OLIG1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OLIG1
Entrez Gene ID	116448
Full Name	oligodendrocyte transcription factor 1
Synonyms	BHLHB6,BHLHE21
General protein information	Preferred Names oligodendrocyte transcription factor 1 Names oligodendrocyte transcription factor 1 basic domain, helix-loop-helix protein, class B, 6 class B basic helix-loop-helix protein 6 class E basic helix-loop-helix protein 21 oligo1 oligodendrocyte lineage transcription factor 1 oligodendrocyte-specific bHLH transcription factor 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.11
Disorder MIM:	606385

mRNA and Protein(s)

mRNA	Protein	Name
NM_138983.2	NP_620450.2	oligodendrocyte transcription factor 1
NM_138983.3	NP_620450.2	oligodendrocyte transcription factor 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	OLIG1	NP_001193690.1
	LOC706574	XP_002803209.1
Pan troglodytes (chimpanzee)	OLIG1	XP_530336.2
Canis lupus familiaris (dog)	OLIG1	XP_852212.3
Danio rerio (zebrafish)	olig1	NP_001018632.1
Mus musculus (house mouse)	Olig1	NP_058664.2
Xenopus tropicalis (tropical clawed frog)	olig1	XP_004912200.1
Homo sapiens (human)	OLIG1	NP_620450.2
Rattus norvegicus (Norway rat)	Olig1	NP_068538.2

Gene Ontology
Bibliography

Related articles in PubMed

Olig1 is required for noggin-induced neonatal myelin repair.
Sabo JK, Heine V, Silbereis JC, Schirmer L, Levison SW, Rowitch DH
Annals of neurology81(4)560-571(2017 Apr)

Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder.
Rajkowska G, Mahajan G, Maciag D, Sathyanesan M, Iyo AH, Moulana M, Kyle PB, Woolverton WL, Miguel-Hidalgo JJ, Stockmeier CA, Newton SS
Journal of psychiatric research6553-62(2015 Jun)

Phospho-tyrosine dependent protein-protein interaction network.
Grossmann A, Benlasfer N, Birth P, Hegele A, Wachsmuth F, Apelt L, Stelzl U
Molecular systems biology11(3)794(2015 Mar)

Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-?.
Motizuki M, Isogaya K, Miyake K, Ikushima H, Kubota T, Miyazono K, Saitoh M, Miyazawa K
The Journal of biological chemistry288(26)18911-22(2013 Jun)

Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.
Meijer DH, Kane MF, Mehta S, Liu H, Harrington E, Taylor CM, Stiles CD, Rowitch DH
Nature reviews. Neuroscience13(12)819-31(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Olig1 has a critical function in regulation of postnatal neural progenitor cell production in response to Noggin.
Title: Olig1 is required for noggin-induced neonatal myelin repair.

This study demonstrated that increased expression of mRNA of OLIG1 in ventral prefrontal white matter in major depressive disorder.
Title: Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder.

Olig1 is a Smad cofactor involved in TGF-beta-induced cell motility
Title: Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-?.

This study review OLIG1 have developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes and play the role in the postnatal brain during repair processes and in neurological disease states.
Title: Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.

Olig1 was not expressed in freshly isolated oligodendrocytes, but is expressed from the beginning of process extension until membrane maintenance.
Title: Olig1 is expressed in human oligodendrocytes during maturation and regeneration.

The following OLIG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OLIG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31845	NM_138983.3 Latest version!	Homo sapiens oligodendrocyte transcription factor 1 (OLIG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$216.30 $309.00
View Old Accession Versions >>
OHu31845	NM_138983.2	Homo sapiens oligodendrocyte transcription factor 1 (OLIG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OLIG1 ( NM_138983.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_620450.2 Homo sapiens oligodendrocyte transcription factor 1 (OLIG1), mRNA.

Price & Availability↑

CloneID	OHu31845
Clone ID Related Accession (Same CDS sequence)	NM_138983.2 , NM_138983.3
Accession Version	NM_138983.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	oligodendrocyte transcription factor 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC033290.1, AL834450.1, AL355743.1 and AW298788.1. On May 19, 2009 this sequence version replaced NM_138983.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC033290.1, AL834450.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTACTATG CGGTTTCCCA GGCGCGCGTG AACGCGGTCC CCGGGACCAT GCTGCGGCCA 
CAGCGGCCCG GAGACTTGCA GCTCGGGGCC TCCCTCTACG AGCTGGTGGG CTACAGGCAG 
CCGCCCTCCT CCTCCTCCTC CTCCACCTCC TCCACCTCCT CCACTTCCTC CTCCTCCACG 
ACGGCCCCCC TCCTCCCCAA GGCTGCGCGC GAGAAGCCGG AGGCGCCGGC CGAGCCTCCA 
GGCCCCGGGC CCGGGTCAGG CGCGCACCCG GGCGGCAGCG CCCGGCCGGA CGCCAAGGAG 
GAGCAGCAGC AGCAGCTGCG GCGCAAGATC AACAGCCGCG AGCGGAAGCG CATGCAGGAC 
CTGAACCTGG CCATGGACGC CCTGCGCGAG GTCATCCTGC CCTACTCAGC GGCGCACTGC 
CAGGGCGCGC CCGGCCGCAA GCTCTCCAAG ATAGCCACGC TGCTGCTCGC CCGCAACTAC 
ATCCTACTGC TGGGCAGCTC GCTGCAGGAG CTGCGCCGCG CGCTGGGCGA GGGCGCCGGG 
CCCGCCGCGC CGCGCCTGCT GCTGGCCGGG CTGCCCCTGC TCGCCGCCGC GCCCGGCTCC 
GTGCTGCTGG CGCCCGGCGC CGTAGGACCC CCCGACGCGC TGCGCCCCGC CAAGTACCTG 
TCGCTGGCGC TGGACGAGCC GCCGTGCGGC CAGTTCGCTC TCCCCGGCGG CGGCGCAGGC 
GGCCCCGGCC TCTGCACCTG CGCCGTGTGC AAGTTCCCGC ACCTGGTCCC GGCCAGCCTG 
GGCCTGGCCG CCGTGCAGGC GCAATTCTCC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620450.2
CDS	104..919
Translation	MYYAVSQARVNAVPGTMLRPQRPGDLQLGASLYELVGYRQPPSSSSSSTSSTSSTSSSSTTAPLLPKAAREKPEAPAEPPGPGPGSGAHPGGSARPDAKEEQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGEGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPDALRPAKYLSLALDEPPCGQFALPGGGAGGPGLCTCAVCKFPHLVPASLGLAAVQAQFSK

Target ORF information:

RefSeq Version	NM_138983.2
Organism	Homo sapiens(human)
Definition	Homo sapiens oligodendrocyte transcription factor 1 (OLIG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138983.2

ORF Insert Sequence:

ATGTACTATG CGGTTTCCCA GGCGCGCGTG AACGCGGTCC CCGGGACCAT GCTGCGGCCA 
CAGCGGCCCG GAGACTTGCA GCTCGGGGCC TCCCTCTACG AGCTGGTGGG CTACAGGCAG 
CCGCCCTCCT CCTCCTCCTC CTCCACCTCC TCCACCTCCT CCACTTCCTC CTCCTCCACG 
ACGGCCCCCC TCCTCCCCAA GGCTGCGCGC GAGAAGCCGG AGGCGCCGGC CGAGCCTCCA 
GGCCCCGGGC CCGGGTCAGG CGCGCACCCG GGCGGCAGCG CCCGGCCGGA CGCCAAGGAG 
GAGCAGCAGC AGCAGCTGCG GCGCAAGATC AACAGCCGCG AGCGGAAGCG CATGCAGGAC 
CTGAACCTGG CCATGGACGC CCTGCGCGAG GTCATCCTGC CCTACTCAGC GGCGCACTGC 
CAGGGCGCGC CCGGCCGCAA GCTCTCCAAG ATAGCCACGC TGCTGCTCGC CCGCAACTAC 
ATCCTACTGC TGGGCAGCTC GCTGCAGGAG CTGCGCCGCG CGCTGGGCGA GGGCGCCGGG 
CCCGCCGCGC CGCGCCTGCT GCTGGCCGGG CTGCCCCTGC TCGCCGCCGC GCCCGGCTCC 
GTGCTGCTGG CGCCCGGCGC CGTAGGACCC CCCGACGCGC TGCGCCCCGC CAAGTACCTG 
TCGCTGGCGC TGGACGAGCC GCCGTGCGGC CAGTTCGCTC TCCCCGGCGG CGGCGCAGGC 
GGCCCCGGCC TCTGCACCTG CGCCGTGTGC AAGTTCCCGC ACCTGGTCCC GGCCAGCCTG 
GGCCTGGCCG CCGTGCAGGC GCAATTCTCC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OLIG1 ( NM_138983.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_620450.2 Homo sapiens oligodendrocyte transcription factor 1 (OLIG1), mRNA.

Price & Availability↑

CloneID	OHu31845
Clone ID Related Accession (Same CDS sequence)	NM_138983.2 , NM_138983.3
Accession Version	NM_138983.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-20
Organism	Homo sapiens(human)
Product	oligodendrocyte transcription factor 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP000289.1, BC033290.1, AL834450.1 and AL355743.1. On Nov 22, 2018 this sequence version replaced NM_138983.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AL834450.1, BC033290.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000382348.2/ ENSP00000371785.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTACTATG CGGTTTCCCA GGCGCGCGTG AACGCGGTCC CCGGGACCAT GCTGCGGCCA 
CAGCGGCCCG GAGACTTGCA GCTCGGGGCC TCCCTCTACG AGCTGGTGGG CTACAGGCAG 
CCGCCCTCCT CCTCCTCCTC CTCCACCTCC TCCACCTCCT CCACTTCCTC CTCCTCCACG 
ACGGCCCCCC TCCTCCCCAA GGCTGCGCGC GAGAAGCCGG AGGCGCCGGC CGAGCCTCCA 
GGCCCCGGGC CCGGGTCAGG CGCGCACCCG GGCGGCAGCG CCCGGCCGGA CGCCAAGGAG 
GAGCAGCAGC AGCAGCTGCG GCGCAAGATC AACAGCCGCG AGCGGAAGCG CATGCAGGAC 
CTGAACCTGG CCATGGACGC CCTGCGCGAG GTCATCCTGC CCTACTCAGC GGCGCACTGC 
CAGGGCGCGC CCGGCCGCAA GCTCTCCAAG ATAGCCACGC TGCTGCTCGC CCGCAACTAC 
ATCCTACTGC TGGGCAGCTC GCTGCAGGAG CTGCGCCGCG CGCTGGGCGA GGGCGCCGGG 
CCCGCCGCGC CGCGCCTGCT GCTGGCCGGG CTGCCCCTGC TCGCCGCCGC GCCCGGCTCC 
GTGCTGCTGG CGCCCGGCGC CGTAGGACCC CCCGACGCGC TGCGCCCCGC CAAGTACCTG 
TCGCTGGCGC TGGACGAGCC GCCGTGCGGC CAGTTCGCTC TCCCCGGCGG CGGCGCAGGC 
GGCCCCGGCC TCTGCACCTG CGCCGTGTGC AAGTTCCCGC ACCTGGTCCC GGCCAGCCTG 
GGCCTGGCCG CCGTGCAGGC GCAATTCTCC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620450.2
CDS	107..922
Translation	MYYAVSQARVNAVPGTMLRPQRPGDLQLGASLYELVGYRQPPSSSSSSTSSTSSTSSSSTTAPLLPKAAREKPEAPAEPPGPGPGSGAHPGGSARPDAKEEQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGEGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPDALRPAKYLSLALDEPPCGQFALPGGGAGGPGLCTCAVCKFPHLVPASLGLAAVQAQFSK

Target ORF information:

RefSeq Version	NM_138983.3
Organism	Homo sapiens(human)
Definition	Homo sapiens oligodendrocyte transcription factor 1 (OLIG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138983.3

ORF Insert Sequence:

ATGTACTATG CGGTTTCCCA GGCGCGCGTG AACGCGGTCC CCGGGACCAT GCTGCGGCCA 
CAGCGGCCCG GAGACTTGCA GCTCGGGGCC TCCCTCTACG AGCTGGTGGG CTACAGGCAG 
CCGCCCTCCT CCTCCTCCTC CTCCACCTCC TCCACCTCCT CCACTTCCTC CTCCTCCACG 
ACGGCCCCCC TCCTCCCCAA GGCTGCGCGC GAGAAGCCGG AGGCGCCGGC CGAGCCTCCA 
GGCCCCGGGC CCGGGTCAGG CGCGCACCCG GGCGGCAGCG CCCGGCCGGA CGCCAAGGAG 
GAGCAGCAGC AGCAGCTGCG GCGCAAGATC AACAGCCGCG AGCGGAAGCG CATGCAGGAC 
CTGAACCTGG CCATGGACGC CCTGCGCGAG GTCATCCTGC CCTACTCAGC GGCGCACTGC 
CAGGGCGCGC CCGGCCGCAA GCTCTCCAAG ATAGCCACGC TGCTGCTCGC CCGCAACTAC 
ATCCTACTGC TGGGCAGCTC GCTGCAGGAG CTGCGCCGCG CGCTGGGCGA GGGCGCCGGG 
CCCGCCGCGC CGCGCCTGCT GCTGGCCGGG CTGCCCCTGC TCGCCGCCGC GCCCGGCTCC 
GTGCTGCTGG CGCCCGGCGC CGTAGGACCC CCCGACGCGC TGCGCCCCGC CAAGTACCTG 
TCGCTGGCGC TGGACGAGCC GCCGTGCGGC CAGTTCGCTC TCCCCGGCGG CGGCGCAGGC 
GGCCCCGGCC TCTGCACCTG CGCCGTGTGC AAGTTCCCGC ACCTGGTCCC GGCCAGCCTG 
GGCCTGGCCG CCGTGCAGGC GCAATTCTCC AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Olig1 is required for noggin-induced neonatal myelin repair.
Annals of neurology81(4)560-571(2017 Apr)
Sabo JK,Heine V,Silbereis JC,Schirmer L,Levison SW,Rowitch DH

Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder.
Journal of psychiatric research6553-62(2015 Jun)
Rajkowska G,Mahajan G,Maciag D,Sathyanesan M,Iyo AH,Moulana M,Kyle PB,Woolverton WL,Miguel-Hidalgo JJ,Stockmeier CA,Newton SS

Phospho-tyrosine dependent protein-protein interaction network.
Molecular systems biology11(3)794(2015 Mar)
Grossmann A,Benlasfer N,Birth P,Hegele A,Wachsmuth F,Apelt L,Stelzl U

Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-?.
The Journal of biological chemistry288(26)18911-22(2013 Jun)
Motizuki M,Isogaya K,Miyake K,Ikushima H,Kubota T,Miyazono K,Saitoh M,Miyazawa K

Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.
Nature reviews. Neuroscience13(12)819-31(2012 Dec)
Meijer DH,Kane MF,Mehta S,Liu H,Harrington E,Taylor CM,Stiles CD,Rowitch DH

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OLIG1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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