PET100 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PET100
Entrez Gene ID	100131801
Full Name	PET100 homolog
Synonyms	C19orf79
General protein information	Preferred Names PET100 homolog Names protein PET100 homolog, mitochondrial
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	Mitochondrial complex IV, or cytochrome c oxidase, is a large transmembrane protein complex that is part of the respiratory electron transport chain of mitochondria. The small protein encoded by this gene plays a role in the biogenesis of mitochondrial complex IV. This protein localizes to the inner mitochondrial membrane and is exposed to the intermembrane space. Mutations in this gene are associated with mitochondrial complex IV deficiency. This gene has a pseudogene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Disorder MIM:	614770
Disorder Html:	Mitochondrial complex IV deficiency, 220110 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001171155.1	NP_001164626.1	protein PET100 homolog, mitochondrial
NM_001171155.2	NP_001164626.1	protein PET100 homolog, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	PET100	NP_001164626.1
	PET100	XP_001097045.1
Canis lupus familiaris (dog)	PET100	XP_005632993.1
Bos taurus (cattle)	PET100	XP_002688903.1
Rattus norvegicus (Norway rat)	Pet100	NP_001182174.1
Pan troglodytes (chimpanzee)	PET100	XP_003953382.1
Mus musculus (house mouse)	Pet100	NP_001182173.1
Danio rerio (zebrafish)	LOC100334510	XP_002661292.1
Xenopus tropicalis (tropical clawed frog)	pet100	XP_002941530.1

Gene Ontology
Bibliography

Related articles in PubMed

MR-1S Interacts with PET100 and PET117 in Module-Based Assembly of Human Cytochrome c Oxidase.
Vidoni S, Harbour ME, Guerrero-Castillo S, Signes A, Ding S, Fearnley IM, Taylor RW, Tiranti V, Arnold S, Fernandez-Vizarra E, Zeviani M
Cell reports18(7)1727-1738(2017 Feb)

A founder mutation in PET100 causes isolated complex IV deficiency in Lebanese individuals with Leigh syndrome.
Lim SC, Smith KR, Stroud DA, Compton AG, Tucker EJ, Dasvarma A, Gandolfo LC, Marum JE, McKenzie M, Peters HL, Mowat D, Procopis PG, Wilcken B, Christodoulou J, Brown GK, Ryan MT, Bahlo M, Thorburn DR
American journal of human genetics94(2)209-22(2014 Feb)

Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.
Szklarczyk R, Wanschers BF, Cuypers TD, Esseling JJ, Riemersma M, van den Brand MA, Gloerich J, Lasonder E, van den Heuvel LP, Nijtmans LG, Huynen MA
Genome biology13(2)R12(2012 Feb)

Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
Wang AG, Yoon SY, Oh JH, Jeon YJ, Kim M, Kim JM, Byun SS, Yang JO, Kim JH, Kim DG, Yeom YI, Yoo HS, Kim YS, Kim NS
Biochemical and biophysical research communications345(3)1022-32(2006 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The short isoform of the myofibrillogenesis regulator 1 (MR-1S) as a new COX assembly factor, which works with the highly conserved PET100 and PET117 chaperones to assist COX biogenesis in higher eukaryotes.
Title: MR-1S Interacts with PET100 and PET117 in Module-Based Assembly of Human Cytochrome c Oxidase.

We identify PET100 as a complex IV biogenesis factor in humans and characterize its location and role in mitochondria.We found PET100 (MIM 614770) mutations in ten Lebanese individuals with Leigh syndrome and isolated complex IV deficiency.
Title: A founder mutation in PET100 causes isolated complex IV deficiency in Lebanese individuals with Leigh syndrome.

COX assembly candidate, ortholog of fungal PET100
Title: Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.

The following PET100 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PET100 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18457	NM_001171155.2 Latest version!	Homo sapiens PET100 cytochrome c oxidase chaperone (PET100), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu18457	NM_001171155.1	Homo sapiens PET100 homolog (PET100), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PET100 ( NM_001171155.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001164626.1 Homo sapiens PET100 homolog (PET100), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18457
Clone ID Related Accession (Same CDS sequence)	NM_001171155.1 , NM_001171155.2
Accession Version	NM_001171155.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	protein PET100 homolog, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW009489.1, CD641681.1 and BU740873.1. This sequence is a reference standard in the RefSeqGene project. On or before Jan 15, 2010 this sequence version replaced XM_001726504.2, XM_001723846.2. Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein. ##Evidence-Data-START## Transcript exon combination :: BU740873.1, HY032097.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGTGA AGCTGGAGAT ATTTCGGATG ATAATCTACC TCACTTTCCC TGTGGCTATG 
TTCTGGGTTT CCAATCAGGC CGAGTGGTTT GAGGACGATG TCATACAGCG CAAGAGGGAG 
CTGTGGCCAC CTGAGAAGCT TCAAGAGATA GAGGAATTCA AAGAGAGGTT ACGGAAGCGG 
CGGGAGGAGA AGCTCCTTCG CGACGCCCAG CAGAACTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001164626.1
CDS	50..271
Translation	MGVKLEIFRMIIYLTFPVAMFWVSNQAEWFEDDVIQRKRELWPPEKLQEIEEFKERLRKRREEKLLRDAQQNS

Target ORF information:

RefSeq Version	NM_001171155.1
Organism	Homo sapiens(human)
Definition	Homo sapiens PET100 homolog (PET100), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001171155.1

ORF Insert Sequence:

ATGGGGGTGA AGCTGGAGAT ATTTCGGATG ATAATCTACC TCACTTTCCC TGTGGCTATG 
TTCTGGGTTT CCAATCAGGC CGAGTGGTTT GAGGACGATG TCATACAGCG CAAGAGGGAG 
CTGTGGCCAC CTGAGAAGCT TCAAGAGATA GAGGAATTCA AAGAGAGGTT ACGGAAGCGG 
CGGGAGGAGA AGCTCCTTCG CGACGCCCAG CAGAACTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PET100 ( NM_001171155.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001164626.1 Homo sapiens PET100 cytochrome c oxidase chaperone (PET100), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18457
Clone ID Related Accession (Same CDS sequence)	NM_001171155.1 , NM_001171155.2
Accession Version	NM_001171155.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	protein PET100 homolog, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD641681.1, BU740873.1 and AC008763.9. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001171155.1. Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein. ##Evidence-Data-START## Transcript exon combination :: CB162948.1, HY216625.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000594797.6/ ENSP00000470539.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGGTGA AGCTGGAGAT ATTTCGGATG ATAATCTACC TCACTTTCCC TGTGGCTATG 
TTCTGGGTTT CCAATCAGGC CGAGTGGTTT GAGGACGATG TCATACAGCG CAAGAGGGAG 
CTGTGGCCAC CTGAGAAGCT TCAAGAGATA GAGGAATTCA AAGAGAGGTT ACGGAAGCGG 
CGGGAGGAGA AGCTCCTTCG CGACGCCCAG CAGAACTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001164626.1
CDS	42..263
Translation	MGVKLEIFRMIIYLTFPVAMFWVSNQAEWFEDDVIQRKRELWPPEKLQEIEEFKERLRKRREEKLLRDAQQNS

Target ORF information:

RefSeq Version	NM_001171155.2
Organism	Homo sapiens(human)
Definition	Homo sapiens PET100 cytochrome c oxidase chaperone (PET100), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001171155.2

ORF Insert Sequence:

ATGGGGGTGA AGCTGGAGAT ATTTCGGATG ATAATCTACC TCACTTTCCC TGTGGCTATG 
TTCTGGGTTT CCAATCAGGC CGAGTGGTTT GAGGACGATG TCATACAGCG CAAGAGGGAG 
CTGTGGCCAC CTGAGAAGCT TCAAGAGATA GAGGAATTCA AAGAGAGGTT ACGGAAGCGG 
CGGGAGGAGA AGCTCCTTCG CGACGCCCAG CAGAACTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MR-1S Interacts with PET100 and PET117 in Module-Based Assembly of Human Cytochrome c Oxidase.
Cell reports18(7)1727-1738(2017 Feb)
Vidoni S,Harbour ME,Guerrero-Castillo S,Signes A,Ding S,Fearnley IM,Taylor RW,Tiranti V,Arnold S,Fernandez-Vizarra E,Zeviani M

A founder mutation in PET100 causes isolated complex IV deficiency in Lebanese individuals with Leigh syndrome.
American journal of human genetics94(2)209-22(2014 Feb)
Lim SC,Smith KR,Stroud DA,Compton AG,Tucker EJ,Dasvarma A,Gandolfo LC,Marum JE,McKenzie M,Peters HL,Mowat D,Procopis PG,Wilcken B,Christodoulou J,Brown GK,Ryan MT,Bahlo M,Thorburn DR

Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.
Genome biology13(2)R12(2012 Feb)
Szklarczyk R,Wanschers BF,Cuypers TD,Esseling JJ,Riemersma M,van den Brand MA,Gloerich J,Lasonder E,van den Heuvel LP,Nijtmans LG,Huynen MA

Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
Biochemical and biophysical research communications345(3)1022-32(2006 Jul)
Wang AG,Yoon SY,Oh JH,Jeon YJ,Kim M,Kim JM,Byun SS,Yang JO,Kim JH,Kim DG,Yeom YI,Yoo HS,Kim YS,Kim NS

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PET100 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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