Akh cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Akh
Entrez Gene ID	38495
Full Name	Adipokinetic hormone
Synonyms	AKH,AKH1,CG1171,Dmel\CG1171,Drm-AKH,Hrth,akh,dAkh
General protein information	Preferred Names Adipokinetic hormone Names CG1171 gene product from transcript CG1171-RA Akh-PA CG1171-PA Hypertrehaloseaemic-hormone adipo- kinetic hormone adipokinetic hormone adipokinetic hormone-like
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 64A7-64A7

mRNA and Protein(s)

mRNA	Protein	Name
NM_079194.2	NP_523918.1	adipokinetic hormone

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

During adulthood, however, AKH regulates body fat content and the hemolymph sugar level as well as nutritional and oxidative stress responses. Finally, we provide evidence for a negative autoregulatory loop in Akh gene regulation.
Title: Energy Homeostasis Control in Drosophila Adipokinetic Hormone Mutants.

Akh is an important regulator of metabolic homeostasis in Drosophila
Title: Targeted mutagenesis and functional analysis of adipokinetic hormone-encoding gene in Drosophila.

Data (including data from studies using transgenic flies) suggest that FoxO (forkhead box sub-group O) acts downstream of AKH (adipokinetic hormone) as transcription factor to mediate response to oxidative stress.
Title: Knockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila--a role for dFoxO?

AKH signaling is required in insulin-producing cells for sugar-dependent Dilp3 release.
Title: Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3.

Loss of ppk28 increased neuronal glucagon-like adipokinetic hormone (AKH) signaling, and the AKH receptor was necessary for ppk28 mutant effects.
Title: Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling.

The following Akh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Akh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa17470	NM_079194.2 Latest version!	Drosophila melanogaster adipokinetic hormone (Akh), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Akh ( NM_079194.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_523918.1 Drosophila melanogaster adipokinetic hormone (Akh), mRNA.

Price & Availability↑

CloneID	OFa17470
Clone ID Related Accession (Same CDS sequence)	NM_079194.2
Accession Version	NM_079194.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 240bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	adipokinetic hormone
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Dec 17, 2009 this sequence version replaced NM_079194.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGAATCCCA AGAGCGAAGT CCTCATTGCA GCCGTGCTCT TCATGCTGCT GGCCTGCGTC 
CAGTGTCAAT TGACCTTCTC GCCGGATTGG GGCAAGCGTT CGGTGGGCGG AGCTGGTCCT 
GGAACCTTTT TCGAGACACA GCAGGGCAAC TGCAAGACCT CCAACGAAAT GCTGCTCGAG 
ATCTTCCGCT TCGTGCAATC TCAGGCACAG CTCTTTCTGG ACTGCAAGCA CCGCGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_523918.1
CDS	120..359
Translation	MNPKSEVLIAAVLFMLLACVQCQLTFSPDWGKRSVGGAGPGTFFETQQGNCKTSNEMLLEIFRFVQSQAQLFLDCKHRE

Target ORF information:

RefSeq Version	NM_079194.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster adipokinetic hormone (Akh), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079194.2

ORF Insert Sequence:

ATGAATCCCA AGAGCGAAGT CCTCATTGCA GCCGTGCTCT TCATGCTGCT GGCCTGCGTC 
CAGTGTCAAT TGACCTTCTC GCCGGATTGG GGCAAGCGTT CGGTGGGCGG AGCTGGTCCT 
GGAACCTTTT TCGAGACACA GCAGGGCAAC TGCAAGACCT CCAACGAAAT GCTGCTCGAG 
ATCTTCCGCT TCGTGCAATC TCAGGCACAG CTCTTTCTGG ACTGCAAGCA CCGCGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Akh cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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