CLC cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLC
Entrez Gene ID	1178
Full Name	Charcot-Leyden crystal galectin
Synonyms	GAL10,Gal-10,LGALS10,LGALS10A,LPPL_HUMAN
General protein information	Preferred Names Charcot-Leyden crystal galectin Names galectin-10 Charcot-Leyden crystal protein eosinophil lysophospholipase lectin, galactoside-binding, soluble, 10 lysolecithin acylhydrolase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Summary	Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008].
Disorder MIM:	153310

mRNA and Protein(s)

mRNA	Protein	Name
NM_001828.5	NP_001819.2	galectin-10
NM_001828.6	NP_001819.2	galectin-10

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC100610880	XP_003318218.2
Homo sapiens (human)	CLC	NP_001819.2
	LOC699418	XP_001087874.2

Gene Ontology
Bibliography

Related articles in PubMed

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Glavey SV, Naba A, Manier S, Clauser K, Tahri S, Park J, Reagan MR, Moschetta M, Mishima Y, Gambella M, Rocci A, Sacco A, O'Dwyer ME, Asara JM, Palumbo A, Roccaro AM, Hynes RO, Ghobrial IM
Leukemia31(11)2426-2434(2017 Nov)

Regulatory Eosinophils Suppress T Cells Partly through Galectin-10.
Lingblom C, Andersson J, Andersson K, Wenner?s C
Journal of immunology (Baltimore, Md. : 1950)198(12)4672-4681(2017 Jun)

A comprehensive family-based replication study of schizophrenia genes.
Aberg KA, Liu Y, Buksz?r J, McClay JL, Khachane AN, Andreassen OA, Blackwood D, Corvin A, Djurovic S, Gurling H, Ophoff R, Pato CN, Pato MT, Riley B, Webb T, Kendler K, O'Donovan M, Craddock N, Kirov G, Owen M, Rujescu D, St Clair D, Werge T, Hultman CM, Delisi LE, Sullivan P, van den Oord EJ
JAMA psychiatry70(6)573-81(2013 Jun)

Galectin-10, a potential biomarker of eosinophilic airway inflammation.
Chua JC, Douglass JA, Gillman A, O'Hehir RE, Meeusen EN
PloS one7(8)e42549(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings show that galectin-10 functions as a T cell-suppressive molecule in eosinophils
Title: Regulatory Eosinophils Suppress T Cells Partly through Galectin-10.

The results support the potential for galectin-10 to be used as a surrogate biomarker of eosinophilic airway inflammation.
Title: Galectin-10, a potential biomarker of eosinophilic airway inflammation.

CLC and IFNAR1 were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC.
Title: CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer.

DK-PGD-induced CLC/Gal-10 mRNA level can serve as a potential marker for monitoring pharmacodynamic effects of blood exposure to CRTH2 modulating agents
Title: The mRNA level of Charcot-Leyden crystal protein/galectin-10 is a marker for CRTH2 activation in human whole blood in vitro.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

The following CLC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55884	NM_001828.6 Latest version!	Homo sapiens Charcot-Leyden crystal galectin (CLC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu55884	NM_001828.5	Homo sapiens Charcot-Leyden crystal galectin (CLC), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLC ( NM_001828.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001819.2 Homo sapiens Charcot-Leyden crystal galectin (CLC), mRNA.

Price & Availability↑

CloneID	OHu55884
Clone ID Related Accession (Same CDS sequence)	NM_001828.5 , NM_001828.6
Accession Version	NM_001828.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	galectin-10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV762486.1, AV715261.1 and AW292557.1. This sequence is a reference standard in the RefSeqGene project. On Nov 19, 2011 this sequence version replaced NM_001828.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV714443.1, AV713515.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCTGC TACCCGTGCC ATACACAGAG GCTGCCTCTT TGTCTACTGG TTCTACTGTG 
ACAATCAAAG GGCGACCACT TGCCTGTTTC TTGAATGAAC CATATCTGCA GGTGGATTTC 
CACACTGAGA TGAAGGAGGA ATCAGACATT GTCTTCCATT TCCAAGTGTG CTTTGGTCGT 
CGTGTGGTCA TGAACAGCCG TGAGTATGGG GCCTGGAAGC AGCAGGTGGA ATCCAAGAAT 
ATGCCCTTTC AGGATGGCCA AGAATTTGAA CTGAGCATCT CAGTGCTGCC AGATAAGTAC 
CAGGTAATGG TCAATGGCCA ATCCTCTTAC ACCTTTGACC ATAGAATCAA GCCTGAGGCT 
GTGAAGATGG TGCAAGTGTG GAGAGATATC TCCCTGACCA AATTTAATGT CAGCTATTTA 
AAGAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001819.2
CDS	78..506
Translation	MSLLPVPYTEAASLSTGSTVTIKGRPLACFLNEPYLQVDFHTEMKEESDIVFHFQVCFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR

Target ORF information:

RefSeq Version	NM_001828.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Charcot-Leyden crystal galectin (CLC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001828.5

ORF Insert Sequence:

ATGTCCCTGC TACCCGTGCC ATACACAGAG GCTGCCTCTT TGTCTACTGG TTCTACTGTG 
ACAATCAAAG GGCGACCACT TGCCTGTTTC TTGAATGAAC CATATCTGCA GGTGGATTTC 
CACACTGAGA TGAAGGAGGA ATCAGACATT GTCTTCCATT TCCAAGTGTG CTTTGGTCGT 
CGTGTGGTCA TGAACAGCCG TGAGTATGGG GCCTGGAAGC AGCAGGTGGA ATCCAAGAAT 
ATGCCCTTTC AGGATGGCCA AGAATTTGAA CTGAGCATCT CAGTGCTGCC AGATAAGTAC 
CAGGTAATGG TCAATGGCCA ATCCTCTTAC ACCTTTGACC ATAGAATCAA GCCTGAGGCT 
GTGAAGATGG TGCAAGTGTG GAGAGATATC TCCCTGACCA AATTTAATGT CAGCTATTTA 
AAGAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLC ( NM_001828.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_001819.2 Homo sapiens Charcot-Leyden crystal galectin (CLC), mRNA.

Price & Availability↑

CloneID	OHu55884
Clone ID Related Accession (Same CDS sequence)	NM_001828.5 , NM_001828.6
Accession Version	NM_001828.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	galectin-10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV762486.1, AV715261.1 and AW292557.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001828.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV715152.1, AV714984.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000221804.5/ ENSP00000221804.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCCTGC TACCCGTGCC ATACACAGAG GCTGCCTCTT TGTCTACTGG TTCTACTGTG 
ACAATCAAAG GGCGACCACT TGCCTGTTTC TTGAATGAAC CATATCTGCA GGTGGATTTC 
CACACTGAGA TGAAGGAGGA ATCAGACATT GTCTTCCATT TCCAAGTGTG CTTTGGTCGT 
CGTGTGGTCA TGAACAGCCG TGAGTATGGG GCCTGGAAGC AGCAGGTGGA ATCCAAGAAT 
ATGCCCTTTC AGGATGGCCA AGAATTTGAA CTGAGCATCT CAGTGCTGCC AGATAAGTAC 
CAGGTAATGG TCAATGGCCA ATCCTCTTAC ACCTTTGACC ATAGAATCAA GCCTGAGGCT 
GTGAAGATGG TGCAAGTGTG GAGAGATATC TCCCTGACCA AATTTAATGT CAGCTATTTA 
AAGAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001819.2
CDS	78..506
Translation	MSLLPVPYTEAASLSTGSTVTIKGRPLACFLNEPYLQVDFHTEMKEESDIVFHFQVCFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR

Target ORF information:

RefSeq Version	NM_001828.6
Organism	Homo sapiens(human)
Definition	Homo sapiens Charcot-Leyden crystal galectin (CLC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001828.6

ORF Insert Sequence:

ATGTCCCTGC TACCCGTGCC ATACACAGAG GCTGCCTCTT TGTCTACTGG TTCTACTGTG 
ACAATCAAAG GGCGACCACT TGCCTGTTTC TTGAATGAAC CATATCTGCA GGTGGATTTC 
CACACTGAGA TGAAGGAGGA ATCAGACATT GTCTTCCATT TCCAAGTGTG CTTTGGTCGT 
CGTGTGGTCA TGAACAGCCG TGAGTATGGG GCCTGGAAGC AGCAGGTGGA ATCCAAGAAT 
ATGCCCTTTC AGGATGGCCA AGAATTTGAA CTGAGCATCT CAGTGCTGCC AGATAAGTAC 
CAGGTAATGG TCAATGGCCA ATCCTCTTAC ACCTTTGACC ATAGAATCAA GCCTGAGGCT 
GTGAAGATGG TGCAAGTGTG GAGAGATATC TCCCTGACCA AATTTAATGT CAGCTATTTA 
AAGAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Leukemia31(11)2426-2434(2017 Nov)
Glavey SV,Naba A,Manier S,Clauser K,Tahri S,Park J,Reagan MR,Moschetta M,Mishima Y,Gambella M,Rocci A,Sacco A,O'Dwyer ME,Asara JM,Palumbo A,Roccaro AM,Hynes RO,Ghobrial IM

Regulatory Eosinophils Suppress T Cells Partly through Galectin-10.
Journal of immunology (Baltimore, Md. : 1950)198(12)4672-4681(2017 Jun)
Lingblom C,Andersson J,Andersson K,Wenner?s C

A comprehensive family-based replication study of schizophrenia genes.
JAMA psychiatry70(6)573-81(2013 Jun)
Aberg KA,Liu Y,Buksz?r J,McClay JL,Khachane AN,Andreassen OA,Blackwood D,Corvin A,Djurovic S,Gurling H,Ophoff R,Pato CN,Pato MT,Riley B,Webb T,Kendler K,O'Donovan M,Craddock N,Kirov G,Owen M,Rujescu D,St Clair D,Werge T,Hultman CM,Delisi LE,Sullivan P,van den Oord EJ

Galectin-10, a potential biomarker of eosinophilic airway inflammation.
PloS one7(8)e42549(2012)
Chua JC,Douglass JA,Gillman A,O'Hehir RE,Meeusen EN

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

CLC cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報