Gene Symbol | AKR1C4 |
Entrez Gene ID | 1109 |
Full Name | aldo-keto reductase family 1 member C4 |
Synonyms | 3-alpha-HSD,C11,CDR,CHDR,DD-4,DD4,HAKRA |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | {46XY sex reversal 8, modifier of}, 614279 (3) |