HOXB8 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOXB8
Entrez Gene ID	395737
Full Name	homeobox B8
Synonyms	CHOX-2.4,Hoxb-8,OX2.4
General protein information	Preferred Names homeobox B8 Names homeobox protein Hox-B8 Homeobox protein Hox-2.4 homeo box B8
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204911.2	NP_990242.1	homeobox protein Hox-B8

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC100337349	XP_002695987.2
Rattus norvegicus (Norway rat)	Hoxb8	NP_001178578.1
Gallus gallus (chicken)	HOXB8	NP_990242.1
Danio rerio (zebrafish)	hoxb8a	NP_571195.1
Mus musculus (house mouse)	Hoxb8	NP_034591.1
Homo sapiens (human)	HOXB8	NP_076921.1
Canis lupus familiaris (dog)	HOXB8	XP_548179.1
Xenopus tropicalis (tropical clawed frog)	hoxb8	XP_004918718.1

Gene Ontology
Bibliography

Related articles in PubMed

A Complex Structural Variation on Chromosome 27 Leads to the Ectopic Expression of HOXB8 and the Muffs and Beard Phenotype in Chickens.
Guo Y, Gu X, Sheng Z, Wang Y, Luo C, Liu R, Qu H, Shu D, Wen J, Crooijmans RP, Carlborg ?, Zhao Y, Hu X, Li N
PLoS genetics12(6)e1006071(2016 06)

HoxB8 in noradrenergic specification and differentiation of the autonomic nervous system.
Huber L, Ferdin M, Holzmann J, Stubbusch J, Rohrer H
Developmental biology363(1)219-33(2012 Mar)

Isolation and analysis of chick homeobox cDNA clones.
Scotting PJ, Hewitt M, Keynes RJ
Nucleic acids research18(13)3999(1990 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results strongly suggest the Mb allele leading to the Muffs and beard phenotype in chickens leads to an altered ectopic expression of a homeotic gene HOXB8, to suggest a novel role for HOXB8 in modulating the regional development of the feather.
Title: A Complex Structural Variation on Chromosome 27 Leads to the Ectopic Expression of HOXB8 and the Muffs and Beard Phenotype in Chickens.

Data suggest that HoxB8 acts by maintaining noradrenergic properties transiently expressed in ciliary neuron progenitors during normal development.
Title: HoxB8 in noradrenergic specification and differentiation of the autonomic nervous system.

The following HOXB8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOXB8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa24387	NM_204911.2 Latest version!	Gallus gallus homeobox B8 (HOXB8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOXB8 ( NM_204911.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990242.1 Gallus gallus homeobox B8 (HOXB8), mRNA.

Price & Availability↑

CloneID	OGa24387
Clone ID Related Accession (Same CDS sequence)	NM_204911.2
Accession Version	NM_204911.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Gallus gallus(chicken)
Product	homeobox protein Hox-B8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U81801.1. On Mar 26, 2015 this sequence version replaced NM_204911.1. ##Evidence-Data-START## Transcript exon combination :: U81801.1 [ECO:0000332] ##Evidence-Data-END##

ATGAGCTCCT ATTTTGTCAA CTCACTCTTC TCCAAATACA AAACCGGGGA CTCGTTGCGT 
CCCAATTACT ATGACTGCGG GTTCGCTCAG GATCTTGGGG GCAGACCCAC GGTGGTGTAC 
GGACCCAGCA CGGGGGGCAC CTTCCAGCAT CCGACCCAAA TCCAGGAGTT CTACCACGGA 
GCATCCTCAC TCTCCAGCTC CCCTTACCAA CAGAATCCCT GCGCCGTGGC GTGCCATGGG 
GACCCGAGCA ACTTCTATGG CTACGACCCT TTGCAAAGGC AGAGCCTCTT CAGCGCCCAG 
GAGTCGGACT TGGTGCAGTA CACGGACTGC AAGCTTGCTG CCAGCGGCCT TGGAGAGGAG 
GCGGAGAGCT CGGAGCAGAG CCCTTCTCCG ACCCAGCTTT TCCCCTGGAT GCGACCGCAA 
GCCGCTGGAC GGAGGAGGGG GAGGCAAACC TACAGCCGCT ACCAGACGCT GGAACTGGAG 
AAGGAATTTC TATTTAATCC CTACCTGACC CGCAAACGGA GGATCGAGGT CTCGCATGCC 
CTGGGATTGA CAGAAAGGCA GGTCAAAATC TGGTTCCAGA ACAGGAGGAT GAAATGGAAA 
AAGGAAAACA ACAAAGACAA GTTTCCCAGC AGCAAATGCG AGCAGGAAGA ACTGGAAAAA 
CAGAAAATGG AAAGAGCCCA GGAGGTGGAC GAGGAAGGGG AAGCACAGAA GGCGGACAAG 
AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990242.1
CDS	42..767
Translation	MSSYFVNSLFSKYKTGDSLRPNYYDCGFAQDLGGRPTVVYGPSTGGTFQHPTQIQEFYHGASSLSSSPYQQNPCAVACHGDPSNFYGYDPLQRQSLFSAQESDLVQYTDCKLAASGLGEEAESSEQSPSPTQLFPWMRPQAAGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQEELEKQKMERAQEVDEEGEAQKADKK

Target ORF information:

RefSeq Version	NM_204911.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus homeobox B8 (HOXB8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204911.2

ORF Insert Sequence:

ATGAGCTCCT ATTTTGTCAA CTCACTCTTC TCCAAATACA AAACCGGGGA CTCGTTGCGT 
CCCAATTACT ATGACTGCGG GTTCGCTCAG GATCTTGGGG GCAGACCCAC GGTGGTGTAC 
GGACCCAGCA CGGGGGGCAC CTTCCAGCAT CCGACCCAAA TCCAGGAGTT CTACCACGGA 
GCATCCTCAC TCTCCAGCTC CCCTTACCAA CAGAATCCCT GCGCCGTGGC GTGCCATGGG 
GACCCGAGCA ACTTCTATGG CTACGACCCT TTGCAAAGGC AGAGCCTCTT CAGCGCCCAG 
GAGTCGGACT TGGTGCAGTA CACGGACTGC AAGCTTGCTG CCAGCGGCCT TGGAGAGGAG 
GCGGAGAGCT CGGAGCAGAG CCCTTCTCCG ACCCAGCTTT TCCCCTGGAT GCGACCGCAA 
GCCGCTGGAC GGAGGAGGGG GAGGCAAACC TACAGCCGCT ACCAGACGCT GGAACTGGAG 
AAGGAATTTC TATTTAATCC CTACCTGACC CGCAAACGGA GGATCGAGGT CTCGCATGCC 
CTGGGATTGA CAGAAAGGCA GGTCAAAATC TGGTTCCAGA ACAGGAGGAT GAAATGGAAA 
AAGGAAAACA ACAAAGACAA GTTTCCCAGC AGCAAATGCG AGCAGGAAGA ACTGGAAAAA 
CAGAAAATGG AAAGAGCCCA GGAGGTGGAC GAGGAAGGGG AAGCACAGAA GGCGGACAAG 
AAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Complex Structural Variation on Chromosome 27 Leads to the Ectopic Expression of HOXB8 and the Muffs and Beard Phenotype in Chickens.
PLoS genetics12(6)e1006071(2016 06)
Guo Y,Gu X,Sheng Z,Wang Y,Luo C,Liu R,Qu H,Shu D,Wen J,Crooijmans RP,Carlborg ?,Zhao Y,Hu X,Li N

HoxB8 in noradrenergic specification and differentiation of the autonomic nervous system.
Developmental biology363(1)219-33(2012 Mar)
Huber L,Ferdin M,Holzmann J,Stubbusch J,Rohrer H

Isolation and analysis of chick homeobox cDNA clones.
Nucleic acids research18(13)3999(1990 Jul)
Scotting PJ,Hewitt M,Keynes RJ