SEC63 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SEC63
Entrez Gene ID	11231
Full Name	SEC63 homolog, protein translocation regulator
Synonyms	DNAJC23,ERdj2,PCLD2,PRO2507,SEC63L
General protein information	Preferred Names SEC63 homolog, protein translocation regulator Names translocation protein SEC63 homolog SEC63 protein translocation regulator SEC63-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q21
Summary	The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008].
Disorder MIM:	608648
Disorder Html:	Polycystic liver disease 2, 617004 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_007214.4	NP_009145.1	translocation protein SEC63 homolog
XM_017010218.1	XP_016865707.1	translocation protein SEC63 homolog isoform X2
XM_011535399.2	XP_011533701.1	translocation protein SEC63 homolog isoform X1
XM_017010218.2	XP_016865707.1	translocation protein SEC63 homolog isoform X1
NM_007214.5	NP_009145.1	translocation protein SEC63 homolog

Pathways from BioSystems

Homologies

	SEC63	XP_001092234.1
Canis lupus familiaris (dog)	SEC63	XP_532252.4
Drosophila melanogaster (fruit fly)	sec63	NP_648111.1
Rattus norvegicus (Norway rat)	Sec63	NP_001101107.1
Caenorhabditis elegans (roundworm)	dnj-29	NP_493463.1
Homo sapiens (human)	SEC63	NP_009145.1
Mus musculus (house mouse)	Sec63	NP_694695.3
Danio rerio (zebrafish)	sec63	NP_001002588.1
Xenopus tropicalis (tropical clawed frog)	sec63	NP_001096475.1
Pan troglodytes (chimpanzee)	SEC63	XP_001148185.1
Bos taurus (cattle)	SEC63	NP_001179744.1
Gallus gallus (chicken)	SEC63	XP_004940397.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007361	XP_308470.4

Gene Ontology
Bibliography

Related articles in PubMed

Liver cyst gene knockout in cholangiocytes inhibits cilium formation and Wnt signaling.
Wills ES, Te Morsche RHM, van Reeuwijk J, Horn N, Geomini I, van de Laarschot LFM, Mans DA, Ueffing M, Boldt K, Drenth JPH, Roepman R
Human molecular genetics26(21)4190-4202(2017 Nov)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

CK2 phosphorylation of human Sec63 regulates its interaction with Sec62.
Ampofo E, Welker S, Jung M, M?ller L, Greiner M, Zimmermann R, Montenarh M
Biochimica et biophysica acta1830(4)2938-45(2013 Apr)

Loss of heterozygosity is present in SEC63 germline carriers with polycystic liver disease.
Janssen MJ, Salomon J, Te Morsche RH, Drenth JP
PloS one7(11)e50324(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Phosphorylation of Sec63 by CK2 enhanced its binding to Sec62
Title: CK2 phosphorylation of human Sec63 regulates its interaction with Sec62.

Silencing the human SEC63 genes inhibits transport of only a subset of signal-peptide-containing precursor proteins to endoplasmic reticulum.
Title: Different effects of Sec61?, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.

a SEC63 germline mutation may play a role in cyst formation in polycystic liver disease
Title: Loss of heterozygosity is present in SEC63 germline carriers with polycystic liver disease.

Sec63 may perform a substrate-selective quantity control function during cotranslational endoplasmic reticulum import.
Title: Role of human sec63 in modulating the steady-state levels of multi-spanning membrane proteins.

identified nucleoredoxin as an interaction partner of Sec63; characterized this interaction; Sec63 is linked to the Wnt signaling pathways and this interaction may be the reason why mutations in SEC63 can lead to polycystic liver disease
Title: An interaction between human Sec63 and nucleoredoxin may provide the missing link between the SEC63 gene and polycystic liver disease.

The following SEC63 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SEC63 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18295	NM_007214.5 Latest version!	Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu96278	XM_017010218.2 Latest version!	Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu64848	XM_011535399.2 Latest version!	Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu96278	XM_017010218.1	Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu18295	NM_007214.4	Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SEC63 ( NM_007214.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_009145.1 Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), mRNA.

Price & Availability↑

CloneID	OHu18295
Clone ID Related Accession (Same CDS sequence)	NM_007214.4 , NM_007214.5
Accession Version	NM_007214.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2283bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	translocation protein SEC63 homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB049187.1, BM764168.1, BC047221.1, AJ011779.1 and AL024507.7. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_007214.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.170125.1, SRR1803613.60285.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369002.9/ ENSP00000357998.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGGGC AGCAGTTCCA GTACGATGAC AGTGGGAACA CCTTCTTCTA CTTCCTCACC 
TCCTTCGTGG GGCTCATCGT GATCCCGGCG ACATACTACC TCTGGCCCCG AGATCAGAAT 
GCCGAGCAAA TTCGATTAAA GAATATCAGA AAAGTATATG GAAGGTGTAT GTGGTATCGT 
TTACGGTTAT TAAAACCCCA GCCAAATATT ATTCCTACAG TAAAGAAAAT AGTTCTGCTT 
GCAGGATGGG CATTGTTCTT ATTCCTTGCA TATAAAGTTT CCAAAACAGA CCGAGAATAC 
CAAGAATACA ATCCTTATGA AGTATTAAAT TTGGATCCTG GAGCCACAGT AGCAGAAATT 
AAAAAACAAT ATCGTTTGCT GTCACTTAAA TATCATCCAG ATAAAGGAGG TGATGAGGTT 
ATGTTCATGA GGATAGCAAA AGCTTATGCT GCTTTAACGG ATGAAGAGTC CCGGAAAAAT 
TGGGAAGAAT TTGGAAATCC AGATGGGCCT CAAGCCACAA GCTTTGGAAT TGCCCTGCCA 
GCTTGGATAG TTGACCAGAA AAACTCAATT CTGGTTTTAC TTGTATATGG ATTGGCATTT 
ATGGTTATCC TTCCAGTTGT TGTGGGCTCT TGGTGGTATC GCTCAATACG CTATAGTGGA 
GACCAGATTC TAATACGCAC AACACAGATT TATACATACT TTGTTTATAA AACCCGAAAT 
ATGGATATGA AACGTCTTAT CATGGTTTTG GCTGGAGCTT CTGAATTTGA TCCTCAGTAT 
AATAAAGATG CCACAAGCAG ACCAACGGAT AATATTCTAA TACCACAGCT AATCAGAGAA 
ATTGGCAGCA TTAATTTAAA GAAGAATGAG CCTCCACTTA CCTGCCCATA TAGCCTGAAG 
GCCAGAGTTC TTTTACTGTC TCATCTTGCT AGAATGAAAA TTCCTGAGAC CCTTGAAGAA 
GATCAGCAAT TCATGCTAAA AAAGTGTCCT GCCCTACTTC AAGAAATGGT TAATGTAATC 
TGCCAACTAA TAGTAATGGC CCGGAACCGT GAAGAAAGGG AGTTTCGTGC TCCAACTTTG 
GCATCCCTAG AAAACTGCAT GAAGCTTTCT CAGATGGCCG TTCAGGGACT TCAGCAATTT 
AAGTCTCCCC TTCTGCAGCT CCCTCATATT GAAGAGGACA ATCTTAGACG GGTTTCTAAT 
CATAAGAAGT ATAAAATTAA AACTATCCAG GATTTGGTGA GTTTAAAAGA ATCAGATCGT 
CACACTCTAC TGCACTTCCT TGAAGATGAA AAATATGAAG AGGTTATGGC TGTCCTTGGG 
AGTTTTCCAT ATGTGACCAT GGATATAAAA TCACAGGTGT TAGATGATGA AGATAGCAAC 
AACATCACAG TAGGATCCTT AGTTACAGTG TTGGTTAAGT TGACAAGGCA AACAATGGCT 
GAAGTATTTG AAAAGGAGCA GTCCATCTGT GCTGCAGAGG AACAGCCAGC AGAAGATGGG 
CAGGGTGAAA CTAACAAGAA CAGGACAAAA GGAGGATGGC AACAGAAGAG TAAAGGACCC 
AAGAAAACTG CTAAATCAAA AAAAAAGAAA CCTTTAAAAA AAAAACCTAC ACCTGTGCTA 
TTACCACAGT CAAAGCAACA GAAACAAAAG CAGGCAAATG GAGTCGTTGG GAATGAAGCT 
GCAGTAAAGG AAGATGAAGA AGAAGTTTCA GATAAGGGCA GTGATTCTGA AGAAGAAGAA 
ACCAATAGAG ATTCCCAAAG TGAGAAAGAT GATGGTAGTG ACAGAGACTC TGATAGAGAG 
CAAGATGAAA AACAAAACAA AGATGATGAA GCAGAGTGGC AAGAATTACA ACAAAGCATA 
CAGCGAAAAG AGAGAGCTCT ATTGGAAACC AAATCAAAAA TAACACATCC TGTGTATAGC 
CTTTACTTTC CTGAGGAAAA ACAAGAATGG TGGTGGCTTT ACATTGCAGA TAGGAAGGAG 
CAGACATTAA TATCCATGCC ATATCATGTG TGTACGCTGA AAGATACAGA GGAGGTAGAG 
CTGAAGTTTC CTGCACCAGG CAAGCCTGGA AATTATCAGT ATACTGTGTT TCTGAGATCA 
GACTCCTATA TGGGTTTGGA TCAGATTAAA CCATTGAAGT TGGAAGTTCA TGAGGCTAAG 
CCTGTGCCAG AAAATCACCC ACAGTGGGAT ACAGCAATAG AGGGGGATGA AGACCAGGAG 
GACAGTGAGG GCTTTGAAGA TAGCTTTGAG GAAGAAGAGG AGGAAGAAGA AGATGATGAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009145.1
CDS	200..2482
Translation	MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPRDQNAEQIRLKNIRKVYGRCMWYRLRLLKPQPNIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQEYNPYEVLNLDPGATVAEIKKQYRLLSLKYHPDKGGDEVMFMRIAKAYAALTDEESRKNWEEFGNPDGPQATSFGIALPAWIVDQKNSILVLLVYGLAFMVILPVVVGSWWYRSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFDPQYNKDATSRPTDNILIPQLIREIGSINLKKNEPPLTCPYSLKARVLLLSHLARMKIPETLEEDQQFMLKKCPALLQEMVNVICQLIVMARNREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQLPHIEEDNLRRVSNHKKYKIKTIQDLVSLKESDRHTLLHFLEDEKYEEVMAVLGSFPYVTMDIKSQVLDDEDSNNITVGSLVTVLVKLTRQTMAEVFEKEQSICAAEEQPAEDGQGETNKNRTKGGWQQKSKGPKKTAKSKKKKPLKKKPTPVLLPQSKQQKQKQANGVVGNEAAVKEDEEEVSDKGSDSEEEETNRDSQSEKDDGSDRDSDREQDEKQNKDDEAEWQELQQSIQRKERALLETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELKFPAPGKPGNYQYTVFLRSDSYMGLDQIKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEEDDD

Target ORF information:

RefSeq Version	NM_007214.5
Organism	Homo sapiens(human)
Definition	Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007214.5

ORF Insert Sequence:

ATGGCCGGGC AGCAGTTCCA GTACGATGAC AGTGGGAACA CCTTCTTCTA CTTCCTCACC 
TCCTTCGTGG GGCTCATCGT GATCCCGGCG ACATACTACC TCTGGCCCCG AGATCAGAAT 
GCCGAGCAAA TTCGATTAAA GAATATCAGA AAAGTATATG GAAGGTGTAT GTGGTATCGT 
TTACGGTTAT TAAAACCCCA GCCAAATATT ATTCCTACAG TAAAGAAAAT AGTTCTGCTT 
GCAGGATGGG CATTGTTCTT ATTCCTTGCA TATAAAGTTT CCAAAACAGA CCGAGAATAC 
CAAGAATACA ATCCTTATGA AGTATTAAAT TTGGATCCTG GAGCCACAGT AGCAGAAATT 
AAAAAACAAT ATCGTTTGCT GTCACTTAAA TATCATCCAG ATAAAGGAGG TGATGAGGTT 
ATGTTCATGA GGATAGCAAA AGCTTATGCT GCTTTAACGG ATGAAGAGTC CCGGAAAAAT 
TGGGAAGAAT TTGGAAATCC AGATGGGCCT CAAGCCACAA GCTTTGGAAT TGCCCTGCCA 
GCTTGGATAG TTGACCAGAA AAACTCAATT CTGGTTTTAC TTGTATATGG ATTGGCATTT 
ATGGTTATCC TTCCAGTTGT TGTGGGCTCT TGGTGGTATC GCTCAATACG CTATAGTGGA 
GACCAGATTC TAATACGCAC AACACAGATT TATACATACT TTGTTTATAA AACCCGAAAT 
ATGGATATGA AACGTCTTAT CATGGTTTTG GCTGGAGCTT CTGAATTTGA TCCTCAGTAT 
AATAAAGATG CCACAAGCAG ACCAACGGAT AATATTCTAA TACCACAGCT AATCAGAGAA 
ATTGGCAGCA TTAATTTAAA GAAGAATGAG CCTCCACTTA CCTGCCCATA TAGCCTGAAG 
GCCAGAGTTC TTTTACTGTC TCATCTTGCT AGAATGAAAA TTCCTGAGAC CCTTGAAGAA 
GATCAGCAAT TCATGCTAAA AAAGTGTCCT GCCCTACTTC AAGAAATGGT TAATGTAATC 
TGCCAACTAA TAGTAATGGC CCGGAACCGT GAAGAAAGGG AGTTTCGTGC TCCAACTTTG 
GCATCCCTAG AAAACTGCAT GAAGCTTTCT CAGATGGCCG TTCAGGGACT TCAGCAATTT 
AAGTCTCCCC TTCTGCAGCT CCCTCATATT GAAGAGGACA ATCTTAGACG GGTTTCTAAT 
CATAAGAAGT ATAAAATTAA AACTATCCAG GATTTGGTGA GTTTAAAAGA ATCAGATCGT 
CACACTCTAC TGCACTTCCT TGAAGATGAA AAATATGAAG AGGTTATGGC TGTCCTTGGG 
AGTTTTCCAT ATGTGACCAT GGATATAAAA TCACAGGTGT TAGATGATGA AGATAGCAAC 
AACATCACAG TAGGATCCTT AGTTACAGTG TTGGTTAAGT TGACAAGGCA AACAATGGCT 
GAAGTATTTG AAAAGGAGCA GTCCATCTGT GCTGCAGAGG AACAGCCAGC AGAAGATGGG 
CAGGGTGAAA CTAACAAGAA CAGGACAAAA GGAGGATGGC AACAGAAGAG TAAAGGACCC 
AAGAAAACTG CTAAATCAAA AAAAAAGAAA CCTTTAAAAA AAAAACCTAC ACCTGTGCTA 
TTACCACAGT CAAAGCAACA GAAACAAAAG CAGGCAAATG GAGTCGTTGG GAATGAAGCT 
GCAGTAAAGG AAGATGAAGA AGAAGTTTCA GATAAGGGCA GTGATTCTGA AGAAGAAGAA 
ACCAATAGAG ATTCCCAAAG TGAGAAAGAT GATGGTAGTG ACAGAGACTC TGATAGAGAG 
CAAGATGAAA AACAAAACAA AGATGATGAA GCAGAGTGGC AAGAATTACA ACAAAGCATA 
CAGCGAAAAG AGAGAGCTCT ATTGGAAACC AAATCAAAAA TAACACATCC TGTGTATAGC 
CTTTACTTTC CTGAGGAAAA ACAAGAATGG TGGTGGCTTT ACATTGCAGA TAGGAAGGAG 
CAGACATTAA TATCCATGCC ATATCATGTG TGTACGCTGA AAGATACAGA GGAGGTAGAG 
CTGAAGTTTC CTGCACCAGG CAAGCCTGGA AATTATCAGT ATACTGTGTT TCTGAGATCA 
GACTCCTATA TGGGTTTGGA TCAGATTAAA CCATTGAAGT TGGAAGTTCA TGAGGCTAAG 
CCTGTGCCAG AAAATCACCC ACAGTGGGAT ACAGCAATAG AGGGGGATGA AGACCAGGAG 
GACAGTGAGG GCTTTGAAGA TAGCTTTGAG GAAGAAGAGG AGGAAGAAGA AGATGATGAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SEC63 ( XM_017010218.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016865707.1 Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu96278
Clone ID Related Accession (Same CDS sequence)	XM_017010218.1 , XM_017010218.2
Accession Version	XM_017010218.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	translocation protein SEC63 homolog isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCTTT CTCAGATGGC CGTTCAGGGA CTTCAGCAAT TTAAGTCTCC CCTTCTGCAG 
CTCCCTCATA TTGAAGAGGA CAATCTTAGA CGGGTTTCTA ATCATAAGAA GTATAAAATT 
AAAACTATCC AGGATTTGGT GAGTTTAAAA GAATCAGATC GTCACACTCT ACTGCACTTC 
CTTGAAGATG AAAAATATGA AGAGGTTATG GCTGTCCTTG GGAGTTTTCC ATATGTGACC 
ATGGATATAA AATCACAGGT GTTAGATGAT GAAGATAGCA ACAACATCAC AGTAGGATCC 
TTAGTTACAG TGTTGGTTAA GTTGACAAGG CAAACAATGG CTGAAGTATT TGAAAAGGAG 
CAGTCCATCT GTGCTGCAGA GGAACAGCCA GCAGAAGATG GGCAGGGTGA AACTAACAAG 
AACAGGACAA AAGGAGGATG GCAACAGAAG AGTAAAGGAC CCAAGAAAAC TGCTAAATCA 
AAAAAAAAGA AACCTTTAAA AAAAAAACCT ACACCTGTGC TATTACCACA GTCAAAGCAA 
CAGAAACAAA AGCAGGCAAA TGGAGTCGTT GGGAATGAAG CTGCAGTAAA GGAAGATGAA 
GAAGAAGTTT CAGATAAGGG CAGTGATTCT GAAGAAGAAG AAACCAATAG AGATTCCCAA 
AGTGAGAAAG ATGATGGTAG TGACAGAGAC TCTGATAGAG AGCAAGATGA AAAACAAAAC 
AAAGATGATG AAGCAGAGTG GCAAGAATTA CAACAAAGCA TACAGCGAAA AGAGAGAGCT 
CTATTGGAAA CCAAATCAAA AATAACACAT CCTGTGTATA GCCTTTACTT TCCTGAGGAA 
AAACAAGAAT GGTGGTGGCT TTACATTGCA GATAGGAAGG AGCAGACATT AATATCCATG 
CCATATCATG TGTGTACGCT GAAAGATACA GAGGAGGTAG AGCTGAAGTT TCCTGCACCA 
GGCAAGCCTG GAAATTATCA GTATACTGTG TTTCTGAGAT CAGACTCCTA TATGGGTTTG 
GATCAGATTA AACCATTGAA GTTGGAAGTT CATGAGGCTA AGCCTGTGCC AGAAAATCAC 
CCACAGTGGG ATACAGCAAT AGAGGGGGAT GAAGACCAGG AGGACAGTGA GGGCTTTGAA 
GATAGCTTTG AGGAAGAAGA GGAGGAAGAA GAAGATGATG ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016865707.1
CDS	1197..2381
Translation	MKLSQMAVQGLQQFKSPLLQLPHIEEDNLRRVSNHKKYKIKTIQDLVSLKESDRHTLLHFLEDEKYEEVMAVLGSFPYVTMDIKSQVLDDEDSNNITVGSLVTVLVKLTRQTMAEVFEKEQSICAAEEQPAEDGQGETNKNRTKGGWQQKSKGPKKTAKSKKKKPLKKKPTPVLLPQSKQQKQKQANGVVGNEAAVKEDEEEVSDKGSDSEEEETNRDSQSEKDDGSDRDSDREQDEKQNKDDEAEWQELQQSIQRKERALLETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELKFPAPGKPGNYQYTVFLRSDSYMGLDQIKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEEDDD

Target ORF information:

RefSeq Version	XM_017010218.1
Organism	Homo sapiens(human)
Definition	Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017010218.1

ORF Insert Sequence:

ATGAAGCTTT CTCAGATGGC CGTTCAGGGA CTTCAGCAAT TTAAGTCTCC CCTTCTGCAG 
CTCCCTCATA TTGAAGAGGA CAATCTTAGA CGGGTTTCTA ATCATAAGAA GTATAAAATT 
AAAACTATCC AGGATTTGGT GAGTTTAAAA GAATCAGATC GTCACACTCT ACTGCACTTC 
CTTGAAGATG AAAAATATGA AGAGGTTATG GCTGTCCTTG GGAGTTTTCC ATATGTGACC 
ATGGATATAA AATCACAGGT GTTAGATGAT GAAGATAGCA ACAACATCAC AGTAGGATCC 
TTAGTTACAG TGTTGGTTAA GTTGACAAGG CAAACAATGG CTGAAGTATT TGAAAAGGAG 
CAGTCCATCT GTGCTGCAGA GGAACAGCCA GCAGAAGATG GGCAGGGTGA AACTAACAAG 
AACAGGACAA AAGGAGGATG GCAACAGAAG AGTAAAGGAC CCAAGAAAAC TGCTAAATCA 
AAAAAAAAGA AACCTTTAAA AAAAAAACCT ACACCTGTGC TATTACCACA GTCAAAGCAA 
CAGAAACAAA AGCAGGCAAA TGGAGTCGTT GGGAATGAAG CTGCAGTAAA GGAAGATGAA 
GAAGAAGTTT CAGATAAGGG CAGTGATTCT GAAGAAGAAG AAACCAATAG AGATTCCCAA 
AGTGAGAAAG ATGATGGTAG TGACAGAGAC TCTGATAGAG AGCAAGATGA AAAACAAAAC 
AAAGATGATG AAGCAGAGTG GCAAGAATTA CAACAAAGCA TACAGCGAAA AGAGAGAGCT 
CTATTGGAAA CCAAATCAAA AATAACACAT CCTGTGTATA GCCTTTACTT TCCTGAGGAA 
AAACAAGAAT GGTGGTGGCT TTACATTGCA GATAGGAAGG AGCAGACATT AATATCCATG 
CCATATCATG TGTGTACGCT GAAAGATACA GAGGAGGTAG AGCTGAAGTT TCCTGCACCA 
GGCAAGCCTG GAAATTATCA GTATACTGTG TTTCTGAGAT CAGACTCCTA TATGGGTTTG 
GATCAGATTA AACCATTGAA GTTGGAAGTT CATGAGGCTA AGCCTGTGCC AGAAAATCAC 
CCACAGTGGG ATACAGCAAT AGAGGGGGAT GAAGACCAGG AGGACAGTGA GGGCTTTGAA 
GATAGCTTTG AGGAAGAAGA GGAGGAAGAA GAAGATGATG ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SEC63 ( XM_017010218.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016865707.1 Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu96278
Clone ID Related Accession (Same CDS sequence)	XM_017010218.1 , XM_017010218.2
Accession Version	XM_017010218.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	translocation protein SEC63 homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017010218.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCTTT CTCAGATGGC CGTTCAGGGA CTTCAGCAAT TTAAGTCTCC CCTTCTGCAG 
CTCCCTCATA TTGAAGAGGA CAATCTTAGA CGGGTTTCTA ATCATAAGAA GTATAAAATT 
AAAACTATCC AGGATTTGGT GAGTTTAAAA GAATCAGATC GTCACACTCT ACTGCACTTC 
CTTGAAGATG AAAAATATGA AGAGGTTATG GCTGTCCTTG GGAGTTTTCC ATATGTGACC 
ATGGATATAA AATCACAGGT GTTAGATGAT GAAGATAGCA ACAACATCAC AGTAGGATCC 
TTAGTTACAG TGTTGGTTAA GTTGACAAGG CAAACAATGG CTGAAGTATT TGAAAAGGAG 
CAGTCCATCT GTGCTGCAGA GGAACAGCCA GCAGAAGATG GGCAGGGTGA AACTAACAAG 
AACAGGACAA AAGGAGGATG GCAACAGAAG AGTAAAGGAC CCAAGAAAAC TGCTAAATCA 
AAAAAAAAGA AACCTTTAAA AAAAAAACCT ACACCTGTGC TATTACCACA GTCAAAGCAA 
CAGAAACAAA AGCAGGCAAA TGGAGTCGTT GGGAATGAAG CTGCAGTAAA GGAAGATGAA 
GAAGAAGTTT CAGATAAGGG CAGTGATTCT GAAGAAGAAG AAACCAATAG AGATTCCCAA 
AGTGAGAAAG ATGATGGTAG TGACAGAGAC TCTGATAGAG AGCAAGATGA AAAACAAAAC 
AAAGATGATG AAGCAGAGTG GCAAGAATTA CAACAAAGCA TACAGCGAAA AGAGAGAGCT 
CTATTGGAAA CCAAATCAAA AATAACACAT CCTGTGTATA GCCTTTACTT TCCTGAGGAA 
AAACAAGAAT GGTGGTGGCT TTACATTGCA GATAGGAAGG AGCAGACATT AATATCCATG 
CCATATCATG TGTGTACGCT GAAAGATACA GAGGAGGTAG AGCTGAAGTT TCCTGCACCA 
GGCAAGCCTG GAAATTATCA GTATACTGTG TTTCTGAGAT CAGACTCCTA TATGGGTTTG 
GATCAGATTA AACCATTGAA GTTGGAAGTT CATGAGGCTA AGCCTGTGCC AGAAAATCAC 
CCACAGTGGG ATACAGCAAT AGAGGGGGAT GAAGACCAGG AGGACAGTGA GGGCTTTGAA 
GATAGCTTTG AGGAAGAAGA GGAGGAAGAA GAAGATGATG ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016865707.1
CDS	1200..2384
Translation	MKLSQMAVQGLQQFKSPLLQLPHIEEDNLRRVSNHKKYKIKTIQDLVSLKESDRHTLLHFLEDEKYEEVMAVLGSFPYVTMDIKSQVLDDEDSNNITVGSLVTVLVKLTRQTMAEVFEKEQSICAAEEQPAEDGQGETNKNRTKGGWQQKSKGPKKTAKSKKKKPLKKKPTPVLLPQSKQQKQKQANGVVGNEAAVKEDEEEVSDKGSDSEEEETNRDSQSEKDDGSDRDSDREQDEKQNKDDEAEWQELQQSIQRKERALLETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELKFPAPGKPGNYQYTVFLRSDSYMGLDQIKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEEDDD

Target ORF information:

RefSeq Version	XM_017010218.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017010218.2

ORF Insert Sequence:

ATGAAGCTTT CTCAGATGGC CGTTCAGGGA CTTCAGCAAT TTAAGTCTCC CCTTCTGCAG 
CTCCCTCATA TTGAAGAGGA CAATCTTAGA CGGGTTTCTA ATCATAAGAA GTATAAAATT 
AAAACTATCC AGGATTTGGT GAGTTTAAAA GAATCAGATC GTCACACTCT ACTGCACTTC 
CTTGAAGATG AAAAATATGA AGAGGTTATG GCTGTCCTTG GGAGTTTTCC ATATGTGACC 
ATGGATATAA AATCACAGGT GTTAGATGAT GAAGATAGCA ACAACATCAC AGTAGGATCC 
TTAGTTACAG TGTTGGTTAA GTTGACAAGG CAAACAATGG CTGAAGTATT TGAAAAGGAG 
CAGTCCATCT GTGCTGCAGA GGAACAGCCA GCAGAAGATG GGCAGGGTGA AACTAACAAG 
AACAGGACAA AAGGAGGATG GCAACAGAAG AGTAAAGGAC CCAAGAAAAC TGCTAAATCA 
AAAAAAAAGA AACCTTTAAA AAAAAAACCT ACACCTGTGC TATTACCACA GTCAAAGCAA 
CAGAAACAAA AGCAGGCAAA TGGAGTCGTT GGGAATGAAG CTGCAGTAAA GGAAGATGAA 
GAAGAAGTTT CAGATAAGGG CAGTGATTCT GAAGAAGAAG AAACCAATAG AGATTCCCAA 
AGTGAGAAAG ATGATGGTAG TGACAGAGAC TCTGATAGAG AGCAAGATGA AAAACAAAAC 
AAAGATGATG AAGCAGAGTG GCAAGAATTA CAACAAAGCA TACAGCGAAA AGAGAGAGCT 
CTATTGGAAA CCAAATCAAA AATAACACAT CCTGTGTATA GCCTTTACTT TCCTGAGGAA 
AAACAAGAAT GGTGGTGGCT TTACATTGCA GATAGGAAGG AGCAGACATT AATATCCATG 
CCATATCATG TGTGTACGCT GAAAGATACA GAGGAGGTAG AGCTGAAGTT TCCTGCACCA 
GGCAAGCCTG GAAATTATCA GTATACTGTG TTTCTGAGAT CAGACTCCTA TATGGGTTTG 
GATCAGATTA AACCATTGAA GTTGGAAGTT CATGAGGCTA AGCCTGTGCC AGAAAATCAC 
CCACAGTGGG ATACAGCAAT AGAGGGGGAT GAAGACCAGG AGGACAGTGA GGGCTTTGAA 
GATAGCTTTG AGGAAGAAGA GGAGGAAGAA GAAGATGATG ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SEC63 ( NM_007214.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_009145.1 Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), mRNA.

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CloneID	OHu18295
Clone ID Related Accession (Same CDS sequence)	NM_007214.4 , NM_007214.5
Accession Version	NM_007214.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2283bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	translocation protein SEC63 homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB049187.1, BM764168.1, BC047221.1, AJ011779.1 and AL024507.7. This sequence is a reference standard in the RefSeqGene project. On Jun 8, 2008 this sequence version replaced NM_007214.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.60285.1, SRR1803612.214378.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGGC AGCAGTTCCA GTACGATGAC AGTGGGAACA CCTTCTTCTA CTTCCTCACC 
TCCTTCGTGG GGCTCATCGT GATCCCGGCG ACATACTACC TCTGGCCCCG AGATCAGAAT 
GCCGAGCAAA TTCGATTAAA GAATATCAGA AAAGTATATG GAAGGTGTAT GTGGTATCGT 
TTACGGTTAT TAAAACCCCA GCCAAATATT ATTCCTACAG TAAAGAAAAT AGTTCTGCTT 
GCAGGATGGG CATTGTTCTT ATTCCTTGCA TATAAAGTTT CCAAAACAGA CCGAGAATAC 
CAAGAATACA ATCCTTATGA AGTATTAAAT TTGGATCCTG GAGCCACAGT AGCAGAAATT 
AAAAAACAAT ATCGTTTGCT GTCACTTAAA TATCATCCAG ATAAAGGAGG TGATGAGGTT 
ATGTTCATGA GGATAGCAAA AGCTTATGCT GCTTTAACGG ATGAAGAGTC CCGGAAAAAT 
TGGGAAGAAT TTGGAAATCC AGATGGGCCT CAAGCCACAA GCTTTGGAAT TGCCCTGCCA 
GCTTGGATAG TTGACCAGAA AAACTCAATT CTGGTTTTAC TTGTATATGG ATTGGCATTT 
ATGGTTATCC TTCCAGTTGT TGTGGGCTCT TGGTGGTATC GCTCAATACG CTATAGTGGA 
GACCAGATTC TAATACGCAC AACACAGATT TATACATACT TTGTTTATAA AACCCGAAAT 
ATGGATATGA AACGTCTTAT CATGGTTTTG GCTGGAGCTT CTGAATTTGA TCCTCAGTAT 
AATAAAGATG CCACAAGCAG ACCAACGGAT AATATTCTAA TACCACAGCT AATCAGAGAA 
ATTGGCAGCA TTAATTTAAA GAAGAATGAG CCTCCACTTA CCTGCCCATA TAGCCTGAAG 
GCCAGAGTTC TTTTACTGTC TCATCTTGCT AGAATGAAAA TTCCTGAGAC CCTTGAAGAA 
GATCAGCAAT TCATGCTAAA AAAGTGTCCT GCCCTACTTC AAGAAATGGT TAATGTAATC 
TGCCAACTAA TAGTAATGGC CCGGAACCGT GAAGAAAGGG AGTTTCGTGC TCCAACTTTG 
GCATCCCTAG AAAACTGCAT GAAGCTTTCT CAGATGGCCG TTCAGGGACT TCAGCAATTT 
AAGTCTCCCC TTCTGCAGCT CCCTCATATT GAAGAGGACA ATCTTAGACG GGTTTCTAAT 
CATAAGAAGT ATAAAATTAA AACTATCCAG GATTTGGTGA GTTTAAAAGA ATCAGATCGT 
CACACTCTAC TGCACTTCCT TGAAGATGAA AAATATGAAG AGGTTATGGC TGTCCTTGGG 
AGTTTTCCAT ATGTGACCAT GGATATAAAA TCACAGGTGT TAGATGATGA AGATAGCAAC 
AACATCACAG TAGGATCCTT AGTTACAGTG TTGGTTAAGT TGACAAGGCA AACAATGGCT 
GAAGTATTTG AAAAGGAGCA GTCCATCTGT GCTGCAGAGG AACAGCCAGC AGAAGATGGG 
CAGGGTGAAA CTAACAAGAA CAGGACAAAA GGAGGATGGC AACAGAAGAG TAAAGGACCC 
AAGAAAACTG CTAAATCAAA AAAAAAGAAA CCTTTAAAAA AAAAACCTAC ACCTGTGCTA 
TTACCACAGT CAAAGCAACA GAAACAAAAG CAGGCAAATG GAGTCGTTGG GAATGAAGCT 
GCAGTAAAGG AAGATGAAGA AGAAGTTTCA GATAAGGGCA GTGATTCTGA AGAAGAAGAA 
ACCAATAGAG ATTCCCAAAG TGAGAAAGAT GATGGTAGTG ACAGAGACTC TGATAGAGAG 
CAAGATGAAA AACAAAACAA AGATGATGAA GCAGAGTGGC AAGAATTACA ACAAAGCATA 
CAGCGAAAAG AGAGAGCTCT ATTGGAAACC AAATCAAAAA TAACACATCC TGTGTATAGC 
CTTTACTTTC CTGAGGAAAA ACAAGAATGG TGGTGGCTTT ACATTGCAGA TAGGAAGGAG 
CAGACATTAA TATCCATGCC ATATCATGTG TGTACGCTGA AAGATACAGA GGAGGTAGAG 
CTGAAGTTTC CTGCACCAGG CAAGCCTGGA AATTATCAGT ATACTGTGTT TCTGAGATCA 
GACTCCTATA TGGGTTTGGA TCAGATTAAA CCATTGAAGT TGGAAGTTCA TGAGGCTAAG 
CCTGTGCCAG AAAATCACCC ACAGTGGGAT ACAGCAATAG AGGGGGATGA AGACCAGGAG 
GACAGTGAGG GCTTTGAAGA TAGCTTTGAG GAAGAAGAGG AGGAAGAAGA AGATGATGAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009145.1
CDS	270..2552
Translation	MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPRDQNAEQIRLKNIRKVYGRCMWYRLRLLKPQPNIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQEYNPYEVLNLDPGATVAEIKKQYRLLSLKYHPDKGGDEVMFMRIAKAYAALTDEESRKNWEEFGNPDGPQATSFGIALPAWIVDQKNSILVLLVYGLAFMVILPVVVGSWWYRSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFDPQYNKDATSRPTDNILIPQLIREIGSINLKKNEPPLTCPYSLKARVLLLSHLARMKIPETLEEDQQFMLKKCPALLQEMVNVICQLIVMARNREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQLPHIEEDNLRRVSNHKKYKIKTIQDLVSLKESDRHTLLHFLEDEKYEEVMAVLGSFPYVTMDIKSQVLDDEDSNNITVGSLVTVLVKLTRQTMAEVFEKEQSICAAEEQPAEDGQGETNKNRTKGGWQQKSKGPKKTAKSKKKKPLKKKPTPVLLPQSKQQKQKQANGVVGNEAAVKEDEEEVSDKGSDSEEEETNRDSQSEKDDGSDRDSDREQDEKQNKDDEAEWQELQQSIQRKERALLETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELKFPAPGKPGNYQYTVFLRSDSYMGLDQIKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEEDDD

Target ORF information:

RefSeq Version	NM_007214.4
Organism	Homo sapiens(human)
Definition	Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007214.4

ORF Insert Sequence:

ATGGCCGGGC AGCAGTTCCA GTACGATGAC AGTGGGAACA CCTTCTTCTA CTTCCTCACC 
TCCTTCGTGG GGCTCATCGT GATCCCGGCG ACATACTACC TCTGGCCCCG AGATCAGAAT 
GCCGAGCAAA TTCGATTAAA GAATATCAGA AAAGTATATG GAAGGTGTAT GTGGTATCGT 
TTACGGTTAT TAAAACCCCA GCCAAATATT ATTCCTACAG TAAAGAAAAT AGTTCTGCTT 
GCAGGATGGG CATTGTTCTT ATTCCTTGCA TATAAAGTTT CCAAAACAGA CCGAGAATAC 
CAAGAATACA ATCCTTATGA AGTATTAAAT TTGGATCCTG GAGCCACAGT AGCAGAAATT 
AAAAAACAAT ATCGTTTGCT GTCACTTAAA TATCATCCAG ATAAAGGAGG TGATGAGGTT 
ATGTTCATGA GGATAGCAAA AGCTTATGCT GCTTTAACGG ATGAAGAGTC CCGGAAAAAT 
TGGGAAGAAT TTGGAAATCC AGATGGGCCT CAAGCCACAA GCTTTGGAAT TGCCCTGCCA 
GCTTGGATAG TTGACCAGAA AAACTCAATT CTGGTTTTAC TTGTATATGG ATTGGCATTT 
ATGGTTATCC TTCCAGTTGT TGTGGGCTCT TGGTGGTATC GCTCAATACG CTATAGTGGA 
GACCAGATTC TAATACGCAC AACACAGATT TATACATACT TTGTTTATAA AACCCGAAAT 
ATGGATATGA AACGTCTTAT CATGGTTTTG GCTGGAGCTT CTGAATTTGA TCCTCAGTAT 
AATAAAGATG CCACAAGCAG ACCAACGGAT AATATTCTAA TACCACAGCT AATCAGAGAA 
ATTGGCAGCA TTAATTTAAA GAAGAATGAG CCTCCACTTA CCTGCCCATA TAGCCTGAAG 
GCCAGAGTTC TTTTACTGTC TCATCTTGCT AGAATGAAAA TTCCTGAGAC CCTTGAAGAA 
GATCAGCAAT TCATGCTAAA AAAGTGTCCT GCCCTACTTC AAGAAATGGT TAATGTAATC 
TGCCAACTAA TAGTAATGGC CCGGAACCGT GAAGAAAGGG AGTTTCGTGC TCCAACTTTG 
GCATCCCTAG AAAACTGCAT GAAGCTTTCT CAGATGGCCG TTCAGGGACT TCAGCAATTT 
AAGTCTCCCC TTCTGCAGCT CCCTCATATT GAAGAGGACA ATCTTAGACG GGTTTCTAAT 
CATAAGAAGT ATAAAATTAA AACTATCCAG GATTTGGTGA GTTTAAAAGA ATCAGATCGT 
CACACTCTAC TGCACTTCCT TGAAGATGAA AAATATGAAG AGGTTATGGC TGTCCTTGGG 
AGTTTTCCAT ATGTGACCAT GGATATAAAA TCACAGGTGT TAGATGATGA AGATAGCAAC 
AACATCACAG TAGGATCCTT AGTTACAGTG TTGGTTAAGT TGACAAGGCA AACAATGGCT 
GAAGTATTTG AAAAGGAGCA GTCCATCTGT GCTGCAGAGG AACAGCCAGC AGAAGATGGG 
CAGGGTGAAA CTAACAAGAA CAGGACAAAA GGAGGATGGC AACAGAAGAG TAAAGGACCC 
AAGAAAACTG CTAAATCAAA AAAAAAGAAA CCTTTAAAAA AAAAACCTAC ACCTGTGCTA 
TTACCACAGT CAAAGCAACA GAAACAAAAG CAGGCAAATG GAGTCGTTGG GAATGAAGCT 
GCAGTAAAGG AAGATGAAGA AGAAGTTTCA GATAAGGGCA GTGATTCTGA AGAAGAAGAA 
ACCAATAGAG ATTCCCAAAG TGAGAAAGAT GATGGTAGTG ACAGAGACTC TGATAGAGAG 
CAAGATGAAA AACAAAACAA AGATGATGAA GCAGAGTGGC AAGAATTACA ACAAAGCATA 
CAGCGAAAAG AGAGAGCTCT ATTGGAAACC AAATCAAAAA TAACACATCC TGTGTATAGC 
CTTTACTTTC CTGAGGAAAA ACAAGAATGG TGGTGGCTTT ACATTGCAGA TAGGAAGGAG 
CAGACATTAA TATCCATGCC ATATCATGTG TGTACGCTGA AAGATACAGA GGAGGTAGAG 
CTGAAGTTTC CTGCACCAGG CAAGCCTGGA AATTATCAGT ATACTGTGTT TCTGAGATCA 
GACTCCTATA TGGGTTTGGA TCAGATTAAA CCATTGAAGT TGGAAGTTCA TGAGGCTAAG 
CCTGTGCCAG AAAATCACCC ACAGTGGGAT ACAGCAATAG AGGGGGATGA AGACCAGGAG 
GACAGTGAGG GCTTTGAAGA TAGCTTTGAG GAAGAAGAGG AGGAAGAAGA AGATGATGAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SEC63 ( XM_011535399.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011533701.1 Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), transcript variant X1, mRNA.

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CloneID	OHu64848
Clone ID Related Accession (Same CDS sequence)	XM_011535399.2
Accession Version	XM_011535399.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2115bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	translocation protein SEC63 homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011535399.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGTATC GTTTACGGTT ATTAAAACCC CAGCCAAATA TTATTCCTAC AGTAAAGAAA 
ATAGTTCTGC TTGCAGGATG GGCATTGTTC TTATTCCTTG CATATAAAGT TTCCAAAACA 
GACCGAGAAT ACCAAGAATA CAATCCTTAT GAAGTATTAA ATTTGGATCC TGGAGCCACA 
GTAGCAGAAA TTAAAAAACA ATATCGTTTG CTGTCACTTA AATATCATCC AGATAAAGGA 
GGTGATGAGG TTATGTTCAT GAGGATAGCA AAAGCTTATG CTGCTTTAAC GGATGAAGAG 
TCCCGGAAAA ATTGGGAAGA ATTTGGAAAT CCAGATGGGC CTCAAGCCAC AAGCTTTGGA 
ATTGCCCTGC CAGCTTGGAT AGTTGACCAG AAAAACTCAA TTCTGGTTTT ACTTGTATAT 
GGATTGGCAT TTATGGTTAT CCTTCCAGTT GTTGTGGGCT CTTGGTGGTA TCGCTCAATA 
CGCTATAGTG GAGACCAGAT TCTAATACGC ACAACACAGA TTTATACATA CTTTGTTTAT 
AAAACCCGAA ATATGGATAT GAAACGTCTT ATCATGGTTT TGGCTGGAGC TTCTGAATTT 
GATCCTCAGT ATAATAAAGA TGCCACAAGC AGACCAACGG ATAATATTCT AATACCACAG 
CTAATCAGAG AAATTGGCAG CATTAATTTA AAGAAGAATG AGCCTCCACT TACCTGCCCA 
TATAGCCTGA AGGCCAGAGT TCTTTTACTG TCTCATCTTG CTAGAATGAA AATTCCTGAG 
ACCCTTGAAG AAGATCAGCA ATTCATGCTA AAAAAGTGTC CTGCCCTACT TCAAGAAATG 
GTTAATGTAA TCTGCCAACT AATAGTAATG GCCCGGAACC GTGAAGAAAG GGAGTTTCGT 
GCTCCAACTT TGGCATCCCT AGAAAACTGC ATGAAGCTTT CTCAGATGGC CGTTCAGGGA 
CTTCAGCAAT TTAAGTCTCC CCTTCTGCAG CTCCCTCATA TTGAAGAGGA CAATCTTAGA 
CGGGTTTCTA ATCATAAGAA GTATAAAATT AAAACTATCC AGGATTTGGT GAGTTTAAAA 
GAATCAGATC GTCACACTCT ACTGCACTTC CTTGAAGATG AAAAATATGA AGAGGTTATG 
GCTGTCCTTG GGAGTTTTCC ATATGTGACC ATGGATATAA AATCACAGGT GTTAGATGAT 
GAAGATAGCA ACAACATCAC AGTAGGATCC TTAGTTACAG TGTTGGTTAA GTTGACAAGG 
CAAACAATGG CTGAAGTATT TGAAAAGGAG CAGTCCATCT GTGCTGCAGA GGAACAGCCA 
GCAGAAGATG GGCAGGGTGA AACTAACAAG AACAGGACAA AAGGAGGATG GCAACAGAAG 
AGTAAAGGAC CCAAGAAAAC TGCTAAATCA AAAAAAAAGA AACCTTTAAA AAAAAAACCT 
ACACCTGTGC TATTACCACA GTCAAAGCAA CAGAAACAAA AGCAGGCAAA TGGAGTCGTT 
GGGAATGAAG CTGCAGTAAA GGAAGATGAA GAAGAAGTTT CAGATAAGGG CAGTGATTCT 
GAAGAAGAAG AAACCAATAG AGATTCCCAA AGTGAGAAAG ATGATGGTAG TGACAGAGAC 
TCTGATAGAG AGCAAGATGA AAAACAAAAC AAAGATGATG AAGCAGAGTG GCAAGAATTA 
CAACAAAGCA TACAGCGAAA AGAGAGAGCT CTATTGGAAA CCAAATCAAA AATAACACAT 
CCTGTGTATA GCCTTTACTT TCCTGAGGAA AAACAAGAAT GGTGGTGGCT TTACATTGCA 
GATAGGAAGG AGCAGACATT AATATCCATG CCATATCATG TGTGTACGCT GAAAGATACA 
GAGGAGGTAG AGCTGAAGTT TCCTGCACCA GGCAAGCCTG GAAATTATCA GTATACTGTG 
TTTCTGAGAT CAGACTCCTA TATGGGTTTG GATCAGATTA AACCATTGAA GTTGGAAGTT 
CATGAGGCTA AGCCTGTGCC AGAAAATCAC CCACAGTGGG ATACAGCAAT AGAGGGGGAT 
GAAGACCAGG AGGACAGTGA GGGCTTTGAA GATAGCTTTG AGGAAGAAGA GGAGGAAGAA 
GAAGATGATG ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011533701.1
CDS	187..2301
Translation	MWYRLRLLKPQPNIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQEYNPYEVLNLDPGATVAEIKKQYRLLSLKYHPDKGGDEVMFMRIAKAYAALTDEESRKNWEEFGNPDGPQATSFGIALPAWIVDQKNSILVLLVYGLAFMVILPVVVGSWWYRSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFDPQYNKDATSRPTDNILIPQLIREIGSINLKKNEPPLTCPYSLKARVLLLSHLARMKIPETLEEDQQFMLKKCPALLQEMVNVICQLIVMARNREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQLPHIEEDNLRRVSNHKKYKIKTIQDLVSLKESDRHTLLHFLEDEKYEEVMAVLGSFPYVTMDIKSQVLDDEDSNNITVGSLVTVLVKLTRQTMAEVFEKEQSICAAEEQPAEDGQGETNKNRTKGGWQQKSKGPKKTAKSKKKKPLKKKPTPVLLPQSKQQKQKQANGVVGNEAAVKEDEEEVSDKGSDSEEEETNRDSQSEKDDGSDRDSDREQDEKQNKDDEAEWQELQQSIQRKERALLETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELKFPAPGKPGNYQYTVFLRSDSYMGLDQIKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEEDDD

Target ORF information:

RefSeq Version	XM_011535399.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SEC63 homolog, protein translocation regulator (SEC63), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011535399.2

ORF Insert Sequence:

ATGTGGTATC GTTTACGGTT ATTAAAACCC CAGCCAAATA TTATTCCTAC AGTAAAGAAA 
ATAGTTCTGC TTGCAGGATG GGCATTGTTC TTATTCCTTG CATATAAAGT TTCCAAAACA 
GACCGAGAAT ACCAAGAATA CAATCCTTAT GAAGTATTAA ATTTGGATCC TGGAGCCACA 
GTAGCAGAAA TTAAAAAACA ATATCGTTTG CTGTCACTTA AATATCATCC AGATAAAGGA 
GGTGATGAGG TTATGTTCAT GAGGATAGCA AAAGCTTATG CTGCTTTAAC GGATGAAGAG 
TCCCGGAAAA ATTGGGAAGA ATTTGGAAAT CCAGATGGGC CTCAAGCCAC AAGCTTTGGA 
ATTGCCCTGC CAGCTTGGAT AGTTGACCAG AAAAACTCAA TTCTGGTTTT ACTTGTATAT 
GGATTGGCAT TTATGGTTAT CCTTCCAGTT GTTGTGGGCT CTTGGTGGTA TCGCTCAATA 
CGCTATAGTG GAGACCAGAT TCTAATACGC ACAACACAGA TTTATACATA CTTTGTTTAT 
AAAACCCGAA ATATGGATAT GAAACGTCTT ATCATGGTTT TGGCTGGAGC TTCTGAATTT 
GATCCTCAGT ATAATAAAGA TGCCACAAGC AGACCAACGG ATAATATTCT AATACCACAG 
CTAATCAGAG AAATTGGCAG CATTAATTTA AAGAAGAATG AGCCTCCACT TACCTGCCCA 
TATAGCCTGA AGGCCAGAGT TCTTTTACTG TCTCATCTTG CTAGAATGAA AATTCCTGAG 
ACCCTTGAAG AAGATCAGCA ATTCATGCTA AAAAAGTGTC CTGCCCTACT TCAAGAAATG 
GTTAATGTAA TCTGCCAACT AATAGTAATG GCCCGGAACC GTGAAGAAAG GGAGTTTCGT 
GCTCCAACTT TGGCATCCCT AGAAAACTGC ATGAAGCTTT CTCAGATGGC CGTTCAGGGA 
CTTCAGCAAT TTAAGTCTCC CCTTCTGCAG CTCCCTCATA TTGAAGAGGA CAATCTTAGA 
CGGGTTTCTA ATCATAAGAA GTATAAAATT AAAACTATCC AGGATTTGGT GAGTTTAAAA 
GAATCAGATC GTCACACTCT ACTGCACTTC CTTGAAGATG AAAAATATGA AGAGGTTATG 
GCTGTCCTTG GGAGTTTTCC ATATGTGACC ATGGATATAA AATCACAGGT GTTAGATGAT 
GAAGATAGCA ACAACATCAC AGTAGGATCC TTAGTTACAG TGTTGGTTAA GTTGACAAGG 
CAAACAATGG CTGAAGTATT TGAAAAGGAG CAGTCCATCT GTGCTGCAGA GGAACAGCCA 
GCAGAAGATG GGCAGGGTGA AACTAACAAG AACAGGACAA AAGGAGGATG GCAACAGAAG 
AGTAAAGGAC CCAAGAAAAC TGCTAAATCA AAAAAAAAGA AACCTTTAAA AAAAAAACCT 
ACACCTGTGC TATTACCACA GTCAAAGCAA CAGAAACAAA AGCAGGCAAA TGGAGTCGTT 
GGGAATGAAG CTGCAGTAAA GGAAGATGAA GAAGAAGTTT CAGATAAGGG CAGTGATTCT 
GAAGAAGAAG AAACCAATAG AGATTCCCAA AGTGAGAAAG ATGATGGTAG TGACAGAGAC 
TCTGATAGAG AGCAAGATGA AAAACAAAAC AAAGATGATG AAGCAGAGTG GCAAGAATTA 
CAACAAAGCA TACAGCGAAA AGAGAGAGCT CTATTGGAAA CCAAATCAAA AATAACACAT 
CCTGTGTATA GCCTTTACTT TCCTGAGGAA AAACAAGAAT GGTGGTGGCT TTACATTGCA 
GATAGGAAGG AGCAGACATT AATATCCATG CCATATCATG TGTGTACGCT GAAAGATACA 
GAGGAGGTAG AGCTGAAGTT TCCTGCACCA GGCAAGCCTG GAAATTATCA GTATACTGTG 
TTTCTGAGAT CAGACTCCTA TATGGGTTTG GATCAGATTA AACCATTGAA GTTGGAAGTT 
CATGAGGCTA AGCCTGTGCC AGAAAATCAC CCACAGTGGG ATACAGCAAT AGAGGGGGAT 
GAAGACCAGG AGGACAGTGA GGGCTTTGAA GATAGCTTTG AGGAAGAAGA GGAGGAAGAA 
GAAGATGATG ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Liver cyst gene knockout in cholangiocytes inhibits cilium formation and Wnt signaling.
Human molecular genetics26(21)4190-4202(2017 Nov)
Wills ES,Te Morsche RHM,van Reeuwijk J,Horn N,Geomini I,van de Laarschot LFM,Mans DA,Ueffing M,Boldt K,Drenth JPH,Roepman R

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

CK2 phosphorylation of human Sec63 regulates its interaction with Sec62.
Biochimica et biophysica acta1830(4)2938-45(2013 Apr)
Ampofo E,Welker S,Jung M,M?ller L,Greiner M,Zimmermann R,Montenarh M

Loss of heterozygosity is present in SEC63 germline carriers with polycystic liver disease.
PloS one7(11)e50324(2012)
Janssen MJ,Salomon J,Te Morsche RH,Drenth JP

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SEC63 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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