HDAC1 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	HDAC1
Entrez Gene ID	38565
Full Name	Histone deacetylase 1
Synonyms	CG7471,DHDAC1,DRpd3,DmHDAC1,Dmel\CG7471,E(var)3-64BC,HDAC,HDAC-1,Hdac,Hdac1,RPD3,Rpd3,Rpd3/HDAC,Su(var)3-26,Su(var)326,Su(var)328,dHDAC-1,dHDAC1,dRPD3,dRpd3,dmHDA401,drpd3,hdac1,l(3)04556,l(3)64Cc,rpd3,rpd[3]
General protein information	Preferred Names Histone deacetylase 1 Names CG7471 gene product from transcript CG7471-RA CG7471-PA HDAC1-PA Rpd3 Rpd3 histone deacetylase histone Deacetylase-1 histone deacetylase histone deacetylase 1 histone deacetylase 1 (HDAC1) reduced potassium dependency 3 suppressor of variegation 326
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 64B12-64B12

mRNA and Protein(s)

mRNA	Protein	Name
NM_139661.4	NP_647918.2	histone deacetylase 1

Pathways from BioSystems

Homologies

	LOC708441	XP_001096929.2
Canis lupus familiaris (dog)	HDAC1	XP_544435.2
Kluyveromyces lactis	KLLA0E01981g	XP_454037.1
Oryza sativa (rice)	Os02g0214900	NP_001046284.1
Xenopus tropicalis (tropical clawed frog)	hdac1	NP_001025564.1
Pan troglodytes (chimpanzee)	HDAC1	XP_519834.2
Pan troglodytes (chimpanzee)	HDAC1	XP_001163573.2
Mus musculus (house mouse)	Hdac1	NP_032254.1
Rattus norvegicus (Norway rat)	Hdac1	NP_001020580.1
Caenorhabditis elegans (roundworm)	hda-3	NP_493026.1
Eremothecium gossypii	AGOS_AGR395W	NP_987061.1
Magnaporthe oryzae (rice blast fungus)	MGG_05857	XP_003711681.1
Arabidopsis thaliana (thale cress)	HD1	NP_195526.1
Homo sapiens (human)	HDAC1	NP_004955.2
Neurospora crassa	NCU00824	XP_964367.1
Oryza sativa (rice)	Os06g0583400	NP_001057943.1
Drosophila melanogaster (fruit fly)	Rpd3	NP_647918.2
Saccharomyces cerevisiae (baker's yeast)	RPD3	NP_014069.1
Schizosaccharomyces pombe (fission yeast)	clr6	NP_595333.1
Bos taurus (cattle)	HDAC1	NP_001032521.1
Gallus gallus (chicken)	HDAC1	NP_989487.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006511	XP_316539.2

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hdac1/Rpd3 functions together with self-renewal transcriptional repressors to maintain the erm immature intermediate neural progenitors enhancer in an inactive but poised state in neuroblasts.
Title: An Hdac1/Rpd3-Poised Circuit Balances Continual Self-Renewal and Rapid Restriction of Developmental Potential during Asymmetric Stem Cell Division.

aken together, these results reveal that inactivation of Rpd3 independently regulates JNK and Yki activities and that both Hippo and JNK signaling pathways contribute to Rpd3 RNAi-induced apoptosis.
Title: Loss of histone deacetylase HDAC1 induces cell death in Drosophila epithelial cells through JNK and Hippo signaling.

Rpd3 accumulates in the nucleolus in the early stage of starvation, upregulates rRNA synthesis, maintains the polysome amount for translation, and finally increases stress tolerance proteins, such as autophagy-related proteins, to acquire starvation stress resistance.
Title: The Histone Deacetylase Gene Rpd3 Is Required for Starvation Stress Resistance.

This study tested the longevity effects of RPD3 on multiple nutrient levels.
Title: RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity.

Rpd3 deacetylase in the heart plays a significant role in cardiac function and longevity to systemically modulate the fly's response to the environment
Title: Heart-specific Rpd3 downregulation enhances cardiac function and longevity.

The following HDAC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HDAC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa17541	NM_139661.4 Latest version!	Drosophila melanogaster histone deacetylase 1 (HDAC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HDAC1 ( NM_139661.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_647918.2 Drosophila melanogaster histone deacetylase 1 (HDAC1), mRNA.

Price & Availability↑

CloneID	OFa17541
Clone ID Related Accession (Same CDS sequence)	NM_139661.4
Accession Version	NM_139661.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1566bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	histone deacetylase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_139661.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGCAGTCTC ACAGCAAAAA GCGCGTTTGT TACTACTACG ACAGCGACAT TGGCAACTAC 
TACTATGGCC AGGGTCATCC CATGAAGCCC CATCGCATAC GCATGACCCA CAACCTGCTG 
CTCAACTATG GGCTCTATCG AAAAATGGAA ATATACCGTC CCCATAAAGC CACTGCCGAT 
GAGATGACCA AGTTCCACTC GGACGAGTAC GTCCGGTTCT TGCGATCCAT TCGGCCGGAC 
AACATGTCGG AGTACAACAA GCAGATGCAG CGTTTCAATG TCGGCGAAGA TTGTCCCGTC 
TTCGATGGAC TATACGAGTT TTGCCAACTC TCCGCCGGAG GATCCGTAGC TGCGGCCGTA 
AAACTGAATA AGCAAGCCTC GGAGATCTGC ATCAATTGGG GCGGTGGGCT GCATCACGCC 
AAAAAATCGG AAGCCTCGGG CTTCTGCTAC GTCAACGACA TTGTTCTGGG AATTCTGGAA 
CTGCTTAAAT ACCATCAGCG TGTTCTCTAC ATAGATATAG ACGTCCATCA CGGCGATGGC 
GTGGAGGAGG CGTTCTATAC CACCGATCGT GTGATGACTG TCAGCTTCCA CAAGTACGGA 
GAGTATTTCC CGGGCACTGG CGATCTGCGA GACATTGGCG CCGGCAAGGG AAAGTACTAT 
GCGGTGAATA TACCCCTGCG TGATGGCATG GATGATGATG CGTACGAGAG CATATTTGTG 
CCCATTATCA GCAAGGTGAT GGAAACATTC CAGCCGGCAG CCGTGGTGTT GCAGTGTGGC 
GCCGATTCGC TGACTGGCGA TCGGTTAGGC TGCTTCAATC TCACCGTCAA GGGTCACGGC 
AAGTGCGTGG AGTTCGTGAA GAAATATAAC CTGCCATTCC TGATGGTCGG CGGTGGTGGT 
TATACCATTC GTAATGTATC CCGCTGCTGG ACCTATGAGA CCTCCGTTGC ACTGGCCGTG 
GAGATAGCCA ACGAACTGCC CTACAACGAT TACTTCGAGT ACTTTGGGCC CGATTTTAAG 
CTGCACATTA GTCCCAGCAA TATGACGAAT CAGAATACAT CCGAGTACCT GGAGAAGATC 
AAGAACCGTC TGTTCGAGAA CCTGCGCATG CTGCCTCACG CTCCGGGCGT TCAAATCCAA 
GCGATTCCCG AGGATGCCAT CAACGATGAG TCCGACGACG AGGACAAGGT CGACAAGGAT 
GATCGCCTGC CGCAGAGCGA CAAGGACAAG CGCATTGTGC CCGAGAACGA GTACTCCGAT 
TCGGAGGATG AGGGCGAAGG CGGTCGCAGG GATAACCGTT CGTACAAGGG TCAGCGGAAG 
CGGCCGCGTC TCGACAAGGA CACCAACAGC AACAAGGCAT CCTCAGAGAC GTCCAGCGAG 
ATCAAGGACG AAAAGGAAAA GGGCGACGGA GCTGATGGCG AGGAATCGAC GGCGTCTAAT 
ACCAATAGCA ACAACAACAG TAACAACAAG AGCGATAATG ATGCCGGAGC GACAGCTAAT 
GCCGGATCCG GTTCGGGATC AGGTTCCGGT GCCGGGGCCA AGGGCGCCAA GGAGAACAAC 
ATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_647918.2
CDS	207..1772
Translation	MQSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDEDKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSYKGQRKRPRLDKDTNSNKASSETSSEIKDEKEKGDGADGEESTASNTNSNNNSNNKSDNDAGATANAGSGSGSGSGAGAKGAKENNI

Target ORF information:

RefSeq Version	NM_139661.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster histone deacetylase 1 (HDAC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139661.4

ORF Insert Sequence:

ATGCAGTCTC ACAGCAAAAA GCGCGTTTGT TACTACTACG ACAGCGACAT TGGCAACTAC 
TACTATGGCC AGGGTCATCC CATGAAGCCC CATCGCATAC GCATGACCCA CAACCTGCTG 
CTCAACTATG GGCTCTATCG AAAAATGGAA ATATACCGTC CCCATAAAGC CACTGCCGAT 
GAGATGACCA AGTTCCACTC GGACGAGTAC GTCCGGTTCT TGCGATCCAT TCGGCCGGAC 
AACATGTCGG AGTACAACAA GCAGATGCAG CGTTTCAATG TCGGCGAAGA TTGTCCCGTC 
TTCGATGGAC TATACGAGTT TTGCCAACTC TCCGCCGGAG GATCCGTAGC TGCGGCCGTA 
AAACTGAATA AGCAAGCCTC GGAGATCTGC ATCAATTGGG GCGGTGGGCT GCATCACGCC 
AAAAAATCGG AAGCCTCGGG CTTCTGCTAC GTCAACGACA TTGTTCTGGG AATTCTGGAA 
CTGCTTAAAT ACCATCAGCG TGTTCTCTAC ATAGATATAG ACGTCCATCA CGGCGATGGC 
GTGGAGGAGG CGTTCTATAC CACCGATCGT GTGATGACTG TCAGCTTCCA CAAGTACGGA 
GAGTATTTCC CGGGCACTGG CGATCTGCGA GACATTGGCG CCGGCAAGGG AAAGTACTAT 
GCGGTGAATA TACCCCTGCG TGATGGCATG GATGATGATG CGTACGAGAG CATATTTGTG 
CCCATTATCA GCAAGGTGAT GGAAACATTC CAGCCGGCAG CCGTGGTGTT GCAGTGTGGC 
GCCGATTCGC TGACTGGCGA TCGGTTAGGC TGCTTCAATC TCACCGTCAA GGGTCACGGC 
AAGTGCGTGG AGTTCGTGAA GAAATATAAC CTGCCATTCC TGATGGTCGG CGGTGGTGGT 
TATACCATTC GTAATGTATC CCGCTGCTGG ACCTATGAGA CCTCCGTTGC ACTGGCCGTG 
GAGATAGCCA ACGAACTGCC CTACAACGAT TACTTCGAGT ACTTTGGGCC CGATTTTAAG 
CTGCACATTA GTCCCAGCAA TATGACGAAT CAGAATACAT CCGAGTACCT GGAGAAGATC 
AAGAACCGTC TGTTCGAGAA CCTGCGCATG CTGCCTCACG CTCCGGGCGT TCAAATCCAA 
GCGATTCCCG AGGATGCCAT CAACGATGAG TCCGACGACG AGGACAAGGT CGACAAGGAT 
GATCGCCTGC CGCAGAGCGA CAAGGACAAG CGCATTGTGC CCGAGAACGA GTACTCCGAT 
TCGGAGGATG AGGGCGAAGG CGGTCGCAGG GATAACCGTT CGTACAAGGG TCAGCGGAAG 
CGGCCGCGTC TCGACAAGGA CACCAACAGC AACAAGGCAT CCTCAGAGAC GTCCAGCGAG 
ATCAAGGACG AAAAGGAAAA GGGCGACGGA GCTGATGGCG AGGAATCGAC GGCGTCTAAT 
ACCAATAGCA ACAACAACAG TAACAACAAG AGCGATAATG ATGCCGGAGC GACAGCTAAT 
GCCGGATCCG GTTCGGGATC AGGTTCCGGT GCCGGGGCCA AGGGCGCCAA GGAGAACAAC 
ATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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HDAC1 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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