OCLM cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OCLM
Entrez Gene ID	10896
Full Name	oculomedin
Synonyms	TISR
General protein information	Preferred Names oculomedin Names oculomedin trabecular meshwork inducible stretch response protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q31.1
Summary	The protein encoded by this gene is induced by cyclic mechanical stretching in trabecular cells of the eye and it is also expressed in retina. This protein may play a role in trabecular meshwork function and the development of glaucoma. [provided by RefSeq, Jul 2008].
Disorder MIM:	604301

mRNA and Protein(s)

mRNA	Protein	Name
NM_022375.3	NP_071770.1	oculomedin

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Protein expression, genomic structure, and polymorphisms of oculomedin.
Fujiwara N, Matsuo T, Ohtsuki H
Ophthalmic genetics24(3)141-51(2003 Sep)

Evaluation of the Oculomedin gene in the etiology of primary open angle and exfoliative glaucoma.
Jansson M, Tomic L, Larsson LI, Wadelius C
Molecular vision993-5(2003 Mar)

Absence of trabecular meshwork-inducible stretch response (TISR)/oculomedin gene and proximal promoter mutation in primary open angle glaucoma patients.
Leung YF, Baum L, Lam DS, Fan DS, Chua JK, Pang CP
Human genetics107(4)404-5(2000 Oct)

A novel gene (oculomedin) induced by mechanical stretching in human trabecular cells of the eye.
Sato Y, Matsuo T, Ohtsuki H
Biochemical and biophysical research communications259(2)349-51(1999 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

There was no evidence that the oculomedin gene participates in the etiology of glaucoma.
Title: Evaluation of the Oculomedin gene in the etiology of primary open angle and exfoliative glaucoma.

The following OCLM gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OCLM cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31916	NM_022375.3 Latest version!	Homo sapiens oculomedin (OCLM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OCLM ( NM_022375.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071770.1 Homo sapiens oculomedin (OCLM), mRNA.

Price & Availability↑

CloneID	OHu31916
Clone ID Related Accession (Same CDS sequence)	NM_022375.3
Accession Version	NM_022375.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 135bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	oculomedin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069096.1. On or before Jun 28, 2011 this sequence version replaced NM_001199906.1, NM_022375.2. ##Evidence-Data-START## Transcript exon combination :: BC069096.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

1
61
121

ATGGGGATGT ATCCACCATT ATTGTTAAAG ATTTACCTTA GCAGACACAT TAGTATACTC 
TTCTATTTAA AAATCCTTTA TAAAAGTGGT ATTATATGGC TATCCTGGTA TTCTTTCATA 
TTGTTAGTAC TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071770.1
CDS	475..609
Translation	MGMYPPLLLKIYLSRHISILFYLKILYKSGIIWLSWYSFILLVL

Target ORF information:

RefSeq Version	NM_022375.3
Organism	Homo sapiens(human)
Definition	Homo sapiens oculomedin (OCLM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022375.3

ORF Insert Sequence:

1
61
121

ATGGGGATGT ATCCACCATT ATTGTTAAAG ATTTACCTTA GCAGACACAT TAGTATACTC 
TTCTATTTAA AAATCCTTTA TAAAAGTGGT ATTATATGGC TATCCTGGTA TTCTTTCATA 
TTGTTAGTAC TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protein expression, genomic structure, and polymorphisms of oculomedin.
Ophthalmic genetics24(3)141-51(2003 Sep)
Fujiwara N,Matsuo T,Ohtsuki H

Evaluation of the Oculomedin gene in the etiology of primary open angle and exfoliative glaucoma.
Molecular vision993-5(2003 Mar)
Jansson M,Tomic L,Larsson LI,Wadelius C

Absence of trabecular meshwork-inducible stretch response (TISR)/oculomedin gene and proximal promoter mutation in primary open angle glaucoma patients.
Human genetics107(4)404-5(2000 Oct)
Leung YF,Baum L,Lam DS,Fan DS,Chua JK,Pang CP

A novel gene (oculomedin) induced by mechanical stretching in human trabecular cells of the eye.
Biochemical and biophysical research communications259(2)349-51(1999 Jun)
Sato Y,Matsuo T,Ohtsuki H

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OCLM cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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