Hdac1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hdac1
Entrez Gene ID	297893
Full Name	histone deacetylase 1
General protein information	Preferred Names histone deacetylase 1 Names histone deacetylase 1 HD1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36

mRNA and Protein(s)

mRNA	Protein	Name
NM_001025409.1	NP_001020580.1	histone deacetylase 1

Pathways from BioSystems

Homologies

	LOC708441	XP_001096929.2
Canis lupus familiaris (dog)	HDAC1	XP_544435.2
Kluyveromyces lactis	KLLA0E01981g	XP_454037.1
Oryza sativa (rice)	Os02g0214900	NP_001046284.1
Xenopus tropicalis (tropical clawed frog)	hdac1	NP_001025564.1
Pan troglodytes (chimpanzee)	HDAC1	XP_519834.2
Pan troglodytes (chimpanzee)	HDAC1	XP_001163573.2
Mus musculus (house mouse)	Hdac1	NP_032254.1
Rattus norvegicus (Norway rat)	Hdac1	NP_001020580.1
Caenorhabditis elegans (roundworm)	hda-3	NP_493026.1
Eremothecium gossypii	AGOS_AGR395W	NP_987061.1
Magnaporthe oryzae (rice blast fungus)	MGG_05857	XP_003711681.1
Arabidopsis thaliana (thale cress)	HD1	NP_195526.1
Homo sapiens (human)	HDAC1	NP_004955.2
Neurospora crassa	NCU00824	XP_964367.1
Oryza sativa (rice)	Os06g0583400	NP_001057943.1
Drosophila melanogaster (fruit fly)	Rpd3	NP_647918.2
Saccharomyces cerevisiae (baker's yeast)	RPD3	NP_014069.1
Schizosaccharomyces pombe (fission yeast)	clr6	NP_595333.1
Bos taurus (cattle)	HDAC1	NP_001032521.1
Gallus gallus (chicken)	HDAC1	NP_989487.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006511	XP_316539.2

Gene Ontology
Bibliography

Related articles in PubMed

Histone Deacetylase 1 Inhibition Protects Against Hypoxia-Induced Swelling in H9c2 Cardiomyocytes Through Regulating Cell Stiffness.
Li Y, Zhang Z, Zhou X, Li R, Cheng Y, Shang B, Han Y, Liu B, Xie X
Circulation journal : official journal of the Japanese Circulation Society82(1)192-202(2017 Dec)

HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins.
Cai RL, Yan-Neale Y, Cueto MA, Xu H, Cohen D
The Journal of biological chemistry275(36)27909-16(2000 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Co-regulation of H3K9ac by HDAC1 and HDAC3 is important development of the pathophysiology of a schizophrenia-like phenotype.
Title: HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals.

Resveratrol restores the antinociceptive effect of morphine by reversing morphine infusion-induced spinal cord neuroinflammation and increase in TNFR1 expression. The reversal of the morphine-induced increase in TNFR1 expression by resveratrol is partially due to reversal of the morphine infusion-induced increase in HDAC1 expression.
Title: Resveratrol reverses morphine-induced neuroinflammation in morphine-tolerant rats by reversal HDAC1 expression.

In conclusion, this study demonstrates that HDAC inhibitors affect oval cells by suppressing AKT/mTOR signaling.
Title: Histone deacetylase inhibitors reduce WB-F344 oval cell viability and migration capability by suppressing AKT/mTOR signaling in?vitro.

nuclear Hdac1 may control intestinal epithelial cell metabolism by regulating the supply of acetyl groups
Title: Loss of histone deacetylase Hdac1 disrupts metabolic processes in intestinal epithelial cells.

Suggest that HDAC1 played an important role in carcinogenesis of pancreaticobiliary maljunction through the regulation of COX-2.
Title: Carcinogenic Potential of Biliary Epithelium of Congenital Choledochal Cyst Model in Rats: A Special Reference to HDAC Expression.

The following Hdac1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hdac1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13308	NM_001025409.1 Latest version!	Rattus norvegicus histone deacetylase 1 (Hdac1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$286.30 $409.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hdac1 ( NM_001025409.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001020580.1 Rattus norvegicus histone deacetylase 1 (Hdac1), mRNA.

Price & Availability↑

CloneID	ORa13308
Clone ID Related Accession (Same CDS sequence)	NM_001025409.1
Accession Version	NM_001025409.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1449bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	histone deacetylase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC097943.1. On Jul 15, 2005 this sequence version replaced XM_216349.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC097943.1, BC107476.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGCAGA CTCAGGGCAC CAAGAGGAAA GTCTGTTACT ACTACGACGG GGATGTTGGA 
AACTACTATT ATGGACAAGG GCACCCAATG AAGCCTCACC GAATCCGAAT GACTCATAAT 
TTGCTGCTCA ACTATGGTCT CTACCGAAAA ATGGAAATCT ATCGTCCTCA CAAAGCCAAC 
GCTGAGGAGA TGACCAAGTA CCACAGCGAC GACTACATCA AGTTCTTGCG TTCTATTCGC 
CCAGACAATA TGTCTGAATA CAGCAAGCAG ATGCAGAGAT TCAACGTGGG TGAGGACTGT 
CCGGTATTTG ATGGCTTGTT TGAGTTCTGT CAGTTGTCCA CGGGTGGCTC TGTCGCGAGT 
GCTGTGAAAC TCAATAAGCA GCAGACGGAC ATCGCTGTGA ACTGGGCTGG GGGCCTGCAC 
CATGCGAAGA AGTCTGAAGC ATCCGGCTTC TGTTACGTCA ATGATATTGT CTTGGCCATC 
CTGGAACTGC TAAAGTATCA CCAGAGGGTG CTGTATATTG ACATTGACAT TCACCATGGC 
GATGGCGTGG AAGAGGCCTT CTATACCACA GACCGGGTCA TGACTGTGTC CTTTCATAAA 
TACGGAGAGT ACTTCCCAGG AACTGGGGAC CTACGGGATA TTGGGGCTGG CAAAGGCAAG 
TACTACGCCG TTAACTACCC ACTGCGAGAT GGCATTGATG ATGAGTCCTA TGAAGCCATC 
TTTAAGCCAG TCATGTCCAA AGTAATGGAG ATGTTCCAGC CTAGTGCAGT GGTCCTACAG 
TGCGGCTCAG ACTCCCTGTC TGGGGATCGG CTAGGTTGCT TCAATCTGAC CATCAAAGGA 
CATGCCAAGT GTGTGGAGTT CGTGAAGAGT TTCAACTTGC CGATGCTAAT GTTGGGAGGA 
GGTGGCTATA CCATCCGTAA TGTCGCTCGG TGCTGGACTT ACGAGACAGC TGTGGCCCTG 
GACACAGAGA TCCCTAATGA GCTACCATAC AATGACTACT TTGAATACTT TGGACCAGAT 
TTCAAGCTTC ACATCAGCCC TTCCAATATG ACTAACCAGA ACACTAATGA ATACCTGGAG 
AAGATCAAGC AGCGGCTCTT TGAGAACTTG AGAATGCTGC CCCATGCCCC TGGGGTCCAA 
ATGCAGGCCA TCCCAGAGGA TGCCATCCCA GAAGAGAGCG GTGATGAGGA TGAGGAAGAC 
CCTGACAAAC GAATTTCCAT CTGCTCCTCT GACAAACGCA TTGCCTGTGA GGAGGAATTC 
TCTGATTCTG ATGAGGAGGG AGAAGGAGGT CGCAAGAACT CTTCTAACTT CAAAAAAGCC 
AAAAGAGTCA AAACAGAAGA TGAAAAAGAA AAAGATCCCG AGGAGAAAAA AGAAGTCACA 
GAAGAGGAGA AAACCAAGGA GGAGAAGCCA GAAGCCAAAG GGGTCAAAGA AGAGGTCAAG 
ATGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020580.1
CDS	19..1467
Translation	MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKMA

Target ORF information:

RefSeq Version	NM_001025409.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus histone deacetylase 1 (Hdac1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025409.1

ORF Insert Sequence:

ATGGCGCAGA CTCAGGGCAC CAAGAGGAAA GTCTGTTACT ACTACGACGG GGATGTTGGA 
AACTACTATT ATGGACAAGG GCACCCAATG AAGCCTCACC GAATCCGAAT GACTCATAAT 
TTGCTGCTCA ACTATGGTCT CTACCGAAAA ATGGAAATCT ATCGTCCTCA CAAAGCCAAC 
GCTGAGGAGA TGACCAAGTA CCACAGCGAC GACTACATCA AGTTCTTGCG TTCTATTCGC 
CCAGACAATA TGTCTGAATA CAGCAAGCAG ATGCAGAGAT TCAACGTGGG TGAGGACTGT 
CCGGTATTTG ATGGCTTGTT TGAGTTCTGT CAGTTGTCCA CGGGTGGCTC TGTCGCGAGT 
GCTGTGAAAC TCAATAAGCA GCAGACGGAC ATCGCTGTGA ACTGGGCTGG GGGCCTGCAC 
CATGCGAAGA AGTCTGAAGC ATCCGGCTTC TGTTACGTCA ATGATATTGT CTTGGCCATC 
CTGGAACTGC TAAAGTATCA CCAGAGGGTG CTGTATATTG ACATTGACAT TCACCATGGC 
GATGGCGTGG AAGAGGCCTT CTATACCACA GACCGGGTCA TGACTGTGTC CTTTCATAAA 
TACGGAGAGT ACTTCCCAGG AACTGGGGAC CTACGGGATA TTGGGGCTGG CAAAGGCAAG 
TACTACGCCG TTAACTACCC ACTGCGAGAT GGCATTGATG ATGAGTCCTA TGAAGCCATC 
TTTAAGCCAG TCATGTCCAA AGTAATGGAG ATGTTCCAGC CTAGTGCAGT GGTCCTACAG 
TGCGGCTCAG ACTCCCTGTC TGGGGATCGG CTAGGTTGCT TCAATCTGAC CATCAAAGGA 
CATGCCAAGT GTGTGGAGTT CGTGAAGAGT TTCAACTTGC CGATGCTAAT GTTGGGAGGA 
GGTGGCTATA CCATCCGTAA TGTCGCTCGG TGCTGGACTT ACGAGACAGC TGTGGCCCTG 
GACACAGAGA TCCCTAATGA GCTACCATAC AATGACTACT TTGAATACTT TGGACCAGAT 
TTCAAGCTTC ACATCAGCCC TTCCAATATG ACTAACCAGA ACACTAATGA ATACCTGGAG 
AAGATCAAGC AGCGGCTCTT TGAGAACTTG AGAATGCTGC CCCATGCCCC TGGGGTCCAA 
ATGCAGGCCA TCCCAGAGGA TGCCATCCCA GAAGAGAGCG GTGATGAGGA TGAGGAAGAC 
CCTGACAAAC GAATTTCCAT CTGCTCCTCT GACAAACGCA TTGCCTGTGA GGAGGAATTC 
TCTGATTCTG ATGAGGAGGG AGAAGGAGGT CGCAAGAACT CTTCTAACTT CAAAAAAGCC 
AAAAGAGTCA AAACAGAAGA TGAAAAAGAA AAAGATCCCG AGGAGAAAAA AGAAGTCACA 
GAAGAGGAGA AAACCAAGGA GGAGAAGCCA GAAGCCAAAG GGGTCAAAGA AGAGGTCAAG 
ATGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Histone Deacetylase 1 Inhibition Protects Against Hypoxia-Induced Swelling in H9c2 Cardiomyocytes Through Regulating Cell Stiffness.
Circulation journal : official journal of the Japanese Circulation Society82(1)192-202(2017 Dec)
Li Y,Zhang Z,Zhou X,Li R,Cheng Y,Shang B,Han Y,Liu B,Xie X

HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins.
The Journal of biological chemistry275(36)27909-16(2000 Sep)
Cai RL,Yan-Neale Y,Cueto MA,Xu H,Cohen D

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Hdac1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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