SCGB3A2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SCGB3A2
Entrez Gene ID	117156
Full Name	secretoglobin family 3A member 2
Synonyms	LU103,PNSP1,UGRP1,pnSP-1
General protein information	Preferred Names secretoglobin family 3A member 2 Names secretoglobin family 3A member 2 pneumo secretory protein 1 uteroglobin-related protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q32
Summary	The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.[provided by RefSeq, Mar 2010].
Disorder MIM:	606531
Disorder Html:	{Asthma, susceptibility to}, 600807 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_054023.5	NP_473364.1	secretoglobin family 3A member 2 precursor
NM_054023.4	NP_473364.1	secretoglobin family 3A member 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SCGB3A2	NP_473364.1
Pan troglodytes (chimpanzee)	SCGB3A2	XP_001160330.1
	SCGB3A2	XP_001102976.1
Canis lupus familiaris (dog)	SCGB3A2	XP_003433811.1
Mus musculus (house mouse)	Scgb3a2	NP_473379.1
Rattus norvegicus (Norway rat)	Scgb3a2	NP_001019454.1

Gene Ontology
Bibliography

Related articles in PubMed

Association Between Secretoglobin Family 3A Member 2 (SCGB3A2) Gene Polymorphisms and Asthma in a Korean Population.
Kim SK, Seok H, Park HJ, Han K, Kang SW, Ban JY, Jung HJ, Kim KI, Lee BJ, Kim J, Chung JH
Medical science monitor : international medical journal of experimental and clinical research231880-1885(2017 Apr)

The association of SCGB3A2 polymorphisms with the risk of Graves' disease: a meta-analysis.
Xue L, Han B, Pan C, Song H
Endocrine45(3)365-9(2014 Apr)

Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily.
Jackson BC, Thompson DC, Wright MW, McAndrews M, Bernard A, Nebert DW, Vasiliou V
Human genomics5(6)691-702(2011 Oct)

Variation in Uteroglobin-Related Protein 1 (UGRP1) gene is associated with allergic rhinitis in Singapore Chinese.
Andiappan AK, Yeo WS, Parate PN, Anantharaman R, Suri BK, Wang de Y, Chew FT
BMC medical genetics1239(2011 Mar)

The cytokine-driven regulation of secretoglobins in normal human upper airway and their expression, particularly that of uteroglobin-related protein 1, in chronic rhinosinusitis.
Lu X, Wang N, Long XB, You XJ, Cui YH, Liu Z
Respiratory research1228(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This meta-analysis suggests that SCGB3A2 polymorphism at positions -112G>A was associated with Graves' disease both in Chinese and Caucasian population.
Title: The association of SCGB3A2 polymorphisms with the risk of Graves' disease: a meta-analysis.

the SCGB3A2 -112G >A polymorphism may be considered as a likely marker linking susceptibility to allergy/asthma and Graves' disease
Title: The -112G>A polymorphism of the secretoglobin 3A2 (SCGB3A2) gene encoding uteroglobin-related protein 1 (UGRP1) increases risk for the development of Graves' disease in subsets of patients with elevated levels of immunoglobulin E.

This study documents the association between polymorphisms in UGRP1 and the common cold, suggesting a potential role in its pathogenesis.
Title: Variation in Uteroglobin-Related Protein 1 (UGRP1) gene is associated with allergic rhinitis in Singapore Chinese.

Reduced production of UGRP1, which is likely due, at least in part, to a local cytokine environment, may contribute to the hyper-inflammation in chronic rhinosinusitis and correlates with response to surgery.
Title: The cytokine-driven regulation of secretoglobins in normal human upper airway and their expression, particularly that of uteroglobin-related protein 1, in chronic rhinosinusitis.

pattern of UGRP-1 concentration resembled that of Clara cell protein, both proteins occurring in high concentrations in amniotic fluid, sputum and BALF and in much lower concentrations in serum and urine
Title: Development of a new sensitive ELISA for the determination of uteroglobin-related protein 1, a new potential biomarker.

The following SCGB3A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCGB3A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18391	NM_054023.5 Latest version!	Homo sapiens secretoglobin family 3A member 2 (SCGB3A2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18391	NM_054023.4	Homo sapiens secretoglobin family 3A member 2 (SCGB3A2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SCGB3A2 ( NM_054023.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_473364.1 Homo sapiens secretoglobin family 3A member 2 (SCGB3A2), mRNA.

Price & Availability↑

CloneID	OHu18391
Clone ID Related Accession (Same CDS sequence)	NM_054023.5 , NM_054023.4
Accession Version	NM_054023.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	secretoglobin family 3A member 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC024232.1 and AA988559.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_054023.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF433853.1, BC024232.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000296694.5/ ENSP00000296694.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCTGG TAACTATCTT CCTGCTGGTG ACCATCAGCC TTTGTAGTTA CTCTGCTACT 
GCCTTCCTCA TCAACAAAGT GCCCCTTCCT GTTGACAAGT TGGCACCTTT ACCTCTGGAC 
AACATTCTTC CCTTTATGGA TCCATTAAAG CTTCTTCTGA AAACTCTGGG CATTTCTGTT 
GAGCACCTTG TGGAGGGGCT AAGGAAGTGT GTAAATGAGC TGGGACCAGA GGCTTCTGAA 
GCTGTGAAGA AACTGCTGGA GGCGCTATCA CACTTGGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_473364.1
CDS	94..375
Translation	MKLVTIFLLVTISLCSYSATAFLINKVPLPVDKLAPLPLDNILPFMDPLKLLLKTLGISVEHLVEGLRKCVNELGPEASEAVKKLLEALSHLV

Target ORF information:

RefSeq Version	NM_054023.5
Organism	Homo sapiens(human)
Definition	Homo sapiens secretoglobin family 3A member 2 (SCGB3A2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_054023.5

ORF Insert Sequence:

ATGAAGCTGG TAACTATCTT CCTGCTGGTG ACCATCAGCC TTTGTAGTTA CTCTGCTACT 
GCCTTCCTCA TCAACAAAGT GCCCCTTCCT GTTGACAAGT TGGCACCTTT ACCTCTGGAC 
AACATTCTTC CCTTTATGGA TCCATTAAAG CTTCTTCTGA AAACTCTGGG CATTTCTGTT 
GAGCACCTTG TGGAGGGGCT AAGGAAGTGT GTAAATGAGC TGGGACCAGA GGCTTCTGAA 
GCTGTGAAGA AACTGCTGGA GGCGCTATCA CACTTGGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCGB3A2 ( NM_054023.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_473364.1 Homo sapiens secretoglobin family 3A member 2 (SCGB3A2), mRNA.

Price & Availability↑

CloneID	OHu18391
Clone ID Related Accession (Same CDS sequence)	NM_054023.5 , NM_054023.4
Accession Version	NM_054023.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	secretoglobin family 3A member 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC024232.1 and AA988559.1. This sequence is a reference standard in the RefSeqGene project. On Mar 3, 2010 this sequence version replaced NM_054023.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358979.1, BC024232.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTGG TAACTATCTT CCTGCTGGTG ACCATCAGCC TTTGTAGTTA CTCTGCTACT 
GCCTTCCTCA TCAACAAAGT GCCCCTTCCT GTTGACAAGT TGGCACCTTT ACCTCTGGAC 
AACATTCTTC CCTTTATGGA TCCATTAAAG CTTCTTCTGA AAACTCTGGG CATTTCTGTT 
GAGCACCTTG TGGAGGGGCT AAGGAAGTGT GTAAATGAGC TGGGACCAGA GGCTTCTGAA 
GCTGTGAAGA AACTGCTGGA GGCGCTATCA CACTTGGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_473364.1
CDS	94..375
Translation	MKLVTIFLLVTISLCSYSATAFLINKVPLPVDKLAPLPLDNILPFMDPLKLLLKTLGISVEHLVEGLRKCVNELGPEASEAVKKLLEALSHLV

Target ORF information:

RefSeq Version	NM_054023.4
Organism	Homo sapiens(human)
Definition	Homo sapiens secretoglobin family 3A member 2 (SCGB3A2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_054023.4

ORF Insert Sequence:

ATGAAGCTGG TAACTATCTT CCTGCTGGTG ACCATCAGCC TTTGTAGTTA CTCTGCTACT 
GCCTTCCTCA TCAACAAAGT GCCCCTTCCT GTTGACAAGT TGGCACCTTT ACCTCTGGAC 
AACATTCTTC CCTTTATGGA TCCATTAAAG CTTCTTCTGA AAACTCTGGG CATTTCTGTT 
GAGCACCTTG TGGAGGGGCT AAGGAAGTGT GTAAATGAGC TGGGACCAGA GGCTTCTGAA 
GCTGTGAAGA AACTGCTGGA GGCGCTATCA CACTTGGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association Between Secretoglobin Family 3A Member 2 (SCGB3A2) Gene Polymorphisms and Asthma in a Korean Population.
Medical science monitor : international medical journal of experimental and clinical research231880-1885(2017 Apr)
Kim SK,Seok H,Park HJ,Han K,Kang SW,Ban JY,Jung HJ,Kim KI,Lee BJ,Kim J,Chung JH

The association of SCGB3A2 polymorphisms with the risk of Graves' disease: a meta-analysis.
Endocrine45(3)365-9(2014 Apr)
Xue L,Han B,Pan C,Song H

Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily.
Human genomics5(6)691-702(2011 Oct)
Jackson BC,Thompson DC,Wright MW,McAndrews M,Bernard A,Nebert DW,Vasiliou V

Variation in Uteroglobin-Related Protein 1 (UGRP1) gene is associated with allergic rhinitis in Singapore Chinese.
BMC medical genetics1239(2011 Mar)
Andiappan AK,Yeo WS,Parate PN,Anantharaman R,Suri BK,Wang de Y,Chew FT

The cytokine-driven regulation of secretoglobins in normal human upper airway and their expression, particularly that of uteroglobin-related protein 1, in chronic rhinosinusitis.
Respiratory research1228(2011 Mar)
Lu X,Wang N,Long XB,You XJ,Cui YH,Liu Z

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SCGB3A2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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