MX1 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	MX1
Entrez Gene ID	395313
Full Name	MX dynamin like GTPase 1
Synonyms	GTPase,MX
General protein information	Preferred Names MX dynamin like GTPase 1 Names interferon-induced GTP-binding protein Mx dynamin family GTP-binding interferon-inducible Mx protein myxocirus-resistance protein myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 myxovirus resistance protein 1 myxovirus resistence myxovirus-resistance protein
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204609.1	NP_989940.1	interferon-induced GTP-binding protein Mx

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MX2	XP_001171751.1
Gallus gallus (chicken)	MX1	NP_989940.1
	MX2	NP_001073164.1
Bos taurus (cattle)	MX2	NP_776366.1
Danio rerio (zebrafish)	mxc	NP_001007285.1
Homo sapiens (human)	MX2	NP_002454.1
Canis lupus familiaris (dog)	MX2	NP_001003133.1
Danio rerio (zebrafish)	mxe	NP_878287.1

Gene Ontology
Bibliography

Related articles in PubMed

Pathogenicity of Genetically Similar, H5N1 Highly Pathogenic Avian Influenza Virus Strains in Chicken and the Differences in Sensitivity among Different Chicken Breeds.
Matsuu A, Kobayashi T, Patchimasiri T, Shiina T, Suzuki S, Chaichoune K, Ratanakorn P, Hiromoto Y, Abe H, Parchariyanon S, Saito T
PloS one11(4)e0153649(2016)

[Ectopic expression of duck albumin down-regulates the expressions of IFN-? and myxovirus resistance 1 mRNA in DF-1 cells].
Tong Y, Chen Y, Xu Q, Zhu Z, Yu Q, Zhang Y, Huang Z, Chen G
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology30(9)917-20(2014 Sep)

Both antiviral activity and intracellular localization of chicken Mx protein depend on a polymorphism at amino acid position 631.
Sasaki K, Yoneda A, Ninomiya A, Kawahara M, Watanabe T
Biochemical and biophysical research communications430(1)161-6(2013 Jan)

Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers.
Wang Y, Brahmakshatriya V, Lupiani B, Reddy S, Okimoto R, Li X, Chiang H, Zhou H
Poultry science91(12)3019-24(2012 Dec)

Mx is dispensable for interferon-mediated resistance of chicken cells against influenza A virus.
Schusser B, Reuter A, von der Malsburg A, Penski N, Weigend S, Kaspers B, Staeheli P, H?rtle S
Journal of virology85(16)8307-15(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that the expression levels of chick fibroblast DF-1 interferon beta (IFN-beta) and myxovirus resistance-1 (Mx1) mRNA were down-regulated by over-expression of duck albumin (ALB) gene.
Title: [Ectopic expression of duck albumin down-regulates the expressions of IFN-? and myxovirus resistance 1 mRNA in DF-1 cells].

These results demonstrated that a single amino acid polymorphism at 631 aa of the chicken Mx protein altered both the antiviral activity and intracellular localization.
Title: Both antiviral activity and intracellular localization of chicken Mx protein depend on a polymorphism at amino acid position 631.

The current study provides valuable information on the effect of the Mx1 gene on the genetic resistance to avian influenza virus in chickens, and Mx1 will not be applicable for enhancing genetic resistance to AIV infection in chickens.
Title: Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers.

the antiviral effect of type I IFN in chicken cells was not dependent on Mx, and both isoforms of chicken Mx protein appear to lack GTPase activity
Title: Mx is dispensable for interferon-mediated resistance of chicken cells against influenza A virus.

Following intranasal infection with HPAIV strain A/Chicken/Queretaro/14588-19/1995 H5N2, chickens homozygous for Asn631 allele were significantly more resistant to disease based on early mortality, morbidity, or virus shedding than Ser631 homozygotes.
Title: Association of Mx1 Asn631 variant alleles with reductions in morbidity, early mortality, viral shedding, and cytokine responses in chickens infected with a highly pathogenic avian influenza virus.

The following MX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa27594	NM_204609.1 Latest version!	Gallus gallus myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (MX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MX1 ( NM_204609.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_989940.1 Gallus gallus myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (MX1), mRNA.

Price & Availability↑

CloneID	OGa27594
Clone ID Related Accession (Same CDS sequence)	NM_204609.1
Accession Version	NM_204609.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2118bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Gallus gallus(chicken)
Product	interferon-induced GTP-binding protein Mx
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Z23168.1. On Jan 18, 2005 this sequence version replaced XM_429240.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z23168.1, EU348752.1 [ECO:0000332] ##Evidence-Data-END##

ATGAACAATC CATGGTCCAA CTTCAGCTCA GCTTTTGGAT GTCCCATTCA GATCCCAAAG 
CAGAATAGTA ATGTACCACC TTCCTTACCA GTACCTGTAG GAGTTTTTGG GGTGCCTCTG 
CGATCAGGCT GCAGCAATCA GATGGCTTTC TGTGCACCAG AACTGACTGA CAGAAAGCCT 
GAGCATGAGC AGAAAGTGTC CAAGAGGCTG AATGACAGAG AAGAGGACAA GGATGAGGCA 
GCAGCATGCA GCTTGGACAA CCAATATGAC AGAAAGATCC AACCTTGCAT TGATCTTGTT 
GACAGCCTGA GAAAGCTTGA TATAGGAAAC GACCTGATGT TGCCTGCAAT TGCAGTGATT 
GGAGACCGGA ACTCTGGGAA AAGCTCTGTC CTTGAAGCTT TGTCTGGTGT TGCTCTTCCT 
AGGGACAAAG GTGTCATTAC TCGCTGTCCT CTGGAACTTA AACTGAAAAA AATGACAGCT 
CCGCAGGAAT GGAAAGGGGT AATTTATTAC CGCAACACAG AAATACAGCT CCAGAATGCA 
TCAGAGGTGA AGAAAGCAAT AAGAAAAGCC CAAGATATAG TGGCTGGCAC TAATGGTAGC 
ATTAGTGGAG AACTAATTTC CCTTGAAATC TGGTCTCCTG ACGTCCCAGA CCTGACACTA 
ATTGATCTTC CTGGAATTGC CAGAGAGGCC GTGGGGAACC AGCCACAAGA TAATGGCCAA 
CAGATCAAAA CACTACTTAA AAAATATATT GGCTGCAAAG AGACAATCAT TGTGGTAGTG 
GTACCATGTA ACGTGGATAT TGCAACAACA GAGGCGCTGA AAATGGCTCA AGAGGTGGAT 
CCCACAGGAG AAAGGACGCT TGGGGTCCTC ACTAAACCAG ACCTAGTGAA CGAAGGAACT 
GAAGAGACTG TCCTTAAGAT AATACAAAAC GAGGTCATCC CACTCAGAAA AGGTTATATG 
ATTGTGAAAT GTTATGGGCA AATGGACTTC TGCAACGAAT TGTCCTTCAC CTCCGCAATC 
CAGCAAGAGA GAGAATTCTT TGAGACTCAC AAACATTTCA GCACTCTTCT GGATGAAAAT 
AAGGCTACTA TCCCACATCT GGCAAATAAG CTTACAGATG AACTTGTGGG ACGTATTATT 
AAAACTTTGC CTGCAATAGA GAAGCAAGTA CATGATGCAC TGCAACAAGC AAAGAAGGAA 
CTCCAAAAGT ACACACAAAG CACACACCCA ACTGTCAGCG ATAAGACGAT TTTCCTTGTG 
GGGTTGATCA AAGCGTTTAA TGAAGACATC TCTCAGACAA TGCATGGAAA GGAATCCTGG 
TTTGGAAACG AAATCAGACT GTTTCCAAAA ATCCGCAGAG AGTTTCGGAC ATGGGGAGTA 
AAGCTCCTGG AGAGCTCTGC CAAAGTTGAA GAAATCGTAT GCAGTAAATT GCCCAAATAT 
GAAGACCAGT ACCGCGGACG GGAGTTCCCA GACTTTATCA GCTACTGGAC ATTTGAGGAC 
ATTATAAAAG AGCAAATTAC GAAGCTGGAG GAGCCAGCTG TTGCGATGCT GAACAAAGTG 
ATCTATATGG TTGAAGAGAA ATTTTTGCAG CTGGCTAACA AGCGTTTTGC TAATTTTCAG 
AACTTAAACA ACGCTGCTCA GGCCAGAATT GGTTGCATTA GTGACAGACA AGCAACGACT 
GCGAAAAATT GCATCCTGAC TCAATTTAAA ATGGAGAGAA TTATATACTG CCAGGATAAC 
ATCTACGCAG ATGATTTAAA AGCTGCCAGG GCAGAAGGCA TCAGCAAAGA TACAAAAATC 
AAAGACCTTG CTTTTGGATG TGCTTCACGT CAATGTCCCA GCTTTGCCCT GGAAATGGTT 
TCTCACGTAA AGGCCTATTT CACTGGAGCA AGTAAACGCC TGAGCAATCA GATTCCTCTG 
ATCATCCTCT CTACTGTCCT TCATGACTTT GGAAATTATT TGCAGACCTC AATGTTGCAT 
CTCTTGCAAG GAAAAGAAGA AATAAACTAT TTACTCCAGG AAGATCATGA AGCTGCTAAC 
CAGCAGAAGT TACTGACCAG CAGAATTAGT CACCTCAACA AAGCCTACCA ATACCTGGTA 
GACTTTAAGT CTCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_989940.1
CDS	141..2258
Translation	MNNPWSNFSSAFGCPIQIPKQNSNVPPSLPVPVGVFGVPLRSGCSNQMAFCAPELTDRKPEHEQKVSKRLNDREEDKDEAAACSLDNQYDRKIQPCIDLVDSLRKLDIGNDLMLPAIAVIGDRNSGKSSVLEALSGVALPRDKGVITRCPLELKLKKMTAPQEWKGVIYYRNTEIQLQNASEVKKAIRKAQDIVAGTNGSISGELISLEIWSPDVPDLTLIDLPGIAREAVGNQPQDNGQQIKTLLKKYIGCKETIIVVVVPCNVDIATTEALKMAQEVDPTGERTLGVLTKPDLVNEGTEETVLKIIQNEVIPLRKGYMIVKCYGQMDFCNELSFTSAIQQEREFFETHKHFSTLLDENKATIPHLANKLTDELVGRIIKTLPAIEKQVHDALQQAKKELQKYTQSTHPTVSDKTIFLVGLIKAFNEDISQTMHGKESWFGNEIRLFPKIRREFRTWGVKLLESSAKVEEIVCSKLPKYEDQYRGREFPDFISYWTFEDIIKEQITKLEEPAVAMLNKVIYMVEEKFLQLANKRFANFQNLNNAAQARIGCISDRQATTAKNCILTQFKMERIIYCQDNIYADDLKAARAEGISKDTKIKDLAFGCASRQCPSFALEMVSHVKAYFTGASKRLSNQIPLIILSTVLHDFGNYLQTSMLHLLQGKEEINYLLQEDHEAANQQKLLTSRISHLNKAYQYLVDFKSL

Target ORF information:

RefSeq Version	NM_204609.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (MX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204609.1

ORF Insert Sequence:

ATGAACAATC CATGGTCCAA CTTCAGCTCA GCTTTTGGAT GTCCCATTCA GATCCCAAAG 
CAGAATAGTA ATGTACCACC TTCCTTACCA GTACCTGTAG GAGTTTTTGG GGTGCCTCTG 
CGATCAGGCT GCAGCAATCA GATGGCTTTC TGTGCACCAG AACTGACTGA CAGAAAGCCT 
GAGCATGAGC AGAAAGTGTC CAAGAGGCTG AATGACAGAG AAGAGGACAA GGATGAGGCA 
GCAGCATGCA GCTTGGACAA CCAATATGAC AGAAAGATCC AACCTTGCAT TGATCTTGTT 
GACAGCCTGA GAAAGCTTGA TATAGGAAAC GACCTGATGT TGCCTGCAAT TGCAGTGATT 
GGAGACCGGA ACTCTGGGAA AAGCTCTGTC CTTGAAGCTT TGTCTGGTGT TGCTCTTCCT 
AGGGACAAAG GTGTCATTAC TCGCTGTCCT CTGGAACTTA AACTGAAAAA AATGACAGCT 
CCGCAGGAAT GGAAAGGGGT AATTTATTAC CGCAACACAG AAATACAGCT CCAGAATGCA 
TCAGAGGTGA AGAAAGCAAT AAGAAAAGCC CAAGATATAG TGGCTGGCAC TAATGGTAGC 
ATTAGTGGAG AACTAATTTC CCTTGAAATC TGGTCTCCTG ACGTCCCAGA CCTGACACTA 
ATTGATCTTC CTGGAATTGC CAGAGAGGCC GTGGGGAACC AGCCACAAGA TAATGGCCAA 
CAGATCAAAA CACTACTTAA AAAATATATT GGCTGCAAAG AGACAATCAT TGTGGTAGTG 
GTACCATGTA ACGTGGATAT TGCAACAACA GAGGCGCTGA AAATGGCTCA AGAGGTGGAT 
CCCACAGGAG AAAGGACGCT TGGGGTCCTC ACTAAACCAG ACCTAGTGAA CGAAGGAACT 
GAAGAGACTG TCCTTAAGAT AATACAAAAC GAGGTCATCC CACTCAGAAA AGGTTATATG 
ATTGTGAAAT GTTATGGGCA AATGGACTTC TGCAACGAAT TGTCCTTCAC CTCCGCAATC 
CAGCAAGAGA GAGAATTCTT TGAGACTCAC AAACATTTCA GCACTCTTCT GGATGAAAAT 
AAGGCTACTA TCCCACATCT GGCAAATAAG CTTACAGATG AACTTGTGGG ACGTATTATT 
AAAACTTTGC CTGCAATAGA GAAGCAAGTA CATGATGCAC TGCAACAAGC AAAGAAGGAA 
CTCCAAAAGT ACACACAAAG CACACACCCA ACTGTCAGCG ATAAGACGAT TTTCCTTGTG 
GGGTTGATCA AAGCGTTTAA TGAAGACATC TCTCAGACAA TGCATGGAAA GGAATCCTGG 
TTTGGAAACG AAATCAGACT GTTTCCAAAA ATCCGCAGAG AGTTTCGGAC ATGGGGAGTA 
AAGCTCCTGG AGAGCTCTGC CAAAGTTGAA GAAATCGTAT GCAGTAAATT GCCCAAATAT 
GAAGACCAGT ACCGCGGACG GGAGTTCCCA GACTTTATCA GCTACTGGAC ATTTGAGGAC 
ATTATAAAAG AGCAAATTAC GAAGCTGGAG GAGCCAGCTG TTGCGATGCT GAACAAAGTG 
ATCTATATGG TTGAAGAGAA ATTTTTGCAG CTGGCTAACA AGCGTTTTGC TAATTTTCAG 
AACTTAAACA ACGCTGCTCA GGCCAGAATT GGTTGCATTA GTGACAGACA AGCAACGACT 
GCGAAAAATT GCATCCTGAC TCAATTTAAA ATGGAGAGAA TTATATACTG CCAGGATAAC 
ATCTACGCAG ATGATTTAAA AGCTGCCAGG GCAGAAGGCA TCAGCAAAGA TACAAAAATC 
AAAGACCTTG CTTTTGGATG TGCTTCACGT CAATGTCCCA GCTTTGCCCT GGAAATGGTT 
TCTCACGTAA AGGCCTATTT CACTGGAGCA AGTAAACGCC TGAGCAATCA GATTCCTCTG 
ATCATCCTCT CTACTGTCCT TCATGACTTT GGAAATTATT TGCAGACCTC AATGTTGCAT 
CTCTTGCAAG GAAAAGAAGA AATAAACTAT TTACTCCAGG AAGATCATGA AGCTGCTAAC 
CAGCAGAAGT TACTGACCAG CAGAATTAGT CACCTCAACA AAGCCTACCA ATACCTGGTA 
GACTTTAAGT CTCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pathogenicity of Genetically Similar, H5N1 Highly Pathogenic Avian Influenza Virus Strains in Chicken and the Differences in Sensitivity among Different Chicken Breeds.
PloS one11(4)e0153649(2016)
Matsuu A,Kobayashi T,Patchimasiri T,Shiina T,Suzuki S,Chaichoune K,Ratanakorn P,Hiromoto Y,Abe H,Parchariyanon S,Saito T

[Ectopic expression of duck albumin down-regulates the expressions of IFN-? and myxovirus resistance 1 mRNA in DF-1 cells].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology30(9)917-20(2014 Sep)
Tong Y,Chen Y,Xu Q,Zhu Z,Yu Q,Zhang Y,Huang Z,Chen G

Both antiviral activity and intracellular localization of chicken Mx protein depend on a polymorphism at amino acid position 631.
Biochemical and biophysical research communications430(1)161-6(2013 Jan)
Sasaki K,Yoneda A,Ninomiya A,Kawahara M,Watanabe T

Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers.
Poultry science91(12)3019-24(2012 Dec)
Wang Y,Brahmakshatriya V,Lupiani B,Reddy S,Okimoto R,Li X,Chiang H,Zhou H

Mx is dispensable for interferon-mediated resistance of chicken cells against influenza A virus.
Journal of virology85(16)8307-15(2011 Aug)
Schusser B,Reuter A,von der Malsburg A,Penski N,Weigend S,Kaspers B,Staeheli P,H?rtle S

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MX1 cDNA ORF clone, Gallus gallus(chicken)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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