qvr cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	qvr
Entrez Gene ID	2768718
Full Name	quiver
Synonyms	BcDNA:GH06755,CG30032,CG33472,Dmel\CG33472,anon-WO02059370.1,mdcds_22455,sss
General protein information	Preferred Names quiver Names CG33472 gene product from transcript CG33472-RC CG33472-PB CG33472-PC qvr-PB qvr-PC sleepless
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 47F13-47F13\|2-62 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001144174.3	NP_001137646.1	quiver, isoform B
NM_001299389.1	NP_001286318.1	quiver, isoform C

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

QVR/SSS, and by extension perhaps other Ly6 proteins, target effector molecules using limited protein motifs.
Title: Structural Analysis and Deletion Mutagenesis Define Regions of QUIVER/SLEEPLESS that Are Responsible for Interactions with Shaker-Type Potassium Channels and Nicotinic Acetylcholine Receptors.

role in controlling excitability and synaptic transmission in fundamental processes of the nervous system such as sleep
Title: SLEEPLESS is a bifunctional regulator of excitability and cholinergic synaptic transmission.

Day-night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis.
Title: Day-night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis.

This study demonstrated that SLEEPLESS (SSS) protein modulates Shaker channel activity, possibly through a direct interaction at the plasma membrane.
Title: Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K(+) channels.

Two different functional states of Shaker I(A) current are observed in qvr larval muscles, as reflected by two distinct components differing in their kinetics of recovery from inactivation and sensitivity to a potassium channel blocker.
Title: Modulation of the frequency response of Shaker potassium channels by the quiver peptide suggesting a novel extracellular interaction mechanism.

The following qvr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the qvr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa11769	NM_001144174.3 Latest version!	Drosophila melanogaster quiver (qvr), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OFa22350	NM_001299389.1 Latest version!	Drosophila melanogaster quiver (qvr), transcript variant C, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

qvr ( NM_001144174.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001137646.1 Drosophila melanogaster quiver (qvr), transcript variant B, mRNA.

Price & Availability↑

CloneID	OFa11769
Clone ID Related Accession (Same CDS sequence)	NM_001144174.3
Accession Version	NM_001144174.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	quiver, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_001144174.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTGGACGC AGAGAAATGC AGTTGGCAAT TGGCTGTTGG TATTAACAGC CGTTATCGGA 
TTTCTAACTT TCATATGGAT TCCGCAGACC TCAGCCGAAT GTCAAACGCG ATCGATTTAC 
TGCTATGAGT GCGACTCCTG GACTGATGCC CGCTGCAAGG ATCCTTTCAA CTATACAGCC 
CTGCCAAGGG ACCAACCTCC CTTGATGACC TGCAACGGTT GCTGCGTGAA AATGGTGCGG 
CATCAGAGAT CACCGTACGA GGTGGTGCGA CGCATGTGTA CGTCACAGTT ACAGATCAAT 
TTATTCATGG TCGATCACGT GTGCATGATG GAAAGTTCAG GCAATGGACA TATGTGCTTT 
TGTGAGGAAG ATATGTGCAA TTCTAGTAAA AATTTACACA CTAATGGTTG CCAGCTGCAT 
CTCATACCCA TCGCAGTGGC AGTATCTTGG CTAATGGGTC AATTGCTCAG CAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001137646.1
CDS	725..1201
Translation	MWTQRNAVGNWLLVLTAVIGFLTFIWIPQTSAECQTRSIYCYECDSWTDARCKDPFNYTALPRDQPPLMTCNGCCVKMVRHQRSPYEVVRRMCTSQLQINLFMVDHVCMMESSGNGHMCFCEEDMCNSSKNLHTNGCQLHLIPIAVAVSWLMGQLLSR

Target ORF information:

RefSeq Version	NM_001144174.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster quiver (qvr), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001144174.3

ORF Insert Sequence:

ATGTGGACGC AGAGAAATGC AGTTGGCAAT TGGCTGTTGG TATTAACAGC CGTTATCGGA 
TTTCTAACTT TCATATGGAT TCCGCAGACC TCAGCCGAAT GTCAAACGCG ATCGATTTAC 
TGCTATGAGT GCGACTCCTG GACTGATGCC CGCTGCAAGG ATCCTTTCAA CTATACAGCC 
CTGCCAAGGG ACCAACCTCC CTTGATGACC TGCAACGGTT GCTGCGTGAA AATGGTGCGG 
CATCAGAGAT CACCGTACGA GGTGGTGCGA CGCATGTGTA CGTCACAGTT ACAGATCAAT 
TTATTCATGG TCGATCACGT GTGCATGATG GAAAGTTCAG GCAATGGACA TATGTGCTTT 
TGTGAGGAAG ATATGTGCAA TTCTAGTAAA AATTTACACA CTAATGGTTG CCAGCTGCAT 
CTCATACCCA TCGCAGTGGC AGTATCTTGG CTAATGGGTC AATTGCTCAG CAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

qvr ( NM_001299389.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001286318.1 Drosophila melanogaster quiver (qvr), transcript variant C, mRNA.

Price & Availability↑

CloneID	OFa22350
Clone ID Related Accession (Same CDS sequence)	NM_001299389.1
Accession Version	NM_001299389.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 468bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	quiver, isoform C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTGGACGC AGAGAAATGC AGTTGGCAAT TGGCTGTTGG TATTAACAGT TTTTTTGGCA 
TTGGCAAAAT TCGCTACCAC CGATAATTGT TTTCCAACGC GATCGATTTA CTGCTATGAG 
TGCGACTCCT GGACTGATGC CCGCTGCAAG GATCCTTTCA ACTATACAGC CCTGCCAAGG 
GACCAACCTC CCTTGATGAC CTGCAACGGT TGCTGCGTGA AAATGGTGCG GCATCAGAGA 
TCACCGTACG AGGTGGTGCG ACGCATGTGT ACGTCACAGT TACAGATCAA TTTATTCATG 
GTCGATCACG TGTGCATGAT GGAAAGTTCA GGCAATGGAC ATATGTGCTT TTGTGAGGAA 
GATATGTGCA ATTCTAGTAA AAATTTACAC ACTAATGGTT GCCAGCTGCA TCTCATACCC 
ATCGCAGTGG CAGTATCTTG GCTAATGGGT CAATTGCTCA GCAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001286318.1
CDS	725..1192
Translation	MWTQRNAVGNWLLVLTVFLALAKFATTDNCFPTRSIYCYECDSWTDARCKDPFNYTALPRDQPPLMTCNGCCVKMVRHQRSPYEVVRRMCTSQLQINLFMVDHVCMMESSGNGHMCFCEEDMCNSSKNLHTNGCQLHLIPIAVAVSWLMGQLLSR

Target ORF information:

RefSeq Version	NM_001299389.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster quiver (qvr), transcript variant C, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001299389.1

ORF Insert Sequence:

ATGTGGACGC AGAGAAATGC AGTTGGCAAT TGGCTGTTGG TATTAACAGT TTTTTTGGCA 
TTGGCAAAAT TCGCTACCAC CGATAATTGT TTTCCAACGC GATCGATTTA CTGCTATGAG 
TGCGACTCCT GGACTGATGC CCGCTGCAAG GATCCTTTCA ACTATACAGC CCTGCCAAGG 
GACCAACCTC CCTTGATGAC CTGCAACGGT TGCTGCGTGA AAATGGTGCG GCATCAGAGA 
TCACCGTACG AGGTGGTGCG ACGCATGTGT ACGTCACAGT TACAGATCAA TTTATTCATG 
GTCGATCACG TGTGCATGAT GGAAAGTTCA GGCAATGGAC ATATGTGCTT TTGTGAGGAA 
GATATGTGCA ATTCTAGTAA AAATTTACAC ACTAATGGTT GCCAGCTGCA TCTCATACCC 
ATCGCAGTGG CAGTATCTTG GCTAATGGGT CAATTGCTCA GCAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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qvr cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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