
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q11.2
Summary	Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008].
Disorder MIM:	611137

mRNA and Protein(s)

mRNA	Protein	Name
NM_001099780.2	NP_001093250.1	proteasome subunit beta type-11 precursor
NM_001099780.1	NP_001093250.1	proteasome subunit beta type-11 precursor

Pathways from BioSystems

Homologies

	PSMB11	XP_002805028.1
Bos taurus (cattle)	PSMB11	NP_001092856.1
Mus musculus (house mouse)	Psmb11	NP_780413.1
Danio rerio (zebrafish)	psmb11b	XP_002667581.3
Pan troglodytes (chimpanzee)	PSMB11	XP_522799.2
Rattus norvegicus (Norway rat)	Psmb11	NP_001099502.1
Danio rerio (zebrafish)	si:ch211-14a17.13	NP_001007179.1
Homo sapiens (human)	PSMB11	NP_001093250.1
Canis lupus familiaris (dog)	PSMB11	XP_003639262.1
Xenopus tropicalis (tropical clawed frog)	psmb11	XP_002941563.1

Gene Ontology
Bibliography

Related articles in PubMed

Decreased expression of thymus-specific proteasome subunit ?5t in Down syndrome patients.
Tomaru U, Tsuji T, Kiuchi S, Ishizu A, Suzuki A, Otsuka N, Ito T, Ikeda H, Fukasawa Y, Kasahara M
Histopathology67(2)235-44(2015 Aug)

Expression of thymoproteasome subunit ?5t in type AB thymoma.
Yamada Y, Tomaru U, Ishizu A, Kiuchi T, Kasahara M, Matsuno Y
Journal of clinical pathology67(3)276-8(2014 Mar)

Impaired bortezomib binding to mutant ?5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells.
Franke NE, Niewerth D, Assaraf YG, van Meerloo J, Vojtekova K, van Zantwijk CH, Zweegman S, Chan ET, Kirk CJ, Geerke DP, Schimmer AD, Kaspers GJ, Jansen G, Cloos J
Leukemia26(4)757-68(2012 Apr)

Expression of proteasome subunit ?5t in thymic epithelial tumors.
Yamada Y, Tomaru U, Ishizu A, Kiuchi T, Marukawa K, Matsuno Y, Kasahara M
The American journal of surgical pathology35(9)1296-304(2011 Sep)

Exclusive expression of proteasome subunit {beta}5t in the human thymic cortex.
Tomaru U, Ishizu A, Murata S, Miyatake Y, Suzuki S, Takahashi S, Kazamaki T, Ohara J, Baba T, Iwasaki S, Fugo K, Otsuka N, Tanaka K, Kasahara M
Blood113(21)5186-91(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We analysed thymic tissues from patients with trisomy 13 (n = 4), trisomy 18 (n = 14) and trisomy 21 (n = 13) for histological alterations, and for the expression of functionally important molecules such as beta5t, a thymoproteasome subunit, and cathepsins.
Title: Decreased expression of thymus-specific proteasome subunit ?5t in Down syndrome patients.

Histological diversity of type AB thymoma correlates with expression of a functional marker beta5t and abundance of TdT-positive lymphocytes.
Title: Expression of thymoproteasome subunit ?5t in type AB thymoma.

provide the first evidence that the mechanism underlying BTZ resistance in these tumor cells is impaired binding of BTZ to the mutant beta5 subunit of the proteasome
Title: Impaired bortezomib binding to mutant ?5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells.

Proteasome beta5t is expressed in most type B and in some type AB thymomas and is a marker useful in differentiating type B3 thymomas from thymic carcinomas when used in combination with other diagnostic markers.
Title: Expression of proteasome subunit ?5t in thymic epithelial tumors.

Human beta5t was expressed in approximately 80% of cortical thymic epithelial cells and some cortical dendritic cells
Title: Exclusive expression of proteasome subunit {beta}5t in the human thymic cortex.

The following PSMB11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSMB11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15921	NM_001099780.2 Latest version!	Homo sapiens proteasome subunit beta 11 (PSMB11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu15921	NM_001099780.1	Homo sapiens proteasome subunit beta 11 (PSMB11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSMB11 ( NM_001099780.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001093250.1 Homo sapiens proteasome subunit beta 11 (PSMB11), mRNA.

Price & Availability↑

CloneID	OHu15921
Clone ID Related Accession (Same CDS sequence)	NM_001099780.2 , NM_001099780.1
Accession Version	NM_001099780.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 903bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	proteasome subunit beta type-11 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK122797.1, AB299437.1 and AL132780.5. On May 17, 2019 this sequence version replaced NM_001099780.1. ##Evidence-Data-START## Transcript is intronless :: AK122797.1, AB299437.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000408907.5/ ENSP00000386212.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCTCTGC AGGATGTGTG CAAGTGGCAG TCCCCTGACA CCCAGGGACC ATCACCTCAC 
CTGCCTCGGG CTGGCGGCTG GGCTGTGCCC CGGGGTTGTG ACCCTCAAAC CTTCCTGCAG 
ATCCATGGCC CCAGACTGGC CCACGGCACC ACCACTCTGG CCTTCCGCTT CCGTCATGGA 
GTCATTGCTG CAGCTGACAC GCGTTCCTCC TGTGGCAGCT ATGTGGCGTG TCCAGCCTCA 
TGCAAGGTCA TCCCTGTGCA CCAGCACCTC CTGGGTACCA CCTCTGGCAC CTCTGCCGAC 
TGTGCTACCT GGTATCGGGT ATTACAGCGG GAGCTGCGGC TTCGGGAACT GAGGGAGGGT 
CAGCTGCCCA GTGTGGCCAG TGCTGCCAAG CTCTTGTCAG CCATGATGTC TCAATACCGG 
GGACTGGATC TCTGTGTGGC CACTGCCCTC TGCGGCTGGG ACCGCTCTGG CCCTGAGCTC 
TTCTACGTCT ATAGCGACGG CACCCGCCTG CAGGGGGACA TCTTCTCTGT GGGCTCTGGA 
TCTCCCTATG CCTACGGCGT GCTAGACCGT GGCTATCGCT ACGACATGAG CACCCAGGAA 
GCCTACGCCC TGGCTCGCTG CGCCGTGGCC CACGCCACCC ACCGTGATGC CTATTCAGGG 
GGCTCTGTAG ACCTTTTCCA CGTGCGGGAG AGTGGATGGG AGCATGTGTC ACGCAGTGAT 
GCCTGTGTGC TGTACGTGGA GTTACAGAAG CTCCTGGAGC CGGAGCCAGA GGAGGATGCC 
AGCCATGCCC ATCCTGAGCC TGCCACTGCC CACAGAGCTG CAGAAGATAG AGAGCTCTCT 
GTGGGGCCAG GGGAGGTGAC ACCAGGAGAC TCCAGGATGC CAGCAGGGAC TGAGACGGTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001093250.1
CDS	15..917
Translation	MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGDIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTETV

Target ORF information:

RefSeq Version	NM_001099780.2
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome subunit beta 11 (PSMB11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001099780.2

ORF Insert Sequence:

ATGGCTCTGC AGGATGTGTG CAAGTGGCAG TCCCCTGACA CCCAGGGACC ATCACCTCAC 
CTGCCTCGGG CTGGCGGCTG GGCTGTGCCC CGGGGTTGTG ACCCTCAAAC CTTCCTGCAG 
ATCCATGGCC CCAGACTGGC CCACGGCACC ACCACTCTGG CCTTCCGCTT CCGTCATGGA 
GTCATTGCTG CAGCTGACAC GCGTTCCTCC TGTGGCAGCT ATGTGGCGTG TCCAGCCTCA 
TGCAAGGTCA TCCCTGTGCA CCAGCACCTC CTGGGTACCA CCTCTGGCAC CTCTGCCGAC 
TGTGCTACCT GGTATCGGGT ATTACAGCGG GAGCTGCGGC TTCGGGAACT GAGGGAGGGT 
CAGCTGCCCA GTGTGGCCAG TGCTGCCAAG CTCTTGTCAG CCATGATGTC TCAATACCGG 
GGACTGGATC TCTGTGTGGC CACTGCCCTC TGCGGCTGGG ACCGCTCTGG CCCTGAGCTC 
TTCTACGTCT ATAGCGACGG CACCCGCCTG CAGGGGGACA TCTTCTCTGT GGGCTCTGGA 
TCTCCCTATG CCTACGGCGT GCTAGACCGT GGCTATCGCT ACGACATGAG CACCCAGGAA 
GCCTACGCCC TGGCTCGCTG CGCCGTGGCC CACGCCACCC ACCGTGATGC CTATTCAGGG 
GGCTCTGTAG ACCTTTTCCA CGTGCGGGAG AGTGGATGGG AGCATGTGTC ACGCAGTGAT 
GCCTGTGTGC TGTACGTGGA GTTACAGAAG CTCCTGGAGC CGGAGCCAGA GGAGGATGCC 
AGCCATGCCC ATCCTGAGCC TGCCACTGCC CACAGAGCTG CAGAAGATAG AGAGCTCTCT 
GTGGGGCCAG GGGAGGTGAC ACCAGGAGAC TCCAGGATGC CAGCAGGGAC TGAGACGGTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMB11 ( NM_001099780.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001093250.1 Homo sapiens proteasome subunit beta 11 (PSMB11), mRNA.

Price & Availability↑

CloneID	OHu15921
Clone ID Related Accession (Same CDS sequence)	NM_001099780.2 , NM_001099780.1
Accession Version	NM_001099780.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 903bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	proteasome subunit beta type-11 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK122797.1, AB299437.1 and AL132780.5. On or before Jul 26, 2007 this sequence version replaced XM_063287.9, XM_940039.2.

ATGGCTCTGC AGGATGTGTG CAAGTGGCAG TCCCCTGACA CCCAGGGACC ATCACCTCAC 
CTGCCTCGGG CTGGCGGCTG GGCTGTGCCC CGGGGTTGTG ACCCTCAAAC CTTCCTGCAG 
ATCCATGGCC CCAGACTGGC CCACGGCACC ACCACTCTGG CCTTCCGCTT CCGTCATGGA 
GTCATTGCTG CAGCTGACAC GCGTTCCTCC TGTGGCAGCT ATGTGGCGTG TCCAGCCTCA 
TGCAAGGTCA TCCCTGTGCA CCAGCACCTC CTGGGTACCA CCTCTGGCAC CTCTGCCGAC 
TGTGCTACCT GGTATCGGGT ATTACAGCGG GAGCTGCGGC TTCGGGAACT GAGGGAGGGT 
CAGCTGCCCA GTGTGGCCAG TGCTGCCAAG CTCTTGTCAG CCATGATGTC TCAATACCGG 
GGACTGGATC TCTGTGTGGC CACTGCCCTC TGCGGCTGGG ACCGCTCTGG CCCTGAGCTC 
TTCTACGTCT ATAGCGACGG CACCCGCCTG CAGGGGGACA TCTTCTCTGT GGGCTCTGGA 
TCTCCCTATG CCTACGGCGT GCTAGACCGT GGCTATCGCT ACGACATGAG CACCCAGGAA 
GCCTACGCCC TGGCTCGCTG CGCCGTGGCC CACGCCACCC ACCGTGATGC CTATTCAGGG 
GGCTCTGTAG ACCTTTTCCA CGTGCGGGAG AGTGGATGGG AGCATGTGTC ACGCAGTGAT 
GCCTGTGTGC TGTACGTGGA GTTACAGAAG CTCCTGGAGC CGGAGCCAGA GGAGGATGCC 
AGCCATGCCC ATCCTGAGCC TGCCACTGCC CACAGAGCTG CAGAAGATAG AGAGCTCTCT 
GTGGGGCCAG GGGAGGTGAC ACCAGGAGAC TCCAGGATGC CAGCAGGGAC TGAGACGGTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001093250.1
CDS	60..962
Translation	MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGDIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTETV

Target ORF information:

RefSeq Version	NM_001099780.1
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome subunit beta 11 (PSMB11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001099780.1

ORF Insert Sequence:

ATGGCTCTGC AGGATGTGTG CAAGTGGCAG TCCCCTGACA CCCAGGGACC ATCACCTCAC 
CTGCCTCGGG CTGGCGGCTG GGCTGTGCCC CGGGGTTGTG ACCCTCAAAC CTTCCTGCAG 
ATCCATGGCC CCAGACTGGC CCACGGCACC ACCACTCTGG CCTTCCGCTT CCGTCATGGA 
GTCATTGCTG CAGCTGACAC GCGTTCCTCC TGTGGCAGCT ATGTGGCGTG TCCAGCCTCA 
TGCAAGGTCA TCCCTGTGCA CCAGCACCTC CTGGGTACCA CCTCTGGCAC CTCTGCCGAC 
TGTGCTACCT GGTATCGGGT ATTACAGCGG GAGCTGCGGC TTCGGGAACT GAGGGAGGGT 
CAGCTGCCCA GTGTGGCCAG TGCTGCCAAG CTCTTGTCAG CCATGATGTC TCAATACCGG 
GGACTGGATC TCTGTGTGGC CACTGCCCTC TGCGGCTGGG ACCGCTCTGG CCCTGAGCTC 
TTCTACGTCT ATAGCGACGG CACCCGCCTG CAGGGGGACA TCTTCTCTGT GGGCTCTGGA 
TCTCCCTATG CCTACGGCGT GCTAGACCGT GGCTATCGCT ACGACATGAG CACCCAGGAA 
GCCTACGCCC TGGCTCGCTG CGCCGTGGCC CACGCCACCC ACCGTGATGC CTATTCAGGG 
GGCTCTGTAG ACCTTTTCCA CGTGCGGGAG AGTGGATGGG AGCATGTGTC ACGCAGTGAT 
GCCTGTGTGC TGTACGTGGA GTTACAGAAG CTCCTGGAGC CGGAGCCAGA GGAGGATGCC 
AGCCATGCCC ATCCTGAGCC TGCCACTGCC CACAGAGCTG CAGAAGATAG AGAGCTCTCT 
GTGGGGCCAG GGGAGGTGAC ACCAGGAGAC TCCAGGATGC CAGCAGGGAC TGAGACGGTG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decreased expression of thymus-specific proteasome subunit ?5t in Down syndrome patients.
Histopathology67(2)235-44(2015 Aug)
Tomaru U,Tsuji T,Kiuchi S,Ishizu A,Suzuki A,Otsuka N,Ito T,Ikeda H,Fukasawa Y,Kasahara M

Expression of thymoproteasome subunit ?5t in type AB thymoma.
Journal of clinical pathology67(3)276-8(2014 Mar)
Yamada Y,Tomaru U,Ishizu A,Kiuchi T,Kasahara M,Matsuno Y

Impaired bortezomib binding to mutant ?5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells.
Leukemia26(4)757-68(2012 Apr)
Franke NE,Niewerth D,Assaraf YG,van Meerloo J,Vojtekova K,van Zantwijk CH,Zweegman S,Chan ET,Kirk CJ,Geerke DP,Schimmer AD,Kaspers GJ,Jansen G,Cloos J

Expression of proteasome subunit ?5t in thymic epithelial tumors.
The American journal of surgical pathology35(9)1296-304(2011 Sep)
Yamada Y,Tomaru U,Ishizu A,Kiuchi T,Marukawa K,Matsuno Y,Kasahara M

Exclusive expression of proteasome subunit {beta}5t in the human thymic cortex.
Blood113(21)5186-91(2009 May)
Tomaru U,Ishizu A,Murata S,Miyatake Y,Suzuki S,Takahashi S,Kazamaki T,Ohara J,Baba T,Iwasaki S,Fugo K,Otsuka N,Tanaka K,Kasahara M

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PSMB11 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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