Cyp6a2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cyp6a2
Entrez Gene ID	35587
Full Name	Cytochrome P450-6a2
Synonyms	143127_at,6a2,91-R,91R,CG9438,CYP6A2,CYP6a2,Cyp6A2,Cyp6a,Cyt-P450-B1,Dmel\CG9438,P-450,P-450-B,P450,P450-B,P450-B1,cyp6a2
General protein information	Preferred Names Cytochrome P450-6a2 Names CG9438 gene product from transcript CG9438-RA CG9438-PA Cyp6a2-PA cytochrome P450 cytochrome P450 6a2 cytochrome P450 B1 cytochrome P450-6a2 cytochrome P450-B1
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 42D1-42D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_078904.2	NP_523628.1	cytochrome P450-6a2

Pathways from BioSystems

Homologies

Homo sapiens (human)	TBXAS1	NP_001052.2
Rattus norvegicus (Norway rat)	Tbxas1	NP_036819.1
Gallus gallus (chicken)	TBXAS1	XP_416334.4
Danio rerio (zebrafish)	tbxas1	NP_991172.1
Drosophila melanogaster (fruit fly)	Cyp6a20	NP_611002.3
Drosophila melanogaster (fruit fly)	Cyp6a21	NP_611003.2
Drosophila melanogaster (fruit fly)	Cyp6a19	NP_611001.2
Drosophila melanogaster (fruit fly)	Cyp6a23	NP_611000.2
Drosophila melanogaster (fruit fly)	Cyp6a17	NP_652018.1
Arabidopsis thaliana (thale cress)	CYP711A1	NP_565617.2
Oryza sativa (rice)	Os01g0701300	NP_001172524.1
Oryza sativa (rice)	Os01g0700900	NP_001043986.1
Xenopus tropicalis (tropical clawed frog)	tbxas1	NP_001164997.1
Mus musculus (house mouse)	Tbxas1	NP_035669.3
Drosophila melanogaster (fruit fly)	Cyp6a2	NP_523628.1
Drosophila melanogaster (fruit fly)	Cyp6a9	NP_523748.2
Oryza sativa (rice)	Os01g0701500	NP_001043989.2
Canis lupus familiaris (dog)	TBXAS1	XP_539887.2
Bos taurus (cattle)	TBXAS1	NP_001039492.1
Drosophila melanogaster (fruit fly)	Cyp6a18	NP_651563.1
Drosophila melanogaster (fruit fly)	Cyp6a8	NP_523749.2
Drosophila melanogaster (fruit fly)	Cyp6a22	NP_652075.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Overexpression of functional Cyp6a2 was consistently associated with DDT resistance. Luciferase reporter gene assays revealed that an intact Nrf2/Maf binding site in the 5'-promoter core region enhanced the constitutive transcription of Cyp6a2.
Title: Nrf2/Maf-binding-site-containing functional Cyp6a2 allele is associated with DDT resistance in Drosophila?melanogaster.

We find that Imidacloprid does not induce expression of the analyzed Cyp6g1 and Cyp6a2 genes.
Title: Imidacloprid does not induce Cyp genes involved in insecticide resistance of a mutant Drosophila melanogaster line.

The active site of CYP6G1 is significantly smaller than that of CYP6A2 or the CYP3A4.
Title: Homology modelling of Drosophila cytochrome P450 enzymes associated with insecticide resistance.

point mutations in cytochrome P450 Cyp6a2 can have a prominent role in insecticide resistance
Title: Point mutations associated with insecticide resistance in the Drosophila cytochrome P450 Cyp6a2 enable DDT metabolism.

The following Cyp6a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cyp6a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa09058	NM_078904.2 Latest version!	Drosophila melanogaster cytochrome P450-6a2 (Cyp6a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cyp6a2 ( NM_078904.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_523628.1 Drosophila melanogaster cytochrome P450-6a2 (Cyp6a2), mRNA.

Price & Availability↑

CloneID	OFa09058
Clone ID Related Accession (Same CDS sequence)	NM_078904.2
Accession Version	NM_078904.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1521bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	cytochrome P450-6a2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jan 16, 2013 this sequence version replaced NM_078904.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTTTGTTC TAATATACCT GTTGATCGCG ATCTCCTCGC TTTTGGCCTA CTTGTACCAC 
CGCAACTTCA ACTACTGGAA TCGCCGCGGC GTGCCACACG ATGCTCCTCA CCCACTGTAT 
GGCAACATGG TCGGGTTCCG GAAGAACCGG GTGATGCACG ACTTCTTCTA CGACTACTAC 
AACAAGTACC GGAAGAGCGG CTTTCCCTTC GTGGGCTTTT ACTTTCTGCA CAAGCCGGCC 
GCCTTCATCG TGGACACCCA GCTGGCCAAG AACATCCTGA TCAAGGATTT CTCGAACTTT 
GCCGATCGTG GCCAGTTTCA CAACGGGCGC GACGACCCGC TCACGCAGCA CCTGTTCAAC 
CTGGACGGAA AGAAGTGGAA GGACATGCGC CAGAGGCTGA CGCCGACTTT CACCTCGGGC 
AAGATGAAGT TCATGTTCCC GACGGTGATC AAGGTGTCTG AGGAGTTCGT CAAGGTGATC 
ACGGAGCAGG TGCCCGCCGC CCAGAACGGC GCTGTGCTCG AGATCAAGGA GCTGATGGCC 
AGGTTCACCA CCGATGTGAT TGGCACCTGT GCCTTCGGCA TTGAGTGTAA CACGCTGCGC 
ACCCCTGTCA GTGATTTCCG CACCATGGGA CAGAAGGTGT TCACCGATAT GCGCCACGGG 
AAACTGCTGA CCATGTTCGT GTTCAGCTTT CCCAAGCTGG CCAGCAGGTT GAGAATGCGC 
ATGATGCCCG AGGACGTCCA CCAGTTCTTC ATGCGCCTGG TCAACGACAC GATTGCCCTC 
AGGGAGCGGG AGAACTTCAA GAGGAACGAC TTCATGAACC TGCTGATTGA ACTGAAGCAG 
AAGGGGCGCG TCACCCTGGA CAACGGAGAG GTGATCGAGG GCATGGACAT CGGCGAACTG 
GCCGCCCAGG TGTTCGTCTT TTATGTGGCC GGATTTGAGA CCTCCTCCTC GACAATGAGT 
TACTGCCTGT ATGAGTTGGC TCAGAATCAG GACATTCAGG ACAGGCTGCG CAACGAGATC 
CAAACGGTGC TGGAGGAACA GGAGGGGCAG CTAACGTACG AATCCATCAA AGCCATGACC 
TACTTGAACC AGGTCATCTC AGAAACCCTG AGGCTCTACA CACTGGTGCC CCACCTCGAA 
CGGAAGGCCC TCAACGACTA CGTGGTGCCG GGCCATGAAA AGCTTGTGAT TGAGAAGGGC 
ACACAGGTCA TAATCCCCGC TTGCGCCTAC CACCGCGACG AGGATCTTTA TCCGAATCCG 
GAGACCTTTG ATCCGGAGCG CTTCTCGCCG GAGAAAGTGG CCGCCCGGGA GTCCGTGGAG 
TGGCTGCCCT TCGGCGACGG GCCGCGGAAC TGCATCGGGA TGCGGTTTGG ACAAATGCAG 
GCTCGCATCG GTTTGGCTCA GATCATCAGC CGGTTCAGGG TATCCGTCTG CGATACGACA 
GAGATCCCAC TGAAGTATAG TCCCATGTCC ATAGTTTTGG GCACCGTTGG GGGCATCTAC 
TTGCGAGTGG AACGCATCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_523628.1
CDS	60..1580
Translation	MFVLIYLLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRMMPEDVHQFFMRLVNDTIALRERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVLGTVGGIYLRVERI

Target ORF information:

RefSeq Version	NM_078904.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster cytochrome P450-6a2 (Cyp6a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_078904.2

ORF Insert Sequence:

ATGTTTGTTC TAATATACCT GTTGATCGCG ATCTCCTCGC TTTTGGCCTA CTTGTACCAC 
CGCAACTTCA ACTACTGGAA TCGCCGCGGC GTGCCACACG ATGCTCCTCA CCCACTGTAT 
GGCAACATGG TCGGGTTCCG GAAGAACCGG GTGATGCACG ACTTCTTCTA CGACTACTAC 
AACAAGTACC GGAAGAGCGG CTTTCCCTTC GTGGGCTTTT ACTTTCTGCA CAAGCCGGCC 
GCCTTCATCG TGGACACCCA GCTGGCCAAG AACATCCTGA TCAAGGATTT CTCGAACTTT 
GCCGATCGTG GCCAGTTTCA CAACGGGCGC GACGACCCGC TCACGCAGCA CCTGTTCAAC 
CTGGACGGAA AGAAGTGGAA GGACATGCGC CAGAGGCTGA CGCCGACTTT CACCTCGGGC 
AAGATGAAGT TCATGTTCCC GACGGTGATC AAGGTGTCTG AGGAGTTCGT CAAGGTGATC 
ACGGAGCAGG TGCCCGCCGC CCAGAACGGC GCTGTGCTCG AGATCAAGGA GCTGATGGCC 
AGGTTCACCA CCGATGTGAT TGGCACCTGT GCCTTCGGCA TTGAGTGTAA CACGCTGCGC 
ACCCCTGTCA GTGATTTCCG CACCATGGGA CAGAAGGTGT TCACCGATAT GCGCCACGGG 
AAACTGCTGA CCATGTTCGT GTTCAGCTTT CCCAAGCTGG CCAGCAGGTT GAGAATGCGC 
ATGATGCCCG AGGACGTCCA CCAGTTCTTC ATGCGCCTGG TCAACGACAC GATTGCCCTC 
AGGGAGCGGG AGAACTTCAA GAGGAACGAC TTCATGAACC TGCTGATTGA ACTGAAGCAG 
AAGGGGCGCG TCACCCTGGA CAACGGAGAG GTGATCGAGG GCATGGACAT CGGCGAACTG 
GCCGCCCAGG TGTTCGTCTT TTATGTGGCC GGATTTGAGA CCTCCTCCTC GACAATGAGT 
TACTGCCTGT ATGAGTTGGC TCAGAATCAG GACATTCAGG ACAGGCTGCG CAACGAGATC 
CAAACGGTGC TGGAGGAACA GGAGGGGCAG CTAACGTACG AATCCATCAA AGCCATGACC 
TACTTGAACC AGGTCATCTC AGAAACCCTG AGGCTCTACA CACTGGTGCC CCACCTCGAA 
CGGAAGGCCC TCAACGACTA CGTGGTGCCG GGCCATGAAA AGCTTGTGAT TGAGAAGGGC 
ACACAGGTCA TAATCCCCGC TTGCGCCTAC CACCGCGACG AGGATCTTTA TCCGAATCCG 
GAGACCTTTG ATCCGGAGCG CTTCTCGCCG GAGAAAGTGG CCGCCCGGGA GTCCGTGGAG 
TGGCTGCCCT TCGGCGACGG GCCGCGGAAC TGCATCGGGA TGCGGTTTGG ACAAATGCAG 
GCTCGCATCG GTTTGGCTCA GATCATCAGC CGGTTCAGGG TATCCGTCTG CGATACGACA 
GAGATCCCAC TGAAGTATAG TCCCATGTCC ATAGTTTTGG GCACCGTTGG GGGCATCTAC 
TTGCGAGTGG AACGCATCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Cyp6a2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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